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| Number | Title | Issue Date |
| 7635788 | Alpha-amino acid derivatives with antiinflammatory activity Compounds of the formula: are described in which Z, Q, X, L, m and n assume the meanings stated in the description. The compounds (I) inhibit the production of TNF α and may thus be useful in the t... | 12/22/2009 |
| 7420089 | Hydroxamates as therapeutic agents The present invention is directed to certain hydroxamate derivatives that are useful in the treatment of hepatitis C. These compounds are also inhibitors of histone deacetylase and are therefore useful in the treatment of diseases associated with histone deacetylase... | 09/02/2008 |
| 7282496 | Allenic aryl sulfonamide hydroxamic acids as matrix metalloproteinase and TACE inhibitors Compounds of the formula are useful in treating disease conditions mediated by TNF-α, such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease, degenera... | 10/16/2007 |
| 7282522 | Hydroxamic acid derivatives and the method for preparing thereof The present invention provides hydroxamic acid derivatives which have anti-aging efficacy and a method for preparation thereof. It is further provided skin-care external compositions for preventing skin aging, containing the hydroxamic acid derivatives represented b... | 10/16/2007 |
| 7276570 | Compositions for golf equipment Golf balls comprising thermoplastic, thermoset, castable, or millable elastomer compositions are presently disclosed. These compositions comprise at least one polymer having a plurality of amide linkages and a plurality of anionic moieties attached thereto. These co... | 10/02/2007 |
| 7269457 | Method and system for vagal nerve stimulation with multi-site cardiac pacing A method of performing a medical procedure is provided. The medical procedure includes stimulation of a patient's heart while stimulating a nerve of the patient in order to modulate the patient's inflammatory process. More particularly, the medical procedure include... | 09/11/2007 |
| 7265195 | Compositions for golf equipment Golf balls comprising thermoplastic, thermoset, castable, or millable elastomer compositions are presently disclosed. These compositions comprise at least one polymer having a plurality of amide linkages and a plurality of cationic moieties attached thereto. These c... | 09/04/2007 |
| 7256249 | Compositions for golf equipment Golf balls comprising thermoplastic, thermoset, castable, or millable elastomer compositions are presently disclosed. The compositions comprise at least one regioselective polyisocyanate having an asymmetric structure and comprising at least a first NCO group and a ... | 08/14/2007 |
| 7253242 | Compositions for golf equipment Golf balls comprising thermoplastic, thermoset, castable, or millable materials are presently disclosed. The materials have a rebound height percentage of greater than 60% and are formed from compositions comprising at least one resilient polyamine polydiene and/or ... | 08/07/2007 |
| 7253245 | Compositions for golf equipment Golf balls comprising thermoplastic, thermoset, castable, or millable elastomer compositions are presently disclosed. These elastomer compositions comprise reaction products of polyisocyanates and telechelic polymers having isocyanate-reactive end-groups such as hyd... | 08/07/2007 |
| 7247736 | Method of identifying inhibitors of DHODH The present invention provides a compound capable of binding to the ubiquinone binding site of DHODH which contains a non-aromatic ring system as a core structure, a group capable of interacting with structural elements of subsite 2 or 3 of the ubiquinone binding si... | 07/24/2007 |
| 7184829 | Method and system for nerve stimulation prior to and during a medical procedure A method of performing a medical procedure, such as surgery, is provided. A nerve is stimulated in order to adjust the beating of the heart to a first condition, such as a stopped or slowed condition. The medical procedure is performed on the heart or another organ.... | 02/27/2007 |
| 7157545 | Compositions for golf equipment Golf balls comprising thermoplastic, thermoset, castable, or millable elastomer compositions are presently disclosed. These elastomer compositions comprise reaction products of polyisocyanates and telechelic polymers having isocyanate-reactive end-groups such as hyd... | 01/02/2007 |
| 7138476 | Compositions for golf equipment Golf balls comprising thermoplastic, thermoset, castable, or millable elastomer compositions are presently disclosed. These compositions comprise at least one fatty compound chosen from fatty polyamines and fatty polyamine telechelics. These elastomer compositions c... | 11/21/2006 |
| 7138475 | Compositions for golf equipment Golf balls comprising thermoplastic, thermoset, castable, or millable elastomer compositions are presently disclosed. These elastomer compositions comprise at least one amine-terminated polyamide and at least one isocyanate-containing prepolymer. These elastomer com... | 11/21/2006 |
| 7138477 | Compositions for golf equipment Golf balls comprising thermoplastic, thermoset, castable, or millable elastomer compositions are presently disclosed. These elastomer compositions comprise reaction products of polyisocyanates and telechelic polymers having isocyanate-reactive end-groups such as hyd... | 11/21/2006 |
| 7126001 | Class of cytodifferentiating agents and histone deacetylase inhibitors, and methods of use thereof The present invention provides the compound having the formula: wherein each of R1 and R2 is, substituted or unsubstituted, aryl, cycloalkyl, cycloalkylamino, naphtha, pyridineamino, piperid... | 10/24/2006 |
| 7115703 | Compositions for golf equipment Golf balls comprising thermoplastic, thermoset, castable, or millable compositions are presently disclosed. These compositions comprise reaction products of polyacids and polyamines. The polyacid is chosen from polymerized fatty polyacids and polyacid telechelics. T... | 10/03/2006 |
| 7105628 | Compositions for golf equipment Golf balls comprising thermoplastic, thermoset, castable, or millable elastomer compositions are presently disclosed. These elastomer compositions comprise reaction products of polyisocyanates and telechelic polymers having isocyanate-reactive end-groups such as hyd... | 09/12/2006 |
| 7105623 | Compositions for golf equipment Golf balls comprising thermoplastic, thermoset, castable, or millable elastomer compositions are presently disclosed. These elastomer compositions comprise at least one poly(urethane-co-urea) prepolymer and at least one curative. These elastomer compositions can be ... | 09/12/2006 |
| 7101951 | Compositions for golf equipment A golf ball comprising at least one thermoplastic, thermoset, castable, or millable material formed from a composition comprising at least one telechelic polycarbonate having a generic structure of: where R1... | 09/05/2006 |
| 7098274 | Compositions for golf equipment A golf ball comprising at least one thermoplastic, thermoset, castable, or millable material formed from a composition comprising at least one telechelic polycarbonate copolymer formed from at least one polyol telechelic and at least one carbonate-forming compound; | 08/29/2006 |
| 7091378 | Preparation of hydroxamic acids from esters in solution and on the solid phase The present invention provides a novel method for the formation of hydroxamic acids comprising reacting under suitable conditions an ester with hydroxylamine in the presence of cyanide anion. ... | 08/15/2006 |
| 7071355 | Compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents The present invention relates to compounds of the general formula (I) and salt and physiologically functional derivatives thereof, wherein A is a non-aromatic ring system... | 07/04/2006 |
| 7001905 | Substituted diarylamines as MEK inhibitors Diarylamines, such as 5-amide substituted diarylamines of formula (I) or formula (II) wherein A is hydroxy, C1-6 alkoxy, or NR6OR7; X is OR12, NR13R12, or NR14; inhibitors of MEK and are us... | 02/21/2006 |
| 6870065 | Bifunctional boronic compound complexing reagents and complexes A reagent having the general formula of General Formula I: wherein group R is an electrophilic or a nucleophilic moiety suitable for reaction of the reagent with a biologically active species; group R2 is on... | 03/22/2005 |
| 6716878 | Antimicrobial agents Compounds of formula (I) are antibacterial agents: wherein Z represents a radical of formula —N(OH)CH(═O) or of formula —C(═O)NH(OH), and R1-R4 are as defined in the specification. A method ... | 04/06/2004 |
| 6696472 | Substituted N-phenoxy-N-phenyl aminoalcohol compounds useful for inhibiting cholesteryl ester transfer protein activity The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating... | 02/24/2004 |
| 6649612 | Biphenyl derivatives substituted with an aromatic or heteroaromatic radical, and pharmaceutical and cosmetic compositions containing them Compounds of formula (I): ##STR1## in which: Ar represents an aromatic or a heteroaromatic radical optionally substituted, in particular, with an alkyl or a carboxyl group, R2 and R3 represent, in particular, H or alkyl, or R | 11/18/2003 |
| 6610729 | Hydroxamic acid derivatives and medicinal utilization thereof The present invention relates to a hydroxamic acid derivative of the formula (I) ##STR1## wherein each symbol is as defined in the specification, a pharmacologically acceptable salt thereof, a pharmaceutical composition containing the derivative or a... | 08/26/2003 |
| 6605742 | Cyclo azaphospha hydrocarbons Novel cyclo azaphospha hydrocarbons according to formula I ##STR1## are provided. The compounds are useful as metalloprotease inhibitors.... | 08/12/2003 |
| 6511990 | Class of cytodifferentiating agents and histone deacetylase inhibitors, and methods of use thereof The present invention provides the compound having the formula: ##STR1## wherein each of R1 and R2 is, substituted or unsubstituted, aryl, cycloalkyl, cycloalkylamino, naphtha, pyridineamino, piperidino, t-butyl, aryloxy, arylalkylox... | 01/28/2003 |
| 6465468 | Hydroxamic and carboxylic acid derivatives The subject invention concerns methods and compounds that have utility in the treatment of a condition associated with matrix metalloproteinase, ADAM or ADAM-TS enzymes, a condition that is mediated by TNF or a condition involving a membrane-shedd... | 10/15/2002 |
| 6462042 | Hydroxamic acid derivatives as matrix metalloproteinase (mmp) inhibitors Compounds having therapeutic utility are of formula (I) wherein B1, B2, R1 and R2 are each various sub-stituents, or R1 and R2 together form a ring. ##STR1##... | 10/08/2002 |
| 6451859 | C16 unsaturated FP-selective prostaglandins analogs Compounds having a structure according to the following formula: ##STR1## are effective in treating disorders such as bone disorders and glaucoma in a subject in need thereof.... | 09/17/2002 |
| 6380219 | Arylsulfonylamino hydroxamic acid derivatives A compound of the formula ##STR1## wherein n, X, R3, R4 and Ar are as defined above, useful in the treatment of a condition selected from the group consisting of arthritis, cancer, tissue ulceration, restenosis, periodontal disease, ... | 04/30/2002 |
| 6326516 | Acetylenic ଲ-sulfonamido and phosphinic acid amide hydroxamic acid TACE inhibitors The invention discloses hydroxamide acids of the formula: ##STR1## which are useful in treating disease conditions mediated by TNF-, such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease... | 12/04/2001 |
| 6310084 | Metalloproteinase inhibitors The present invention relates to therapeutically active hydroxamic acid, N-formyl-N-hydroxyamino and carboxylic acid derivatives, their preparation, and pharmaceutical compositions containing them. These compounds are useful in the inhibition of metallopr... | 10/30/2001 |
| 6291709 | Solid supported synthesis of hydroxamic acids The subject invention involves processes for making hydroxamic acid compounds using a solid-support resin having an oxime moiety as the linking moiety of the resin, comprising the steps of (a) treating the resin with a carboxylic acid compound, such that ... | 09/18/2001 |
| 6288261 | Inhibitors of matrix metalloproteinases Compounds having the formula ##STR1## and pharmaceutically acceptable salts and prodrugs thereof are matrix metalloproteinase inhibitors. Also disclosed are matrix metalloproteinase-inhibiting compositions and methods of inhibiting matrix metalloprot... | 09/11/2001 |
