Did You Know...
...that in 1800 ether was first used by partyers as a fun diversion? Sniffing the gas led to hilarious and raucous laughter as people watched each other become more and more intoxicated and silly. Several doctors independently realized the value ether would have to anesthetize surgery patients. Of those who claimed rights to the "discovery," none had a happy ending. One had a seizure and died defending his rights. Another spent his life in an asylum because he had been denied acclaim. A third became addicted to chloroform and, in a New York City jail, he soaked a cloth in the drug, severed an artery and bled to death.
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| Number | Title | Issue Date |
| 7560589 | Cycloalkylidene compounds as modulators of estrogen receptor The present invention relates to novel compounds with a variety of therapeutic uses, more particularly novel substituted cyclic alkylidene compounds that are particularly useful for selective estrogen receptor modulation. ... | 07/14/2009 |
| 7442833 | Triphenylethylene compounds as selective estrogen receptor modulators Compounds of formula (I): with a variety of therapeutic uses, more particularly novel prodrugs that are particularly useful for delivering a parent compound for selective estrogen receptor modulation. ... | 10/28/2008 |
| 7442832 | Painless injectable compositions containing salts of 2-arylpropionic acids The invention relates to pharmaceutical compositions of alkylammonium salts of 2-aryipropionic acids, including ketoprofen, ibuprofen, naproxen and tiaprofenic acid. The compositions are suitable for parenteral administration arid, due to buffering at pH 8 to 9, cau... | 10/28/2008 |
| 7425650 | Synthesis of asymmetric tetracarboxylic acids and corresponding dianhydrides This invention relates to processes for preparing asymmetrical biphenyl tetracarboxylic acids and the corresponding asymmetrical dianhydrides, namely 2,3,3′,4′-biphenyl dianhydride (a-BPDA), 2,3,3′,4′-benzophenone dianhydride (a-BTDA) and 3,4′-methylenedip... | 09/16/2008 |
| 7338977 | Anti-viral compounds Compounds of formula I wherein at least one R1 is H and the remainder are CH2CO2K; R2 is and L is H are described. The compounds are us... | 03/04/2008 |
| 6864390 | Method for the stereoselective synthesis of cyclic amino acids The instant invention is a route to stereospecific 3-substituted 5-membered ring isomers of Formula (A). The final products are useful as agents in the treatment of epilepsy, faintness attacks, hypokinesia, cranial disorders, neurodegenerative disorders, depression,... | 03/08/2005 |
| 6838574 | Dicarba-closo-dodecarborane derivatives A medicament comprising as an active ingredient a compound or a physiologically acceptable salt thereof represented by general formula (I): wherein R1 represents a dicarba-closo-dodecaboran-yl which may be s... | 01/04/2005 |
| 6825378 | Process for the synthesis of enantiomerically pure cyclohexylphenyl glycolic acid The present invention provides a process for the synthesis of enantiomerically pure cyclohexylphenyl glycolic acid of formula (1). The present invention more particularly relates to a process using cyclohexylphenyl ketone for the synthesis of enantiomerically... | 11/30/2004 |
| 6743784 | Estrogen mimetics lacking reproductive tract effects A method for treating symptoms, diseases and conditions in extra-reproductive tract tissues that are responsive to treatment with estrogen, using triarylethanes of formula (I) wherein R1 is —O(CH2... | 06/01/2004 |
| 6700012 | Antihistaminic piperidine derivatives and intermediates for the preparation thereof This invention relates to compounds of the formula: ##STR1## wherein R1 is H or C1 -C6 alkyl and the C1 -C6 alkyl moiety is straight or branched; R2 and R3 are each independen... | 03/02/2004 |
| 6566548 | Molecular compounds containing novel carboxylic acid derivatives as the constituent compound Novel molecular compounds containing carboxylic acid derivatives represented by general formula (I) or (II) as the constituent compound and exhibiting excellent performances in various technical fields including selective separation of useful substances, ... | 05/20/2003 |
| 6528681 | Halogenated triphenylethylene derivatives as selective estrogen receptor modulators The present invention describes novel halogenated triphenylethylene derivatives, or pharmaceutically acceptable prodrug or salt forms thereof, as selective estrogen receptor modulators for the treatment of and/or prevention of breast, uterine, ovarian, pr... | 03/04/2003 |
| 6417394 | Specific salt forms of triphenylethylene derivatives as selective estrogen receptor modulators This invention pertains to novel salt forms of trophenylethylene compound, such as 3-[4(1,2-diphenyl-but-1-enyl)-phenyl]-acrylic acid, as selective estrogen receptor modulators. This invention also provides methods for the treatment and/or prevention of b... | 07/09/2002 |
| 6376684 | Stereoselective process for alkyl phenylglycolic acids A process for preparing an alkyl phenylglycolic acid is disclosed. It follows the sequence of condensing a substituted acetaldehyde with mandelic acid to provide a 5-phenyl-1,3-dioxolan-4-one, which is condensed with an alkyl ketone or aldehyde to provide... | 04/23/2002 |
| 6323190 | Estrogen mimetics lacking reproductive tract effects A method for treating symptoms, diseases and conditions in extra-reproductive tract tissues that are responsive to treatment with estrogen, using triarylethanes of formula (I) ##STR1## wherein R1 is --O(CH2)m R3... | 11/27/2001 |
| 6268535 | Synthesis of 3-aryl-1-indanamines The present invention is a method of preparing a 3-aryl-1-indanamine represented by structural formula I: ##STR1## and physiologically acceptable salts thereof. In structure I, phenyl ring A can be unsubstituted or substituted with 1-4 substitutents. R | 07/31/2001 |
| 6239284 | Aromatic tetracyclic compounds of the retinoid type method for preparing and use The invention concerns aromatic tetralcyclic compounds of the retinoid type of general formula (I). The invention also concerns the method for preparing them and the pharmaceutical compositions containing at least one of said compounds.... | 05/29/2001 |
| 6235923 | Trisubstituted phenyl derivatives having retinoid agonist, antagonist or inverse agonist type biological activity Compounds of the formula ##STR1## where the symbols have the meaning defined in the specification, have retinoid, retinois antagonist or retinoid inverse agonist type biological activity.... | 05/22/2001 |
| 6207716 | Non-steroidal ligands for the estrogen receptor Novel non-steroidal ligands for the estrogen receptor which possess tissue-dependent estrogenic and antiestrogenic activity as well as methods for making the same and their applications in treating a variety of disease states.... | 03/27/2001 |
| 6180823 | Stereoselective process for alkyl phenylglycolic acids A process for preparing an alkyl phenylglycolic acid is disclosed. It follows the sequence of condensing a substituted acetaldehyde with mandelic acid to provide a 5-phenyl-1,3-dioxolan-4-one, which is condensed with an alkyl ketone or aldehyde to provide... | 01/30/2001 |
| 6127573 | Oxidaton of primary alcohols to carboxylic acids with a TEMPO catalyst using NaClO2 and NaClO The present invention relates to a TEMPO-catalyzed oxidation of primary alcohols, RCH2 OH to corresponding carboxylic acids, RCOOH in the presence of catalytic in the presence of catalytic amount of NaClO and stoichiometric amount of NaClO... | 10/03/2000 |
| 6043279 | Compounds having selective activity for retinoid X receptors, and means for modulation of processes mediated by retinoid X receptors Compounds, compositions, and methods for modulating processes mediated by Retinoid X Receptors using retinoid-like compounds which have activity selective for members of the subclass of Retinoid X Receptors (RXRs), in preference to members of the subclass... | 03/28/2000 |
| 6043247 | Modulators of molecules with phosphotyrosine recognition units The present invention relates to novel substituted acrylic acids, to methods for their preparation, compositions containing them, and their use for treatment of human and animal disorders, to their use for purification of proteins or glycoproteins, and to... | 03/28/2000 |
| 6037488 | Trisubstituted phenyl derivatives having retinoid agonist, antagonist or inverse agonist type biological activity Compounds of the formula ##STR1## where the symbols have the meaning defined in the specification, have retinoid, retinois antagonist or retinoid inverse agonist type biological activity.... | 03/14/2000 |
| 5877219 | Non-steroidal ligands for the estrogen receptor Described herein are non-steroidal ligands for the estrogen receptor which possess tissue-dependent estrogenic and antiestrogenic activity as well as methods for making the same and their applications in treating a variety of disease states.... | 03/02/1999 |
| 5639894 | Carbonylation of allylic alcohols and synthesis of an ambergris fragrance compound A process for the carbonylation of allylic alcohols such as nerolidol, farnesol, or their monocyclic analogues with carbon monoxide at a pressure of at least 30 bar in the presence of a polar solvent and a palladium halide catalyst, optionally an alkali m... | 06/17/1997 |
| 5530157 | Anti-inflammatory benzoic acid derivatives Novel benzoic acid derivatives have the formula: ##STR1## wherein --X-- represents C1 to C6 alkylene, C2 to C6 alkenylene or a divalent moiety having the structure --(CH2)m --Z-- in wh... | 06/25/1996 |
| 5288908 | Process for the preparation of fluorine containing monomers Compounds of the formula ##STR1## in which X represents hydrogen, --NO2 or --NH2 and Y represents --CH3, --COOH, --CONH2, --NH2 or --N.dbd.N--Z, in which the group --Z is ##STR2## with ... | 02/22/1994 |
| 5235091 | Process for preparing diphenylmethane compounds A diphenylmethane compound (III) can be produced in a good yield by allowing a phenol compound (I) to react with a stilbene compound (II) in the presence of methanesulfonic acid ##STR1##... | 08/10/1993 |
| 5208388 | 2,2-difluorocyclopropyl derivatives 2,2-Difluorocyclopropyl derivatives of the formula ##STR1## in which R represents alkyl, optionally substituted aryl or optionally substituted aralkyl and X represents hydroxymethyl, 2-hydroxyethyl, isocyanato, amino, amino hydrohalide or a radical o... | 05/04/1993 |
| 5189181 | Process for preparation 2,6-dihydrobenzo[1:26, 4:5-6]-difuran dyes A process for the preparation of a polycyclic dye of the Formula (1): ##STR1## by reacting a substituted acetic acid of the Formula (2): ##STR2## with a compound of the Formula (3): ##STR3## and oxidation of the intermediate leuco compound ... | 02/23/1993 |
| 5189212 | Triarylethylene carboxylic acids with estrogenic activity Nonsteroidal estrogenic triarylethylene carboxylic acids of the formula ##STR1## wherein R is (CH2)m O or (CH2)n, where m is an integer from 1 to 4 and n is an integer from 0 to 4, X is hydrogen or hydroxyl, Y ... | 02/23/1993 |
| 5136081 | Process for the preparation of cyclopentene, cyclopentane and cyclohexane derivatives The invention provides a process for the preparation of fungicidally active cyclopentene derivatives of the general formula ##STR1## cyclopentane derivatives of the general formula ##STR2## and cyclohexane derivatives of the general formula ... | 08/04/1992 |
| 5095147 | 2,2-difluorocyclopropyl derivatives 2,2-Difluorocyclopropyl derivatives of the formula ##STR1## in which R represents alkyl, optionally substituted aryl or optionally substituted aralkyl and X represents hydroxymethyl, 2-hydroxyethyl, isocyanato, amino, amino hydrohalide or a radical o... | 03/10/1992 |
| 5081283 | Fluorocyclopropyl derivative fungicide intermediates Novel intermediates for fungicides, comprising fluorocyclopropyl derivatives of the formula ##STR1## in which R represents alkyl, optionally substituted aryl or optionally substituted aralkyl, X represents hydrogen, chlorine or bromine and R1 | 01/14/1992 |
| 4999450 | Process for preparing alpha-(3-benzylphenyl) propionic acid derivative A process for preparing -(3-benzylphenyl)-propionic acid or its derivative, a precursor of ketoprofen (trade name), which comprises dehydrogenating a by-product oil fraction formed in the production of ethylbenzene using synthetic zeolite as an alk... | 03/12/1991 |
| 4962230 | Process for producing optically active carboxylic acid A process for producing an optically active carboxylic acid represented by formula (I): ##STR1## wherein R1, and R2, and R3 each represents a hydrogen atom, an alkyl group, an alkenyl group, or a phenyl or naphthyl gr... | 10/09/1990 |
| 4937375 | (Phenylethenyl)phenylpropionic acid and its ester, and method for producing (benzoylphenyl)propionic acid or its ester New compounds of -(3-(1-phenylethenyl)phenyl)-propionic acid and its esters and a method for producing -(3-benzoylphenyl)propionic acid which is prepared by oxidizing the former compound as an intermediate. The method is characterized in the... | 06/26/1990 |
| 4897397 | Aryl-alkynoic, alkenoic or alkanoic compounds and compositions useful as antiallergy and anti-inflammatory agents Certain aryl-alkynoic, alkenoic and alkanoic acids and derivatives and their use in treating inflammation, allergy and hyperproliferative skin disease are disclosed.... | 01/30/1990 |
| 4889947 | Ultraviolet radiation absorbing naphthalenylidene compositions Sunscreen compositions are described which contain certain substituted naphthalenylidenes which act as UV filters when incorporated in a carrier in amounts ranging from 0.1-50% by weight.... | 12/26/1989 |
