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| Number | Title | Issue Date |
| 7687664 | Carboxylic acid derivative, a salt thereof or an ester of them, and medicament comprising it The present invention provides novel carboxylic acid derivatives useful as an insulin sensitizer, a salt thereof or a hydrate of them, and a medicament comprising the derivative as the active ingredient. Specifically, it provides a carboxylic acid derivative represe... | 03/30/2010 |
| 7544835 | Carboxylic acid derivative and salt thereof Carboxylic acid compound or salt or hydrate thereof useful as insulin sensitizer, represented by the formula wherein R1 represents hydrogen, hydroxyl, halogen, carboxyl, or C1-6 alkyl, L represents sin... | 06/09/2009 |
| 7439383 | Sodium channel blockers The present invention is directed to novel phenytoin derivative compounds and the use of such compounds as sodium channel blockers. Such compositions have utility as anti-cancer agents and can be used to limit or prevent PCa growth and/or metastasis. ... | 10/21/2008 |
| 7288676 | Arylphenyl-substituted cyclic ketoenols The present invention relates to novel arylphenyl-substituted cyclic ketoenols of the formula (I) in which X represents halogen, alkyl, alkoxy, alkenyloxy, alkylthio, alkylsulph... | 10/30/2007 |
| 7223582 | Esterase, its DNA, its overexpression and production of optically active aryl propionic acids using the same The present invention relates to an esterase, its DNA, its overexpression and a method for preparing an optically active aryl propionic acid of formula (1) using the same in high yield, wherein R1 repr... | 05/29/2007 |
| 7105471 | Arylphenyl-substituted cyclic ketoenols The present invention relates to novel arylphenyl-substituted cyclic ketoenols of the formula (I) in which X represents halogen, alkyl, alkoxy, alkenyloxy, alkylthio, alkylsulph... | 09/12/2006 |
| 6870067 | Process for the synthesis of trifluorophenylacetic acids The present invention is concerned with a process for the preparation of trifluorophenylacetic acids using a Grignard reagent and an allylating agent, such as allyl bromide. ... | 03/22/2005 |
| 6825378 | Process for the synthesis of enantiomerically pure cyclohexylphenyl glycolic acid The present invention provides a process for the synthesis of enantiomerically pure cyclohexylphenyl glycolic acid of formula (1). The present invention more particularly relates to a process using cyclohexylphenyl ketone for the synthesis of enantiomerically... | 11/30/2004 |
| 6743941 | Process for the production of piperidine derivatives The present invention relates to processes for preparing certain piperidine derivatives, including fexofenadine (F), the active ingredient in the non-sedating antihistamine sold in the U.S. under the designation “Allegra®”. This invention also relates to novel ... | 06/01/2004 |
| 6700012 | Antihistaminic piperidine derivatives and intermediates for the preparation thereof This invention relates to compounds of the formula: ##STR1## wherein R1 is H or C1 -C6 alkyl and the C1 -C6 alkyl moiety is straight or branched; R2 and R3 are each independen... | 03/02/2004 |
| 6689903 | Crystallization method for production of purified aromatic dicarboxylic acids Disclosed is a method for the recovery of crystalline terephthalic acid containing less than about 150 ppmw p-toluic acid by subjecting a solution of terephthalic acid containing minor amounts of p-toluic acid to crystallization in a crystallization zone ... | 02/10/2004 |
| 6555287 | Non-subliming, difunctionalized ultraviolet dyes for use in anti-reflective coatings An improved light attenuating compound for use in the production of microdevices is provided. Broadly, the light attenuating compound is difunctional and can be directly incorporated (either physically or chemically) into photolithographic compositions su... | 04/29/2003 |
| 6525093 | Compounds to treat diabetes and associated conditions Compounds are provided that lower blood glucose concentrations, lower serum triglyceride concentrations, lower systolic blood pressure, and increase glucose uptake by adipose tissue, but do not affect the expression of PPAR-γ by adipose tissue.... | 02/25/2003 |
| 6465700 | Coupling reactions of 2-substituted, 7-haloindenes with aryl substituents to produce metallocene catalyst ligands Novel 2-substituted 7-haloindenes and methods for synthesizing such indenes are described. The 2-substituted 7-haloindenes may be coupled with any aryl group to produce a metallocene catalyst intermediate.... | 10/15/2002 |
| 6399549 | Condensates A cyclic compound comprising m units of the formula Ia. ##STR1## and n units of the formula (Ib) ##STR2## joined together to form a ring, wherein Y and y2 are divalent bridging groups which may be the same or different in each unit; Ro | 06/04/2002 |
| 6376684 | Stereoselective process for alkyl phenylglycolic acids A process for preparing an alkyl phenylglycolic acid is disclosed. It follows the sequence of condensing a substituted acetaldehyde with mandelic acid to provide a 5-phenyl-1,3-dioxolan-4-one, which is condensed with an alkyl ketone or aldehyde to provide... | 04/23/2002 |
| 6265609 | Thio-substituted pentanedioic acid derivatives The present invention relate to thio-substituted pentanedioic acid derivatives that inhibit N-Acetylated -Linked Acidic Dipeptidase (NAALADase) enzyme activity, pharmaceutical compositions comprising the same, and methods of using the same to inhib... | 07/24/2001 |
| 6201151 | Processes for preparing optically active (S)--aryl propionic acid or ester therof A process for preparing an optically active (S)--aryl propionic acid, by hydrolyzing a racemic thioester of -aryl propionic acid at various temperature in different aqueous organic solvents in the presence of an (S)-stereoselective lipase to... | 03/13/2001 |
| 6180823 | Stereoselective process for alkyl phenylglycolic acids A process for preparing an alkyl phenylglycolic acid is disclosed. It follows the sequence of condensing a substituted acetaldehyde with mandelic acid to provide a 5-phenyl-1,3-dioxolan-4-one, which is condensed with an alkyl ketone or aldehyde to provide... | 01/30/2001 |
| 6001877 | Phenylalkan(en)oic acid The phenylalkan(en)oic acids of the formula: ##STR1## as defined herein, posses an antagonistic activity on leukotriene B4.... | 12/14/1999 |
| 5866604 | Thiol derivatives with metallopeptidase inhibitory activity Compounds of formula (I) wherein R, R1, R2, R3, R4, m and n have the meanings reported in the description, processes for their preparation and pharmaceutical compositions which contain them as active ingredients... | 02/02/1999 |
| 5783593 | Inhibitors of squalene synthetase and protein farnesyltransferase The present invention provides a compound of the formula ##STR1## which inhibit squalene synthetase and cholesterol biosynthesis and are useful in the treatment of e.g., hyperlipidaemia, atherosclerosis, or fungal infections, processes for the prepar... | 07/21/1998 |
| 5777176 | 4,4-(disubstituted)cyclohexan-1-ol dimers and related compounds The present invention relates to novel dimers of 4.4-(disubstituted)cyclohexan-1-ol dimers and delated compounds, pharmaceutical compositions containing these compounds, and their use in treating allergic and inflammatory diseases and for inhibiting the ... | 07/07/1998 |
| 5777160 | 1, 4, 4-(trisubstituted) cyclohex-1-ene dimers and related compounds This invention relates to certain 1,4,4-(trsubstituted)cyclohex-1-ene dimers and rlated compounds which are useful in treating allergic and inflammatory diseases and for inhibiting the production of Tumor Necrosis Factor (TNF).... | 07/07/1998 |
| 5739389 | Aryl carboxylic acid derivatives There are provided an aryl carboxylic acid derivatives of the formula (XVIa) ##STR1## Aryl carboxylic acid derivatives of the formula (XVIa) have a particularly pronounced activity against animal pests, in particular against insects and arachnid... | 04/14/1998 |
| 5582814 | 1-(p-n-butylbenzyl) DTPA for magnetic resonance imaging Paramagnetic metal complexes of 1-(p-n-butylbenzyl)diethylenetriamine pentaacetic acid and pharmaceutically acceptable salts thereof are effective as tissue-specific MRI contrast agents, and in particular as hepatobiliary MRI contrast agents.... | 12/10/1996 |
| 5446186 | Structure and synthesis of nitrophenyl-EGTA, a caged calcium, intermediates thereof and a method of producing a high photochemical yield of liberated calcium The synthesis and compound of a new caged calcium which is an ortho-nitrophenyl derivative of EGTA and various intermediates. It is synthesized in ten steps and 24% overall yield. The photosensitive chelator, nitrophenyl-EGTA, has a Kd for Ca | 08/29/1995 |
| 5436369 | Alicyclic phospholipase A2 inhibitors Certain novel alicyclic compounds are effective phospholipase A2 (PLA2) inhibitors.... | 07/25/1995 |
| 5391818 | Tricarboxylic acid-functional monomers and polymers prepared from same An unsaturated acid-functional monomer having the structure: ##STR1## wherein R1 is hydrogen or methyl and Z is a direct bond or is a divalent radial having 1 to about 20 carbon atoms.... | 02/21/1995 |
| 5107053 | Ruthenium phosphine complex A ruthenium phosphine complex having catalytic, hydrogenation activity is disclosed. The catalyst as the formula ##STR1## wherein R and R' are the same or different and are C1 to C6 linear or branched alkyl; R" is hydrogen or C | 04/21/1992 |
| 5087728 | Process for producing carboxylic acids and esters thereof A process for producing a carboxylic acid or an ester thereof represented by formula (I): ##STR1## wherein: R represents a hydrogen atom or a lower alkyl group; R1 represents a lower alkyl group; CH2 COOR3, wherein R | 02/11/1992 |
| 5013854 | Process for preparing acid halides An improved process for preparing trialkylsilyl ester and acid halide derivatives of carboxylic acids is provided along with novel trialkylsilyl ester intermediates of 2-(2-furyl)-2-methoximinoacetic acid.... | 05/07/1991 |
| 4965394 | Difunctional polyfluoroaromatic derivatives and a process of preparing the same The difunctional polyfluoroaromatic compounds represented by the formula ##STR1## wherein X and Y are identical and are selected from the class consisting of --COOR1, --CH2 NH2, --CH2 NCO and ##STR2## ... | 10/23/1990 |
| 4959488 | Polyfunctional hexasubstituted benzene derivatives Polyfunctional hexasubstituted benzene derivatives wherein at least three of the substituents are saturated carbon chains having from 1 to 21 carbon atoms and functional groups containing hetero functionalities at the ends of the carbon chains and the rem... | 09/25/1990 |
| 4808747 | Process for producing alkylidene compounds and arylidene compounds Alkylidene compounds and arylidene compounds are prepared by reacting the corresponding CH-acidic compounds with carbonyl compounds in the presence of a catalyst comprising a metal compound of a metal of Groups IIA, IIIA, IVA, IB, IIB, VIB, VIIB, or VIIIB... | 02/28/1989 |
| 4736044 | Boron compounds to inhibit formation of tar during the "ene" reaction of an ethylenically unsaturated alpha, beta dicarboxylic acid compound and an ethylenically unsaturated hydrocarbon A process for the production of a substituted alpha, beta dicarboxylic acid compound substantially free of tar and other resinous reaction byproducts comprising the reaction at conditions favoring the ENE reaction of an ethylenically unsaturated hydrocarb... | 04/05/1988 |
| 4699995 | Arachidonic acid analogues, processes for their preparation and their use in medicine A compound of formula (I): ##STR1## or a salt thereof, in which Y is a group--O(CH2)m CH | 10/13/1987 |
| 4691047 | Preparation of carboxylic di-esters or acids A process for the carbonylation of a conjugated diene with CO and an alcohol or water in the presence of an aprotic solvent is carried out in the presence of a dissolved catalytic system prepared by combining a Pd(II) compound, at least 5 mol of a triaryl... | 09/01/1987 |
| 4689344 | Long-chain ,ω-dicarboxylic acids and derivatives thereof and pharmaceutical compositions containing them A novel class of compounds has been found to be effective in blocking cholesterol and neutral lipid synthesis in-vivo without adversely affecting energy metabolism, useful for the treatment of obesity, hyperlipidemia and maturity-onset diabetes. The activ... | 08/25/1987 |
| 4645842 | Pyrrole compounds for detecting the presence of hydrolytic analytes A novel compound useful in detecting leukocytes, esterase and protease in a test sample. The compound has the structure ##STR1## in which: A is an acid residue, R is lower alkyl, aryl, carboxyl, carboxyl ester, amido or cyano, R* is H or lower alkyl,... | 02/24/1987 |
