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...that Kleenex tissue was originally designed to be a gas mask filter? It was developed at the beginning of World War I to replace cotton, which was then in short supply as a surgical dressing.
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| Number | Title | Issue Date |
| 7897811 | Process for production of radioactive fluorine-labeled organic compound A process is provided for producing [18F]FACBC, which can reduce the production amount of impurities. Disclosed is a process for producing a radioactive fluorine-labeled organic compound, including a deesterification step of retaining, in a reverse-phase ... | 03/01/2011 |
| 7173151 | Cycloalkyl-substituted alkanoic acid derivatives, processes for their preparation and their use as pharmaceuticals The invention relates to arylcycloalkyl-substituted derivatives and to their physiologically acceptable salts and physiologically functional derivatives. What is described are compounds of the formula I, i... | 02/06/2007 |
| 6921835 | Cyclic amino acids and derivatives thereof useful as pharmaceutical agents The invention is a novel series of cyclic amino acids which are useful in the treatment of epilepsy, faintness attacks, neurodegenerative disorders, depression, anxiety, panic, pain, neuropathological disorders, gastrointestinal disorders such as irritable bowel syn... | 07/26/2005 |
| 6909014 | Intermediates for the synthesis of ether compounds The present invention relates to novel ether compounds, compositions comprising ether compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders comprising administering a compo... | 06/21/2005 |
| 6878723 | LTA4 hydrolase inhibitors The invention concerns compounds inhibiting LTA4 hydrolase of formula (I). The invention also concerns their therapeutic, in particular anti-inflammatory, applications. ... | 04/12/2005 |
| 6417389 | Process for the preparation of HPB esters This invention relates to a novel advantageous process for the stereoselective preparation of 2-hydroxy-4-phenylbutyrates (HPB esters) and of their precursors. This is done by starting from readily accessible -unsaturated -hydroxy-γ-keto es... | 07/09/2002 |
| 6355689 | Nitric oxide synthase inhibitors The present invention relates to novel amidino compounds of formula (I), ##STR1## or a salt, solvate, or physiologically functional derivative thereof; wherein R1 is selected from C1-4 alkyl, C3-4 cycloalkyl, C1-4 hy... | 03/12/2002 |
| 6329429 | Use of GABA analogs such as Gabapentin in the manufacture of a medicament for treating inflammatory diseases GABA analogs such as gabapentin and pregabalin are useful to prevent and treat inflammatory diseases.... | 12/11/2001 |
| 6153650 | Substituted gamma aminobutyric acids as pharmaceutical agents Novel gamma aminobutyric acids of formula (I) are disclosed and are useful as agents in the treatment of epilepsy, faintness attacks, hypokinesia, cranial disorders, neurodegenerative disorders, depression, anxiety, panic, pain, neuropathological disorder... | 11/28/2000 |
| 6084125 | Process for producing aliphatic acids using a reactor system having a shell and a tube reactor configuration to force circulation of reaction liquid A shell and tube heat exchanger reactor with forced circulation is used to improve heat and mass transfer for exothermic liquid--liquid, gas-liquid and gas-liquid-solid reactions. Enhanced productivity and selectivity are obtained.... | 07/04/2000 |
| 5990165 | Pharmaceutical compounds A pharmaceutical compound of the formula: ##STR1## in which n is 1 or 2, R1 is --CO2 H, R2 is hydrogen or C1-4 alkyl and R3 is hydrogen, C1-10 alkyl, C2-10 alkenyl, optionally ... | 11/23/1999 |
| 5959141 | 1-amino-2-hydroxycycloalkanecarboxylic acid derivatives The invention is directed to optically active 1-amino-hydroxycycloalkanecarboxylic acid compounds represented by the formula: ##STR1## wherein n is 0, 1, 2, 3, or 4; methods of their synthesis; and their use as compounds to fix the confirmation ... | 09/28/1999 |
| 5863931 | Amidino derivatives and their use as nitric oxide synthase inhibitors Amidino derivatives of formula (I) and salts, and pharmaceutically acceptable esters and amides thereof, in which: R1 is a C1-6 straight or branched chain alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group,... | 01/26/1999 |
| 5817776 | Amino acid analogs for tumor imaging The invention provides novel amino acid compounds of use in detecting and evaluating brain and body tumors. These compounds combine the advantageous properties of 1-amino-cycloalkyl-1-carboxylic acids, namely, their rapid uptake and prolonged retention in... | 10/06/1998 |
| 5808146 | Amino acid analogs for tumor imaging The invention provides novel amino acid compounds of use in detecting and evaluating brain and body tumors. These compounds combine the advantageous properties of 1-amino-cycloalkyl-1-carboxylic acids, namely, their rapid uptake and prolonged retention in... | 09/15/1998 |
| 5783593 | Inhibitors of squalene synthetase and protein farnesyltransferase The present invention provides a compound of the formula ##STR1## which inhibit squalene synthetase and cholesterol biosynthesis and are useful in the treatment of e.g., hyperlipidaemia, atherosclerosis, or fungal infections, processes for the prepar... | 07/21/1998 |
| 5770763 | Difunctional bitricyclodecatriene monomers Novel difunctionalized cyclobutabenzene monomers of the general formula: ##STR1## wherein Z can be hydrogens or a cyclobutane ring; and X and Y are carboxyl, amino, alcohol, isocyanate, acid halide, or bis-acyl halide groups. Exemplary difunctional b... | 06/23/1998 |
| 5679711 | Hydroxyl ions as novel therapeutic agents and compounds that modulate these ions, compositions employing these agents, therapeutic methods for using such agents The invention concerns the discovery of the surprising and unexpected therapeutic effects of hydroxyl ions. The observed medicinal properties of these ions are both novel and broad in scope. The acute corrosive effects and toxicity of hydroxyl ions on liv... | 10/21/1997 |
| 5631401 | Inhibitors of protein farnesyltransferase and squalene synthase The present invention provides a compound of the formula ##STR1## or a pharmaceutically acceptable salt thereof, which are useful in inhibiting protein farnesyltransferase and the farnesylation of the oncogene protein Ras or inhibiting de novo squale... | 05/20/1997 |
| 5585391 | Hydroxyl ions as unique therapeutic agents and compounds that modulate these ions, compositions employing these agents, therapeutic methods for using such agents and processes for preparing them The invention concerns the discovery of the surprising and unexpected therapeutic effects of hydroxyl ions. The observed medicinal properties of these ions are both novel and broad in scope. The acute corrosive effects and toxicity of hydroxyl ions on liv... | 12/17/1996 |
| 5514808 | Hydroxyl ions as unique therapeutic agents and compounds that modulate these ions The invention concerns the discovery of the surprising and unexpected therapeutic effects of hydroxyl ions. The observed medicinal properties of these ions are both novel and broad in scope. The acute corrosive effects and toxicity of hydroxyl ions on liv... | 05/07/1996 |
| 5506244 | Cyclic amino acid derivatives Disclosed are the compounds of formula I ##STR1## wherein R represents hydrogen, lower alkyl, carbocyclic or heterocyclic aryl-lower alkyl or cycloalkyl-lower alkyl; R1 represents hydrogen, lower alkyl, cycloalkyl, carbocyclic aryl or hete... | 04/09/1996 |
| 5502075 | Leukotriene-B4 derivatives, process for their production and their use as pharmaceutical agents Leukotriene-B4 derivatives of formula I ##STR1## their salts with physiologically compatible bases and their cyclodextrin clathrates are described.... | 03/26/1996 |
| 5455234 | Inhibition of hair growth Mammalian hair growth is reduced by applying to the skin an inhibitor of a cysteine synthetic pathway enzyme.... | 10/03/1995 |
| 5436343 | Alkenecarboxylic acid compounds Compounds of formula (I): ##STR1## in which: R1 and R2, which may be identical or different, represent a linear or branched (C1 C6) alkyl radical, a substituted or unsubstituted phenyl radical, a pyridyl ra... | 07/25/1995 |
| 5393924 | Method for the preparation of arylalkanolamineacylates Acylamides or amine acylate salts of arylalkanolamines are prepared by reacting an arylisonitrosoalkanone with hydrogen and a carboxylic acid, carboxylic acid anhydride or carboxylic acid ester or mixture thereof in the presence of a transition metal cata... | 02/28/1995 |
| 5312963 | Process for preparing substituted cyclobutanes The present invention relates to a process for the preparation of substituted cyclobutanes and their use as intermediates for the preparation of anti-viral nucleoside analogs.... | 05/17/1994 |
| 5240946 | ((2-(amino-3,4-dioxo-1-cyclobuten-1-yl)amino)alkyl)-acid derivatives A compound of the formula: ##STR1## in which R1 is hydrogen, alkyl or phenylalkyl; R2 is hydrogen, alkyl, alkenyl or phenylalkyl; or R1 and R2 taken together are --CH2 CH2 --, --CH | 08/31/1993 |
| 5214056 | 1,3,2-dioxathiolane oxide derivative A 1,3,2-dioxathiolane oxide derivative is represented by the following formula: ##STR1## wherein X represents --S(O)-- or --S(O)2 --; R1 represents a hydrogen atom, an alkali metal atom, a benzyl group, or a lower alkyl group; R... | 05/25/1993 |
| 5202459 | Process for producing cyclobutane derivative The present invention relates to a process for producing cyclobutane derivatives represented by general formula (28): ##STR1## (wherein R represents a substituent; R2 represents an electron attracting group and Nu represents a substituent ... | 04/13/1993 |
| 5153358 | Process for the preparation of alpha-alkylated alpha-amino acids and alpha-halogenated alpha-amino acids A novel process for the preparation of -alkylated -amino acids and -halogenated -amino acids is disclosed. These -alkylated -amino acids and -halogenated -amino acids are useful as intermediates for ... | 10/06/1992 |
| 5095137 | Amides of cyclomethylen-1,2-bicarboxylic acids having therapeutical activity The amides of cyclomethylen-1,2-bicarboxylic acids having the formula: ##STR1## wherein A represents ##STR2## R1 represents --H, --CH3, --CH2 --CH3, --CH(CH3)2, ##STR3## ... | 03/10/1992 |
| 5021602 | Reactive compounds containing perfluorocyclobutane rings Novel compounds have at least one perfluorocyclobutane ring and at least two functional groups suitable for forming condensation polymers. Preferably the compounds have a structures represented by Formula II: ##STR1## wherein R and R' independently r... | 06/04/1991 |
| 4940808 | Process for ozonization of unsaturated organic compounds A process for the ozonization of unsaturated organic compounds in a reaction column through which the unsaturated compounds--in solution in a protic solvent--and an ozone-containing carrier gas and an inert coolant are passed downward in co-current flow t... | 07/10/1990 |
| 4927964 | Method for production of 2-oxyimino-3-oxobutyric acids An advantageous method of producing in large amounts on a commercial scale 2-substituted oxyimino-3-oxobutyric acids, which are useful as intermediates in the synthesis of e.g. aminothiazole cephalosporins, is characterized by reacting a tert-butyl 2-subs... | 05/22/1990 |
| 4918226 | Process for converting formate esters to carboxylic acids A process for converting formic acid esters or transesterification products thereof to carboxylic acids comprising contacting a formic acid ester of the formula (HCOO)n --R where R is aliphatic, cycloaliphatic or aralkyl and n is 1 or 2 with a ... | 04/17/1990 |
| 4874803 | Dianhydride coupled polymer stabilizers The present invention comprises reaction products resulting from the reaction of hydrazido-substituted or certain amino-substituted polymer stabilizers and cyclic dianhydrides, as well as the use of such products. The polymer stabilizers of the invention ... | 10/17/1989 |
| 4788332 | L-aminodicarboxylic acid esters Sweeteners of the formula: ##STR1## and food-acceptable salts thereof, where the substituents are disclosed herein.... | 11/29/1988 |
| 4762548 | Herbicide compositions of extended soil life Herbicidally active thiolcarbamates are employed in combination with a certain amide extender compound, the latter in sufficient quantity to minimize soil degradation and to prolong the soil life of the former. As a result, the herbicidal effectiveness of... | 08/09/1988 |
| 4760175 | L-aminodicarboxylic acid alkenes This invention relates to novel sweeteners of the formula: ##STR1## wherein A is hydroxyalkyl containing 1-3 carbon atoms A' is hydrogen or alkyl containing 1-3 carbon atoms; Y is --(CHR2)n --R1 or --CHR3 R4 | 07/26/1988 |
