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| Number | Title | Issue Date |
| 7408079 | Imaging agents and methods of imaging NAALADase or PSMA The present invention relates to compounds particularly asymmetric urea compounds which are labeled with one or more radioisotopes and which are suitable for imaging or therapeutic treatment of tissues, organs, or tumors which express NAALADase and/or PSMA. In anoth... | 08/05/2008 |
| 7339077 | Production process of dicreatine malate A process of producing dicreatine malate with high purity, includes the steps of providing a predetermined amount of malic acid, agitating a predetermined amount of anhydrous alcohol to the malic acid to obtain a first solution, filtering the first solution to form ... | 03/04/2008 |
| 7314888 | Compounds and medicinal use thereof A compound or a salt thereof having the atom corresponding to N3 and the two or more atoms selected from N1, N2, N4 and N5, said atoms constitute the pharmacophore represented by the following formula: | 01/01/2008 |
| 7301051 | Creatine salts and method of making same Disclosed are creatine salts having the general formula wherein A is a member of a group consisting of an anion of ketoglutaric acid and succinic acid. ... | 11/27/2007 |
| 7226947 | Use of creatine as a fat substitute The invention relates to the use of creatine or creatine salts as a fat substitute to be given to breeding animals and feeder animals. The creatine or creatine salts are used as a substitute for flesh meal, fish meal and/or antimicrobial performance enhancers, growt... | 06/05/2007 |
| 7128932 | Formulations useful in the treatment of male and female impotence Disclosed are pharmaceutical compositions containing: extracts of Tribulus terrestris, Turnera diffusa and Cinnamon cassia in the weight ratio of 1.5–3.5:1–2:0.1–0.4 respectively; Ginkgo biloba extract, and optionally arginine or a physiol... | 10/31/2006 |
| 7129273 | Dicreatine Malate This invention relates to a novel compound, dicreatine malate, comprising approximately two moles of creatine cations per one mole of malate anion. The creatine salt of this invention has been found to increase the bioavailability of both the creatine and malic acid... | 10/31/2006 |
| 7109373 | Creatine salts and method of making same Disclosed are creatine salts having the general formula wherein A represents an anion of a dicarboxylic acid, and a process of making such salts. ... | 09/19/2006 |
| 7102013 | Methods of making amidino compounds useful as nitric oxide synthase inhibitors Method of making an alpha-amino acid compound having the structure of Formula 32: comprising treating under hydrolyzing conditions a hydantoin compound having the structure of Formula 33: | 09/05/2006 |
| 7026297 | Neuroprotective agents Compounds of formula (I) wherein: Q represents an amidino group, a cyano group or a group of formula XYN—, (where X and Y are hydrogen or various groups); Ra represents alkylene; Rb and Rc each represents alkylene, the total number... | 04/11/2006 |
| 7005450 | 2-amino-2-alkyl-4 hexenoic and hexynoic acid derivatives useful as nitric oxide synthase inhibitors The present invention relates to 2-amino-2-alkyl-4 hexenoic and hexynoic acid derivatives and their use in therapy, in particular their use as nitric oxide synthase inhibitors. ... | 02/28/2006 |
| 6992067 | Diphenylazetidinones, process for their preparation, medicaments comprising these compounds and their use Compounds of the formula I, in which R1, R2, R3, R4, R5, and R6 have the meanings given in the description, and their physiologically acceptable salts. The compounds are suitable for use, for example, as hypolipidemics.... | 01/31/2006 |
| 6962905 | Pharmaceutical formulation comprising a low molecular weight thrombin inhibitor and its prodrug A kit of parts containing (a) a pharmaceutical formulation including a low molecular weight thrombin inhibitor, or a pharmaceutically acceptable derivative thereof, in admixture with a pharmaceutically acceptable adjuvant, diluent or carrier, and (b) a pharmaceutica... | 11/08/2005 |
| 6956131 | 2-amino-3, 4 heptenoic compounds useful as nitric oxide synthase inhibitors The present invention is directed to a compound of formula I: or a pharmaceutically acceptable salt thereof, wherein: R2 is selected from the group consisting of H and methyl; and R... | 10/18/2005 |
| 6951889 | 2-amino-2-alkyl-5 heptenoic and heptynoic acid derivatives useful as nitric oxide synthase inhibitors The present invention relates to 2-amino-2-alkyl-5 heptenoic and heptynoic acid derivatives and their use in therapy, in particular their use as nitric oxide synthase inhibitors. ... | 10/04/2005 |
| 6919449 | Process for the preparation of cephalosporin intermediate and its use for the manufacture of cephalosporin compounds The present invention relates to a method for the preparation of cephalosporin antibiotic of the formula (II), which comprises hydrolyzing and halogenating the ester of formula (III) by photochemical irradiation in one... | 07/19/2005 |
| 6914158 | Amidino compounds useful as nitric oxide synthase inhibitors The present invention relates to amidino compounds and salts and prodrugs thereof. In another embodiment the present invention also provides a use of the present compounds in therapy, particular as nitric oxide synthase inhibitors. In a further embodiment, the prese... | 07/05/2005 |
| 6911470 | Polyoxometalate compounds as antiviral agents Polyoxometalate compounds which exhibit anti-retroviral activity are disclosed. Compounds with anti-retroviral activity include those having the following general molecular formulas: M7PW11O39 M8SiW | 06/28/2005 |
| 6828456 | 2-amino-2-alkyl-3 hexenoic and hexynoic acid derivatives useful as nitric oxide synthase inhibitors The present invention relates to 2-amino-2-alkyl-3 hexenoic and hexynoic acid derivatives and their use in therapy, in particular their use as nitric oxide synthase inhibitors. ... | 12/07/2004 |
| 6797699 | Neuroprotective agents Compounds of formula (I) wherein: Q represents an amidino group, a cyano group or a group of formula XYN—, (where X and Y are hydrogen or various groups); Ra represents alkylene; Rb and Rc each represents alkylene, the total number... | 09/28/2004 |
| 6777391 | Composition for an infant formula having a low threonine content A composition for an infant formula which comprises a low threonine content; a method of producing the composition; use of the composition in the manufacture of a medicament or nutritional product for addressing the nutritional needs and providing healthy growth of ... | 08/17/2004 |
| 6759553 | Process for the preparation of creatine or creatine monohydrate A process for the preparation of creatine or creatine monohydrate by reaction of sodium or potassium sarcosinate with cyanamide at a temperature from 20 to 150° C. and a pH from 7.0 to 14.0 comprises carrying out the pH adjustment with carbonic acid. ... | 07/06/2004 |
| 6756406 | 2-amino-2-alkyl-4 hexenoic and hexynoic acid derivatives useful as nitric oxide synthase inhibitors The present invention relates to 2-amino-2-alkyl-4 hexenoic and hexynoic acid derivatives and their use in therapy, in particular their use as nitric oxide synthase inhibitors. ... | 06/29/2004 |
| 6686345 | DNA-cleaving antitumor agents A chemical composition and method of use of the composition is described. The chemical composition includes an aza-enediyne, aza-enyne allene, or an aza-diallene. These compound are preferably non-hydrolyzable, cationic compounds that bind to nucleic acid... | 02/03/2004 |
| 6653504 | Non-hygroscopic salts of active ingredients having therapeutical and/or nutritional activities and orally administrable compositions containing same Derivatives of active ingredients with creatine and ornithine are disclosed having enhanced nutritional and/or therapeutic effects which favorably lend themselves to the preparation of orally administrable solid compositions.... | 11/25/2003 |
| 6627769 | RGD-analog non-peptidic molecules having anti-adhesive, anti-migration and anti-proliferative effects Novel molecules without intramolecular peptidic bonds, able to mimic the RGD peptide, containing ARG-GLY-ASP motif "arginine-glycine-aspartic acid" (that is a potent inhibitor, in vivo and in vitro, of cellular adhesion) In vitro experimentation demonstra... | 09/30/2003 |
| 6586426 | ଲ-sheet mimetics and use thereof as protease inhibitors There are disclosed ଲ-sheet mimetics and methods relating to the same for imparting or stabilizing the ଲ-sheet structure of a peptide, protein or molecule. In one aspect, the ଲ-sheet mimetics are covalently attached at the end or within ... | 07/01/2003 |
| 6524785 | Perfusion and/or preservation and/or re-perfusion solution during organ transplant The invention concerns a perfusion and/or preservation and/or re-perfusion solution during organ transplant, in particular the cardiac organ, containing the following elements: K+ in the range of about 4 to about 7 mM; Ca2+ in the range of about 0.2 to ab... | 02/25/2003 |
| 6514934 | Imidazoline -adrenergic receptor antagonist compounds in combination with nitric oxide donors, compositions and methods of use The present invention is directed to nitrosated or nitrosylated -adrenergic receptor antagonists, compositions comprising -adrenergic receptor antagonists that are optionally substituted with at least one NO or NO2 moiety and comp... | 02/04/2003 |
| 6509497 | Process for preparing guanidine derivatives A process for preparing guanidine derivatives, in particular creatine, is described and entails continuously combining a cyanamide derivative and a primary or secondary amine in the presence of crystals of the guanidine derivative.... | 01/21/2003 |
| 6465686 | Halogenated 2-amino-5,6 heptenoic acid derivatives useful as nitric oxide synthase inhibitors The present invention discloses halogenated 2-amino-5,6 heptenoic acid derivatives useful as nitric oxide synthase inhibitors.... | 10/15/2002 |
| 6465518 | Halogenated 2-amino-4, 5 heptenoic acid derivatives useful as nitric oxide synthase inhibitors The present invention contains halogenated 2-amino-4,5 heptenoic acid derivatives useful as nitric oxide synthase inhibitors.... | 10/15/2002 |
| 6399819 | Process for purifying creatine A process for purifying creatine is described in which the creatine to be purified in the form free of water of crystallization is introduced into a saturated aqueous solution of creatine monohydrate, in which the creatine free of water of crystallization... | 06/04/2002 |
| 6329545 | Aminoguanidine carboxylates for the treatment of non-insulin-dependent diabetes mellitus The present invention provides novel compounds of the formula I and II for the treatment of non-insulin dependent diabetes mellitius (NIDDM) and a new use of known compounds for this purpose.... | 12/11/2001 |
| 6326403 | Diacylhydrazine derivatives as integrin inhibitors Compounds of the formula I ##STR1## wherein X, Y, Z, R1 and R2 are as defined in claim 1, and their salts and solvates, can be used as integrin inhibitors in particular for the prophylaxis and treatment of circulatory disorders, for ... | 12/04/2001 |
| 6326513 | Process for producing creatine or creatine-monohydrate The present invention relates to a process for producing creatine or creatine-monohydrate, comprising the step of reacting N-methylglycine, sodium N-methylglycinate and/or potassium N-methylglycinate with S-methylisothiourea and/or S-methylisothiourea sul... | 12/04/2001 |
| 6306840 | Cell adhesion inhibitors The present invention relates to novel compounds that are useful for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. This invention also relates to pharmaceutical formulations comprising these compounds and methods of us... | 10/23/2001 |
| 6274557 | Inhibition of nitric oxide synthase by amino acids and dipeptides Methods and compositions for inhibiting at least one isoform of nitric oxide synthase are provided. Pharmaceutical compositions include derivatives of arginine as well as dipeptides and dipeptide analogs that contain nitroarginine or another unnatural ami... | 08/14/2001 |
| 6251869 | Enhancement of oxazolidinone antibacterial agents activity by using arginine derivatives The present invention provides methods and compositions for enhancing the effectiveness of oxazolidinone antibacterial agents against gram-negative organisms infection by using an arginine derivative.... | 06/26/2001 |
| 6211407 | Dicreatine citrate and tricreatine citrate and method of making same A dicreatine citrate or tricreatine citrate, comprising two and three creatine cations per citrate anion, respectively. The dicreatine citrate has a melting point of about 146° F., and the tricreatine citrate has a melting point of about 154° F.... | 04/03/2001 |