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| Number | Title | Issue Date |
| 8026393 | Soft-gelatin capsule formulation The present invention discloses a soft gelatin capsule formulation of a 15-keto-prostaglandin compound, which comprises: a soft gelatin capsule shell comprising gelatin and sugar alcohol as a plasticizer, and a mixture comprising a 15-keto-prostaglandin compound and... | 09/27/2011 |
| 7501539 | Process for the preparation of alkylidenecyclopentanone derivatives The present invention relates to the field of organic synthesis and more particularly to a new process for the preparation of a compound of formula (I), in the form of any one of its isomers or a mixture thereof, wherein, m... | 03/10/2009 |
| 7423057 | Compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents The present invention relates to a novel compounds that can be used as anti-inflammatory, immunomodulatory and antiproliferatory agents. In particular, the invention refers to new compounds which inhibit dihydroorotate dehydrogenase (DHODH), a process for their manu... | 09/09/2008 |
| 7355064 | Method for preparing 15-keto-prostaglandin E derivative Disclosed is an improved method for preparing 15-keto-prostaglandin E derivative. According to the invention, the deprotection of protected hydroxy group required in manufacturing a 15-keto-prostaglandin derivative is conducted under the presence of a phosphoric aci... | 04/08/2008 |
| 7294601 | Phosphines, transition metal complexes containing the same as the ligand, and process for production of optically active carboxylic acids [PROBLEMS] To provide a method by which desired optically active carboxylic acids may be prepared from a carboxylic acid having a carbon-carbon double bond through asymmetric hydrogenation with a catalyst consisting of a transition metal complex containing a water-s... | 11/13/2007 |
| 7179937 | Cyclopentenone derivatives for cancer therapy The invention relates to the use of derivatives of cyclopentenone for the inhibition or prevention of the growth or multiplication of cancer cells, and to therapeutic compositions containing such compounds. The invention relates more specifically to the use of deriv... | 02/20/2007 |
| 7176241 | Compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents The present invention relates to novel compounds that can be used as antiinflammatory, immunomodulatory and antiproliferatory agents. In particular the invention refers to new compounds which inhibit dihydroorotate dehydrogenase (DHODH), a process for their manufact... | 02/13/2007 |
| 7122678 | Cyclic amino acids and derivatives thereof useful as pharmaceutical agents The invention is a novel series of cyclic amino acids which are useful in the treatment of epilepsy, faintness attacks, neurodegenerative disorders, depression, anxiety, panic, pain, neuropathological disorders, gastrointestinal disorders such as irritable bowel syn... | 10/17/2006 |
| 6921835 | Cyclic amino acids and derivatives thereof useful as pharmaceutical agents The invention is a novel series of cyclic amino acids which are useful in the treatment of epilepsy, faintness attacks, neurodegenerative disorders, depression, anxiety, panic, pain, neuropathological disorders, gastrointestinal disorders such as irritable bowel syn... | 07/26/2005 |
| 6909014 | Intermediates for the synthesis of ether compounds The present invention relates to novel ether compounds, compositions comprising ether compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders comprising administering a compo... | 06/21/2005 |
| 6875764 | Urea and thiourea compounds useful for treatment of coccidiosis The present invention relates to novel compounds, pharmaceutical compositions containing the same as well as a method for treatment of parasitic disorders, wherein said compounds are administered. The present compounds are especially well suited for treatment of coc... | 04/05/2005 |
| 6864390 | Method for the stereoselective synthesis of cyclic amino acids The instant invention is a route to stereospecific 3-substituted 5-membered ring isomers of Formula (A). The final products are useful as agents in the treatment of epilepsy, faintness attacks, hypokinesia, cranial disorders, neurodegenerative disorders, depression,... | 03/08/2005 |
| 6800782 | Anhydrous crystalline forms of gabapentin Described are new crystalline anhydrous forms of gabapentin formed from gabapentin monohydrate. The new crystalline forms provide advantages in the manufacture of the therapeutic agent. ... | 10/05/2004 |
| 6794413 | Compounds and related methods for inhibition of γ-aminobutyric acid aminotransferase (1S, 3S)-3-Amino-4-difluoromethylene-1-cyclopentanoic acid illustrates a novel class of compounds as potent irreversible inhibitors of γ-aminobutyric acid aminotransferase (GABA-AT). The corresponding monofluoro-substituted compounds also are potent time-dependent ... | 09/21/2004 |
| 6613782 | Certain thiol inhibitors of endothelin-converting enzyme Disclosed as endothelin converting enzyme inhibitors are the compounds of the formula ##STR1## wherein the variables have the meanings as defined hereinbefore.... | 09/02/2003 |
| 6593489 | Substituted cyclopentenes, their preparation and their use for chiral scaffolds 3,4-Disubstituted-1-cyclopentene compounds, in substantially enantiopure form, have the relative stereochemistry according to formula (1A) or (1B) ##STR1## including the opposite enantiomers thereof, wherein R1 is either COOX, wherein X is selected ... | 07/15/2003 |
| 6576786 | Process for preparing substituted cyclopentane derivatives and novel crystalline structures thereof The invention relates to a process for preparing substituted cyclopentane derivatives represented by the formula (I) ##STR1## wherein R1, R2, R3, R4, X and Y are as described in the specification, and pharmaceut... | 06/10/2003 |
| 6562861 | Substituted cyclopentane and cyclopentene compounds useful as neuraminidase inhibitors ##STR1## Compounds I-III wherein U is CH, O, or S; Z is mono- or di-substituted carbon; R is (CH2)nCO2H, (CH2)nSO3H, (CH2)nPO3H2, (CH2)nNO2, CH(SCH3)3, esters; R1 is H, hydroxyalkyl, aminoalkyl, alkoxyalkyl; RR1 is O; n is 0-4; R2, R3 is H, hydroxyalkyl, ... | 05/13/2003 |
| 6531485 | Prostaglandin agonists This invention relates to prostaglandin agonists, methods of using such prostaglandin agonists, pharmaceutical compositions containing such prostaglandin agonists and kits containing such prostaglandin agonists. The prostaglandin agonists are useful for t... | 03/11/2003 |
| 6531509 | Stable gabapentin containing more than 20 ppm of chlorine ion Pharmaceutical compositions containing substantially pure and stable gabapentin are disclosed wherein gabapentin contains an anion of a mineral acid, such as chloride, in amounts greater than 20 ppm.... | 03/11/2003 |
| 6518305 | Five-membered carbocyclic and heterocyclic inhibitors of neuraminidases Disclosed are compounds of the formula: ##STR1## which are useful for inhibiting neuraminidases from disease-causing microorganisms, especially, influenza neuraminidase. Also disclosed are compositions and methods for preventing and treating diseases caus... | 02/11/2003 |
| 6503745 | Cyclopentane and cyclopentene compounds and use for detecting influenza virus New cyclopentane and cyclopentene compounds are provided along with their use in method for detecting influenza virus.... | 01/07/2003 |
| 6495711 | Process for preparing (-)-(1S, 4R) N-protected 4-amino-2-cyclopentene-1-carboxylate esters The invention relates to a process for preparing (-)-(1S,4R) N protected 4-amino-2-cylcopentene-1-carboxylate esters represented by the formula (I) ##STR1## wherein R1 and R2 are as described within the specification.... | 12/17/2002 |
| 6410594 | Substituted cyclopentane compounds useful as neuraminidase inhibitors Compounds represented by formula (I), and pharmaceutically acceptacle salts thereof; and their method of preparation are provided. Compounds of the above formula are influenza virus neuraminidase inhibitors and can be used in treating patients infected wi... | 06/25/2002 |
| 6395930 | Quenching reagents for solution phase synthesis A method for enhancing the purity of a desired compound comprising: Step (a) treating a crude reaction product which contains at least one desired compound, unreacted starting materials and/or byproducts with at least one bifunctional quenching agent that is c... | 05/28/2002 |
| 6329429 | Use of GABA analogs such as Gabapentin in the manufacture of a medicament for treating inflammatory diseases GABA analogs such as gabapentin and pregabalin are useful to prevent and treat inflammatory diseases.... | 12/11/2001 |
| 6316659 | Method for producing cyclopentanone and cyclopentene-1-carboxylic acid and their esters A process for preparing cyclopentanone and cyclopentene-1-carboxylic acid or an ester thereof of the formula I ##STR1## where R is hydrogen or an aliphatic radical having 1-6 carbon atoms or a cycloaliphatic, araliphatic or aromatic radical having 6-12 ca... | 11/13/2001 |
| 6310084 | Metalloproteinase inhibitors The present invention relates to therapeutically active hydroxamic acid, N-formyl-N-hydroxyamino and carboxylic acid derivatives, their preparation, and pharmaceutical compositions containing them. These compounds are useful in the inhibition of metallopr... | 10/30/2001 |
| 6124476 | Catalyst ligands, catalyst compositions, catalyst metal complexes and processes for cross-coupling aromatic boron compounds with aromatic halogens or perfluoroalkylsulfonates The present invention discloses new organic compounds (e.g., ligands), their metal complexes and compositions using those compounds. The invention also relates to the field of catalysis. In particular, this invention relates to new compounds which when co... | 09/26/2000 |
| 6054482 | Lactam-free amino acids The present invention concerns cyclic amino acids of formula ##STR1## substantially free from the lactam ##STR2## wherein n is an integer of from 4 to 6, a process for the preparation thereof, compositions containing the compounds and methods of... | 04/25/2000 |
| 6025518 | Substituted cyclopentene derivatives and method for preparing the same A substituted cyclopentene derivative of formula (V): wherein X1 is (-OZa, ଲ-H) or (-H, ଲ-OZa), X3 is (-OZd, ଲ-H), (-H, ଲ-OZd), or oxygen atom... | 02/15/2000 |
| 6020370 | Bridged cyclic amino acids as pharmaceutical agents Bridged cyclic amino acids of formula ##STR1## are disclosed and are useful as agents in the treatment of epilepsy, faintness attacks, hypokinesia, cranial disorders, neurodegenerative disorders, depression, anxiety, panic, pain and neuropathological... | 02/01/2000 |
| 5990165 | Pharmaceutical compounds A pharmaceutical compound of the formula: ##STR1## in which n is 1 or 2, R1 is --CO2 H, R2 is hydrogen or C1-4 alkyl and R3 is hydrogen, C1-10 alkyl, C2-10 alkenyl, optionally ... | 11/23/1999 |
| 5959141 | 1-amino-2-hydroxycycloalkanecarboxylic acid derivatives The invention is directed to optically active 1-amino-hydroxycycloalkanecarboxylic acid compounds represented by the formula: ##STR1## wherein n is 0, 1, 2, 3, or 4; methods of their synthesis; and their use as compounds to fix the confirmation ... | 09/28/1999 |
| 5948935 | Process and intermediates for (s)--amino-1-carboxycyclopentaneacetic acid Disclosed herein is a process for preparing (S)--amino-1-carboxycyclopentaneacetic acid which is a useful intermediate for preparing peptidomimetic inhibitors of herpes viral ribonucleotide reductase. The process comprises the preparation of the ke... | 09/07/1999 |
| 5935988 | Tolerability of pharmaceutically active ଲ-amino acids The present invention relates to mixtures of -amino acids and/or derivatives thereof and cyclopentane-ଲ-amino acids and/or derivatives thereof, dipeptides of the abovementioned -amino acids and cyclopentane-ଲ-amino acids and mixt... | 08/10/1999 |
| 5932595 | Matrix metalloprotease inhibitors The present invention relates to compounds of Formula I: ##STR1## that are matrix metalloprotease inhibitors, pharmaceutical compositions containing them, methods for their use and methods of preparing these compounds.... | 08/03/1999 |
| 5877343 | Efficient and highly enantioselective process for the preparation of enantiomerically pure cyclopentane-ଲ-amino acids The process according to the invention for the preparation of enantiomerically pure cyclopentane-ଲ-amino acids of the general formula (I) ##STR1## in which A and D have the meanings given in the description, is characterized in that meso-d... | 03/02/1999 |
| 5817776 | Amino acid analogs for tumor imaging The invention provides novel amino acid compounds of use in detecting and evaluating brain and body tumors. These compounds combine the advantageous properties of 1-amino-cycloalkyl-1-carboxylic acids, namely, their rapid uptake and prolonged retention in... | 10/06/1998 |
| 5808147 | Therapeutic nucleosides The present invention relates to certain purine nucleoside analogues containing a carbocyclic ring in place of the sugar residue, salts, esters and pharmaceutically acceptable derivatives thereof, processes for their preparation, pharmaceutical formulatio... | 09/15/1998 |
