Neuroimaging as a Marketing Tool
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| Number | Title | Issue Date |
| 7598419 | Compounds for modulating cell proliferation Novel styrylacrylonitrile compounds which are useful in treating a variety of cell proliferative disorders such as cancer are disclosed. ... | 10/06/2009 |
| 7592485 | Process for producing (Z)-1-phenyl-1-diethylaminocarbonyl-2-aminomethylcyclopropane hydrochloride The present invention provides a process for producing (Z)-1-phenyl-1-diethylaminocarbonyl-2-aminomethylcyclopropane or hydrochloride thereof, which comprises a step of reacting (Z)-1-phenyl-1-diethylaminocarbonyl-2-phthalimidomethylcyclopropane by contacting said c... | 09/22/2009 |
| 7423154 | Asymmetric process for the preparation of diarylethylpiperazines derivatives and novel asymmetric diarylmethylamines as intermediates An asymmetric synthesis of diarylmethylpiperazines is described. The synthetic route enables preparation of a variety of enatiomerically pure amines with different N-alkyl groups. The invention includes an asymmetric addition of organometallic compounds to chiral su... | 09/09/2008 |
| 7390923 | Propionamide derivatives useful as androgen receptor modulators Compounds of formula (I) wherein R1 to R4, X and A are as defined in the claims and pharmaceutically acceptable salts and esters thereof, are disclosed. The compounds of formula (I) possess utility as tissue-selective andro... | 06/24/2008 |
| 7390925 | Oxime-containing acyl guanidines as beta-secretase inhibitors There is provided a series of substituted oxime-containing acyl guanidines of Formula (I) or a stereoisomer; or a nontoxic pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R | 06/24/2008 |
| RE40259 | Alpha-aminoamide derivatives useful as analgesic agents The present invention relates to novel and known alpha-aminoamide compounds, to a process for their preparation, to pharmaceutical composition containing them and to their use as therapeutic agents. In particular, the compounds of the present invention are en... | 04/22/2008 |
| 7282608 | Inhibitors of histone deacetylase The invention provides compoods and methods for treating cell proliferative-diseases. The invention provides new inhibitors of histone deacetylase enzymatic activity, compositions of the compounds comprising the inhibitors and a pharmaceutically acceptable carrier, ... | 10/16/2007 |
| 7268147 | Compounds useful for the treatment of diseases The invention relates to compounds of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The compounds accord... | 09/11/2007 |
| 7265220 | Amino acid derivatives, method for production thereof and pharmaceutical compositions comprising said derivative Compound of formula (I): wherein: R1 represents aryl, heteroaryl or alkyl which is optionally substituted, or a group of formula —(CO)—CR6R7NR8R9 ... | 09/04/2007 |
| 7247748 | Amide compounds and methods of using the same Disclosed is a compound having the formula (I) pharmaceutically acceptable salts or solvates thereof and pharmaceutical compositions containing the same, wherein the structural variables are as defined herein. The compounds, salts and solvates of this invention are ... | 07/24/2007 |
| 7244866 | Carboxamido opioid compounds This invention is directed to carboxamido opioid compounds pharmaceutically useful as agents for treating or modulating a central nervous system disorder and methods for treating or modulating a central nervous system disorder. ... | 07/17/2007 |
| 7227038 | Adamantane derivatives, processes for their preparation and pharmaceutical composition containing them The invention provides compounds of formula in which m, n, R1, R2, R3, R4, and R5, have the meanings defined in the specification; processes for their prepar... | 06/05/2007 |
| 7151195 | Phthalamide derivative, agricultural or horticultural insecticide, and method of use thereof The present invention relates to a phthalamide derivative represented by the general formula (I): wherein R1, R2, R3, X, Y, m, and n are as defined in the disclosure, which can be... | 12/19/2006 |
| 7144881 | Arylcyclopropylcarboxylic amides as potassium channel openers The present invention provides novel arylcyclopropylcarboxylic amides and related derivatives having the general Formula I wherein R, R1, R2, R3, R4, R5, R | 12/05/2006 |
| 7132455 | Phthalamide derivatives This invention relates to novel phthalamide derivatives of formula (I) wherein R1, R2, R3, R4, and R5 have the meanings given in the... | 11/07/2006 |
| 7132457 | Adamantane derivatives The invention provides adamantane derivatives of formula (I), a process for their preparation, pharmaceutical compositions containing them, a process for preparing the pharmaceutical compositions, and their use in therapy. In formula (I) D represents CH2 ... | 11/07/2006 |
| 7053211 | Process for the preparation of α-aminosubstituted carboxylic acid amides The invention relates to a process for the preparation of α-aminosubstituted carboxylic acid amide compounds and/or their salts comprising reacting a carboxylic acid amide of a primary amine with a nitrosylating agent in the presence of a base followed by hydrolysi... | 05/30/2006 |
| 7049271 | Phenyl-substituted 2-enamino-ketonitriles The present invention relates to novel phenyl-substituted 2-enamino-ketonitriles of the formula (I): in which Ar, X, Z, Y and K are each as defined in the description, to a plurality of pro... | 05/23/2006 |
| 7041844 | Irreversible non-steroidal antagonist compound and its use in the treatment of prostate cancer The present invention relates to an antiandrogen compound and a method of treating prostate cancer in a patient utilizing the compound. The present invention also relates to a pharmaceutical composition which includes the compound. ... | 05/09/2006 |
| 7038085 | Stereoisomers of p-hydroxy-milnacipran, and methods of use thereof The present invention relates generally to the enantiomers of para-hydroxy-milnacipran or congeners thereof. Biological assays revealed that racemic para-hydroxy-milnacipran is approximately equipotent in inhibiting serotonin and norepinephrine uptake (IC50 | 05/02/2006 |
| 7005546 | Acetamidobenzamide compounds for neurodegenerative disorders A group of benzamide compounds are disclosed which are useful for treating neurodegenerative disorders. Methods for making these compounds are provided. These materials are formed into pharmaceutical compositions for oral or intravenous administration to patients su... | 02/28/2006 |
| 6995269 | Guanidinobenzamides Compounds of formula IIA and IIB are novel guanidine compounds where the variables R1 through R10 have the values set forth herein. Such compounds have use in treating diseases such as obesity and ... | 02/07/2006 |
| 6995284 | Synthesis of selective androgen receptor modulators The present invention relates to a synthetic process for the preparation of a novel class of androgen receptor targeting agents (ARTA) which demonstrate androgenic and anabolic activity of a nonsteroidal ligand for the androgen receptor. The agents define a new subc... | 02/07/2006 |
| 6949658 | Process for producing optically active α-amino acid and optically active α-amino acid amide The present invention provides a process for efficiently producing an optically active α-amino acid and an optically active α-amino acid amide. After contacting with cells or processed cells thereof having an ability to asymmetrically hydrolyse, a water solvent is... | 09/27/2005 |
| 6946489 | Substituted biphenyl derivatives The invention relates to compounds of the formula I in which R1, R2, R3, R4 and X have the meaning indicated in the text. The compounds act as inhibitors of factors Xa and VI... | 09/20/2005 |
| 6924391 | Alpha-amino,-thio,-oxo substituted ketones as phospholipase inhibitors Inhibitors of the cytosolic phospholypase A2 enzymes are provided which are of use in controlling a wide variety of inflammatory diseases. The inhibitors of the present invention have the general formula wherein X, Z, ... | 08/02/2005 |
| 6921774 | Compounds and their use as glycine transport inhibitors The invention provides novel compounds of the formula I below: wherein the meaning of each substituent is defined in the application. The compounds are useful as inhibitors of the glycine transporter and useful in the ... | 07/26/2005 |
| 6916957 | Serine protease inhibitors Compounds of formula (I) where R5, R6a, each X, L, Cy and Lp are as defined in the specification, are tryptase inhibitors useful as antiinflammatory agents. ... | 07/12/2005 |
| 6846955 | Process for racemising an enantiomer-enriched schiff base of an amino acid amide The invention relates to a process for racemising an enantiomer-enriched Schiff base of a primary amino acid amide with a strong base that is chemically reactive towards water. The reaction is conducted in an organic solvent. Preferably a metal alkoxide, a metal alk... | 01/25/2005 |
| 6831197 | Methods for producing 2-(2-hydroxyphenyl)-2-(alkoxyimino)-N-methylacetamide derivatives The present application relates to a plurality of novel processes for preparing 2-(2-hydroxyphenyl)-2-(alkoxyimino)-N-methylacetamide derivatives, to novel intermediates for their preparation, and to processes for preparing these intermediates. ... | 12/14/2004 |
| 6803378 | HIV integrase inhibitors Novel diketoacid compounds of Formula I are provided which are useful as HIV integrase inhibitors and for the treatment of AIDS or ARC. ... | 10/12/2004 |
| 6794542 | Method for the preparation of enantiomerically enriched compounds Process for the preparation of a diasteromerically enriched phenylglycine amide derivative in which an enantiomerically enriched phenylglycine amide is converted into the corresponding Schiff base with the aid of compound R2—C(O)—R3, and th... | 09/21/2004 |
| 6787670 | Glyoxyl acid amides, method for producing them and their use for controlling harmful organisms The invention relates to novel gloyoxylic acid amides, to a process for their preparation and to their use for controlling harmful organisms. ... | 09/07/2004 |
| 6780995 | Activated iododerivatives for the treatment of cancer and aids A series of activated iodo-benzamide derivatives are described as antineoplastic and antiviral drug compounds. The compounds generally possess a chelating group, a thiol trapping group and an activating group. The presumptive mechanism of action in preventing cancer... | 08/24/2004 |
| 6774116 | Prodrugs via acylation with cinnamate A prodrug composition containing a cinnamate moiety and a biologically active molecule moiety which can be released by hydrolysis or activated by light is disclosed. The cinnamate moiety can have substituents of various electronically donating or electronically with... | 08/10/2004 |
| 6770778 | N-(4-substituted phenyl)-anthranilic acid hydroxamate esters The present invention relates to oxygenated esters of 4-substituted-phenylamino benzhydroxamic acid derivatives, pharmaceutical compositions, and methods of use thereof. ... | 08/03/2004 |
| 6753327 | Substituted amides, their preparation and use An amide of the formula I and its tautomeric forms, possible enantiomeric and diastereomeric forms, E and Z forms, and possible physiologically tolerated salts, in which the variables have the following meanings: ... | 06/22/2004 |
| 6730705 | Alkoximino acetic acid amides The invention relates to new alkoximinoacetic acid amides, a process for their preparation and their use as agents for combating pests. ... | 05/04/2004 |
| 6720452 | Adamantane derivatives The invention provides adamantane derivatives of formula (I), a process for their preparation, pharmaceutical compositions containing them, a process for preparing the pharmaceutical compositions, and their use in therap... | 04/13/2004 |
| 6706765 | Aminoguanidines and alkoxyguanidines as protease inhibitors Aminoguanidine and alkoxyguanidine compounds, including compounds of the formula: wherein X is O or NR9 and R1-R4, R6-R9, R11, R12, Ra | 03/16/2004 |