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| Number | Title | Issue Date |
| 7427691 | Resolution of p-hydroxyphenyl-2-alkoxypropionic acids The present invention is aimed at a process for the preparation of enantiomerically enriched compounds of general formula (I). These are obtained by classical resolution of the corresponding acid using a chiral amino base in organic solvents. | 09/23/2008 |
| 7402713 | Processes for conversion of tyrosine to p-hydroxystyrene and p-acetoxystyrene Tyrosine was converted to p-hydroxystyrene in a two-step reaction without purification of individual intermediates. Conditions were determined for bromination of tyrosine in which reactive intermediates were formed. The mixture of these intermediates was used direct... | 07/22/2008 |
| 7301050 | 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR delta modulators to treat or inhibit the progression of, for example, dyslipidemia. ... | 11/27/2007 |
| 7137289 | High throughput screening methods for lubricating oil compositions Method for determining dispersancy performance for a plurality of fluid samples of different compositions is provided. Each sample includes one or more base oils of lubricating viscosity and one or more lubricating oil additives and a predetermined amount of an oil-... | 11/21/2006 |
| 6930197 | Antihistaminic piperidine derivatives and intermediates for the preparation thereof This invention relates to a process for the preparation of compounds of the formula: wherein R1 is C1-C6alkyl and the C1-C6alkyl moiety is straight or branched. | 08/16/2005 |
| 6849762 | Process for preparing a trifluoroethoxy-substituted benzoic acid The invention relates to a method for the production of trifluoroethoxy-substituted benzoic acids, by reaction of a corresponding halogenated benzoic acid with trifluoroethanol in the solvent tetrahydrofuran, in the presence of a base and a copper salt, followed by ... | 02/01/2005 |
| 6680345 | Salicylic acid salts of salmeterol The present invention relates to new substituted salicylic acid salts of salmeterol, processes for preparing them and their use... | 01/20/2004 |
| 6437179 | Process for the preparation of fluorogenic phenolic compounds A method is disclosed for preparing a fluorogenic phenolic compound with improved optical qualities for use in formulating a substrate solution for assay of peroxidase or peroxide activity. The method involves forming a solution under anoxic conditions wh... | 08/20/2002 |
| 6417178 | Amyloid binding nitrogen-linked compounds for the antemortem diagnosis of alzheimer's disease, in vivo imaging and prevention of amyloid deposits Amyloid binding compounds which are derivatives of Chrysamine G, pharmaceutical compositions containing, and methods using such compounds to identify Alzheimer's brain in vivo and to diagnose other pathological conditions characterized by amyloidosis, suc... | 07/09/2002 |
| 6168776 | Alkyl, alkenyl and alkynyl Chrysamine G derivatives for the antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition Amyloid binding compounds which are non-azo derivatives of Chrysamine G, pharmaceutical compositions containing, and methods using such compounds to identify Alzheimer's brain in vivo and to diagnose other pathological conditions characterized by amyloido... | 01/02/2001 |
| 6136852 | 3,4-disubstituted phenylethanolaminotetralincarboxylic acid derivatives The present invention relates to 3,4-disubstituted phenylethanolaminotetralincarboxylic acid derivatives represented by the general formula: ##STR1## [wherein Q represents a vinylene group or a group represented by the general formula: -A-(CH | 10/24/2000 |
| 5965766 | Process for synthesizing benzoic acids Nucleophilic substitution reactions on halobenzenes or triflyl substituted benzenes are carried out in the presence of catalysts. In particular the present invention provides a process leading to optionally substituted hydroxybenzoic, alkanoyloxybenzoic, ... | 10/12/1999 |
| 5925487 | Composition, compound and use A toner resin composition comprising a toner resin and the metal salt or complex of a carbocyclic hydroxy caboxylic acid containing at least one methylene group optionally substituted by hydroxy or amino such as 4-(N-methyl-N-2-hydroxyethyl)aminomethyl-3-... | 07/20/1999 |
| 5827805 | Condensates of alkyl phenols and glyoxal and products derived therefrom Compositions represented by the structures ##STR1## where Ar represents an aromatic group, each R is independently a hydrocarbyl group, at least one R having more than 12 carbon atoms, a is 1 to 4, and R' is hydrogen or alkyl, are useful as lubricant... | 10/27/1998 |
| 5795914 | Phenylalkan(en)oic acid The phenylalkan(en)oic acids of the formula: ##STR1## wherein the substituents are defined in the specification.... | 08/18/1998 |
| 5599959 | Analogues of acetylsalicylic acid and novel uses thereof The present invention provides a salicylate analogue having the structure ##STR1## wherein R is selected from the group consisting of hydrogen, methyl, ethyl, n-propyl, i-propyl, n-butyl, i-butyl; pentyl, hexyl, heptyl, octyl, nonyl, decyl, undecyl, ... | 02/04/1997 |
| 5498795 | Acetylenes disubstituted with hydroxyaryl and aryl or heteroaryl groups having retinoid-like biological activity Compounds of the formula ##STR1## wherein R1 -R3 and R5 independently are hydrogen, lower alkyl of 1 to 6 carbons, branched chain alkyl or cycloalkyl of 3 to 15 carbons, lower alkyl substituted cycloalkyl of 3 to 15 c... | 03/12/1996 |
| 5457226 | Process for the manufacture of cinnamic acid derivatives A novel process for the manufacture of a cinnamic acid derivative of the formula ##STR1## wherein R1 signifies hydrogen or C1-8 -alkyl and R2 signifies hydrogen, C1-10 -alkyl, C1-10 -hydroxyalkyl... | 10/10/1995 |
| 5430183 | Para-hydroxyalkylation of hydroxylated aromatic compounds Hydroxylated aromatic compounds devoid of substituents in the para-position to the hydroxyl group thereof are para-hydroxyalkylated, e.g., into optionally substituted p-hydroxymandelic acid compounds, more particularly p-hydroxymandelic acid and 3-methoxy... | 07/04/1995 |
| 5414108 | Process for the preparation of carboxylic acids and derivatives of them The subject matter of the invention is a process for the preparation of carboxylic acids and derivatives of them of the general formula ##STR1## wherein R means hydrogen, or a C1-4 alkyl or a (C1-5 alkoxy)carbonyl group, R1... | 05/09/1995 |
| 5395964 | Preparation process for hydroxyphenylacetic acids Preparation process for a hydroxyphenylacetic acid of formula (I): ##STR1## where R.dbd.H, alkyl or alkoxyl as well as its salts, in which the corresponding free or salified hydroxymandelic acid of formula (II): ##STR2## in which R has the meani... | 03/07/1995 |
| 5306833 | Preparation process for arylacetic acids and their alkali metal salts Process for obtaining an arylacetic acid of general formula (I): Ar--CHR--COOH (I) in which R=H, C1 -C4 alk, Ar=2-thienyl, 3-thienyl, 1-naphthyl, 2-naphthyl, 1-(2-methoxy naphthyl), 3,4-methylenedio... | 04/26/1994 |
| 5288902 | Method of manufacturing ferulic acid A waste oil, an alkaline oil cake, and a crude fatty acid which are discarded as waste materials or obtained as a by-product in the manufacture of rice salad oil are subjected to hydrolysis in the presence of an alkali so as to efficiently manufacture fer... | 02/22/1994 |
| 5283352 | Pharmacologically active compounds, methods for the preparation thereof and compositions containing the same Catechol compounds of formula I ##STR1## where R1, R2, R3 and X are as described herein are effective Catechol-O-methyltransferase inhibitors.... | 02/01/1994 |
| 5248814 | Process for producing regenerated humic acids from coal Process for preparing regenerated humic acids from coal by means of the continuous oxidation on fluidized bed, characterized in that a coal of lignite, sub-bituminous or bituminous type is submitted to a preliminary oxidation under mild conditions in orde... | 09/28/1993 |
| 5221772 | Preparation of 2-hydroxyphenyl-acetic acid A process for the preparation of: ##STR1## the process comprising treating (2-chlorophenyl)acetic acid with an alkali metal hydroxide (for example, sodium hydroxide) in an organic solvent (for example, an inert hydrocarbon solvent), in the presence o... | 06/22/1993 |
| 5216024 | Cell growth inhibitors and methods of treating cancer and cell proliferative diseases The present invention discloses new and useful compounds including methyl p-hydroxyphenyllactate, its analogues, chemical derivatives and chemically related compounds and their use as antitumor agents, as inhibitors of proliferative cell growth and as pro... | 06/01/1993 |
| 5149866 | Process for the preparation of omega-arylalkanoic acids The present inventon pertains to a process for the preparation of omega-arylalkanoic acids of the genral formula R--Ar--R1 --COOH wherein R is hydrogen, hydroxy, C1 -C8 alkyl, C1 -C8 alkoxy, or aryl; where... | 09/22/1992 |
| 5145994 | 4-hydroxyphenyl acetic acid A process for the preparation of 4-hydroxyphenyl acetic acid of the formula I, an important raw material for the preparation of pharmaceutically active substances, from sodium-4-hydroxymandalate monohydrate comprising reducing the sodium-4-hydroxymandalat... | 09/08/1992 |
| 5124489 | Process for preparing phenethanol ethers by the reduction of corresponding phenylglyoxal acetals Substituted phenethanol ethers are prepared by the catalytic reduction of corresponding substituted phenylglyoxal acetals. The catalytic reduction is carried out by reacting a substituted phenylglyoxal acetal with hydrogen in the presence of an acid catal... | 06/23/1992 |
| 5008449 | Method of synthesis of hydroxy-substituted-4-alkoxyphenylacetic acids A process for preparing hydroxy-substituted-4-alkoxyphenylacetic acids by reacting a 4-alkoxyphenylacetic acid with bromine and then treating the brominated acid with a strong base and a copper salt to form the desired hydroxy-substituted-4-alkoxyphenylac... | 04/16/1991 |
| 4970336 | Method of purifying -substituted acetic acids This invention relates to methods of preparing and purifying -substituted acetic acids, which comprise treating an 댚romatic-substituted acetic acid represented by a specific general formula with a weak alkali while shielding light, or subjec... | 11/13/1990 |
| 4962230 | Process for producing optically active carboxylic acid A process for producing an optically active carboxylic acid represented by formula (I): ##STR1## wherein R1, and R2, and R3 each represents a hydrogen atom, an alkyl group, an alkenyl group, or a phenyl or naphthyl gr... | 10/09/1990 |
| 4933367 | Carboxylic acid derivatives, processes for the preparation thereof, the use thereof, and pharmaceutical compositions which contain these compounds This invention relates to carboxylic acid derivatives and their use thereof. The compounds are useful in treatment of various diseases such as diabetes, prediabetic conditions, adipositas ailments or atherosclerosis.... | 06/12/1990 |
| 4912256 | Process for the oxidation of fine coal This invention relates to the production of a solid oxidized coal containing humic acids. Coal with a mean particle size of less than 3 mm is slurried with water and then oxidized with oxygen or mixtures of oxygen and air at temperatures ranging from 100Â... | 03/27/1990 |
| 4906662 | Phenol derivatives, their preparation and the use thereof Disclosed are phenol derivatives of the formula ##STR1## wherein R1 is a substituted phenyl group, R2 and R3 are C1 -C6 alkyl group and of the formula ##STR2## wherein R8, R9... | 03/06/1990 |
| 4904815 | Phenols and their production New phenols are described containing an alkyl substituent containing a functional group; as well as a process for the production of such phenols. The new phenols are useful e.g. as stabilizers in organic or aqueous systems.... | 02/27/1990 |
| 4897420 | Benzoquinone derivatives, their production and use Compounds of the formula: ##STR1## wherein l is an integer of 0 to 18, X is hydrogen, an alkyl having 1 to 4 carbon atoms or a carboxylic acyl having 2 to 4 carbon atoms and Y is a phenylene, a cycloalkylene having 3 to 7 carbon atoms or a group of t... | 01/30/1990 |
| 4888132 | Aqueous rust inhibitor composition An aqueous rust inhibitor containing a soap of a hydroxyaryl fatty acid and an alkali metal. The inhibitor exhibits good rust inhibiting effects without emitting any malodor.... | 12/19/1989 |
| 4883613 | Phenyl substituted-2,4,6,8-nonatetraenoic acid The compounds 9-phenyl-3,7-dimethyl-2,4,6,8 nonatetraenoic acids wherein the phenyl group is substituted with an alkyl, aminoalkyl, hydroxyalkyl, alkoxy, hydroxyalkylamino, and a hydroxy alkoxy group, and derivatives thereof which are used as disease modi... | 11/28/1989 |
