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| Number | Title | Issue Date |
| 8143447 | Treatment of cancer The present invention provides compositions of matter, kits and methods for their use in the treatment of cancer. In particular, the invention provides compositions and methods for treating cancer in a subject by inhibiting a poly-ADP-ribose polymerase, as well as p... | 03/27/2012 |
| 8124807 | Sulfonyl-substituted 6-membered ring derivative [Problem] To provide a compound that is useful as an agent in the prevention and treatment of circulatory system, nervous system, metabolic, reproductive system, and gastrointestinal diseases. [Means for Resolution] A compound or a pharmaceutica... | 02/28/2012 |
| 8119842 | Process for synthesis of amino-methyl tetralin derivatives Methods for producing a compound of formula k1 or k2 by reducing a dihydronapthalene amide compound of formula i with hydrogen gas in the presence of a ruthenium catalyst of formu... | 02/21/2012 |
| 7960586 | Purification of armodafinil The invention encompasses processes for obtaining pure armodafinil substantially free of disulfide impurities that is suitable for use on an industrial scale. In particular, a processes for purifying armodafinil from bis(diphenylmethyl)disulfide comprising: dissolvi... | 06/14/2011 |
| 7915449 | Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation The invention relates to a method for preparing a sulphoxide compound of formula (I) either as a single enantiomer or in an enantiomerically enriched form, comprising the steps of: a) contacting a pro-chiral sulphide of formula (II... | 03/29/2011 |
| 7812193 | Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation The invention relates to a method for preparing a sulphoxide compound of formula (I) either as a single enantiomer or in an enantiomerically enriched form, comprising the steps of: a) contacting a pro-chiral sulphide of formula (II... | 10/12/2010 |
| 7687665 | 2-methylprop anamides and their use as pharmaceuticals The present invention relates to inhibitors of 11-β hydroxyl steroid dehydrogenase type 1, antagonists of the mineralocorticoid receptor (MR), and pharmaceutical compositions thereof. The compounds of the invention can be useful in the treatment of various diseases... | 03/30/2010 |
| 7632971 | Method of crystallization of bicalutamide The present invention provides a method of crystallization of bicalutamide comprising adding an acetone solution containing bicalutamide to water; crystals of bicalutamide wherein particle size distribution of the crystals is 1 to 10 μm of Dp10, 10 to 25... | 12/15/2009 |
| 7629493 | Process for the crystallisation of guandinium salts The invention relates to a process for the crystallization of the compounds of the formula (I) or acid-addition salts thereof, in which R1, R2 and R3 have the meaning indicated in Claim 1. ... | 12/08/2009 |
| 7622611 | Pentafluorosulfanylbenzoylguanidines, process for their preparation, use as a medicament or diagnostic aid, and medicament comprising same Pentafluorosulfanylbenzoylguanidines of formula I wherein R1 to R4 have the meanings stated in the claims, are suitable, for example, as antiarrhythmic medicaments with a cardioprotective component for the prophylaxis of in... | 11/24/2009 |
| 7566805 | Modafinil compositions Co-crystals and solvates of racemic, enantiomerically pure, and enantiomerically mixed modafinil are formed and several important physical properties are modulated. The solubility, dissolution, bioavailability, dose response, and stability of modafinil can be modula... | 07/28/2009 |
| 7446225 | Pentafluorosulfanylphenyl-substituted benzoylguanidines, method for the production thereof, their use as a medicament or diagnostic agent, and a medicament containing these compounds The invention relates to pentafluorosulfanylphenyl-substituted benzoylguanidines of the formula I: and a process for preparing a compound of the formula I and/or the pharmaceutically acceptable salts thereof. ... | 11/04/2008 |
| 7439356 | Substituted indan derivatives The present invention relates to intermediates of the formula useful in the preparation of piperazinyl-substituted indan derivatives, wherein Y is CONR2 wherein R2 is H or C1-C | 10/21/2008 |
| 7423176 | Bicyclic aromatic sulfinyl derivatives The present invention provides compounds of the structure: wherein the constituent members are defined herein, including pharmaceutical compositions thereof and methods of treating diseases therewith. ... | 09/09/2008 |
| 7405323 | Modafinil polymorphic forms Modafinil polymorphic forms of modafinil racemate, methods of preparation thereof, pharmaceutical compositions and methods of therapeutic treatment involving modafinil polymorphic forms. ... | 07/29/2008 |
| 7390923 | Propionamide derivatives useful as androgen receptor modulators Compounds of formula (I) wherein R1 to R4, X and A are as defined in the claims and pharmaceutically acceptable salts and esters thereof, are disclosed. The compounds of formula (I) possess utility as tissue-selective andro... | 06/24/2008 |
| 7381841 | Pentafluorosulfanylphenyl-substituted benzoylguanidines, processes for their preparation, their use as medicament or diagnostic aid, and medicament comprising them Pentafluorosulfany0lphenyl-substituted benzoylguanidines, process for their preparation, theie use as medicament or diagnostic aed, and medicament comprising them Pentafluorosulfany0lphenyl-substituted benzoylguanidines of the formulae I and II | 06/03/2008 |
| 7355079 | Thyronamine derivatives and analogs and methods of use thereof Thyronamine derivatives and analogs, methods of using such compounds, and pharmaceutical compositions containing them are disclosed. Methods of preparing such compounds are also disclosed. ... | 04/08/2008 |
| 7317126 | Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation The invention relates to a method for preparing a sulphoxide compound of formula (I) either as a single enantiomer or in an enantiomerically enriched form, comprising the steps of: a) contacting a pro-chiral sulphide of formula (II... | 01/08/2008 |
| 7314875 | Tricyclic aromatic and bis-phenyl sulfinyl derivatives The present invention provides compounds of the structure: wherein the constituent members are defined herein, including pharmaceutical compositions thereof and methods of treating diseases therewith. ... | 01/01/2008 |
| 7304094 | Cyclohexyl sulphones Novel sulphones of formula I are disclosed: The compounds modulate the processing of amyloid precursor protein by gamma-secretase, and hence are useful in the treatment or prevention of Alzheimer's disease. ... | 12/04/2007 |
| 7297817 | Thio-substituted arylmethanesulfinyl derivatives The present invention is related to chemical compositions, processes for the preparation thereof and uses of the composition. Particularly, the present invention relates to compositions of compounds of Formula (A): wherein ... | 11/20/2007 |
| 7244865 | Process for preparing benzhydrylthioacetamide The present invention is directed to an improved process for preparing modafinil wherein benzhydrylthioacetamide is prepared in high yield and purity by the reaction of a haloacetamide with the reaction product of thiourea and benzhydrol in aqueous solution. The rea... | 07/17/2007 |
| 7235691 | Crystalline forms of modafinil The present invention provides an improved process for preparing modafinil, whereby it may be isolated in high purity by a single crystallization. The process produces modafinil free of sulphone products of over-oxidation and other byproducts. The invention further ... | 06/26/2007 |
| RE39682 | Farnesyl derivatives and pharmaceutical compositions containing them Novel farnesyl derivatives which are inhibitors of the prenylated protein methyltransferase enzyme, and useful as anti-cancer drugs, have the following formula: wherein R1represents f... | 06/05/2007 |
| 7211684 | Method for preparing methyl 2-diphenylmethylsulfinylacetate The invention relates to a method for preparing methyl 2-diphenylmethylsulfinylacetate (MDMSA) comprising the steps of: (i) conversion of benzhydrol into methyldiphenylmethylthioacetate (MDMTA); and (ii) conversion of methyldiphenylmethylthioacetate (MDMTA) into met... | 05/01/2007 |
| 7205438 | Solvent recovery blends from diene production A diene production stream comprising a solvent recovery blend from diene production comprising one or more fouling agent, one or more extractive distillation solvent, and from about 1 ppm to about 1000 ppm of N,N-disubstituted amide. ... | 04/17/2007 |
| 7186860 | Process for the preparation of 2-[(diphenylmethyl) thio] acetamide Process for the preparation of 2-[(diphenylmethyl)thioacetamide, an intermediate for the preparation of Modafinil which is a CNS stimulant and used for the treatment of narcolepsia. The process comprises reacting 2-[(diphenylmethyl)thio]acetic acid with alcohols, in... | 03/06/2007 |
| 7132456 | MCH receptor antagonists The present invention relates to a melanin concentrating hormone antagonist compound of Formula I: (I) wherein Ar1, Ar2, Ar3, L1, L2 and Q areas defined, or a pharmaceutically acceptable salt, solvate, enantiome... | 11/07/2006 |
| 7132570 | Method for the production of crystalline forms and crystalline forms of optical enantiomers of modafinil The invention relates to a process for the preparation of crystalline forms of the optical enantiomers of modafinil, comprising stages comprising: i) dissolving one of the optical enantiomers of modafinil in a solvent other than et... | 11/07/2006 |
| 7132455 | Phthalamide derivatives This invention relates to novel phthalamide derivatives of formula (I) wherein R1, R2, R3, R4, and R5 have the meanings given in the... | 11/07/2006 |
| 7129377 | Irreversible non-steroidal antagonist compound and its use in the treatment of prostate cancer The present invention relates to an androgen receptor alkylating compound, wherein the compound may include, inter alia, an active functional group, which permits the alkylation of the androgen receptor. ... | 10/31/2006 |
| 7126026 | Process for preparing 4-pentafluorosulfanylbenzoylguanidines A process for preparing 4-pentafluorosulfanylbenzoylguanidines of formula I wherein R1 to R4 have the meanings indicated in the specification. The compounds of formula I are NHE1 inhibitors and can be employed, f... | 10/24/2006 |
| 7119229 | Alkaloid derivative and a pharmaceutical composition containing the same Colchicine derivatives represented by the formula (I) with a halogen or nitric ester group, or pharmaceutically acceptable salts thereof, are described. Pharmaceutical compositions containing the same as effectiv... | 10/10/2006 |
| 7102026 | Process for preparing and isolating -bicalutamide and its intermediates The present invention relates to a new process for the synthesis of racemic and optically active bicalutamide starting from ethyl pyruvate and methyl methacrylate. The present invention discloses processes of preparing bicalutamide intermediates including ethyl-[2-{... | 09/05/2006 |
| 7057068 | Process for the preparation of modafinil A process for the preparation of 2-[(diphenylmethyl)sulfinyl]acetamide (I) comprising the oxidation of sodium 2-[(diphenylmethyl)sulfenyl]acetate to the corresponding sulfoxide and the derivatization of the latter to amide ... | 06/06/2006 |
| 7057069 | Preparations of a sulfinyl acetamide The present invention provides processes for the preparation of modafinil which includes the step of reacting benzhydrylthiol and chloroacetamide. ... | 06/06/2006 |
| 7045660 | Compounds as PDE IV and TNF-inhibitors This invention is directed to a [di(ether or thioether)heteroaryl or fluoro substituted aryl] compound or an N-oxide thereof or a pharmaceutically acceptable salt thereof, which is useful for inhibiting the production or physiological effects of TNF in the treatment... | 05/16/2006 |
| 7045649 | C2-substituted idan-1-ols and their derivatives, processes for their preparation and their use as pharmaceuticals Embodiments of the invention relate to C2-substituted indan-1-ols and to their physiologically acceptable salts and physiologically functional derivatives. Compounds of embodiments of the invention may include compounds of formula I | 05/16/2006 |
| 7041702 | Pharmaceutically active compounds and methods of use The present invention relates to pharmaceutically acceptable compounds, including acylguanidine compounds, and methods of treatment and pharmaceutical compositions that utilize or comprise one or more such compounds. Compounds of the invention are particularly usefu... | 05/09/2006 |
