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| Number | Title | Issue Date |
| 8178723 | Process for preparing amides from alcohols and amines The present invention provides a process for preparing amides, by reacting a primary amine and a primary alcohol in the presence of a Ruthenium catalyst, to generate the amide and molecular hydrogen. According to the process of the invention, primary amines are dire... | 05/15/2012 |
| 8088951 | Epigenetic mechanisms re-establish access to long-term memory after neuronal loss The invention relates to methods and products for enhancing and improving recovery of lost memories. In particular the methods are accomplished through the increase of histone acetylation. ... | 01/03/2012 |
| 8013186 | Haloalkyl containing compounds as cysteine protease inhibitors The present invention is directed to compounds that are inhibitors of cysteine proteases, in particular, cathepsins B, K, L, F, and S and are therefore useful in treating diseases mediated by these proteases. The present invention is directed to pharmaceutical compo... | 09/06/2011 |
| 7902400 | Amide compounds and their use Since an amide compound represented by the formula (1) is effectiveness for controlling plant diseases, it is useful as an effective ingredient of a composition for controlling plant diseases. ... | 03/08/2011 |
| 7884243 | Process for the synthesis of eneamide derivatives A process for the production of ene-amide derivatives represented by the formula (I) wherein R1 and R2 and R3 are independently a hydrogen atom, an alkyl, a cycloalkyl, a cycloalkylalkyl, an alkylaryl, an aryl, a heterocycl... | 02/08/2011 |
| 7868204 | Inhibitors of histone deacetylase The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and cond... | 01/11/2011 |
| 7786328 | Cyclohexyl-1,4-diamine compounds Novel cyclohexyl-1,4-diamine compounds corresponding to formula I processes for preparing such compounds, pharmaceutical formulations comprising these compounds, methods of making such pharmaceutical formulations and the re... | 08/31/2010 |
| 7518017 | Fenicol compounds and methods synthesizing 2-trifluoroacetamido-3-substituted propiophenone compounds Methods of preparing compounds of formula (I): wherein Y, Y1, and R2 are defined herein; methods of making D-(threo)-1-aryl-2-acylamido-1-propanol compounds, D-(threo)-1-aryl-2-acylamido-3-fluoro-1-pro... | 04/14/2009 |
| 7439383 | Sodium channel blockers The present invention is directed to novel phenytoin derivative compounds and the use of such compounds as sodium channel blockers. Such compositions have utility as anti-cancer agents and can be used to limit or prevent PCa growth and/or metastasis. ... | 10/21/2008 |
| 7439394 | Cyclohexyl-1,4-diamine compounds Novel cyclohexyl-1,4-diamine compounds corresponding to formula I, processes for the production thereof, pharmaceutical compositions containing these compounds, methods of producing pharmaceutical compositions including the... | 10/21/2008 |
| 7435850 | Naphthalene compounds A compound selected from those of formula (I): Medicinal products containing the same which are useful in the treatment of disorders of the melatoninergic system. ... | 10/14/2008 |
| 7429618 | Potassium channel modulators This invention relates to novel compounds useful as potassium channel modulators. More specifically the invention provides chemical compounds useful as modulators of SKCa and/or IKCa channels. ... | 09/30/2008 |
| 7425578 | Immunoregulatory compounds and derivatives and methods of treating diseases therewith Compounds are disclosed having the structure of Formula I: where R1, R3, and R4 are independently hydrogen or C1 to C4 alkyl, and R2 is: ... | 09/16/2008 |
| 7399879 | Process for preparing alkylidene-substituted-1,4-dions derivatives A process for the preparation of a monoalkylidene substituted 1,4-dions derivatives of formula (Ia) or (Ib) or a mixture of (Ia) and (Ib): wherein: R1, R2 and R3, equal to or different from each other, are hydrogen atoms or C1 | 07/15/2008 |
| 7361688 | Substituted aminoalcohols useful in treatment of Alzheimer's disease The invention provides compounds of formula (I): useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characteriz... | 04/22/2008 |
| 7348456 | Substituted amides Novel compounds of the structural formula (I) are antagonists and/or inverse agonists of the Cannabinoid-1 (CB1) receptor and are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. The compounds of the present invention are... | 03/25/2008 |
| 7348353 | Acetylene derivatives having mGluR 5 antagonistic activity The invention provides compounds of formula (I) wherein m, n, A, R, R′, R″, R0, X and Y are as defined in the description, and their preparation. The compounds of formula (I) are useful as pharmaceuticals in the treatment of e.g. nervous system disord... | 03/25/2008 |
| 7348457 | Ketol fatty acid derivatives and plant growth regulators α-Ketol unsaturated fatty acid derivatives represented by the following formula (1), α-ketol unsaturated fatty acid amide derivatives represented by the following formula (6), and plant growth regulators containing, as the active ingredient, at least one of these ... | 03/25/2008 |
| 7348437 | Proteomic analysis Activity-based compositions for analyzing metalloproteases are disclosed, where the compositions include a chemical compound including a hydroxamate moiety and a benzophenone moiety. Methods for synthesizing these compounds are also disclosed, as well as methods of ... | 03/25/2008 |
| 7345174 | Cytodifferentiating agents and histone deacetylase inhibitors, and methods of use thereof The present invention provides the compound having the formula: wherein each of R1 and R2 is, substituted or unsubstituted, aryl, cycloalkyl, cycloalkylamino, naphtha, pyridineamino, piperidino, t-buty... | 03/18/2008 |
| 7345094 | Paclitaxel enhancer compounds Disclosed is a compound represented by the Structural Formula (I): Y is a covalent bond, a phenylene group or a substituted or unsubstituted straight chained hydrocarbyl group. In addition, Y, taken... | 03/18/2008 |
| 7332499 | Sulfonyl substituted n-(biarylmethyl) aminocyclopropanecarboxamides N-(Sulfonyloxybiarylmethyl) aminocyclopropanecarboxamide derivatives are bradykinin B1 antagonists or inverse agonists useful in the treatment or prevention of symptoms such as pain and inflammation associated with the bradykinin B1 pathway. ... | 02/19/2008 |
| 7329634 | 3-Phenyl substituted 3-substituted-4ketolactams and ketolactones The invention relates to novel 3-phenyl-substituted, 3-substituted 4-ketolactams and -lactones of the formula (I) in which Q, W, X, Y, A, B and G are as defined in the disclosure, to proc... | 02/12/2008 |
| 7317129 | Chemical synthesis of reagents for peptide coupling The present invention provides improved methods for synthesis of phosphinothiol reagents, as well as novel protected reagents, for use in formation of amide bonds, and particularly, for peptide ligation. The invention provides phosphine-borane complexes useful as re... | 01/08/2008 |
| 7304093 | Ketone compounds and compositions for cholesterol management and related uses The present invention relates to novel ketone compounds, compositions comprising ketone compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders comprising administering a com... | 12/04/2007 |
| 7288262 | Composition comprising a cyclohexane-based compound, compound and use of said compound to structure a composition Compositions, in particular cosmetic compositions, comprising a cyclohexane-based compound defined by formula (I): wherein: R, which may be identical or different, are each chosen from hydrogen atoms an... | 10/30/2007 |
| 7288619 | Fluorinated polyether polyamine and method of making the same A composition comprises a condensation product of an amine-reactive fluorinated polyether and a polyamine. The compositions may be in dispersed in water. ... | 10/30/2007 |
| 7285600 | Reagents for heat activated polymer crosslinking The present invention is directed to nitrile-oxide precursor compounds, and their preparation and use as an irreversible cross-linking agent in polymers having appropriate functionality, i.e., alkenes, alkynes nitriles, and isocyanates. The present invention is also... | 10/23/2007 |
| 7282301 | Method for making a composite electrode material A composite material includes a first phase which comprises LixMy(PO4)z wherein M is at least one metal, y and z are independently 0, and x is less than or equal to 1. The material includes a second phase which has an elec... | 10/16/2007 |
| 7279340 | Synthesis and application of procainamide analogs for use in an immunoassay The present invention relates to immobilized procainamide analogs, as well as to a method of making immobilized procainamide analogs. These immobilized analogs are prepared by activating the carboxyl group on a substituted p-benzoic acid derivative toward nucleophil... | 10/09/2007 |
| 7271130 | N-alkynyl-2-(substituted phenoxy) alkylamides and their use as fungicides Fungicidal compounds of the general formula (1) wherein X, Y, Z, R1, R2, R3, R4 and R5 have the definitions given in claim 1 ... | 09/18/2007 |
| 7271186 | Nanomolar β-lactamase inhibitors New carboxyphenyl-glycylboronic acid transition-state analog inhibitors, representative of a class of compounds effective against class C β-lactamase AmpC. The new compounds improve inhibition by over two-orders of magnitude compared to analogous glycylboronic acid... | 09/18/2007 |
| 7259187 | Tropolone derivatives Tropolone derivatives represented by the formula (I), which have retinoid actions and are useful as active ingredients of medicaments [R1 to R4 represent hydrogen atom, an alkyl group, or an alkoxyl group; the ring represented by Ar represents ... | 08/21/2007 |
| 7220814 | Hydrophilicized blocked polyisocyanates The present invention relates to new hydrophilicized blocked polyisocyanates, a process for preparing them and their use. ... | 05/22/2007 |
| 7214701 | Active substance combinations having insecticidal and acaricdal properties The invention relates to insecticidal mixtures for protecting plants against attack by pests comprising (a) compounds of the formula (I) ... | 05/08/2007 |
| 7208628 | Compositions and methods for the treatment of hepatitis C virus infection This invention relates to methods and compositions directed towards the diagnosis and treatment of Hepatitis C virus infection and the screening of potential therapeutic compounds using novel small molecules based on imidazole-4,5-dicarboxylic acids scaffolds. ... | 04/24/2007 |
| 7208527 | Potassium channel modulators This invention relates to novel compounds useful as potassium channel modulators. More specifically the invention provides chemical compounds useful as modulators of SKCa and/or IKCa channels. ... | 04/24/2007 |
| 7205435 | Type B botulism toxin inhibitors Novel compounds of general formula (I), are provided with inhibitory properties for the type B botulism toxin activity, along with methods for preparation thereof and corresponding pharmaceutical compositions. ... | 04/17/2007 |
| 7201876 | Ion-detecting sensors comprising plasticizer-free copolymers Ion-detecting sensors for detecting a target ion in a sample are provided. The sensor comprises a plasticizer-free copolymer comprised of polymerized units of methacrylate monomers having pendent alkyl groups of different length and a functionalized ionophore of sai... | 04/10/2007 |
| 7192983 | N-protected/N-substituted-beta-amino hydroxy sulfonates N-protected/N-substituted alpha-amino aldehydes, which are useful as pharmaceuticals and pharmaceutical intermediates, can be stored and shipped in a more stable form as N-protected/N-substituted-beta-amino hydroxy sulfonates which can be readily converted back into... | 03/20/2007 |
