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| Number | Title | Issue Date |
| 8183409 | High yield and rapid synthesis methods for producing metallo-organic salts A new method for preparing salts of metal cations and organic acids, especially divalent salts of alkaline earth metal ions from group II of the periodic system and carboxylic acids. The method comprising the use of a high temperature (about 90° or more) and, optio... | 05/22/2012 |
| 7777075 | Fluoroethercarboxylic acid and production method thereof, surfactant, method of producing fluoropolymer and aqueous dispersion used thereof The invention provides a fluoroethercarboxylic acid which is represented by the general formula (I): Rf1OCHFCF2ORf2COOM  (I) wherein Rf1 represents a partially or fully fluorinated alkyl group, whic... | 08/17/2010 |
| 7247652 | β-benzyloxyaspartate derivatives with amino group on benzene ring L-threo-β-benzyloxyaspartate derivatives having a substituent on the benzene ring, represented by the following formula (1): wherein R is hydrogen, a linear or branched lower aliphatic acyl group with the acyl p... | 07/24/2007 |
| 7141608 | Calcium dicarboxylate ethers, methods of making same, and treatment of vascular disease and diabetes therewith Alcohol and water solvates of 6-(5-carboxy-5-methyl-hexyloxy)-2,2-dimethylhexanoic acid monocalcium salt are crystalline and have the formula wherein R1 is H or lower alkyl, and x is a number from 0 to... | 11/28/2006 |
| 6984739 | Process for preparing R-(−)-carnitin from S-(−)-chlorosuccinic acid or from a derivative thereof An inner salt of L-carnitine is prepared by reduction, with a suitable reducing agent, of a compound of formula (I): where X1 and X2, which may be the same or different, are hydroxy, C1â... | 01/10/2006 |
| 6861555 | Calcium dicarboxylate ethers, methods of making same, and treatment of vascular disease and diabetes therewith Alcohol and water solvates of 6-(5-carboxy-5-methyl-hexyloxy)-2,2-dimethylhexanoic acid monocalcium salt are crystalline and have the formula (I), wherein R1 is H or lower alkyl, and x is a number from 0 to 10, and are useful for treating dyslipidemia. | 03/01/2005 |
| 6632830 | ACE-2 inhibiting compounds and methods of use thereof ACE-2 inhibiting compounds are disclosed. These compounds include compounds of formula (IV): ##STR1## wherein the variables are as described in the specification. Pharmaceutical compositions containing the compounds are also discussed. The pharmaceut... | 10/14/2003 |
| 6627772 | Preparation of N-[2-(carboxymethoxy) ethyl]-N-(carboxymethyl) glycine Compounds represented by the formula ##STR1## wherein R and R1 independently represent H, --CH2 CN or --CH2 CO2 X, with the proviso that R and R1 can not be both H or --CH2 CO2 X... | 09/30/2003 |
| 6627771 | Gamma amino butyric and acid analogs The instant invention is improved gamma amino butyric acid analogs, processes for their preparation, and methods of using them as agents for treating epilepsy and other neurodegenerative disorders, depression, anxiety, panic, pain, neuropathological disor... | 09/30/2003 |
| 6590120 | Methods for the preparation of an N-bis-[2-(1,2-dicarboxy-ethoxy)-ethyl]amine derivative and products of the methods and their uses Methods for the preparation of an N-alkyl-N-bis-(2-( 1,2-dicarboxy-ethoxy)-ethyl)-amine derivative are described, products of the methods as well as uses of the products. The derivative is prepared by reacting an alkali or earth alkali metal salt of malei... | 07/08/2003 |
| 6555706 | Process for making iminodiacetic acid compounds from monoethanolamine substrates This invention is directed to a process for making an iminodiacetic acid compound from a monoethanolamine substrate having the formula: ##STR1## wherein R1 is hydrogen, hydrocarbyl, or substituted hydrocarbyl. The process includes a series of r... | 04/29/2003 |
| 6504054 | Amino acid derivative and producing method thereof An amino acid derivative composition which comprises two or more kinds of amino acid derivatives represented by the general formula (1): ##STR1## wherein R's are the same or different and each represents a hydrogen atom or an alkyl group containing 1 to 1... | 01/07/2003 |
| 6392095 | Intermediates for the preparation of N-[2-(carboxymethoxy) ethyl]-N-(carboxymethyl) glycine Compounds represented by the formula ##STR1## wherein R and R1 independently represent H, --CH2 CN or --CH2 CO2 X, with the proviso that R and R1 can not be both H or --CH2 CO2 X... | 05/21/2002 |
| 6346648 | Amphoteric surfactants based upon epoxy succinic acid The present invention deals with novel compounds their applications and a process their preparation. The compounds are novel amphoteric surfactants that contain a hydroxyl group and two carboxylic groups per hydroxyl group. The compounds have a unique str... | 02/12/2002 |
| 6303761 | Triaminepentaacetic acid compound and paramagnetic metal complex prepared from using the compound as ligand The present invention provides a triaminepentaacetic acid compound which can be used as a ligand to coordinate to a metal ion to form a paramagnetic metal complex. The paramagnetic metal complex of the present invention can be used as a contrast agent for... | 10/16/2001 |
| 6288244 | Process for the preparation of 3, 4-dihydroxybutanoic acid and derivatives thereof from substituted pentose sugars A process for the preparation of 3,4-dihydroxybutanoic acid (I) and 3-hydroxy-γ-butyrolactone (V) thereof from a 3-leaving group substituted pentose source is described. In particular, the process relates to the synthesis of (R)-3,4-dihydroxybutanoic aci... | 09/11/2001 |
| 6288263 | Intermediates for the preparation of N-[2-(carboxymethoxy)ethyl]-N-(carboxymethyl)glycine Compounds represented by the formula ##STR1## wherein R and R1 independently represent H, --CH2 CN or --CH2 CO2 X, with the proviso that R and R1 can not be both H or --CH2 CO2 X... | 09/11/2001 |
| 6147113 | ଲ-hydroxyaspartic acid derivatives The present invention provides blockers for glutamate transporters. During a series of syntheses searching for glutamate uptake inhibition in Xenopus oocytes injected with bovine glutamate transporter genes (BGLAST), we obtained ଲ-hydroxyaspartic ac... | 11/14/2000 |
| 6096762 | Neurotrophic difluoroamide agents The present invention relates to the design, synthesis, and the peptidyl-prolyl isomerase (PPIase or rotamase) inhibitory activity of novel ,-difluoroacetamido compounds that are neurotrophic agents (i.e. compounds capable of stimulating gro... | 08/01/2000 |
| 6093849 | N-bis- or N-tris-[(1,2-dicarboxy-ethoxy)-ethyl]-amine derivatives and preparation and use of the same The invention relates to N-bis- or N-tris-[(1,2-dicarboxy-ethoxy)-ethyl]-amine derivatives having the formula (I) ##STR1## and R2 is hydrogen, an alkali metal or an earth-alkali metal. The invention also relates to a method for prepar... | 07/25/2000 |
| 6077962 | N-3, 3-dimethylbutyl-L-aspartic acid and esters thereof, the process of preparing the same, and the process for preparing N-(N-(3,3-dimethylbutyl) - L-aspartyl)-L- phenylalanine 1-methyl ester therefrom This invention relates to the chemical synthesis of N-[N-(3,3-dimethylbutyl)-L--aspartyl]-L-phenylalanine 1-methyl ester using peptide coupling methods. The coupling reaction is conducted by condensation of an activated derivative of novel N-neohex... | 06/20/2000 |
| 6063302 | Method for handling iminocarboxylic acid salt An aqueous iminocarboxylic acid salt solution composition the iminocarboxylic acid salt of which has a structure of the formula (II): ##STR1## wherein R is a hydrogen atom or a hydroxyl group and Y is a sodium atom, a potassium atom, or an ammonium g... | 05/16/2000 |
| 5907055 | Use of triacids based on alkoxylated tertiary amines as complexing agents The use of triacids of the formula I ##STR1## where X1 to X3 are, independently of one another, carboxylic acid groups of the formula COOM, sulfonic acid groups of the formula SO3 M or phosphonic acid groups of the fo... | 05/25/1999 |
| 5820881 | Microspheres of diamide-dicarboxylic acids Diamide-dicarboxylic acid microspheres are provided. The diamide-dicarboxylic acids may be combined with active agent(s). The resultant composition may be in microsphere form. Also disclosed are methods for administering the microsphere and/or composition... | 10/13/1998 |
| 5714517 | Fluoroalkenyl compounds and their use as pest repellents Fluorinated alkene compounds useful for and methods of controlling nematodes, insects, and acarids that prey on agricultural crops. Polar compounds, for example, 3,4,4-trifluoro-3-butene-1-amine or 3,4,4-trifluoro-3-butenoic acid, are particularly useful ... | 02/03/1998 |
| 5656656 | Tartronic acids, their acetalic ethers and O-esters Tartronic acid acetalic ethers and esters of the general formula: ##STR1## are provided and are useful in treatment of bone dysmetabolism. As examples, Ra and Rb may be hydrogen, B is a C2 -C12 acyl group, R is phenyl and n is 0... | 08/12/1997 |
| 5608090 | GABA and L-glutamic acid analogs for antiseizure treatment A compound of the formula ##STR1## wherein R1 is a straight or branched alkyl group having from 1 to 6 carbon atoms, phenyl, or cycloalkyl having from 3 to 6 carbon atoms; R2 is hydrogen or methyl; and R3 is hydrogen,... | 03/04/1997 |
| 5491259 | Process to produce aminocarboxylic acids containing low residual salt A method for producing an aqueous solution of an aminocarboxylic acid from an aqueous solution of an alkali metal salt of the aminocarboxylic acid is disclosed. The first step of the method is to adjust the pH of the aqueous solution of the alkali metal s... | 02/13/1996 |
| 5491261 | Poly-perfluoroalkyl-substituted alcohols and acids, and derivatives thereof Di-, tri- and poly-perfluoroalkyl-substituted alcohols and acids and derivatives thereof are described which are prepared from perfluoroalkyl iodides and di-, tri- or polyallyl alcohols or acids. These compounds contain two or more perfluoroalkyl-iodoalky... | 02/13/1996 |
| 5488130 | Amino nitrile intermediate for the preparation of 2-hydroxypropyl iminodiacetic acid A novel intermediate useful in the synthesis of 2-hydroxypropyl iminodiacetic acid is disclosed. The intermediate can be formed by contacting 2-hydroxypropyl amine with glycolonitrile to form an aminonitrile which can be hydrolyzed and contacted with addi... | 01/30/1996 |
| 5446186 | Structure and synthesis of nitrophenyl-EGTA, a caged calcium, intermediates thereof and a method of producing a high photochemical yield of liberated calcium The synthesis and compound of a new caged calcium which is an ortho-nitrophenyl derivative of EGTA and various intermediates. It is synthesized in ten steps and 24% overall yield. The photosensitive chelator, nitrophenyl-EGTA, has a Kd for Ca | 08/29/1995 |
| 5389680 | Fluoroalkenyl compounds and their use as pest repellents Fluorinated alkene compounds useful for and methods of controlling nematodes, insects, and acarids that prey on agricultural crops. Polar compounds, for example, 3,4,4-trifluoro-3-butene-1-amine or 3,4,4-trifluoro-3-butenoic acid, are particularly useful ... | 02/14/1995 |
| 5359128 | Malic acid derivatives and compositions for the treatment of psoriasis The invention comprises compositions and methods for the treatment of psoriasis. The compositions comprise compounds of the formula: ##STR1##... | 10/25/1994 |
| 5350872 | Process for the preparation of carboxylic acids and derivatives of them The subject matter of the invention is a process for the preparation of carboxylic acids and derivatives of them of the general formula ##STR1## wherein R means hydrogen, or a C1-4 alkyl or a (C1-5 alkoxy)carbonyl group, R1... | 09/27/1994 |
| 5334757 | 2-(2,3-dicarboxycyclopropyl) glycine and method for producing the same (2S,1'R,2'R,3'R)-2-(2,3-dicarboxycyclopropyl)-glycine (DCG-I) and (2S,1'S,2'S,3'S)-2-(2,3-dicarboxycyclopropyl)glycine (DCG-II), as well as methods for synthesizing these compounds are provided. Studies on L-glutamate receptors with the use of DCG-I and D... | 08/02/1994 |
| 5318726 | Derivative of aminosuccinic acid as a complexing agent 3-Hydroxy-2,2'-iminodisuccinic acid, water soluble salts thereof, a process for their preparation, and their use as biodegradable complexing agents in detergents.... | 06/07/1994 |
| 5312914 | Process for the manufacture of 4-acetoxy-3-hydroxyethyl-azetidinone The invention relates to a novel process for the manufacture of 4-acetoxy-3-hydroxyethyl-azetidinone of the formula ##STR1## especially 4(R)-acetoxy-3(R)-(1'(R)-hydroxyethyl)-2-azetidinone, from enantiomerically pure compounds of the formula ##S... | 05/17/1994 |
| 5312972 | Conversion of hydroxymethyl-iminodiacetic acid to phosphonomethyl-iminodiacetic acid A process for preparing N-phosphonomethyl iminodiacetic acid wherein solutions of an alkali metal salt of IDA are reacted with formaldehyde so as to form the alkali metal salt of hydroxymethyliminodiacetic acid (HMIDA). The HMIDA can be subsequently react... | 05/17/1994 |
| 5294739 | Catalyttic oxidation of hydrocarbons The invention relates to a process for the catalytic oxidation of hydrocarbons with molecular oxygen using a cobalt-containing molecular sieve material having the cobalt ions substantially incorporated in the crystal lattice of the molecular sieve. Prefer... | 03/15/1994 |
| 5283339 | Immobilized metal aqueous two-phase extraction and precipitation Metallated compounds can be used to extract or precipitate proteins from solution. The compounds can be polymers, such as polyalkylene glycols, which can be mono- or bimetallated or smaller bis-metal chelates, such as ethylenebis(oxyethylenenitrilo)tetraa... | 02/01/1994 |
