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| Number | Title | Issue Date |
| 8314268 | 1-phenylalkanecarboxylic acid derivatives for the treatment of neurodegenerative diseases 1-Phenylalkanecarboxylic acid derivatives, the processes for the preparation thereof and the use thereof in the treatment and/or prevention of neurodegenerative diseases such as Alzheimer's disease. ... | 11/20/2012 |
| 8158820 | Compounds The invention relates to substituted phenoxyacetic acids (I) as useful pharmaceutical compounds for treating respiratory disorders, pharmaceutical compositions containing them, and processes for their preparation. ... | 04/17/2012 |
| 8008526 | Synthesis reaction catalyst and method of synthesizing compound using the same To improve a catalytic activity of a composite oxide, to carry out a reaction in a high yield, and to provide a synthesis reaction catalyst having excellent handling properties and a method of a synthesizing a compound using the same, a synthesis reaction catalyst c... | 08/30/2011 |
| 7816558 | Triarylcarboxylic acid derivative Provided is a triarylcarboxylic acid derivative, or an isomer, a prodrug, a hydrate, a solvate, a polymorph, or a pharmaceutically acceptable salt thereof, represented by the following general formula (I): wherein A is an o... | 10/19/2010 |
| 7572934 | Substituted biphenyl GPR40 modulators The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: where the definitions of the variables are provided herein. The present... | 08/11/2009 |
| 7338977 | Anti-viral compounds Compounds of formula I wherein at least one R1 is H and the remainder are CH2CO2K; R2 is and L is H are described. The compounds are us... | 03/04/2008 |
| 7326803 | Ligand inhibitors of the RAR receptors, process for preparing same and therapeutic/cosmetic applications thereof Novel bicyclic compounds having the structural formula (I): are useful in a variety of pharmaceutical applications, whether human or veterinary, and also in cosmetics. ... | 02/05/2008 |
| 7285680 | β-alanine derivatives and the use thereof A compound of the general formula (I) (wherein the symbols are as defined in the description), or a prodrug or a salt thereof. This compound engages in LPA receptor bonding and antagonism and hence is use... | 10/23/2007 |
| 7148245 | Biphenyl derivatives substituted with an aromatic or heteroaromatic radical, and pharmaceutical and cosmetic compositions containing them Compounds of formula (I): in which: Ar represents an aromatic or a heteroaromatic radical optionally substituted, in particular, with an alkyl or a carboxyl group, ... | 12/12/2006 |
| 6992095 | Stilbene compounds comprising an adamantyl group, compositions and methods thereof The invention relates to novel stilbene compounds having the general formula (I): as well as to pharmaceutical compositions for use in human or veterinary medicine, including dermatological, rheumatic, respiratory, card... | 01/31/2006 |
| 6936636 | 5-[phenyl-tetrahydronaphthalene-2-yl dihydronaphthalen-2-yl and heteroaryl-cyclopropyl]-pentadienoic acid derivatives having serum glucose reducing activity Compounds of the formula: where the variables have the meaning defined in the specification are capable of reducing serum glucose levels in diabetic mammals without the undesirable side effects... | 08/30/2005 |
| 6924388 | Bicyclic aromatic compounds and pharmaceutical/cosmetic compositions comprised thereof Novel pharmaceutically/cosmetically-active bicyclic aromatic compounds having the structural formula (I): in which Ar1 is a radical having one of the structural formulae (a)-(c): | 08/02/2005 |
| 6849757 | Antiangiogenic drug to treat cancer, arthritis and retinopathy Compounds having Formula I or pharmaceutically acceptable salts or prodrugs thereof, are useful for treating pathological states which arise from or are exacerbated by angiogenesis. The invention also relates to pharma... | 02/01/2005 |
| 6756508 | Cinnamic acid salts, processes for their preparation, and their use as medicaments The present invention relates to new cinnamic acid salts of salmeterol, processes for the preparation thereof as well as the use thereof as pharmaceutical compositions. ... | 06/29/2004 |
| 6713515 | Retinoic acid receptor antagonists as promoters of angiogenesis Methods and compositions for treating various disorders by administering a therapeutically effective amount of a retinoic acid receptor antagonist alone or in combination or in conjunction with other therapeutic agents to promote angiogenesis are provided. Also prov... | 03/30/2004 |
| 6580002 | Process for the preparation of trifluoromethyl-substituted biphenylcarboxylic acids and novel trichloromethyl-and trifluoromethyl-substituted biphenylcarbonitriles Trifluoromethyl-substituted biphenylcarboxylic acids are prepared by converting methyl-substituted biphenylcarbonitriles into the corresponding trichloromethyl-substituted biphenylcarbonitriles, converting the trichloromethyl group thereof to a trifluorom... | 06/17/2003 |
| 6515021 | Bicyclic aromatic compounds The invention relates to novel bicyclic aromatic compounds which have the general formula (I): ##STR1## as well as to the use of these compounds in pharmaceutical compositions intended for use in human or veterinary medicine (dermatological, rheumati... | 02/04/2003 |
| 6465688 | Process for the preparation of trifluoromethyl-substituted biphenylcarboxylic acids and novel trichloromethyl-and trifluoromethyl-substituted biphenylcarbonitriles Trifluoromethyl-substituted biphenylcarboxylic acids are prepared by converting methyl-substituted biphenylcarbonitriles into the corresponding trichloromethyl-substituted biphenylcarbonitriles, converting the trichloromethyl group thereof to a trifluorom... | 10/15/2002 |
| 6452045 | Process for improving yields in a disproportionation reaction (high yield Henkel) Disclosed is a process for disproportionation of potassium naphthoate to the dipotassium salt of 2,6-NDA which gives reproducible improved yields of up to 40% which comprises: a) reacting naphthoic acid in the presence of excess base to produce a dispropo... | 09/17/2002 |
| 6403638 | 2,4-pentadienoic acid derivatives having selective activity for retinoid X (RXR) receptors Compounds having the formulas below, where R is H, lower alkyl, or a pharmaceutically acceptable salt, and where R1 represents i-propyl, t-butyl or n-butyl groups, have selective RXR retionoid agonist activity. ##STR1##... | 06/11/2002 |
| 6376546 | Biphenyl-5-alkanoic acid derivatives and use thereof ##STR1## Compounds represented by general formula I or salts thereof, wherein n is an integer of 2 or 3; R represents a straight-chain or branched saturated alkyl group having 4 or 4 carbon atoms, a cyclopentyl group, a cyclohexyl group or the like, Y rep... | 04/23/2002 |
| 6369266 | Process for producing tert-butyl 4'-methyl-2-biphenylcarboxlate A process for preparing tert-butyl 4'-methyl-2-biphenylcarboxylate characterized in that 4'-methyl-2-biphenylcarboxylic acid is reacted with isobutene in the presence of an acid catalyst. According to the present invention, tert-butyl 4'-methyl-2-biphenyl... | 04/09/2002 |
| 6369271 | Process for preparing derivatives of biphenyl-2-carboxylic acid The invention relates to a process for large-scale industrial production of biphenyl-2-carboxylic acid derivatives (I) ##STR1## wherein R1 and R2 may have the meanings given in the specification and claims.... | 04/09/2002 |
| 6319948 | Retinoid antagonists and uses thereof Retinoid antagonist compounds have been found to be useful in the prevention and/or minimization of surgical adhesion formation. Also provided by the invention are certain novel substituted (5,6)-dihydronaphthalenyl compounds which are retinoid antagonists and... | 11/20/2001 |
| 6316009 | Biphenyl derivatives substituted by an aromatic or heteroaromatic radical and pharamaceutical and cosmetic compositions containing same "Biphenyl derivatives substituted with an aromatic or heteroaromatic radical, and pharmaceutical and cosmetic compositions containing them" ##STR1## in which: Ar represents an aromatic or a heteroaromatic radical optionally substituted, in particular, wit... | 11/13/2001 |
| 6294568 | 5-arylpyrrole derivatives The present invention provides compounds represented by the general formula (I): ##STR1## and a salt thereof, and anti-inflammatory agents and antitumor agents containing the compounds as the active ingredients.... | 09/25/2001 |
| 6248919 | Process for the preparation of farnesyltransferase inhibitors A process for the preparation of preparation of farnesyltransferase inhibitors of formula (I) ##STR1## or pharmaceutically acceptable salts or prodrugs thereof, is disclosed.... | 06/19/2001 |
| 6214878 | Stilbene compounds comprising an adamantyl group, compositions and methods thereof The invention relates to novel stilbene compounds having the general formula (I): ##STR1## as well as to pharmaceutical compositions for use in human or veterinary medicine, including dermatological, rheumatic, respiratory, cardiovascular and ophthal... | 04/10/2001 |
| 6172112 | Retinoids and use thereof The present invention provides new retinoid compounds and uses of the compounds in humans and animals for chemoprevention of skin and/or breast cancer and for therapy of leukemia.... | 01/09/2001 |
| 6169103 | Fluorine-substituted biphenyl butyric acids and their derivatives as inhibitors of matrix metalloproteinases Fluorine-substituted biphenyl butyric acid compounds and derivatives are described as well as acid methods for the preparation and pharmaceutical compositions of same, which are useful as inhibitors of matrix metalloproteinases, particularly gelatinase A,... | 01/02/2001 |
| 6147255 | Bicyclic-aromatic compounds The invention relates to novel bicyclic aromatic compounds which have the general formula (I): ##STR1## as well as to the use of these compounds in pharmaceutical compositions intended for use in human or veterinary medicine (dermatological, rhe... | 11/14/2000 |
| 6147224 | 2,4-pentadienoic acid derivatives having selective activity for retinoid X (RXR) receptors Compounds of Formula 1, Formula 2 or Formula 3 where X is O, S, or (CR1 R1)n where n is 0, 1 or 2; Y is a bivalent radical having Formula 4 or Formula 5 where o is an integer from 1 to 4 ##STR1## or Y is a bivalent ar... | 11/14/2000 |
| 6133286 | Tetrahydronaphthalene and tetrahydroquinoline compounds, their preparation and their use as leukotriene B4 (LTB4) antagonists This invention relates to novel benzopyran and other benzo-fused leukotriene B4 (LTB4) antagonists and the pharmaceutically acceptable salts thereof, to pharmaceutical compositions containing such compounds or a pharmaceutically acce... | 10/17/2000 |
| 6127415 | Apoptosis inducing adamantyl derivatives and their usage as anti-cancer agents The present invention relates to specific adamantyl or adamantyl group derivative containing retinoid compounds induce apoptosis of cancer cells. These adamantyl retinoid derivatives are useful for the treatment of many cancers and solid tumors, especiall... | 10/03/2000 |
| 6093830 | Enantioselective resolution process for arylpropionic acid drugs from the racemic mixture The invention relates to a novel non-catalytic enantioselective resolution process for the separation of enantiomer of arylpropionic acid drugs from the racemic mixture, which comprises dissolving the racemic mixture of the said drug an organic solvent, r... | 07/25/2000 |
| 5994379 | Bisaryl COX-2 inhibiting compounds, compositions and methods of use The present invention relates to inhibitors of COX-2, compositions which contain such compounds and methods of use. The compounds are represented by formula I: ##STR1## and include pharmaceutically acceptable salts and esters thereof.... | 11/30/1999 |
| 5968908 | Restricted 9-cis retinoids The invention is novel analogs of 9-cis-retinoic acid which are useful for the treatment and prevention of coronary artery disease and to protect against premature atherosclerosis by increasing HDL levels. The invention includes processes for preparing th... | 10/19/1999 |
| 5962731 | Compounds having selective activity for retinoid X receptors, and means for modulation of processes mediated by retinoid X receptors Compounds, compositions, and methods for modulating processes mediated by Retinoid X Receptors using retinoid-like compounds which have activity selective for members of the subclass of Retinoid X Receptors (RXRs), in preference to members of the subclass... | 10/05/1999 |
| 5945561 | Retinoid-like compounds Certain novel substituted (5,6)-dihydroanthracenyl compounds of the general formula ##STR1## wherein A, n, p, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined in ... | 08/31/1999 |
| 5883106 | 5-lipoxygenase inhibitors Novel compounds having the ability to inhibit 5-lipoxygenase enzyme and having the following formula I: ##STR1## and the pharmaceutically acceptable salts thereof, wherein Ar1 is a heterocyclic moiety which is selected from imidazolyl, pyr... | 03/16/1999 |
