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| Number | Title | Issue Date |
| 8093422 | Method for deuteration of an aromatic ring The present invention relates to a method for deuteration of a compound having an aromatic ring, using an activated catalyst, and the method comprises reacting a compound having an aromatic ring with heavy hydrogen source in the presence of an activated catalyst sel... | 01/10/2012 |
| 7750182 | Process for production of iodine compounds and process for production of high-purity 5-iodo-2-methylbenzoic acid Provided is a production method for an iodine compound in which iodine is reacted with a substrate in the presence of a porous material having a pore diameter of 500 nm or less or in the presence of the above porous material and an oxidizing agent and a production p... | 07/06/2010 |
| 7723538 | Sulfonamides as L-CPT1 inhibitors The invention is concerned with novel sulfonamide derivatives of formula (I) wherein R2, R3, R4, A, X, Y1, Y2, Y3, Y4 and Z1 are as def... | 05/25/2010 |
| 7645901 | Modified release formulations of a bupropion salt The present invention relates to pharmaceutical compositions, formulations and medicaments comprising a bupropion salt, in particular, modified-release tablets comprising an effective amount of bupropion hydrobromide, and the use of the bupropion salt to prepare a m... | 01/12/2010 |
| 7572935 | Modified release formulations of a bupropion salt The present invention relates to pharmaceutical compositions, formulations and medicaments comprising a bupropion salt, in particular, modified-release tablets comprising an effective amount of bupropion hydrobromide, and the use of the bupropion salt to prepare a m... | 08/11/2009 |
| 7439372 | Therapeutic compounds A compound having a structure is disclosed herein. Compositions, medicaments, and therapeutic methods related thereto are also disclosed. ... | 10/21/2008 |
| 7365225 | Aryl dicarboxamides The present invention is related to aryl dicarboxamides of formula (I) and use thereof for the treatment and/or prevention of obesity and/or metabolic disorders mediated by insulin resistance or hyperglycemia, comprising diabetes type I and/or II, inadequate glucose... | 04/29/2008 |
| 7294278 | Method for oxygenating wastewater A method and apparatus creates gas-enriched fluid that is used to treat wastewater. In one embodiment, the wastewater is withdrawn from a supply of wastewater to be treated, and the wastewater is delivered in an atomized manner to a vessel pressurized with gas to fo... | 11/13/2007 |
| 7176240 | Pentanoic acid derivatives The compound of the formula (I): wherein R1 is alkyl substituted by fluorine(s); R2 is hydroxy, alkoxy, alkoxy substituted by phenyl, NR3R4, in w... | 02/13/2007 |
| 7109238 | Calcilytic compounds Novel calcilytic compounds and methods of using them are provided. ... | 09/19/2006 |
| 7057067 | Process for the preparation of 2-halobenzoic acids The present invention provides a process for producing 2-halobenzoic acids of the general formula (I), characterized by reacting a benzoic acid of formula (II) with a halogenating agent in the presence of Pd catalyst: ... | 06/06/2006 |
| 7057038 | Kinetic resolutions of chiral 2- and 3-substituted carboxylic acids One aspect of the present invention relates to a method for the kinetic resolution of racemic and diastereomeric mixtures of chiral compounds. The critical elements of the method are: a non-racemic chiral tertiary-amine-containing catalyst; a racemic or diastereomer... | 06/06/2006 |
| 7057055 | Process for preparing a deuterated or tritiated compound A process for labeling organic compounds with deuterium and tritium is described using specific catalysts. ... | 06/06/2006 |
| 7015349 | Reduction of hair growth Compositions including a conjugate of α-difluoromethylornithine can be applied topically to reduce hair growth. ... | 03/21/2006 |
| 7008535 | Apparatus for oxygenating wastewater A method and apparatus creates gas-enriched fluid that is used to treat wastewater. In one embodiment, the wastewater is withdrawn from a supply of wastewater to be treated, and the wastewater is delivered in an atomized manner to a vessel pressurized with gas to fo... | 03/07/2006 |
| 6989462 | Synthesis of 2-chloromethyl-6-methylbenzoic ester A process is described for preparing compounds of formula (I) where R is H, optionally halogen-substituted alkyl, cycloalkyl, aryl, alkyl-aryl or heteroaryl, and, in alkyl and cycloalkyl, one or more CH2 grou... | 01/24/2006 |
| 6943257 | Process for preparation of aromatic halides from aromatic amines The present invention provides a process for preparing an aromatic bromide or aromatic iodide from an aromatic amine derivative using nitrite anion and halodimethylsulfonium halide generated in situ from hydrobromic acid/DMSO or hydriodic acid/DMSO. The process for ... | 09/13/2005 |
| 6936636 | 5-[phenyl-tetrahydronaphthalene-2-yl dihydronaphthalen-2-yl and heteroaryl-cyclopropyl]-pentadienoic acid derivatives having serum glucose reducing activity Compounds of the formula: where the variables have the meaning defined in the specification are capable of reducing serum glucose levels in diabetic mammals without the undesirable side effects... | 08/30/2005 |
| 6727098 | Biaryl-type compounds, CD color fixing agent and method for determination of absolute configuration A novel achiral biaryl-type compound and a circular dichroism (CD) color fixing agent are provided. Furthermore, a method for determining an absolute configuration of a chiral compound is carried out by introducing the above achiral biaryl-type compound into the chi... | 04/27/2004 |
| 6689891 | 2-bromomethyl-6-methyl-benzoic acid and a process for the preparation thereof A process for the preparation of 2-bromomethyl-6-methyl-benzoic acid (I) and derivatives thereof by selective bromination of 2,6-dimethylbenzoic acid (II) with sodium bromate and hydrobromic acid in the presence of light.... | 02/10/2004 |
| 6586625 | Synthesis of 2-halobenzyl alkanoic acid A method for synthesizing compounds of Formula I ##STR1## in which R is alkyl or aryl and X is any halogen is described.... | 07/01/2003 |
| 6555078 | Method of preparing lithium salts The present invention provides an inexpensive process for the preparation of lithium salts of formula LiX having a desired or required level of purity using lithium chloride and lithium sulfate. In the process of the invention, a lithium salt selected fro... | 04/29/2003 |
| 6489507 | Process for the synthesis of 3,5-bis(trifluoromethyl)benzoic acid The present invention is concerned with a novel process for the preparation of 3,5-bis(trifluoromethyl)benzoic acid (CAS 725-89-3). This compound is useful as an intermediate in the synthesis of compounds which possess pharmacological activity, in particu... | 12/03/2002 |
| 6462227 | Stabilized o-iodoxybenzoic acid compositions and process for the preparation thereof Compositions that comprise, for one mole of o-iodoxybenzoic acid, from 0.5 to 4 moles of an aliphatic acid of formula CH3 (CH2)n COOH, in which n is from 8 to 20, of a benzenecarboxylic acid of formula ##STR1## in which R... | 10/08/2002 |
| 6455725 | Substituted cinnamic acids and cinnamic acid esters The invention relates to substituted cinnamic acids and cinnamic acid esters of formula (I), wherein X represents F, Cl or J and R1 and R2 are the same or different and represent hydrogen, an optionally substituted C1 -C | 09/24/2002 |
| 6420601 | Process for the preparation of 3,5-bis(trifluoro-methyl)-benzoyl chlorides and novel 3,5-bis(tri-halogenomethyl)-and 3,5-dimethylbenzoyl halides 3,5-Bis(trifluoromethyl)benzoyl chlorides optionally substituted with fluorine or chlorine are advantageously prepared by converting 3,5-dimethylbenzoic acids optionally substituted with fluorine or chlorine into the corresponding acid chlorides; complete... | 07/16/2002 |
| 6414186 | Process for producing chloromethylphenylacetic acid A method for preparing chloromethylphenylacetic acids represented by formula (II): ##STR1## wherein a methylphenylacetic acid represented by formula (I): ##STR2## is reacted with a chlorine gas, in an inert solvent, under the irradiation with light o... | 07/02/2002 |
| 6410783 | Method of producing carboxylic acid salts The present invention is a method of producing dry, alkali metal or ammonium carboxylic acid salt particles. In accordance with the invention, a molten carboxylic acid is mixed with a solution of an alkali metal-containing or ammonium-containing alkaline ... | 06/25/2002 |
| 6391823 | Separation process A process for separating a compound from a mixture of different compounds is disclosed for compounds comprising at least two negatively charged groups connected by a linker group. The process comprises treating the mixture with a material comprising layer... | 05/21/2002 |
| 6392084 | Method for production of organic fluorine compound A method for the production of an aromatic fluorine compound is provided which is capable of preventing the occurrence of benzoic acid fluorides during the course of a halogenation exchange reaction or allowing removal of the benzoic acid fluorides formed... | 05/21/2002 |
| 6388123 | Substituted phenyl keto enols as pesticides and herbicides The present invention relates to novel compounds of the formula (I) ##STR1## in which Het represents one of the groups ##STR2## in which A, B, D, G, V, W, X, Y and Z are as defined in the description, processes and intermediates for their preparation, and to ... | 05/14/2002 |
| 6362365 | Preparation of trifluorobenzoic acids The present invention relates to a process for preparing trifluorobenzoic acids of the formula ##STR1## in which R is a straight-chain or branched alkyl radical having 1 to 6 C-atoms, an unsubstituted phenyl radical, a substituted phenyl radical whic... | 03/26/2002 |
| 6348624 | Process for making certain benzoic acid compounds The subject invention involves processes for making 2,4-difluoro-3-Q1-benzoic acid, wherein Q1 is derived from an electrophilic reagent, comprising the steps of: (a) treating 1-bromo-2,4-difluorobenzene with a strong, non-nucleophilic base; then trea... | 02/19/2002 |
| 6333431 | Processes for the preparation of fluorinated benzoic acids An object of the present invention is to provide a commercially advantageous process for preparing a fluoro benzoic acid. The process according to the present invention comprises either alkylating a fluoro benzoic acid of the formula ##STR1## wherein... | 12/25/2001 |
| 6307091 | Trifluoro-substituted benzoic acid, esters thereof and processes for preparing the same The present invention is to provided a trifluoro-substituted benzoic acid, an ester thereof, particularly 2,3,4-trifluoro-5-iodobenzonic acid, 2,3,4-trifluoro-5-trifluoromethylbenzonic acid, esters thereof, which are useful as a starting material for synt... | 10/23/2001 |
| 6303812 | Isolation of products from selective dehalogenation of haloaromatics Disclosed is a method of isolating the aromatic product formed when a substrate having the general formula ##STR1## is dehalogenated, forming a product mixture of copper salts and aromatic product, where X is the halogen removed from the substrate to form... | 10/16/2001 |
| 6288271 | Process for the preparation of (2,2,2-trifluoroethoxy)benzoic acids A process for producing trifluoroethoxybenzoic acids or salts thereof by reaction of halobenzoic acids or salts thereof with 2,2,2-trifluoroethanol in the presence of a strong base and copper containing materials. The compounds obtained by the process of ... | 09/11/2001 |
| 6268527 | Method for producing benzoic acid derivatives The invention relates to a method for producing a benzoic acid derivative represented by the general formula (1). The method includes the step of reacting an aromatic compound represented by the general formula (2), with carbon monoxide and a hydroxy comp... | 07/31/2001 |
| 6268513 | Phosphine ligands metal complexes and compositions thereof for cross-coupling reactions The present invention discloses new efficient processes for various bond forming reactions, including Suzuki reactions and aryl aminations. Organic compounds (e.g., ligands), their metal complexes and compositions using those compounds, provide useful cat... | 07/31/2001 |
| 6265601 | Methods for using phosphine ligands in compositions for suzuki cross-coupling reactions The present invention discloses new efficient processes for various bond forming reactions, including Suzuki reactions. Organic compounds (e.g., ligands), their metal complexes and compositions using those compounds, provide useful catalysts. The inventio... | 07/24/2001 |