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| Number | Title | Issue Date |
| 7635789 | Fluoroalkyl acid amide surfactants Compounds of formula (I) and formula (III): wherein A is —F or —CF3; Rf is independently C1-C6 perfluorinated linear or bra... | 12/22/2009 |
| 7501542 | Highly-packed polycationic ammonium, sulfonium and phosphonium lipids The present invention discloses highly packed polycationic ammonium, sulfonium and phosphonium lipid compounds useful for making lipid aggregates for delivery of macromolecules and other compounds into cells. They are especially useful for the DNA-dependent transfor... | 03/10/2009 |
| 7390875 | Method for binding, in solution, a peptide and a lipophilic vector and uses thereof The invention concerns a method for binding, in solution, at least a peptide composition and at least a lipophilic vector bearing an aldehyde function, the coupling comprising a step which consists in producing a hydrazone bond between the peptide compound and the l... | 06/24/2008 |
| 7358394 | Process for preparing N,N′-dialkoxy-N, N′-dialkyl oxamide The present invention provides a process for preparing an N,N′-dialkoxy-N,N′-dialkyl oxamide represented by the formula (3): wherein R2 and R3 may be the same or different ... | 04/15/2008 |
| 7332485 | Peptide deformylase inhibitors Novel PDF inhibitors and novel methods for their use are provided. ... | 02/19/2008 |
| 7323594 | Transfection reagents Disclosed are compounds capable of facilitating transport of biologically active agents or substances into cells having the general structure: wherein Q is selected from the gro... | 01/29/2008 |
| 7238834 | Piperidine derivatives and process for their production The present invention relates to substantially pure piperidine derivative compounds of the formulae: wherein R1 is hydrogen or hydroxy; R2 | 07/03/2007 |
| 7220814 | Hydrophilicized blocked polyisocyanates The present invention relates to new hydrophilicized blocked polyisocyanates, a process for preparing them and their use. ... | 05/22/2007 |
| 7166745 | Transfection reagents Disclosed are compounds capable of facilitating transport of biologically active agents or substances into cells having the general structure: wherein Q is selected from the gro... | 01/23/2007 |
| 7157092 | Acyl pseudodipeptides, preparation method and pharmaceutical compositions containing same Compounds of the formula wherein the substitutents are defined as in the specification useful for modulating immune responses in warm-blooded animals. ... | 01/02/2007 |
| 7067697 | Cationic liposomes for gene transfer The present invention relates to synthetic cationic lipids, liposome formulations and the use of such compounds to introduce functional bioactive agents into cultured cells. ... | 06/27/2006 |
| 7030201 | Bottom antireflective coatings The present invention relates to bottom antireflective coating compositions and polymers useful in making such compositions. ... | 04/18/2006 |
| 7002042 | Cationic liposomes for gene transfer The present invention relates to synthetic cationic lipids, liposome formulations and the use of such compounds to introduce functional bioactive agents into cultured cells. ... | 02/21/2006 |
| 6969728 | Modulators of TNF-α signaling The present invention provides compounds which are modulators of TNF-α signaling and methods of use thereof for treating a patient having a TNF-α mediated condition. The compounds can be represented by the following structural formulas: | 11/29/2005 |
| 6963010 | Hydrophobic polyamine analogs and methods for their use The disclosed invention provides new polyamine analogs and derivatives containing a hydrophobic region and a polyamine region as well as methods and compositions for their use. ... | 11/08/2005 |
| 6855826 | Antagonists of the magnesium binding defect as therapeutic agents and methods for treatment of abnormal physiological states This invention provides a class of therapeutic compounds and methods for the treatment of mammals with physiological disorders, such as for example a frequently occurring type of essential hypertension, which are critically associated with the decreased binding of m... | 02/15/2005 |
| 6777387 | Terminally-branched polymeric linkers containing extension moieties and polymeric conjugates containing the same The present invention is directed to polymeric prodrug transport forms and methods of making and using the same. In one preferred aspect, the prodrugs are of the formula: wherein G is a polymeric residue; Z... | 08/17/2004 |
| 6699910 | Ketone compounds and compositions for cholesterol management and related uses The present invention relates to novel ketone compounds, compositions comprising ketone compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders comprising administ... | 03/02/2004 |
| 6664420 | Antagonists of the magnesium binding defect as therapeutic agents and methods for treatment of abnormal physiological states This invention provides a class of therapeutic compounds and methods for the treatment of mammals with physiological disorders, such as for example a frequently occurring type of essential hypertension, which are critically associated with the decreased b... | 12/16/2003 |
| 6660886 | Amphiphilic lubricants for magnetic media A magnetic recording medium including a lubricant topcoat having increased bonding to the medium surface comprises an amphiphilic lubricant molecule having a hydrophilic central portion including a plurality of polar functional groups bound to the medium ... | 12/09/2003 |
| 6652834 | Amphipatic polycarboxylic chelates and complexes with paramagnetic metals as MRI contrast agents Substituted polycarboxylic ligand molecules and corresponding metal complexes of said ligands, preferably paramagnetic metals complexes for generating responses in the field of magnetic resonance imaging (MRI) The paramagnetic complexes of the polycarboxy... | 11/25/2003 |
| 6627775 | Process for manufacturing gasoline additives of ester-free polyoxyalkylene amide An improved process to prepare poly(oxyalkylene)amide for gasoline additives involves three consecutive reactions. The reactions are (1) amidation of water-soluble low molecular weight of polyalkylene polyamine with alkyl acetate at an elevated temperatur... | 09/30/2003 |
| 6566506 | Non-antigenic branched polymer conjugates Branched, substantially non-antigenic polymers are disclosed. Conjugates prepared with the polymers and biologically active molecules such as proteins and peptides demonstrate extended circulating life in vivo. Substantially fewer sites on the biologicall... | 05/20/2003 |
| 6562782 | Oligocycloalkanoid compounds and methods of use The present invention related to an oligocycloalkanoid compound comprising formula (I) ##STR1## wherein m, n, and o are independently an integer from 0 to 2; A1 through A10 are independently a direct link, alkylene, alkylene-O--, ... | 05/13/2003 |
| 6562963 | Process for the preparation of macrocyclic metalloprotease inhibitors The present invention is directed to a process for the preparation of a compound of formula (X-a) ##STR1## or a pharmaceutically acceptable salt form thereof, wherein: R1 is selected from the group consisting of: C1-5 alkyl substituted wi... | 05/13/2003 |
| 6521790 | Alkynyl amides and their therapeutic applications Compounds of formula (I) ##STR1## are novel and useful for treating seizure, migraine and psychiatric disorders.... | 02/18/2003 |
| 6506733 | Compounds and compositions as protease inhibitors Compounds of the formula: ##STR1## are provided, and are useful as cysteine protease inhibitors, particularly in the treatment of diseases such as osteoporosis or autoimmune disorders in which cathepsins K or S contribute to the pathology or symptomatolgy... | 01/14/2003 |
| 6482827 | Matrix metalloproteinase inhibitors A compound, which is an amine derivative of formula (I) wherein W is --CNHOH or --COOH: R1 and R2 are each hydrogen or an organic residue, R3 is an organic group, Q is a secondary or tertiary acyclic or cyclic amido group,... | 11/19/2002 |
| 6476263 | Compounds for inhibiting ଲ-amyloid peptide release and/or its synthesis Disclosed are compounds which inhibit ଲ-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits ଲ-amyloid... | 11/05/2002 |
| 6455734 | Antagonists of the magnesium binding defect as therapeutic agents and methods for treatment of abnormal physiological states This invention provides a class of therapeutic compounds and methods for the treatment of mammals of physiological disorders, for example a frequently occurring type of essential hypertension, which are associated with the decreased binding of magnesium t... | 09/24/2002 |
| 6410749 | Process for the preparation of optically active amino alcohols Process for preparing optically active ଲ-amino alcohols represented by a general formula (2): Ra--C*H(OH)--C*H(Rb)--Rc wherein Ra and Rc are each independently hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, Rb is one memb... | 06/25/2002 |
| 6395713 | Compositions for the delivery of negatively charged molecules This invention features permeability enhancer molecules, and methods, to increase membrane permeability of negatively charged polymers thereby facilitating cellular uptake of such polymers.... | 05/28/2002 |
| 6384279 | Synthesis of a tetraamido macrocycle ligand from a novel diamidodiol A new composition of matter for a diamidodiol and a method for preparing the diamidodiol. The exemplary diamidodiol has the formula C15 H30 N2 O4 and is prepared by reacting a first quantity of 2-amino-2-methyl-... | 05/07/2002 |
| 6339173 | Amide-based cationic lipids The present invention provides novel amide-based cationic lipids of the general structure: ##STR1## or a salt, or solvate, or enantiomers thereof wherein; (a) Y is a direct link or an alkylene of 1 to about 20 carbon atoms; (b) R1 is H or a ... | 01/15/2002 |
| 6335468 | Process for production N-acyl amino acid amide There is provided a process for producing an N-acyl amino acid amide, comprising a condensation reaction of an N-acyl amino acid with an amine and/or an ammonia, preferably a primary amine, a secondary amine and/or an ammonia under dehydration in the pres... | 01/01/2002 |
| 6333426 | Chiral adsorbents and preparation thereof as well as compounds on which the absorbents are based and preparation of the compounds Opticallly active adsorbents based on network polymerized derivative of dicarboxylic acids, diamines or diols which are chemically bonded to a carrier. The derivatives can be polymerized by radical polymerization or through hydrosilylation in the presence... | 12/25/2001 |
| 6326393 | Glycol and hydroxyphosphonate peptidomimetics as inhibitors of aspartyl proteases Compounds of Formula I ##STR1## are disclosed as inhibitors having activity against the aspartyl proteases, plasmepsin and cathepsin D. The compounds are therefore useful for treatment of diseases such as malaria and Alzheimer's disease. In preferred... | 12/04/2001 |
| 6316669 | Bis-amido polybiguanides and the use thereof to disinfect contact lenses and preserve pharmaceutical compositions Bis-amido polybiguanides and their use as antimicrobial agents in pharmaceutical compositions are disclosed. A method of synthesis of bis-amido polybiguanides is also disclosed. The bis-amido polybiguanides are useful in the preservation of pharmaceutical... | 11/13/2001 |
| 6316505 | Pharmaceutical compositions comprising fluorinated co-polymers Block copolymers containing a fluorinated hydrocarbon unit, a hydrocarbon unit, and a poly(oxyethylene) unit are useful in fluid formulations of pharmaceutical agents. A typical embodiment is: C11 H23 --CONHC2 H4 NHC... | 11/13/2001 |
| 6306463 | Citric acid tri-alkylamide surfactants This invention provides water-based compositions which are essentially free of hydrocarbon solvents, particularly coating, ink, fountain solution, adhesive, agricultural and electronics cleaning compositions, manifesting reduced equilibrium and dynamic su... | 10/23/2001 |