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| Number | Title | Issue Date |
| 8153844 | Process for making 3-substituted 2-amino-5-halobenzamides Disclosed is a method for preparing a compound of Formula 1 by contacting compound of Formula 2 with R1—NH2 in the presence of a carboxylic acid and a method for preparing a compound of Formula 2 by contacting a compound of Formula 4 with pho... | 04/10/2012 |
| 8063247 | Bicyclic aryl and heteroaryl receptor modulators Compounds of formula (I) or pharmaceutically acceptable salts thereof, are opioid receptor modulators, e.g. mu-opioid receptor antagonists, neutral antagonists or inverse agonists, and are useful inter alia for the treatment of obesity. | 11/22/2011 |
| 7825278 | Substituted enaminones, their derivatives and uses thereof The invention relates to substituted enaminones of Formula I and their derivatives and the discovery that these compounds modulate the effect of γ-aminobutyric acid (GABA) on the GABAA receptor complex in a therapeutically relevant fashion and may be use... | 11/02/2010 |
| 7622612 | Tricyclic derivatives and their use The present invention relates to tricyclic colchicine derivatives represented by the formulas (I) or (II), pharmaceutically acceptable salts thereof, and a method for providing an immuno-suppressive or immuno-modulating effect, an anti-proliferative effect, an anti-... | 11/24/2009 |
| 7439356 | Substituted indan derivatives The present invention relates to intermediates of the formula useful in the preparation of piperazinyl-substituted indan derivatives, wherein Y is CONR2 wherein R2 is H or C1-C | 10/21/2008 |
| 7405307 | Biphenylcarboxamides useful as lipid lowering agents Biphenylcarboxamide compounds of formula (I) methods for preparing such compounds, pharmaceutical compositions comprising said compounds as well as the use of said compounds as a medicine for the treatment of hyperlipidemia... | 07/29/2008 |
| 7390923 | Propionamide derivatives useful as androgen receptor modulators Compounds of formula (I) wherein R1 to R4, X and A are as defined in the claims and pharmaceutically acceptable salts and esters thereof, are disclosed. The compounds of formula (I) possess utility as tissue-selective andro... | 06/24/2008 |
| 7364596 | Dye compositions comprising at least one hydrophobic direct dye and at least one acid The present disclosure provides dye compositions comprising at least one hydrophobic direct dye with a logP of greater than 2, at least one organic or mineral acid with a pKa of less than 4.5, in an aqueous-alcoholic dyeing medium comprising at least 60% by weight o... | 04/29/2008 |
| RE40259 | Alpha-aminoamide derivatives useful as analgesic agents The present invention relates to novel and known alpha-aminoamide compounds, to a process for their preparation, to pharmaceutical composition containing them and to their use as therapeutic agents. In particular, the compounds of the present invention are en... | 04/22/2008 |
| 7348456 | Substituted amides Novel compounds of the structural formula (I) are antagonists and/or inverse agonists of the Cannabinoid-1 (CB1) receptor and are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. The compounds of the present invention are... | 03/25/2008 |
| 7345200 | Phase change ink formulations, colorant formulations, and methods of forming colorants A compound having the formula wherein R1, Z, and the carbonyl can be comprised by a common ring, wherein R1 comprises a chromophore that absorbs light from the visible wavelength range, and wherein n i... | 03/18/2008 |
| 7323595 | Phase change ink formulations, colorant formulations, and methods of forming colorants A compound having the formula wherein R1, Z, and the carbonyl can be comprised by a common ring, wherein R1 comprises a chromophore that absorbs light from the visible wavelength range, and ... | 01/29/2008 |
| 7294649 | Methamphetamine derivatives and conjugates for immunoassay Compounds of methamphetamine derivatives having a meta-substituted alkyl linker on the benzene ring and a protective group on the nitrogen of the methamphetamine hapten. Such compounds have the structure wherein ... | 11/13/2007 |
| 7285680 | β-alanine derivatives and the use thereof A compound of the general formula (I) (wherein the symbols are as defined in the description), or a prodrug or a salt thereof. This compound engages in LPA receptor bonding and antagonism and hence is use... | 10/23/2007 |
| 7247736 | Method of identifying inhibitors of DHODH The present invention provides a compound capable of binding to the ubiquinone binding site of DHODH which contains a non-aromatic ring system as a core structure, a group capable of interacting with structural elements of subsite 2 or 3 of the ubiquinone binding si... | 07/24/2007 |
| RE39682 | Farnesyl derivatives and pharmaceutical compositions containing them Novel farnesyl derivatives which are inhibitors of the prenylated protein methyltransferase enzyme, and useful as anti-cancer drugs, have the following formula: wherein R1represents f... | 06/05/2007 |
| 7223888 | Mu opioid receptor ligands: methods of use and synthesis Novel compounds and compositions including those compounds, as well as methods of using and making the compounds are herein described. The compounds are useful in therapeutic applications, including modulation of disease or disease symptoms in a subject (e.g., mamma... | 05/29/2007 |
| 7208630 | Heat shock protein 90 inhibitors Novel compounds useful for inhibiting the 90 kDa heat shock proteins containing a quinone-like moiety and a di-hydroxy phenol like moiety, similar to geldanamycin and radicicol. ... | 04/24/2007 |
| 7169816 | 4-bromo or 4-iodo phenylamino benzhydroxamic acid derivatives and their use as MEK inhibitors Phenylamino benzhydroxamic acid derivatives of the formula where R1, R2, R3, R4, R5, and R6 are hydrogen or substituent groups such as alkyl, and ... | 01/30/2007 |
| 7166726 | Aryl substituted 3,4-dihydroanthracene derivatives having retinoid antagonist or retinoid inverse agonist type biological activity Disclosed herein are compounds of the formula wherein R1 is independently H or alkyl of 1 to 6 carbons; R2 is optional and is defined as lower alkyl of 1 to 6 carbons, F, Cl, Br... | 01/23/2007 |
| 7151195 | Phthalamide derivative, agricultural or horticultural insecticide, and method of use thereof The present invention relates to a phthalamide derivative represented by the general formula (I): wherein R1, R2, R3, X, Y, m, and n are as defined in the disclosure, which can be... | 12/19/2006 |
| 7147866 | UV-absorbing lipid vesicles Highly effective vesicular compositions from UV-absorbing lipids are described in the present invention. Combination of UV-absorbing property and the vesicular delivery system results in higher levels of photoprotection to skin and hair. The vesicular compositions o... | 12/12/2006 |
| 7135587 | Urea and urethane derivatives as integrin inhibitors Novel urea and urethane derivatives of general formula (I) in which R1, R2, R3, R5, R5′, X, Y, B, m, n and o are as defined in Patent Claim 1, and physiologically acceptable salts or solvates thereof are integrin inhibitors and can be employed for combating... | 11/14/2006 |
| 7132559 | Non-racemic hexafluoroleucine, and methods of making and using it One aspect of the invention relates to hexafluoroleucine and congeners thereof, and methods of making the compounds. Another aspect of the nvention relates to the synthesis of protein cores comprising hexafluoroleucine and congeners thereof. Certain peptides compris... | 11/07/2006 |
| 7132568 | Aspartyl protease inhibitors The present invention provides compounds having formula (I): wherein R′, R0, R1, X1, R2, R3, R3′, X2, X3 and R4 ... | 11/07/2006 |
| 7129238 | Mandelic acid derivatives The invention is concerned with novel mandelic acid derivatives of formula (I) wherein R1 to R10, X and Y are as defined in the description and in the claims, as well as pharmaceutically acc... | 10/31/2006 |
| 7060856 | Polymorphic form of N-[(R)-2,3-dihydroxy-propoxy]-3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-benzamide This invention provides a novel polymorphic form of N-[(R)-2,3-dihydroxy-propoxy]-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide, as well a pharmaceutical compositions and therapeutic methods utilizing the polymorphic form. ... | 06/13/2006 |
| 7049271 | Phenyl-substituted 2-enamino-ketonitriles The present invention relates to novel phenyl-substituted 2-enamino-ketonitriles of the formula (I): in which Ar, X, Z, Y and K are each as defined in the description, to a plurality of pro... | 05/23/2006 |
| 7045660 | Compounds as PDE IV and TNF-inhibitors This invention is directed to a [di(ether or thioether)heteroaryl or fluoro substituted aryl] compound or an N-oxide thereof or a pharmaceutically acceptable salt thereof, which is useful for inhibiting the production or physiological effects of TNF in the treatment... | 05/16/2006 |
| 7041844 | Irreversible non-steroidal antagonist compound and its use in the treatment of prostate cancer The present invention relates to an antiandrogen compound and a method of treating prostate cancer in a patient utilizing the compound. The present invention also relates to a pharmaceutical composition which includes the compound. ... | 05/09/2006 |
| 7022879 | Phase change ink formulations, colorant formulations, and methods of forming colorants The invention encompasses a compound having the formula: wherein R1, Z and the carbonyl can be comprised by a common ring, wherein R1 comprises a chromophore that absorbs light from the visible wav... | 04/04/2006 |
| 7012081 | Anthranyl amides and their use as medicaments Substituted anthranilamides and use thereof as pharmaceutical agents for treating diseases that are triggered by persistent angiogenesis as well as their intermediate products for the production of anthranilamides are described. ... | 03/14/2006 |
| 7005546 | Acetamidobenzamide compounds for neurodegenerative disorders A group of benzamide compounds are disclosed which are useful for treating neurodegenerative disorders. Methods for making these compounds are provided. These materials are formed into pharmaceutical compositions for oral or intravenous administration to patients su... | 02/28/2006 |
| 7005437 | Substituted aryl and heteroaryl derivatives, the preparation thereof and the use therof as pharmaceutical compositions The present invention relates to new substituted aryl and heteroaryl derivatives of general formula wherein A, Ar, n, X, Y1, Y2, Y3, Y4, R | 02/28/2006 |
| 6995269 | Guanidinobenzamides Compounds of formula IIA and IIB are novel guanidine compounds where the variables R1 through R10 have the values set forth herein. Such compounds have use in treating diseases such as obesity and ... | 02/07/2006 |
| 6995284 | Synthesis of selective androgen receptor modulators The present invention relates to a synthetic process for the preparation of a novel class of androgen receptor targeting agents (ARTA) which demonstrate androgenic and anabolic activity of a nonsteroidal ligand for the androgen receptor. The agents define a new subc... | 02/07/2006 |
| 6992103 | Benzamide derivatives, processes for their preparation, and their pharmaceutical use The present invention relates to novel hydroxyethylene compounds having Asp2 (β-secretase, BACE1 or Memapsin) inhibitory activity, processes for their preparation, to compositions containing them and to their use in the treatment of diseases characterised by elevat... | 01/31/2006 |
| 6960581 | Glucocorticoid mimetics, methods of making them, pharmaceutical formulations, and uses thereof A compound of Formula (I) wherein R1, R2, R3, R4, R5, and R6 are as defined herein, or a tautomer, prodrug, solvate, or salt thereof, pharmaceutical com... | 11/01/2005 |
| RE38856 | Preparation of tri-iodo benzene compounds The invention provides a process by which ultra low salt content triiodinated aromatic compounds may be isolated from a highly acidic hot triiodination raction reaction medium in a straightforward fashion. The process involves increasing the pH to above 5 a value in... | 10/25/2005 |
| 6942980 | Methods of identifying compounds having nuclear receptor negative hormone and/or antagonist activities Methods of characterizing and identifying negative hormones of nuclear receptors. Also disclosed are methods of making modulators of retinoid nuclear receptor transactivation activity, assays for agonists, antagonists, and negative hormones of the RAR receptor, and ... | 09/13/2005 |
