Did You Know...
...that in 1800 ether was first used by partyers as a fun diversion? Sniffing the gas led to hilarious and raucous laughter as people watched each other become more and more intoxicated and silly. Several doctors independently realized the value ether would have to anesthetize surgery patients. Of those who claimed rights to the "discovery," none had a happy ending. One had a seizure and died defending his rights. Another spent his life in an asylum because he had been denied acclaim. A third became addicted to chloroform and, in a New York City jail, he soaked a cloth in the drug, severed an artery and bled to death.
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| Number | Title | Issue Date |
| 7999136 | Amide compound and use thereof Disclosed is an amide compound represented by the formula (1) below, which has excellent plant disease controlling activity. (1) (In the formula, substituents represented by A, Z, X1, X2 and X3 and the like are as defined in the desc... | 08/16/2011 |
| 7714168 | Amide compounds and their use Since an amide compound represented by the formula (1) is effective for controlling plant diseases, it is useful as an effective ingredient of a composition for controlling plant diseases. ... | 05/11/2010 |
| 7547804 | Compounds, compositions, and methods employing same Compounds and pharmaceutical compositions containing the same are provided, which are useful in therapeutic treatment or prevention of various diseases. ... | 06/16/2009 |
| 7332629 | Modulators (inhibitors/activators) of histone acetyltransferases Disclosed are compounds of the formulae: and method of using the compounds to treat cancer, AIDS, HIV infection, and asthma. ... | 02/19/2008 |
| 7314958 | Phenylbenzamides This invention relates to novel phenylbenzamides of the formula (I) in which R1 represents trifluoromethyl, chlorine, bromine or iodine and R2 | 01/01/2008 |
| RE39682 | Farnesyl derivatives and pharmaceutical compositions containing them Novel farnesyl derivatives which are inhibitors of the prenylated protein methyltransferase enzyme, and useful as anti-cancer drugs, have the following formula: wherein R1represents f... | 06/05/2007 |
| 7132455 | Phthalamide derivatives This invention relates to novel phthalamide derivatives of formula (I) wherein R1, R2, R3, R4, and R5 have the meanings given in the... | 11/07/2006 |
| 7119229 | Alkaloid derivative and a pharmaceutical composition containing the same Colchicine derivatives represented by the formula (I) with a halogen or nitric ester group, or pharmaceutically acceptable salts thereof, are described. Pharmaceutical compositions containing the same as effectiv... | 10/10/2006 |
| 7053071 | Induction of apoptosis in cancer cells The present invention provides compounds that are inducers or inhibitors of apoptosis or apoptosis preceded by cell-cycle arrest. In addition, the present invention provides pharmaceutical compositions and methods for treating mammals with leukemia or other forms of... | 05/30/2006 |
| 7041702 | Pharmaceutically active compounds and methods of use The present invention relates to pharmaceutically acceptable compounds, including acylguanidine compounds, and methods of treatment and pharmaceutical compositions that utilize or comprise one or more such compounds. Compounds of the invention are particularly usefu... | 05/09/2006 |
| 6683201 | Analine derivatives as OSC inhibitors The present invention relates to compounds of formula (I) ##STR1## wherein U, Y, V, W, L, X, A1, A2, A3, A4, A5 and A6 are as defined in the description and claims and pharmaceutically acce... | 01/27/2004 |
| 6632836 | Carbocyclic potassium channel inhibitors The present invention relates to a class of carbocyclic compounds of Formula I that are useful as potassium channel inhibitors to treat autoimmune disorders, cardiac arrhythmias, and the like. ##STR1##... | 10/14/2003 |
| 6566403 | N-acetonylbenzamide fungicides This invention relates to new compositions comprising predominantly one enantiomer of an N-acetonylbenzamide fungicide, methods of preparing N-acetonylbenzamides, and their use as fungicides.... | 05/20/2003 |
| 6566394 | Salicylamide derivatives Salicylamide derivatives represented by formulae (1a) and (1b); intermediates in the production thereof; a process for producing the same; and drugs containing the same as the active ingredient. The salicylamide derivatives represented by formulae (1a) an... | 05/20/2003 |
| 6506937 | Substituted benzenesulfonylureas and -thioureas-processes for their preparation and their use as pharmaceuticals Benzenesulfonylureas and -thioureas of the formula I ##STR1## where R(1) is H or (fluoro)methyl, R(2) is H, Hal or (fluoro) (mercapto)alk(oxy)yl, E is O or S; Y is --[CR(3)2 ]n --, where R(3)=H or alkyl and n=1-4, X is H, Hal or alky... | 01/14/2003 |
| 6313088 | 8-[(2-hydroxy-4-methoxy benzoyl) amino]-octanoic acid compositions for delivering active agents Carrier compounds and compositions therewith which are useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well.... | 11/06/2001 |
| 6300368 | Anilide derivatives and antiarrhythmic agents containing the same Preparation of antiarrhythmic agents containing novel anilide derivatives represented by the following formula as active ingredient provides a new type of antiarrhythmic agent of highly safe and effective, without effects on cardiac function. ##STR1#... | 10/09/2001 |
| 6262123 | Ortho-substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic, and medicament comprising them Ortho-substituted benzoylguanidines of the formula I ##STR1## in which R(1) to R(4) have the meanings given in the claims, are suitable, as antiarrhythmic pharmaceuticals having a cardioprotective component, for the prophylaxis and treatment of infarction... | 07/17/2001 |
| 6218565 | Method for producing N-(3-amino-4-fluoro-phenyl)-sulphonamides, N-(3-amino-4-fluoro-phenyl)-carboxylic acid amides and N-(3-amino-4-fluorophenyl) carbamates The invention relates to a process for preparing N-(3-amino-4-fluoro-phenyl)-sulphonamides, N-(3-amino-4-fluoro-phenyl)-carboxamides or N-(3-amino-4-fluoro-phenyl)-carbamates of the general formula (I) ##STR1## in which A represents SO2, C... | 04/17/2001 |
| 6191277 | Hydroxypropylamide peptidomimetics as inhibitors of aspartyl proteases Compounds of Formula I ##STR1## are disclosed as inhibitors having activity against the aspartyl proteases, plasmepsin and cathsepsin D. The compounds are useful for treatment of diseases such as malaria and Alzheimer's disease. In preferred compounds ... | 02/20/2001 |
| 6153651 | Ortho-substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic, and medicament comprising them Ortho-substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic, and medicament comprising them. Ortho-substituted benzoylguanidines of the formula I ##STR1## in which R(1) to R(4) have the meanings given in the... | 11/28/2000 |
| 6114325 | 1,2-di-substituted benzene-carboxamide derivative, hair growth promoter and external composition for skin using the same A 1,2-di-substituted benzene-carboxamide derivative or a salt thereof expressed by the following Formula (I); ##STR1## wherein each of A and B is R1 or --(CH2)n-NR2 R3, wherein when A is R1, B is... | 09/05/2000 |
| 6090981 | Substituted benzenesulfonylureas and -thioureas--process for their preparation and their use as pharmaceuticals Benzenesulfonylureas and -thioureas of the formula I ##STR1## where R(1) is H or (fluoro)methyl, R(2) is H, Hal or (fluoro)(mercapto)alk(ozy)yl, E is O or S; Y is --[CR(3)2 ]n --, where R(3)=H or alkyl and n=1-4, X is H, Hal or ... | 07/18/2000 |
| 6083987 | Phenylenediamine derivative, radical scavenger, brain-infarction depressant, and brain-edema depressant A phenylenediamine derivative or a salt thereof in accordance with the present invention is expressed by the following formula 1: ##STR1## wherein A represents a group expressed by --CO--, --CH2 CO--, --CS--, or --SO2 --; Y repr... | 07/04/2000 |
| 6075054 | Ortho-substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic, and medicament comprising them Benzoylguanidines of formula I ##STR1## with R(1) to R(4) as defined in the specification, are suitable as antiarrhythmic pharmaceuticals having a cardioprotective component for infarct prophylaxis and infarct treatment as well as for the treatment o... | 06/13/2000 |
| 6054457 | Benzamide derivatives and their use as vasopressin antagonists This invention relates to new benzamide derivatives having a vasopressin antagonistic activity, etc, and represented by general formula (I): ##STR1## wherein R1 is aryl optionally substituted with lower alkoxy, etc., R2 is lower... | 04/25/2000 |
| 5977410 | N-[(fluoroalkoxy) phenoxyalkyl]benzamide compounds, intermediates thereof, process for producing the same, and agricultural and horticultural pesticides Disclosed are A N-[(fluoroalkoxy)phenoxyalkyl]benzamide compound represented by the formula (1): ##STR1## wherein R1 and R3 may be the same or different and represent a hydrogen atom, a halogen atom, a C1-4 alkyl grou... | 11/02/1999 |
| 5958376 | Iodinated X-ray contrast media The invention provides iodinated bis phenyl compounds, useful as X-ray contrast agents, of formula (I) (wherein each C6 R5 moiety may be the same or different; each denotes a hydrogen or iodine atom or a group M, two or three non-adj... | 09/28/1999 |
| 5922771 | Benzocycloalkene compounds, their production and use A compound of the formula ##STR1## wherein R1 and R2 independently represent H or an optionally substituted hydrocarbon group; R3 represents an optionally substituted hydrocarbon group; R4 represents H or a... | 07/13/1999 |
| 5891886 | Treatment of cancers A new treatment schedule for administration of N-2-(dimethylamino)ethyl!acridine-4-carboxamide and other related carboxamide anticancer drugs in which the drug is administered in a divided-dose schedule comprising two or more administrations at frequent... | 04/06/1999 |
| 5801195 | Immunotherapeutic aryl amides Novel aryl amides are inhibitors of tumor necrosis factor and can be used to combat cachexia, endotoxic shock, and retrovirus replication. A typical embodiment is N-benzoyl-3-amino-3-(3',4'-dimethoxyphenyl)propanamide.... | 09/01/1998 |
| 5780668 | X-ray opaque dental materials X-ray opaque esters or amides of iodosubstituted benzoic acid according to formula I and polymers and dental materials produced therefrom. ##STR1## R1 =hydrogen or C1 to C3 alkyl, preferably H or CH3 ; R | 07/14/1998 |
| 5747541 | Substituted benzoylguanidines, a process for their preparation, their use as medicament of diagnostic agent, and medicament comprising them The present invention relates to substituted benzoylguanidines, a process for their preparation, their use as medicament or diagnostic agent, and medicament comprising them.... | 05/05/1998 |
| 5747539 | Fluorine-containing benzoylguanidines Fluorine-containing benzoylguanidines of the formula I ##STR1## in which R1, R2 and R3 have the meanings indicated, and their physiologically acceptable salts, have antiarrhythmic properties and act as inhibitors of t... | 05/05/1998 |
| 5705528 | Farnesyl derivatives and pharmaceutical compositions containing them Novel farnesyl derivatives which are inhibitors of the prenylated protein thyltransferase enzyme, and useful as anti-cancer drugs, have the following formula: ##STR1## wherein R1 represents farnesyl, geranyl or geranyl-geranyl; Z represent... | 01/06/1998 |
| 5646184 | Preparation for external application to the skin and novel benzoic acid derivatives Disclosed is a preparation for external application to the skin characterized by containing at least one of benzoic acid derivatives represented by formula (I) or pharmacologically acceptable salts thereof as an active ingredient, the preparation having s... | 07/08/1997 |
| 5614550 | Amide and urea derivatives having anti-hypercholesteremic activity, their preparation and their therapeutic uses Compounds of formula (I) are provided: ##STR1## wherein: R1 represents an alkyl group; or a group of formula (II), (III), (IV) or (V): ##STR2## and wherein the groups R2, R3, R4 and R5 are h... | 03/25/1997 |
| 5543572 | Monocarboxamides of polyamines Monocarboxamides of formula I ##STR1## wherein R is a radical of formula ##STR2## C9 -C19 alkyl, C9 -C19 alkenyl or C9 -C19 alkdienyl, wherein each R2 independently of... | 08/06/1996 |
| 5527955 | Method of treating depression and tri-substituted amines therefor The invention concerns a method for treating depression or senile dementia using a compound which acts selectively as an agonist of gamma aminobutyric acid (GABA) at GABA autoreceptors with the proviso that the compound is not fengabine and progabide.... | 06/18/1996 |
| 5523457 | Retinoid-like compounds This invention relates to a retinoid mpound of formula I ##STR1## in which Y is --CO--NH--, --CR2 .dbd.CR3 --, --CO--O--, --O--CO--, --C(.dbd.S)--NH--, --C.tbd.C--, --O--CH2 --, --CH2 --O--, or --CH2 | 06/04/1996 |
