Class 564/172 - Polycyclo ring system in substituent Q

Subclass of Class 564 - Organic compounds -- part of the class 532-570 series
Definition: Compounds wherein the carboxylic acid residue contains a
No. of patents: 148
Last issue date: 01/12/2010

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Number	Title	Issue Date
7645905	Crystalline form IV of agomelatine, a process for its preparation and pharmaceutical compositions containing it Crystalline form IV of the compound of formula (I): characterised by its powder X-ray diffraction diagram. Medicinal products containing the same which are useful in the treatment of melatoninergic disorders. ...	01/12/2010
7544839	Process for the synthesis and crystalline form agomelatine Process for the industrial synthesis and new crystalline form of the compound of formula (I): Medicinal products containing the same which are useful in treating disorders of the melatoninergic system. ...	06/09/2009
7498465	Process for the synthesis and crystalline form of agomelatine A process for the industrial synthesis and new crystalline form of the compound of formula (I): Medicinal products containing the same which are useful in treating disorders of the melatoninergic system. ...	03/03/2009
7498466	Process for the synthesis and crystalline form of agomelatine A process for the industrial synthesis and new crystalline form of the compound of formula (I): Medicinal products containing the same which are useful in treating disorders of the melatoninergic system. ...	03/03/2009
7358395	Crystalline form V of agomelatine, a process for its preparation and pharmaceutical compositions containing it Crystalline form V of the compound of formula (I): characterised by its powder X-ray diffraction diagram. Medicinal products containing the same which are useful in the treatment of melatoninergic disorders. ...	04/15/2008
7250531	Process for the synthesis and crystalline form of agomelatine A process for the industrial synthesis and a new crystalline form of the compound of formula (I): Medicinal products containing the same which are useful in treating disorders of the melatoninergic system. ...	07/31/2007
7138406	Modulators of the glucocorticoid receptor The present invention provides compounds of the formula wherein A is of the formula and X, Y, n, R1–R25 are as described in the speci...	11/21/2006
7045660	Compounds as PDE IV and TNF-inhibitors This invention is directed to a [di(ether or thioether)heteroaryl or fluoro substituted aryl] compound or an N-oxide thereof or a pharmaceutically acceptable salt thereof, which is useful for inhibiting the production or physiological effects of TNF in the treatment...	05/16/2006
6946575	Trityl-type compounds and their use The present invention pertains to trityl-type compounds comprising, bonded to the same atom, three aryl groups, of which at least one is a fluorophore and at least one has a substituent including a functional group, and wherein the compound can exist in a non-ionize...	09/20/2005
6867320	Substituted phenylalkanoic acid derivatives and use thereof A compound represented by the formula (I) or a salt thereof: wherein n represents an integer of 1 to 3, R represents an alkyl group having 3 to 8 carbon atoms, a group represented by the following formula: R1	03/15/2005
6809220	Trityl-type compounds and their use The present invention pertains to trityl-type compounds comprising, bonded to the same atom, three aryl groups, of which at least one is a fluorophore and at least one has a substituent including a functional group, and wherein the compound can exist in a non-ionise...	10/26/2004
6784314	Process for producing amine derivatives This invention provides a convenient and industrially advantageous process producing amine derivatives having the action of inhibiting the secretion and accumulation of amyloid β protein. In Compound (I), the ether link...	08/31/2004
6635650	Substituted dimeric compounds The invention relates to compounds of formula (I): wherein: A represents NR1 C(Q)R2, C(Q)NR2 R3 or NR1 C(Q)NR2 R3, B represents NR1 C(Q)R2, C(Q)NR2...	10/21/2003
6531472	Tetralone derivatives The present invention provides compounds of formula I ##STR1## and pharmaceutically acceptable salts, wherein R1, R2, R3, R4, R5, X and Y have the meanings defined in the specification. The compounds have histone deacetylase (HDAC) inhibitory activity whi...	03/11/2003
6521663	Aminoguanidinyl- and Alkoxyguanidinyl-substituted phenyl acetamides as protease inhibitors Phenyl acetamide compounds are described, including compounds of Formula I: ##STR1## or a solvate, hydrate or pharmaceutically acceptable salt thereof; wherein R3 -R6, R11, B, Y and W are set forth in the specification. Th...	02/18/2003
6472414	Conformationally restricted aromatic inhibitors of microsomal triglyceride transfer protein and method Novel compounds are provided which are inhibitors of MTP and thus are useful for lowering serum lipids and treating atherosclerosis and related diseases, and have the structure ##STR1## including pharmaceutically acceptable salts thereof or prodrug esters...	10/29/2002
6444860	Naphthopyrans and phenanthropyrans annelated in C5-C6 with a bicyclic group, and compositions and (co) polymer matrices containing them The invention relates to novel naphthopyran- and phenanthropyran-type compounds having a carbobicycle annelated in 5,6- position. These compounds have formula (I) given below: ##STR1## These compounds (I) have interesting photochromic properties. The inve...	09/03/2002
6423870	Tricyclic compounds, preparation method and pharmaceutical compositions containing same The invention concerns compounds of formula (I) in which: A forms a tricyclic system of formula A1, A2, A3 or A4 ; R1 represents a hydrogen atom, an alkyl, hydroxy, alkoxy or oxo group; (R2...	07/23/2002
6403831	Substituted benzylidene indenyl formamides, acetamides and propionamides Substituted benzylidene indenyl formamides, acetamides and propionamides are useful in the treatment of precancerous lesions and neoplasms....	06/11/2002
6369225	Compounds having activity as inhibitors of cytochrome P450RAI Compounds having Formula 8 wherein the symbols have the meaning defined in the specification are inhibitors of the cytochrome P450RAI (retinoic acid inducible) enzyme, and are used for treating diseases responsive to treatment by retinoids. ##STR1##...	04/09/2002
6353109	Certain fused pyrrolecarboxamides; a new class of GABA brain receptor Disclosed are compounds of the formula ##STR1## or the pharmaceutically acceptable non-toxic salts thereof wherein: W represents substituted or unsubstituted aryl or heteroaryl; T is hydrogen, halogen, hydroxyl, amino or alkyl; X is hydrogen, hydroxy, or lower alky...	03/05/2002
6340704	Cell differentiation inducing amide derivatives, their production and use The present invention provides a compound represented by the formula: ##STR1## wherein R1 is an amino group which may be substituted; R2 is a hydrogen atom or a lower alkyl group which may be substituted; X is a methyne group which m...	01/22/2002
6326369	Bicyclic quinone compounds, their production and use A compound of the formula: ##STR1## wherein R1 and R2 each represents a lower alkyl, or R1 and R2 may be bonded together to form a ring; X represents a spacer of which the number of atoms constituting the princi...	12/04/2001
6288234	Multibinding inhibitors of microsomal triglyceride transferase protein Disclosed are multibinding compounds which inhibit microsomal triglyceride transferase protein (MTP), a protein which mediates the transfer of lipids during the assembly of lipoproteins and related biomolecules. The multibinding compounds contain from 2 t...	09/11/2001
6268520	Tricyclic compounds Novel tricyclic compounds of formula I as defined in the specification, a process for their preparation and their use for the preparation of optically active or racemic colchicine and thiocolchicine derivatives....	07/31/2001
6248781	Compounds useful in the treatment of conditions mediated by peroxisome proliferator-activated receptors (PPAR) The present invention relates to compounds of formula (I) ##STR1## wherein R1, R2, R3, R4, R5, R6, R7, R8, Ar, X, Q, A, Y and Z are as defined in the specification. These ...	06/19/2001
6239179	N-aminoalkyl-2-anthracenecarboxamides; new dopamine receptor subtype specific ligands Disclosed are compounds of the formula: ##STR1## or the pharmaceutically acceptable acid addition salts thereof, wherein: R1, R2, R3, R4, R5, R6, R7, R8 and R9 a...	05/29/2001
6162445	Polyaromatic propynyl compounds and pharmaceutical/cosmetic compositions comprised thereof Novel pharmaceutically/cosmetically-active polyaromatic propynyl compounds have the structural formula (I): in which X is one of the radicals: ##STR1## and are useful for the treatment of a wide variety of disease states, whether human or veterinary,...	12/19/2000
6160175	Naphthyl acetamides as sPLA₂ inhibitors A class of novel naphthyl acetamide compounds is disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of conditions such as septic shock....	12/12/2000
6156750	Bioactive bicyclic aromatic compounds and pharmaceutical/cosmetic compositions comprised thereof Novel pharmaceutically/cosmetically-active bicyclic aromatic compounds have the structural formula (I): ##STR1## and are useful for the treatment of a wide variety of disease states, whether human or veterinary, for example dermatological, rheumatic,...	12/05/2000
6133266	3,4-disubstituted phenylethanolaminotetralincarboxamide derivatives The present invention relates to 3,4-disubstituted phenylethanolaminotetralincarboxamide derivatives represented by the general formula: ##STR1## (wherein A represents a lower alkylene group; B represents an amino group, a di(lower alkyl)amino g...	10/17/2000
6124498	Hydroxynaphthoic acids and derivatives In one embodiment, the present invention provides a compound comprising: ##STR1## wherein A=H or OH X=OH, a halogen, OR, NHR, NR'R" where R, R', and R"=H, C1-8 alkyl, C2-8 alkenyl, or C2-8 alkynyl, cycloalkyl, cycloalkenyl...	09/26/2000
6054457	Benzamide derivatives and their use as vasopressin antagonists This invention relates to new benzamide derivatives having a vasopressin antagonistic activity, etc, and represented by general formula (I): ##STR1## wherein R1 is aryl optionally substituted with lower alkoxy, etc., R2 is lower...	04/25/2000
6005003	Derivatives of dihydro or tetrahydronaphthalene, and the pharmaceutical compositions containing them A subject of the invention is the compounds of general formula (I): ##STR1## in which R1=H, alkyl, acyl, R2 and R3=H, alkyl, R4=aryl, heteroaryl, X=O, CH2, Y=OH, O-alkyl or NRaRb, as well as the salts, their preparation processes, the intermediates o...	12/21/1999
5935978	Compounds containing phenyl linked to aryl or heteroaryl by an aliphatic- or heteroatom-containing linking group This invention is directed to the pharmaceutical use of phenyl compounds, which are linked to an aryl moiety by various linkages, for inhibiting tumor necrosis factor. The invention is also directed to the compounds, their preparation and pharmaceutical c...	08/10/1999
5922771	Benzocycloalkene compounds, their production and use A compound of the formula ##STR1## wherein R1 and R2 independently represent H or an optionally substituted hydrocarbon group; R3 represents an optionally substituted hydrocarbon group; R4 represents H or a...	07/13/1999
5900436	Substituted indanylidineacetylguanidines, processes for their preparation, their use as medicaments or diagnostics and medicaments containing them Substituted Indanylidineacetylguanidines, process for their preparation, their use as medicaments or diagnostic and medicaments containing them: Indanylidineacetylguanidines I ##STR1## and their pharmaceutically acceptable salts wherein R1, R2, R3, R4, R5...	05/04/1999
5891886	Treatment of cancers A new treatment schedule for administration of N-2-(dimethylamino)ethyl!acridine-4-carboxamide and other related carboxamide anticancer drugs in which the drug is administered in a divided-dose schedule comprising two or more administrations at frequent...	04/06/1999
5877218	Compositions containing and methods of using 1-aminoindan and derivatives thereof and process for preparing optically active 1-aminoindan derivatives Novel derivatives of 1-aminoindan and their salts are described. Optically active 1-aminoindan derivatives are prepared by reacting a N-benzyl analog of the desired compound with an enantiomer of mandelic acid. Parkinson's disease, dementia, epilepsy, con...	03/02/1999
5827891	HIV protease inhibtors HIV protease inhibitors, obtainable by chemical synthesis, inhibit or block the biological activity of the HIV protease enzyme, causing the replication of the HIV virus to terminate. These compounds, as well as pharmaceutical compositions that contain the...	10/27/1998

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Class 564/172 - Polycyclo ring system in substituent Q