Did You Know...
...that after Parker Brothers executives turned down the game of Monopoly because it had "52 fundamental errors" (including taking too long to play), a copy of the game wound up in the home of the company president who stayed up until 1 a.m. to finish playing it? He was so impressed by the game that the next day he wrote to inventor Charles Darrow and offered to buy it!
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| Number | Title | Issue Date |
| 8158828 | Nuclear receptor binding agents The present invention relates to a novel class of selective estrogen receptor modulators (SERMs). The SERM compounds are applicable for use in the prevention and/or treatment of a variety of diseases and conditions including prevention and treatment of cancers such ... | 04/17/2012 |
| 8097759 | Inflammatory cytokine release inhibitor A medicament having inhibitory activity against NF-κB activation, which comprises a compound represented by the following general formula (I) or a pharmacologically acceptable salt as an active ingredient: wherein X repres... | 01/17/2012 |
| 7514583 | Compounds, compositions and methods for the treatment of amyloid diseases and synucleinopathies such as alzheimer's disease, type 2 diabetes, and parkinson's disease Bis- and tris-dihydroxyaryl compounds and their methylenedioxy analogs and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of amyloid diseases, especially Aβ amyloidosis, such as obser... | 04/07/2009 |
| 7300991 | Cationic conductor, its intermediate, and lithium secondary battery using the conductor The disclosure discloses a polymer represented by the general formula, wherein Rp is a residue of a polymer of a compound having a polymerizable unsaturated bond, Q is an organic residue of n+1 valence... | 11/27/2007 |
| 7202383 | Compounds useful for modulating abnormal cell proliferation There is described compounds of Formula I, and salts, solvates and hydrates thereof: wherein: R1, R2 and R3 are each independently selected from OH, C1-6alkyl, OC1... | 04/10/2007 |
| 7132455 | Phthalamide derivatives This invention relates to novel phthalamide derivatives of formula (I) wherein R1, R2, R3, R4, and R5 have the meanings given in the... | 11/07/2006 |
| 7055183 | Method and apparatus for cleaning and disinfecting a toilet system in a transport vehicle such as a passenger aircraft Water, preferably fresh potable water, is electrochemically, e.g. electrolytically, treated to achieve disinfectant properties. The electrochemically treated water is sprayed onto the toilet seat and directed into the toilet bowl for each flush cycle of an aircraft ... | 06/06/2006 |
| 7041702 | Pharmaceutically active compounds and methods of use The present invention relates to pharmaceutically acceptable compounds, including acylguanidine compounds, and methods of treatment and pharmaceutical compositions that utilize or comprise one or more such compounds. Compounds of the invention are particularly usefu... | 05/09/2006 |
| 6900344 | Method of preparing alkylated salicylamides via a dicarboxylate intermediate The present invention relates to a method of preparing an alkylated salicylamide from a protected and activated salicylamide via a dicarboxylated salicylamide intermediate. The present invention also relates to dicarboxylic salicylamide delivery agent compounds for ... | 05/31/2005 |
| 5958376 | Iodinated X-ray contrast media The invention provides iodinated bis phenyl compounds, useful as X-ray contrast agents, of formula (I) (wherein each C6 R5 moiety may be the same or different; each denotes a hydrogen or iodine atom or a group M, two or three non-adj... | 09/28/1999 |
| 5922771 | Benzocycloalkene compounds, their production and use A compound of the formula ##STR1## wherein R1 and R2 independently represent H or an optionally substituted hydrocarbon group; R3 represents an optionally substituted hydrocarbon group; R4 represents H or a... | 07/13/1999 |
| 5747539 | Fluorine-containing benzoylguanidines Fluorine-containing benzoylguanidines of the formula I ##STR1## in which R1, R2 and R3 have the meanings indicated, and their physiologically acceptable salts, have antiarrhythmic properties and act as inhibitors of t... | 05/05/1998 |
| 5683705 | Sulfur-based amides and bis-amides useful against skin disorders Novel sulfhydryl group-containing amides and disulfide group-containing bis-amides useful for treating or preventing an abnormal biological condition or a disease, and/or improving the texture or appearance of the skin, as well as compositions containing ... | 11/04/1997 |
| 5637121 | Poly(oxyalkylene) aromatic amides and fuel compositions containing the same Poly(oxyalkylene) aromatic amides having the formula: ##STR1## or a fuel-soluble salt thereof; wherein a is hydroxy, nitro, amino, N-alkylamino wherein the alkyl group contains 1 to 6 carbon atoms, or N,N-dialkylamino wherein each alkyl group indepen... | 06/10/1997 |
| 5614550 | Amide and urea derivatives having anti-hypercholesteremic activity, their preparation and their therapeutic uses Compounds of formula (I) are provided: ##STR1## wherein: R1 represents an alkyl group; or a group of formula (II), (III), (IV) or (V): ##STR2## and wherein the groups R2, R3, R4 and R5 are h... | 03/25/1997 |
| 5543572 | Monocarboxamides of polyamines Monocarboxamides of formula I ##STR1## wherein R is a radical of formula ##STR2## C9 -C19 alkyl, C9 -C19 alkenyl or C9 -C19 alkdienyl, wherein each R2 independently of... | 08/06/1996 |
| 5416118 | Bicyclic amides as inhibitors of acyl-coenzyme A: cholesterol acyl transferase Novel bicyclic amides of the formula ##STR1## wherein Ar1 and Ar2 are phenyl, R2 -substituted phenyl, heteroaryl or R2 -substituted heteroaryl, wherein R2 is 1 to 3 substituents independently sel... | 05/16/1995 |
| 5414153 | Hydroxylation of phenolic compounds Phenolic compounds, e.g., the phenols and phenol ethers, are selectively hydroxylated whereby the amounts of the final product para isomer are enhanced, for example in favor of hydroquinone versus pyrocatechol in the event of the hydroxylation of phenol, ... | 05/09/1995 |
| 5331099 | Process for preparing p-nitroaromatic amides and products thereof A process for preparing p-nitroaromatic amides is provided which comprises contacting an amide and nitrobenzene in the presence of a suitable solvent system, and reacting the amide and nitrobenzene in the presence of a suitable base and a controlled amoun... | 07/19/1994 |
| 5296612 | Process for producing enyne derivatives A process for producing an enyne derivative, and intermediate, which is useful for preparing compounds showing strong inhibiting activities against squalane epoxidase of Eumycetes and strong anti-cholesterol activities. The process comprises reacting a co... | 03/22/1994 |
| 5233082 | Method of making 3-hydroxy-2,4,5-trifluorobenzoic acid Disclosed is a method of making 3-hydroxy-2,4,5-trifluorobenzoic acid. A aqueous solution is prepared of an alkali metal base and a tetrafluorophthalimide. The solution is heated to produce a mixture of a salt of a 4-hydroxy-3,5,6-trifluorophthalamic acid... | 08/03/1993 |
| 5231183 | Process for producing enyne derivatives A process for producing an enyne derivative, and intermediate, which is useful for preparing compounds showing strong inhibiting activities against squalane.epoxidase of Eumycetes and strong anti-cholesterol activities. The process comprises reacting a co... | 07/27/1993 |
| 5229442 | Stabilizing compositions for organic polymers Stabilizing compositions for organic polymers, composed of mixtures of at least one liquid phenolic antioxidant and at least one aminic antioxidant, subjected to thermal treatment, are characterized by their stabilizing capacity which is considerably high... | 07/20/1993 |
| 5216153 | Aromatic carboxamides Compounds of the general formula ##STR1## wherein R1 is hydrogen, halogen or OR5 ; R2 is hydrogen, lower-alkyl lower-alkoxy or halogen; R3 and R4 each independently are lower-alkyl or taken toget... | 06/01/1993 |
| 5204468 | Substituted 4,5,6,7-tetrahydrothiens[2,3-C]pyridine compounds This invention provides the single species (-)-(S)-4-(3,4-dihydroxyphenyl)-7, 8-dihydroxy-1,2,3,4-tetrahydroisoquinoline hydrochloride hydrate, which is useful as a nephrovascular dilator.... | 04/20/1993 |
| 5149709 | Inhibitors of acyl-coenzyme A: cholesterol acyl transferase Amides of the formula ##STR1## wherein R1 and R2 are independently heteroaryl, X-substituted heteroaryl, X-substituted phenyl, N-substituted triazinyl or N-substituted imidazolyl; and in addition, one of R1 and R... | 09/22/1992 |
| 4983633 | Amide compounds, process for preparing the same, and composition for activating gastric motor function containing the same Amide-compounds represented by the formula (I): ##STR1## wherein R1 represents hydrogen, lower alkoxy, hydroxy, lower alkyl, halogen, amino which can be substituted by lower alkyl, nitro, cyano, sulfamoyl which can be substituted by lower ... | 01/08/1991 |
| 4904661 | Phenol derivatives A phenol derivative of the formula NU--A--X--R1 wherein NU is a defined bis-phenolic nucleus including a hydroxyphenyl-hydroxynaphthyl; hydroxyphenyl-hydroxyindanyl, hydroxyphenyl-hydroxybenzothienyl or di-hydroxyphenyl-ethylene or vinylene nuc... | 02/27/1990 |
| 4876261 | Substituted tetrahydroisoquinoline compounds and composition containing them A compound of the formula (I) or its salt and a process for producing the compounds; The compounds have the effect to dilate neophrovascular tracts; ##STR1## wherein ##STR2## represents the formula ##STR3## (wherein R4 is ... | 10/24/1989 |
| 4837316 | Alkylamide derivatives with H2 -receptor antagonistic and cytoprotective action Alkylamide derivatives having the formula, These compounds have a strong antiulcer action depend on histamine H2 -receptor antagonistic action and a cytoprotective action upon gastric mucous membrance.... | 06/06/1989 |
| 4822902 | N-acetonylbenzamides and their use as fungicides Certain N-acetonylbenzamides exhibit low toxicity to plants are particularly useful for control of fungi, especially Phycomycetes.... | 04/18/1989 |
| 4757137 | Orthotrifluoromethyl containing phenylazonaphthol dyestuffs Azo dyestuffs of the formula ##STR1## wherein R1 denotes acyl, R2 denotes hydrogen, fluorine, chlorine or trifluoromethyl, R3 denotes hydrogen, optionally substituted C1 -C4 -alkyl, cyclohexyl or opti... | 07/12/1988 |
| 4701527 | Synthesis of salicylamides with improved reaction kinetics and improved effective yields A method of synthesizing with improved reaction kinetics and improved effective yields salicylamide compounds of the formula: ##STR1## wherein R1 is a substituent selected from the group consisting of --H, --COCn H2n+1 | 10/20/1987 |
| 4692553 | Cyclohexenone derivatives and their use for controlling undesirable plant growth Cyclohexenone derivatives of the formula ##STR1## where R1 is hydrogen, methoxycarbonyl, ethoxycarbonyl, methyl or cyano, R2 is alkyl, R3 is alkyl, alkenyl, haloalkenyl, or propargyl, R4 is hydrogen or alky... | 09/08/1987 |
| 4666510 | Cyclohexenone derivatives and their herbicidal use. The invention concerns novel compounds of the formula I ##STR1## wherein: X is selected from halogen, nitro, cyano, alkyl, substituted alkyl, hydroxy, alkoxy, substituted alkoxy, alkenyl, alkynyl, alkenyloxy, alkynyloxy, acyloxy, alkoxycarbonyl, alky... | 05/19/1987 |
| 4659826 | Synthesis of salicylamides with improved yield and purity A method of synthesizing and recovering with high yield and purity salicylamide compounds of the formula: ##STR1## wherein R1 is a substituent having the formula --COCn H2n+1 wherein n is an integer with a value of fr... | 04/21/1987 |
| 4623729 | Acylalkylaminocarbonyl substituted amino and imino acid compounds Compounds of the formula ##STR1## are disclosed. These compounds are useful as hypotensive agents due to their angiotensin converting enzyme inhibition activity and depending upon the definition of X may also be useful as analgesics due to their ... | 11/18/1986 |
| 4587361 | Anthelmintic benzamides Flukicidal N-[4-(1-phenylethenyl)phenyl]-2-hydroxy-3,5-dihalobenzamides are prepared by reacting a halosalicylic acid with a 1-(4-aminophenyl)-1-phenylethylene in the presence of a halo condensing agent. A species of the invention is N-[4-(1-phenylet... | 05/06/1986 |
| 4565888 | Substituted salicylic acid amide anthelmintics Anthelmintically active novel substituted salicylic acid amides of the formula ##STR1## in which X and Y each independently is halogen, and, R1 is hydrogen or acetyl.... | 01/21/1986 |
| 4562201 | Aminomethyl benzanilides The present invention relates to new compounds of the formula ##STR1## where X is ##STR2## alkylene, or --S-- where R1 is hydrogen, alkyl, or aryl; W is hydrogen, hydroxy, amino, alkyloxy, aryloxy, O-alkyl, or O-aralkyl; (Y)... | 12/31/1985 |
