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| Number | Title | Issue Date |
| 6846843 | β-thioamino acids Thio-alpha-amino acids of general formula (I), wherein R1, R2 and R3 have the meanings given in the description, methods for producing them, and medicaments containing these compounds. The invention also provides methods for treating... | 01/25/2005 |
| 6800612 | S-nitrosothiols as agents for the treatment of circulatory dysfunctions The present invention is directed to a S-nitrosothiol derivative of penicillamine or glutathione, of formula I: or its pharmaceutically acceptable salt thereof, in which: A and B are independently phenyl groups or togeth... | 10/05/2004 |
| 6686336 | N-terminal D(-)-penicillamine peptides as aldehyde sequestration agents The invention provides a compound of formula I: ##STR1## wherein R1 -R3 have any of the values described in the specification; or a salt thereof. The compounds are useful as aldehyde sequestration agents (e.g., in the treatment of al... | 02/03/2004 |
| 6521788 | Process for the preparation of 1-aminomethyl-1-cyclohexaneacetic acid A process for the preparation of gabapentin of formula (I) ##STR1## which comprises: a) reduction of (1-nitromethyl-cyclohexyl)acetonitrile of formula (II) ##STR2## to give 3-imino-2-aza-spiro[4.5]decan-2-ol of formula (III) ##STR3## b) transformation of... | 02/18/2003 |
| 6372912 | Process for ring cleavage of thiazolidine derivatives Process for the hydrolytic ring cleavage of thiazolidine derivatives to give 2-aminomercaptan derivatives and carbonyl compounds, which comprises bringing an aqueous solution of the thiazolidine derivative into contact with an acidic cation exchanger in the H | 04/16/2002 |
| 6255277 | Localized use of nitric oxide-adducts to prevent internal tissue damage A method for preventing adverse effects associated with the use of a medical device in a patient by introducing into the patient a device of which at least a portion includes a prophylactic or therapeutic amount of a nitric oxide adduct. The nitric oxide ... | 07/03/2001 |
| 5075469 | Pharmaceutical compositions containing a zinc complex The invention provides a pharmaceutical composition comprising a zinc complex of desferrioxamine or penicillamine as active ingredient therein in combination with a pharmacologically acceptable carrier.... | 12/24/1991 |
| 4918223 | Method of preparing N-acylated mercapto-alpha-amino acids N-acylated mercapto--amino acids of the general formula ##STR1## are prepared by reacting a nitrile of the general formula R1 -CN (II) at a temperature between 0° C. and 100° C. in water or in ... | 04/17/1990 |
| 4731477 | Process for the ring cleavage of 2-isopropyl-5,5-dimethylthiazolidines substituted in the 4-position A process for the ring cleavage of 2-isopropyl-5,5-dimethylthiazolidines in aqueous acid medium at elevated temperature. Whenever the five ring in the 4-position is substituted by a carboxyl group, penicillamine is the resultant product.... | 03/15/1988 |
| 4239644 | Liquid peroxide composition A liquid peroxide composition comprising dicumyl peroxide and a dicumyl peroxide derivative having one nucleus substituted by an alkyl group having 1 to 3 carbon atoms is disclosed. This peroxide composition can easily be handled because it is liquid, and... | 12/16/1980 |
| 4150240 | Method for preparing d-penicillamine and salts thereof D-Penicillamine and salts thereof may be prepared by reacting certain aryl amines with 4-thiazolidinecarboxylic acid compounds obtained by splitting the ଲ-lactam ring of penicillin derivatives such as benzylpenicillin or phenoxymethylpenicillin.... | 04/17/1979 |
| 4060548 | Process of making penicillamine Penicillamine and its hydrochloride are made by reacting i-butyraldehyde with elemental sulfur or a sulfur-containing compound and with gaseous ammonia so as to form 2-isopropyl-5.5-dimethyl-thiazoline-Ɗ3, then reacting the latter compound wit... | 11/29/1977 |
| 4045479 | Process of preparing penicillamine Penicillamine or a homolog thereof is made by reacting an aldehyde branched at the -carbon atom, sulfur and ammonia to form a thiazoline- Ɗ3 ; converting the latter compound by reaction with anhydrous hydrogen cyanide into the correspon... | 08/30/1977 |
| 4028406 | Process of preparing penicillamine Improvements in the process of preparing penicillamine or a homolog thereof by reacting an -carbon atom branched aldehyde, sulfur and ammonia to form a thiazoline-Ɗ3, reacting the thiazoline-Ɗ3 with anhydrous hydrogen cyanid... | 06/07/1977 |
| 3980666 | Process for the resolution of D,L-penicillamine and salts formed during said process D,L-penicillamine is separated into its antipodes employing optically active threo-1-(p-nitrophenyl)-2-aminopropanediol-1,3.... | 09/14/1976 |
| 3980665 | Optically active salt of protected D-penicillamine and L-lysine D,L-penicillamine is converted to D-penicillamine with the aid of L-lysine.... | 09/14/1976 |
| 3968154 | Method of producing penicillamine This invention relates to the production of penicillamine and acid addition salts of penicillamine through the production from penilloic acid or penicilloic acid formed by hydrolytic decomposition of a penicillin of penicillamine-mercuric-mercaptide which... | 07/06/1976 |
| 3966752 | Resolution of D,L-protected-penicillamine The D-form of an optically active protected penicillamine is prepared by treating a solution of D,L protected penicillamine of the formula: ##EQU1## wherein Ac is formyl, and R1 and R2 are both methyl or are joined together to f... | 06/29/1976 |
| 3960940 | Process for the preparation of D(-)-penicillamine and salts thereof D(-)-Penicillamine and salts thereof may be prepared by reacting a 6-amino or blocked 6-amino penicillin e.g. penicillin G or penicillin V, or a salt thereof, with a hydrazine having two --NH-groups, or a salt or solvate thereof.... | 06/01/1976 |
| 3948984 | Process of making penicillamine Penicillamine and its hydrochloride are made by reacting isobutyraldehyde with elemental sulfur or a sulfur-containing compound and with gaseous ammonia so as to form 2-isopropyl-5.5-dimethyl-thiazoline-Ɗ3, then reacting the latter compound wi... | 04/06/1976 |
| 3946069 | Process of making penicillamine Penicillamine or a homolog thereof is obtained by reacting a 2-disubstituted-5,5-alkyl-thiazolidine nitrile, alkyl having 1 to 6 carbon atoms, with a mineral acid in a two-stage proceeding wherein in the first stage relatively low temperatures and a relat... | 03/23/1976 |
