Quotables
"To place a man in a multi-stage rocket and project him into the controlling gravitational field of the moon where the passengers can make scientific observations, perhaps land alive, and then return to earth--all that constitutes a wild dream worthy of Jules Verne. I am bold enough to say that such a man-made voyage will never occur regardless of all future advances."
Lee deForest, American radio pioneer ; 1957
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 7605288 | Heat shock protein 90 inhibitors Novel compounds useful for inhibiting the 90 kDa heat shock proteins containing a quinone-like moiety and a di-hydroxy phenol like moiety, similar to geldanamycin and radicicol. ... | 10/20/2009 |
| 7371887 | Oligo(p-phenylene vinylene) amphiphiles and methods for self-assembly Amphiphilic oligo(p-phenylene vinylene) compounds and methods of use en route to self-assembled composites and device fabrication. ... | 05/13/2008 |
| RE40259 | Alpha-aminoamide derivatives useful as analgesic agents The present invention relates to novel and known alpha-aminoamide compounds, to a process for their preparation, to pharmaceutical composition containing them and to their use as therapeutic agents. In particular, the compounds of the present invention are en... | 04/22/2008 |
| 7312368 | Method for selective reduction of aromatic compounds A method for the selective reduction of an aromatic compound. The present invention provides a method for pre-venting the reduction of at least one halogen substituted aromatic ring of an aromatic compound, while allowing the reduction of at least one functional gro... | 12/25/2007 |
| 7265245 | Compounds useful for the treatment of diseases associated with the formation of amyloid fibrils The present invention provides new amyloidogenesis inhibiting compounds of formula (I): in which R1 is a —NRaRb group, where Ra and... | 09/04/2007 |
| 7253318 | Benzyloxy derivatives as MAOB inhibitors The invention relates to compounds of the formula and their pharmaceutically acceptable salts wherein R1, R2, R3, R4, R5, n, m, and o are... | 08/07/2007 |
| 7223888 | Mu opioid receptor ligands: methods of use and synthesis Novel compounds and compositions including those compounds, as well as methods of using and making the compounds are herein described. The compounds are useful in therapeutic applications, including modulation of disease or disease symptoms in a subject (e.g., mamma... | 05/29/2007 |
| 7208630 | Heat shock protein 90 inhibitors Novel compounds useful for inhibiting the 90 kDa heat shock proteins containing a quinone-like moiety and a di-hydroxy phenol like moiety, similar to geldanamycin and radicicol. ... | 04/24/2007 |
| 7196119 | Development of new selective estrogen receptor modulators The present disclosure concerns a new class of selective estrogen receptor modulators (SERMs). The disclosure also includes the identification of a previously unknown membrane associated estrogen receptor. Methods for making and using the disclosed SERMs are disclos... | 03/27/2007 |
| 7138546 | Compounds and compositions for delivering active agents Compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are provided as well. ... | 11/21/2006 |
| 7053071 | Induction of apoptosis in cancer cells The present invention provides compounds that are inducers or inhibitors of apoptosis or apoptosis preceded by cell-cycle arrest. In addition, the present invention provides pharmaceutical compositions and methods for treating mammals with leukemia or other forms of... | 05/30/2006 |
| 7045660 | Compounds as PDE IV and TNF-inhibitors This invention is directed to a [di(ether or thioether)heteroaryl or fluoro substituted aryl] compound or an N-oxide thereof or a pharmaceutically acceptable salt thereof, which is useful for inhibiting the production or physiological effects of TNF in the treatment... | 05/16/2006 |
| 7038085 | Stereoisomers of p-hydroxy-milnacipran, and methods of use thereof The present invention relates generally to the enantiomers of para-hydroxy-milnacipran or congeners thereof. Biological assays revealed that racemic para-hydroxy-milnacipran is approximately equipotent in inhibiting serotonin and norepinephrine uptake (IC50 | 05/02/2006 |
| 6951884 | Fluorobenzamides and uses thereof The invention relates to fluorobenzamide derivatives of the formula wherein R1, R2, R3 R4, R5, R6 and R7 are as defined herein. =, Th... | 10/04/2005 |
| 6900354 | 3-phenyl-propionamido, 3-phenyl-acrylamido and 3-phenyl-propynamido derivatives The invention relates to 3-phenyl-propionamido, 3-phenyl-acrylamido and 3-phenyl-propynamido derivatives, for example, deriviatives of the formula wherein A is selected from | 05/31/2005 |
| 6777442 | Diphenyl derivatives The present invention relates to compounds of the general formula (I) in which X represents O, S, SO, SO2, CH2, CHF, CF2 or NR8, and Z represents a group of the formula | 08/17/2004 |
| RE38506 | Potent inducers of terminal differentiation and methods of use thereof The present invention provides the compound having the structure: wherein each of R1 and R2 are independently the same as or different from each other; when R1 and R2 are the same, each i... | 04/20/2004 |
| 6703421 | Methods of using phenylmethylbenzoquinone and hydroquinone compounds for treatment of myocarditis, dilated cardiomyopathy and heart failure A method for prevention or treating myocarditis, dilated cardiomyopathy and heart failure comprising administering to a patient in need of such treatment a NF-.kappa.B inhibitor in a therapeutically effective amount, wherein said NF-.kappa.B inhibitor is ... | 03/09/2004 |
| 6693208 | Compounds and compositions for delivering active agents Amino acid derivative as carrier compounds and compositions which are useful in the delivery of active agents are provided. The active agents can be a peptide, mucopolysaccharide, carbohydrate, or lipid. Methods of administration, including oral administr... | 02/17/2004 |
| 6610883 | Compounds having selective activity for retinoid X receptors, and means for modulation of processes mediated by retinoid X receptors Compounds, compositions, and methods for modulating processes mediated by Retinoid X Receptors using retinoid-like compounds which have activity selective for members of the subclass of Retinoid X Receptors (RXRs), in preference to members of the subclass... | 08/26/2003 |
| 6586475 | ଲ-amyloid protein production/secretion inhibitors A compound of the formula: ##STR1## wherein Ar is an aromatic group; X and Y are a bivalent group selected from --O--, --S--, --CO--, --SO2 --, --NR8 --, --CONR8 --, SO2 NR8 and --COO-- (wherein R | 07/01/2003 |
| 6576632 | Biaryl compounds useful as anticancer agents The present invention relates to compounds of formula I ##STR1## and to pharmaceutically acceptable salts, hydrates and prodrugs thereof, wherein R1, R2, R3, R4, R5, R10, R11, b,... | 06/10/2003 |
| 6521663 | Aminoguanidinyl- and Alkoxyguanidinyl-substituted phenyl acetamides as protease inhibitors Phenyl acetamide compounds are described, including compounds of Formula I: ##STR1## or a solvate, hydrate or pharmaceutically acceptable salt thereof; wherein R3 -R6, R11, B, Y and W are set forth in the specification. Th... | 02/18/2003 |
| 6515021 | Bicyclic aromatic compounds The invention relates to novel bicyclic aromatic compounds which have the general formula (I): ##STR1## as well as to the use of these compounds in pharmaceutical compositions intended for use in human or veterinary medicine (dermatological, rheumati... | 02/04/2003 |
| 6495546 | Propanolamine derivatives Propanolamine derivatives represented by the following formula (I): ##STR1## These derivatives may be 댣 agonists and exert sympathomimetic, anti-ulcerous, anti-pancreatitis, lipolytic and anti-urinary incontinence and anti-pollakiuria ac... | 12/17/2002 |
| 6403649 | Non-acidic cyclopentane heptanoic acid,2-cycloalkyl or arylalkyl derivatives as therapeutic agents The present invention provides cydopentane heptanoic acid, 2-cycloalkyl or arylalkyl compounds, which may be substituted in the 1-position with amino, amido, ether or ester groups, e.g., a 1-OH cydopentane heptanoic acid, 2-(cycloalkyl or arylalkyl) compo... | 06/11/2002 |
| 6395787 | Ocular hypotensive lipids Compounds of Formula 1, where the symbols are as defined in the specification, are useful as ocular hypotensive agents but do not exert their activity through the FP prostaglandin receptor. ##STR1## In particular the compound PGF2 1-etha... | 05/28/2002 |
| 6340691 | Alkynyl containing hydroxamic acid compounds as matrix metalloproteinase and tace inhibitors Compounds of the formula ##STR1## are useful in treating disease conditions mediated by TNF-, such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease and degenerative cartilage loss.... | 01/22/2002 |
| 6306903 | Alpha-aminoamide derivatives useful as analgesic agents The present invention relates to novel and known alpha-aminoamide compounds, to a process for their preparation, to pharmaceutical composition containing them and to their use as therapeutic agents. In particular, the compounds of the present invention are end... | 10/23/2001 |
| 6291689 | Method for the preparation of citalopram A method for the preparation of citalopram is described comprising reduction of the oxo group of a compound of formula (IV), ##STR1## wherein R1 is CN, C1-6 alkyloxycarbonyl or C1-6 alkylaminocarbonyl, ring closure of the ... | 09/18/2001 |
| 6229026 | Method for the preparation of citalopram A method for the preparation of citalopram comprising the steps of reacting a compound of Formula (IV) wherein R1 is C1-6 alkyl and X is O or NH, successively with a Grignard reagent of 4-halogen-fluorophenyl and a Grignard reagent o... | 05/08/2001 |
| 6214877 | 2,3,5-substituted biphenyls useful in the treatment of insulin resistance and hyperglycemia This invention provides compounds of Formula I having the structure ##STR1## wherein: B, C, D, and R1 are as defined hereinbefore in the specification, or a pharmaceutically acceptable salt thereof, which are useful in treating metabolic disord... | 04/10/2001 |
| 6207852 | Smooth muscle spasmolytic agents, compositions and methods of use thereof The present invention relates to smooth muscle spasmolytic agents, pharmaceutical compositions containing them and method of using said compounds and compositions for the treatment of urinary incontinence, gastric hyperactivity (ex. Irritable Bowel Syndro... | 03/27/2001 |
| 6147255 | Bicyclic-aromatic compounds The invention relates to novel bicyclic aromatic compounds which have the general formula (I): ##STR1## as well as to the use of these compounds in pharmaceutical compositions intended for use in human or veterinary medicine (dermatological, rhe... | 11/14/2000 |
| 6121255 | Phloroglucide derivatives and their pharmceutical use A phloroglucide derivative having the following formula: ##STR1## wherein Q is halogen; X is CH2 or C.dbd.O; Y is cephalosporin having a formula of ##STR2## wherein Ph is phenyl, Ac is acetoxy, or pharmaceutically acceptable salts ... | 09/19/2000 |
| 6083987 | Phenylenediamine derivative, radical scavenger, brain-infarction depressant, and brain-edema depressant A phenylenediamine derivative or a salt thereof in accordance with the present invention is expressed by the following formula 1: ##STR1## wherein A represents a group expressed by --CO--, --CH2 CO--, --CS--, or --SO2 --; Y repr... | 07/04/2000 |
| 6057342 | Amidinophenyl-pyrrolidines, -pyrrolines, and -isoxazolidines and derivatives thereof The present application describes amidinophenyl-pyrrolidines, -pyrrolines, and -isoxazolidines and derivatives thereof of formula I: ##STR1## or pharmaceutically acceptable salt forms thereof, wherein one of D and D' may be C(.dbd.NH)NH2 a... | 05/02/2000 |
| 6057345 | Substituted aryl and heteroaryl compounds as E-type prostaglandin antagonists Compounds of the formula, ##STR1## and pharmaceutically-acceptable salts thereof, which are useful as antagonists of the pain-enhancing effects of E-type prostaglandins, processes for the preparation of such compounds, pharmaceutical composition... | 05/02/2000 |
| 6054457 | Benzamide derivatives and their use as vasopressin antagonists This invention relates to new benzamide derivatives having a vasopressin antagonistic activity, etc, and represented by general formula (I): ##STR1## wherein R1 is aryl optionally substituted with lower alkoxy, etc., R2 is lower... | 04/25/2000 |
| 6013827 | Compounds This invention relates to componds of formula I ##STR1## which are useful as PDE IV inhibitors and for treating diseases related thereto.... | 01/11/2000 |
