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| Number | Title | Issue Date |
| 7737300 | Processes and intermediates preparing cysteine protease inhibitors The present invention is directed to a process for preparing certain cysteine protease inhibitors. ... | 06/15/2010 |
| 7485751 | Process for the preparation of enantiomers of amidoacetonitrile compounds from their racemates The invention is directed at a new process for the preparation of pure enantiomers from the racemate of amidoacetonitrile compounds of formula wherein R1, R2 and R3, independent... | 02/03/2009 |
| 7227036 | Production process of aminomethyl group-containing benzamide compound There is provided a process for producing an aminomethyl group-containing benzamide compound represented by the general formula (II): wherein —CONH2 and —X represent a substituent on the benzene ring and —CONH2 exists at the meta- or para-position of —CH2NH2... | 06/05/2007 |
| 6861557 | Process for preparing rac-bicalutamide and its intermediates The present invention relates to a new process for the synthesis of racemic and optically active bicalutamide starting from ethyl pyruvate and methyl methacrylate. The present invention discloses processes of preparing bicalutamide intermediates including ethyl-[2-{... | 03/01/2005 |
| 6750368 | Process for preparing sulphuric methacrylamide and device for implementing it The present invention relates to a process for preparing sulphuric methacrylamide. The process can include adding sulphur trioxide and a second part of acetone cyanohydrin without sulfuric add to a reaction medium, after a first part of acetone cyanohydrin with sulp... | 06/15/2004 |
| 6696605 | Process for preparing -hydroxyamides and -ketoamides on a solid phase support The present invention relates to a process for preparing a -hydroxyamide or -ketoamide, said process comprising the steps of: a) reacting a resin which comprises a polymer-supported isocyanide with an aldehyde in the presence of a cataly... | 02/24/2004 |
| 6673967 | Method of processing of hydrogen for reductive acylation of nitro, azido and cyano arenes A method for processing of hydrogen for the reductive acylation of nitro, azido and cyano arenes is disclosed. More particularly, improved process for the preparation of amides and anilides using C3 -C7 carboxylic acids as proton sou... | 01/06/2004 |
| 6649796 | Process for the preparation of acetamide derivatives The invention provides a process for the preparation of diphenylmethylthioacetamide (I) as described in Scheme 4 comprising reacting of the isothiouronium salt or its corresponding base of the formula IV with an acetamide of the formula XCH2 CO... | 11/18/2003 |
| 6521794 | Method for production of aromatic compounds For the production of an aromatic compound by hydrolyzing and decarboxylating a corresponding aromatic cyano compound in the presence of an acidic substance, this invention provides a method for the production of the aromaic compound, characterized by car... | 02/18/2003 |
| 6482983 | Process for obtaining N-monosubstituted amides A process for obtaining an amide of the general formula R--(CO)--NH--CH2 --X involves contacting a nitrile of the general formula R--CN with: a) an acid; and c) an alkoxy-containing compound comprising at least one alkoxy functionality of the g... | 11/19/2002 |
| 6441232 | Selective nitrogen functionalization of organic compounds There is provided a method of selectively replacing a carbon-hydrogen bond at an unactivated saturated sp3 hybridised carbon atom in an organic compound by a carbon-nitrogen bond, the method comprising reacting the compound with a fluorinating agent in a ... | 08/27/2002 |
| 6437183 | Method for making amides The invention relates to the manufacture of amide compounds provided through the reaction of nitrile compounds and a sulfate compound to form the related amide compound. In a preferred embodiment a diol or a triol is employed as a solvent, thereby increas... | 08/20/2002 |
| 6417398 | Benzamidoxim derivatives, intermediate products and methods for preparing them, and their use as fungicides The invention concerns benzamidoxim derivatives of formula (I) in which the substituents have the following meanings: R1 represents hydrogen or fluorine; R2 represents C1 -C6 phenyl-alkyl, bearing on the cyclic ... | 07/09/2002 |
| 6303817 | Method for making amides The invention relates to the manufacture of amide compounds provided through the reaction of nitrile compounds and a sulfate compound to form the related amide compound. In a preferred embodiment a diol or a triol is employed as a solvent, thereby increas... | 10/16/2001 |
| 5866611 | Therapeutic amines Compounds of formula I, and their pharmaceutically acceptable salts, ##STR1## in which R1 and R2 are hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, phenylalkyl or alkenyl; or NR1 R2 is a heterocyclic group; ... | 02/02/1999 |
| 5859054 | Leukotriene B4 derivatives, process for their production and their use as pharmaceutical agents Pharmacologically active leukotriene-B4 derivatives of general formula I, ##STR1## are described, in which R1 represents CH2 OH, CH3, CF3, COOR4, CONR5 R6, or R | 01/12/1999 |
| 5856560 | Preparation of a-methoxyiminocarboxylic acid methylamides and intermediates therefore A process and intermediates for preparing -methoxyiminocarboxylic acid methylamides (I) by Pinner reaction of a cyanoketone (II) with an alcohol and subsequent reaction of the resulting ester (IV) with hydroxylamine to give the oxime (V), methylati... | 01/05/1999 |
| 5763661 | Preparation of acylated -amino carboxylic acid amides A method of preparing acylated -amino carboxylic acid amides directly from amino nitriles in high yield and purity. The method involves acylating the amino nitrile with an acyl halide under Schotten-Baumann conditions, and hydrolyzing the resulting... | 06/09/1998 |
| 5712413 | Process for the preparation of N-hydrocarbyl-substituted amides such as tert-butylacrylamide via the Ritter reaction using solid heteropolyacid catalysts Hydrocarbyl-substituted amides are prepared by a process comprising contacting a nitrile with a hydrocarbylating agent, such as an alkylating agent, in the presence of a catalyst comprising a heteropolyacid or salt thereof.... | 01/27/1998 |
| 5648534 | Method of producing cis-1-aminoindan-2-ol 1,2-di-substituted indan expressed by general formula (I) wherein X is a substituent which can be drawn out under an acidic condition to form a carbocation at 1-position of an indan skeleton, Y is a halogen atom, and X and Y can be in either cis- or trans... | 07/15/1997 |
| 5639881 | Synthesis and elucidation of pyrimido (4,5-Q) quinazoline derivatives Pyrimido[4,5-g]quinazoline quinone derivatives were synthesized as anthranone-like reductive alkylating agents. Like many naturally-occurring antibiotics, these quinone derivatives are designed to afford an alkylating quinone methide species upon reducti... | 06/17/1997 |
| 5633288 | Tri (lower alkoxy) benzene derivatives This invention relates to a tri(lower alkoxy)benzene derivative of the general formula (I), or its salt, optical isomer or solvate, ##STR1## wherein: R1, R2 and R3 : same or different and each represents a lower alkyl... | 05/27/1997 |
| 5498792 | Process of producing N-alkylacetamides There is disclosed a process of producing an N-alkylacetamide of the general formula (III): ##STR1## wherein X1, X2 and X3 are the same or different and are independently hydrogen, lower alkyl, lower alkoxy, lower alk... | 03/12/1996 |
| 5463123 | Process for producing -hydroxyisobutyramide There is disclosed a process for producing -hydroxyisobutyramide by hydration reaction of acetone cyanohydrin in the presence of a catalyst consisting essentially of manganese dioxide which process comprises pretreating the catalyst with a reducing... | 10/31/1995 |
| 5449808 | Method for converting amides to nitriles and nitriles to amides A process which comprises contacting and catalytically reacting under essentially anhydrous conditions in the liquid phase an amide with a nitrile according to the equation: RCONH2 +R1 CN.revreaction.RCN+R1 CONH2 whe... | 09/12/1995 |
| 5436371 | Process for preparing p-nitroaromatic amides and products thereof A process for preparing p-nitroaromatic amides is provided which comprises contacting a nitrile, nitrobenzene, a suitable base and water in the presence of a suitable solvent system to form a mixture, and reacting the mixture at a suitable temperature in ... | 07/25/1995 |
| 5387715 | Process for producing -hydroxy-isobutyramide Alpha-hydroxy-isobutyramide is produced by continuously hydrating acetone cyanohydrin in a liquid phase in the presence of a manganese dioxide catalyst and in the presence of a particular oxide dissolved in water, oxoacid, heteropolyacid or a salt of the ... | 02/07/1995 |
| 5380946 | Process for preparing p-nitroaromatic amides and products thereof A process for preparing p-nitroaromatic amides is provided which comprises contacting a nitrile, nitrobenzene, a suitable base and water in the presence of a suitable solvent system to form a mixture, and reacting the mixture at a suitable temperature in ... | 01/10/1995 |
| 5354891 | Method of producing aromatic amine derivatives Disclosed is a method for producing aromatic amine derivatives in a high yield at a low price, which comprises inducing an aromatic hydroxamic acid derivative to undergo a rearrangement reaction under a mild condition in the presence of a base and a nitri... | 10/11/1994 |
| 5072024 | Synthesis of N-substituted amides by condensation of nitriles with certain organic hydroxyl compounds Disclosed is a method which comprises the reaction in a reaction zone of a nitrile, RCN, with a hydroxyl compound, R'OH, in the presence of an inorganic catalyst introduced into the reaction zone, thereby producing a reaction mixture containing at least o... | 12/10/1991 |
| 5047585 | Process for racemizing an optically active N-benzylidene amino-acid amide The invention relates to a process for racemizing an optically active N-benzylidene amino-acid amide, characterized in that a solution of the N-benzylidene amino-acid amide is mixed in a water-miscible organic solvent with at least 0.05 mole strong base p... | 09/10/1991 |
| 4820872 | Process for hydrolyzing nitriles When making an unsaturated amide by hydrolysis of an unsaturated nitrile in the presence of a catalyst such as Raney copper and an oxidizing agent such as copper nitrate, by-product formation is reduced by including a reagent selected from reducing agents... | 04/11/1989 |
| 4808628 | Amide derivatives and their use as fungicides An amide derivative of the formula (I): ##STR1## or a tautomeric form thereof, wherein R is a phenyl group substituted in the 4-position by a group of R1 XCH2--, where R1 is C1 -C4 alkyl, C3... | 02/28/1989 |
| 4801748 | Catalytic process for preparing amide from nitrile, amine and water Amide compounds are efficiently prepared directly from nitriles, amines and water, using a reaction catalyst. The invention also can applied to the manufacture of polyamides, thereby realizing a simplified and rationalized process for polyamide synthesis.... | 01/31/1989 |
| 4786744 | Method for opening the gem dicyano epoxides and the formation of compounds therefrom The invention relates to a method for opening the ring of gem dicyanepoxides comprising reacting a gem dicyanepoxide with a mononucleophilic compound in the presence of a hydrohalic acid or a weakly nucleophilic acid.... | 11/22/1988 |
| 4731447 | Process for preparing piperidylidene dihydro-dibenzo(a,d)-cycloheptenes or aza-derivatives thereof A process for the preparation of piperidylidene-dihydro-dibenzo[a,d]cycloheptene or aza-derivatives thereof and intermediates in such process are disclosed.... | 03/15/1988 |
| 4663481 | Preparation of bromoacetamides Bromoacetamides of the formula ArCONHCH(Br)CONH2 are obtained by addition to bromine of a solution of ArCONHCH2 CN in a saturated aliphatic carboxylic acid preferably glacial acetic or propionic acid. This is an improvement in a proc... | 05/05/1987 |
| 4634558 | Preparation of -substituted acrylamides -Substituted acrylamides of the general formula I ##STR1## where R1 is a straight-chain, branched or cyclic alkyl radical of not more than 15 carbon atoms which can be unsubstituted or further substituted, are prepared by a process ... | 01/06/1987 |
| 4554345 | Preparation of liquid polyamide from dinitrile and diamine This invention describes a process for preparing liquid polyamides comprising contacting a nitrile, amine and water in the presence of a carbon dioxide catalyst.... | 11/19/1985 |
| 4543423 | Hydration of nitriles A nitrile, such as acrylonitrile, is hydrated to the corresponding amide in the presence of a Raney copper catalyst that, before use in the reaction, is partially oxidized by contact with a controlled oxidizing system comprising oxygen, peroxide, iodate, ... | 09/24/1985 |
