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Class 564/159 - Acyclic


Subclass of Class 564 - Organic compounds -- part of the class 532-570 series
Definition: Compounds which contain no ring.
No. of patents: 232
Last issue date: 12/22/2009


1            
NumberTitleIssue Date
7635789Fluoroalkyl acid amide surfactants
Compounds of formula (I) and formula (III): wherein A is —F or —CF3; Rf is independently C1-C6 perfluorinated linear or bra...
12/22/2009
7501542Highly-packed polycationic ammonium, sulfonium and phosphonium lipids
The present invention discloses highly packed polycationic ammonium, sulfonium and phosphonium lipid compounds useful for making lipid aggregates for delivery of macromolecules and other compounds into cells. They are especially useful for the DNA-dependent transfor...
03/10/2009
7390875Method for binding, in solution, a peptide and a lipophilic vector and uses thereof
The invention concerns a method for binding, in solution, at least a peptide composition and at least a lipophilic vector bearing an aldehyde function, the coupling comprising a step which consists in producing a hydrazone bond between the peptide compound and the l...
06/24/2008
7358394Process for preparing N,N′-dialkoxy-N, N′-dialkyl oxamide
The present invention provides a process for preparing an N,N′-dialkoxy-N,N′-dialkyl oxamide represented by the formula (3): wherein R2 and R3 may be the same or different ...
04/15/2008
7332485Peptide deformylase inhibitors
Novel PDF inhibitors and novel methods for their use are provided. ...
02/19/2008
7323594Transfection reagents
Disclosed are compounds capable of facilitating transport of biologically active agents or substances into cells having the general structure: wherein Q is selected from the gro...
01/29/2008
7238834Piperidine derivatives and process for their production
The present invention relates to substantially pure piperidine derivative compounds of the formulae: wherein R1 is hydrogen or hydroxy; R2
07/03/2007
7220814Hydrophilicized blocked polyisocyanates
The present invention relates to new hydrophilicized blocked polyisocyanates, a process for preparing them and their use. ...
05/22/2007
7166745Transfection reagents
Disclosed are compounds capable of facilitating transport of biologically active agents or substances into cells having the general structure: wherein Q is selected from the gro...
01/23/2007
7157092Acyl pseudodipeptides, preparation method and pharmaceutical compositions containing same
Compounds of the formula wherein the substitutents are defined as in the specification useful for modulating immune responses in warm-blooded animals. ...
01/02/2007
7067697Cationic liposomes for gene transfer
The present invention relates to synthetic cationic lipids, liposome formulations and the use of such compounds to introduce functional bioactive agents into cultured cells. ...
06/27/2006
7030201Bottom antireflective coatings
The present invention relates to bottom antireflective coating compositions and polymers useful in making such compositions. ...
04/18/2006
7002042Cationic liposomes for gene transfer
The present invention relates to synthetic cationic lipids, liposome formulations and the use of such compounds to introduce functional bioactive agents into cultured cells. ...
02/21/2006
6969728Modulators of TNF-α signaling
The present invention provides compounds which are modulators of TNF-α signaling and methods of use thereof for treating a patient having a TNF-α mediated condition. The compounds can be represented by the following structural formulas:
11/29/2005
6963010Hydrophobic polyamine analogs and methods for their use
The disclosed invention provides new polyamine analogs and derivatives containing a hydrophobic region and a polyamine region as well as methods and compositions for their use. ...
11/08/2005
6855826Antagonists of the magnesium binding defect as therapeutic agents and methods for treatment of abnormal physiological states
This invention provides a class of therapeutic compounds and methods for the treatment of mammals with physiological disorders, such as for example a frequently occurring type of essential hypertension, which are critically associated with the decreased binding of m...
02/15/2005
6777387Terminally-branched polymeric linkers containing extension moieties and polymeric conjugates containing the same
The present invention is directed to polymeric prodrug transport forms and methods of making and using the same. In one preferred aspect, the prodrugs are of the formula: wherein G is a polymeric residue; Z...
08/17/2004
6699910Ketone compounds and compositions for cholesterol management and related uses
The present invention relates to novel ketone compounds, compositions comprising ketone compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders comprising administ...
03/02/2004
6664420Antagonists of the magnesium binding defect as therapeutic agents and methods for treatment of abnormal physiological states
This invention provides a class of therapeutic compounds and methods for the treatment of mammals with physiological disorders, such as for example a frequently occurring type of essential hypertension, which are critically associated with the decreased b...
12/16/2003
6660886Amphiphilic lubricants for magnetic media
A magnetic recording medium including a lubricant topcoat having increased bonding to the medium surface comprises an amphiphilic lubricant molecule having a hydrophilic central portion including a plurality of polar functional groups bound to the medium ...
12/09/2003
6652834Amphipatic polycarboxylic chelates and complexes with paramagnetic metals as MRI contrast agents
Substituted polycarboxylic ligand molecules and corresponding metal complexes of said ligands, preferably paramagnetic metals complexes for generating responses in the field of magnetic resonance imaging (MRI) The paramagnetic complexes of the polycarboxy...
11/25/2003
6627775Process for manufacturing gasoline additives of ester-free polyoxyalkylene amide
An improved process to prepare poly(oxyalkylene)amide for gasoline additives involves three consecutive reactions. The reactions are (1) amidation of water-soluble low molecular weight of polyalkylene polyamine with alkyl acetate at an elevated temperatur...
09/30/2003
6566506Non-antigenic branched polymer conjugates
Branched, substantially non-antigenic polymers are disclosed. Conjugates prepared with the polymers and biologically active molecules such as proteins and peptides demonstrate extended circulating life in vivo. Substantially fewer sites on the biologicall...
05/20/2003
6562782Oligocycloalkanoid compounds and methods of use
The present invention related to an oligocycloalkanoid compound comprising formula (I) ##STR1## wherein m, n, and o are independently an integer from 0 to 2; A1 through A10 are independently a direct link, alkylene, alkylene-O--, ...
05/13/2003
6562963Process for the preparation of macrocyclic metalloprotease inhibitors
The present invention is directed to a process for the preparation of a compound of formula (X-a) ##STR1## or a pharmaceutically acceptable salt form thereof, wherein: R1 is selected from the group consisting of: C1-5 alkyl substituted wi...
05/13/2003
6521790Alkynyl amides and their therapeutic applications
Compounds of formula (I) ##STR1## are novel and useful for treating seizure, migraine and psychiatric disorders....
02/18/2003
6506733Compounds and compositions as protease inhibitors
Compounds of the formula: ##STR1## are provided, and are useful as cysteine protease inhibitors, particularly in the treatment of diseases such as osteoporosis or autoimmune disorders in which cathepsins K or S contribute to the pathology or symptomatolgy...
01/14/2003
6482827Matrix metalloproteinase inhibitors
A compound, which is an amine derivative of formula (I) wherein W is --CNHOH or --COOH: R1 and R2 are each hydrogen or an organic residue, R3 is an organic group, Q is a secondary or tertiary acyclic or cyclic amido group,...
11/19/2002
6476263Compounds for inhibiting ଲ-amyloid peptide release and/or its synthesis
Disclosed are compounds which inhibit ଲ-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits ଲ-amyloid...
11/05/2002
6455734Antagonists of the magnesium binding defect as therapeutic agents and methods for treatment of abnormal physiological states
This invention provides a class of therapeutic compounds and methods for the treatment of mammals of physiological disorders, for example a frequently occurring type of essential hypertension, which are associated with the decreased binding of magnesium t...
09/24/2002
6410749Process for the preparation of optically active amino alcohols
Process for preparing optically active ଲ-amino alcohols represented by a general formula (2): Ra--C*H(OH)--C*H(Rb)--Rc wherein Ra and Rc are each independently hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, Rb is one memb...
06/25/2002
6395713Compositions for the delivery of negatively charged molecules
This invention features permeability enhancer molecules, and methods, to increase membrane permeability of negatively charged polymers thereby facilitating cellular uptake of such polymers....
05/28/2002
6384279Synthesis of a tetraamido macrocycle ligand from a novel diamidodiol
A new composition of matter for a diamidodiol and a method for preparing the diamidodiol. The exemplary diamidodiol has the formula C15 H30 N2 O4 and is prepared by reacting a first quantity of 2-amino-2-methyl-...
05/07/2002
6339173Amide-based cationic lipids
The present invention provides novel amide-based cationic lipids of the general structure: ##STR1## or a salt, or solvate, or enantiomers thereof wherein; (a) Y is a direct link or an alkylene of 1 to about 20 carbon atoms; (b) R1 is H or a ...
01/15/2002
6335468Process for production N-acyl amino acid amide
There is provided a process for producing an N-acyl amino acid amide, comprising a condensation reaction of an N-acyl amino acid with an amine and/or an ammonia, preferably a primary amine, a secondary amine and/or an ammonia under dehydration in the pres...
01/01/2002
6333426Chiral adsorbents and preparation thereof as well as compounds on which the absorbents are based and preparation of the compounds
Opticallly active adsorbents based on network polymerized derivative of dicarboxylic acids, diamines or diols which are chemically bonded to a carrier. The derivatives can be polymerized by radical polymerization or through hydrosilylation in the presence...
12/25/2001
6326393Glycol and hydroxyphosphonate peptidomimetics as inhibitors of aspartyl proteases
Compounds of Formula I ##STR1## are disclosed as inhibitors having activity against the aspartyl proteases, plasmepsin and cathepsin D. The compounds are therefore useful for treatment of diseases such as malaria and Alzheimer's disease. In preferred...
12/04/2001
6316669Bis-amido polybiguanides and the use thereof to disinfect contact lenses and preserve pharmaceutical compositions
Bis-amido polybiguanides and their use as antimicrobial agents in pharmaceutical compositions are disclosed. A method of synthesis of bis-amido polybiguanides is also disclosed. The bis-amido polybiguanides are useful in the preservation of pharmaceutical...
11/13/2001
6316505Pharmaceutical compositions comprising fluorinated co-polymers
Block copolymers containing a fluorinated hydrocarbon unit, a hydrocarbon unit, and a poly(oxyethylene) unit are useful in fluid formulations of pharmaceutical agents. A typical embodiment is: C11 H23 --CONHC2 H4 NHC...
11/13/2001
6306463Citric acid tri-alkylamide surfactants
This invention provides water-based compositions which are essentially free of hydrocarbon solvents, particularly coating, ink, fountain solution, adhesive, agricultural and electronics cleaning compositions, manifesting reduced equilibrium and dynamic su...
10/23/2001
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