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| Number | Title | Issue Date |
| 8063242 | 2-aryl-propionic acids and pharmaceutical compositions containing them (R) and (S) 2-Aryl-propionic acids, and pharmaceutical compositions that contain them, are useful in inhibiting chemotactic activation of neutrophils (PMN leukocytes) induced by the interaction of Interleukin-8 (IL-8) with CXCR1 and CXCR2 membrane receptors. The aci... | 11/22/2011 |
| 7875743 | Bis(formylphenyl)alkane and novel polynuclear phenol derived from the same Manufacture a novel bis(formylphenyl)alkane according to General Formula (1), as well as a novel polynuclear phenol derived therefrom, by causing a bis(hydroxymethyl-hydroxyphenyl)alkane to react with hexamethylene tetramine in the presence of an acid and hydrolyzin... | 01/25/2011 |
| 7153394 | System to isolate dianhydrides A process to isolate dianhydride from an exchange reaction comprises extracting a bisimide/anhydride exchange reaction aqueous phase with an organic solution comprising an exchange catalyst at a first temperature and pressure to form an extracted aqueous phase compr... | 12/26/2006 |
| 7141573 | Polypharmacophoric agents One aspect of the present invention relates to polypharmacophoric compounds. In certain embodiments, the polyphamacophore compounds comprise individual pharmacophore units selected from the group consisting of D-1 agonists, D-2 agonists, D-3 agonists, D-4 agonists, ... | 11/28/2006 |
| 7129268 | Peroxisome proliferator activated receptor-active arylene acetic acid derivatives Novel compounds of the general formula (I), wherein Ar, R1, R2, X1, X2, Y1, Y, and Z are as defined in the specification, the use of these compounds as pharm... | 10/31/2006 |
| 7094550 | Method to determine TGF-beta A method for treating or preventing cardiovascular pathologies by administering a compound of the formula (I): wherein Z is C═O or a covalent bond; Y is H or O(C1–C4)alkyl, R1 | 08/22/2006 |
| 7084171 | Compounds and therapies for the prevention of vascular and non-vascular pathologies The invention provides a method of treating a mammal having, or at risk of, an indication associated with a TGF-beta deficiency comprising administering one or more agents that is effective to elevate the level of TGF-beta. The invention also provides novel compound... | 08/01/2006 |
| 6972294 | Compounds, their preparation and use Disclosed are novel compounds of formula (I) wherein A1, A2, Ar, R5, R6, R8, M, Q, Y, Z, k, m and n are as defined in the specification. These compounds are useful ... | 12/06/2005 |
| 6943196 | NF-κB inhibitor comprising phenylmethyl benzoquinone as the active ingredient An NF-κB inhibitor having as an active ingredient a benzoquinone derivative represented by the general formula (1) wherein R1, R2, and R3 are each independently H, alkyl having 1 to 5 carbons, or alkoxy having 1 to 5 carbons; R... | 09/13/2005 |
| 6930197 | Antihistaminic piperidine derivatives and intermediates for the preparation thereof This invention relates to a process for the preparation of compounds of the formula: wherein R1 is C1-C6alkyl and the C1-C6alkyl moiety is straight or branched. | 08/16/2005 |
| 6924390 | Surface coating agents Compounds useful as surface coating agents, including compounds of the formula: wherein X1 comprises a first photoreactive species; X2 comprises a second photoreactive species; Y comprises a nonpo... | 08/02/2005 |
| 6802874 | Linear compounds containing phenol and salicylic acid units The invention disclosed herein relates to linear compounds in the form of oligomers or polymers containing unsubstituted or substituted phenol units and unsubstituted or substituted salicylic acid units. These compounds are useful as additives for lubricants and fue... | 10/12/2004 |
| 6803480 | Diphenylmethane derivatives The invention relates to novel diphenylmethane derivatives, processes for their preparation and their use in medicaments, in particular for the indications of arteriosclerosis and hypercholesterolaemia. ... | 10/12/2004 |
| 6777576 | Production method of 2-cyclohexyl-2-hydroxy-2-phenylacetic acid intermediate therefor and production method thereof The present invention relates to production of 2-cyclohexyl-2-hydroxy-2-phenylacetic acid useful as an intermediate for pharmaceutical products, by an industrial means, economically, safely in a good yield. Novel 2-(2′-cyclohexen-1′-yl)-2-hydroxy-2-phenylacetic ... | 08/17/2004 |
| 6747154 | Process for preparing scopine esters A process for preparing a compound of formula 1 from a compound of formula 2 the process comprising reacting in one step the compound of formula 2 with a compound of formula ... | 06/08/2004 |
| 6743784 | Estrogen mimetics lacking reproductive tract effects A method for treating symptoms, diseases and conditions in extra-reproductive tract tissues that are responsive to treatment with estrogen, using triarylethanes of formula (I) wherein R1 is —O(CH2... | 06/01/2004 |
| 6703421 | Methods of using phenylmethylbenzoquinone and hydroquinone compounds for treatment of myocarditis, dilated cardiomyopathy and heart failure A method for prevention or treating myocarditis, dilated cardiomyopathy and heart failure comprising administering to a patient in need of such treatment a NF-.kappa.B inhibitor in a therapeutically effective amount, wherein said NF-.kappa.B inhibitor is ... | 03/09/2004 |
| 6603040 | Surface coating agents Compounds useful as surface coating agents, including compounds of the formula: ##STR1## wherein X1 comprises a first photoreactive species; X2 comprises a second photoreactive species; Y comprises a nonpolymeric core molecule c... | 08/05/2003 |
| 6596038 | Linear compounds containing phenol and salicylic acid units The invention disclosed herein relates to linear compounds in the form of oligomers or polymers containing unsubstituted or substituted phenol units and unsubstituted or substituted salicylic acid units. These compounds are useful as additives for lubrica... | 07/22/2003 |
| 6566548 | Molecular compounds containing novel carboxylic acid derivatives as the constituent compound Novel molecular compounds containing carboxylic acid derivatives represented by general formula (I) or (II) as the constituent compound and exhibiting excellent performances in various technical fields including selective separation of useful substances, ... | 05/20/2003 |
| 6399549 | Condensates A cyclic compound comprising m units of the formula Ia. ##STR1## and n units of the formula (Ib) ##STR2## joined together to form a ring, wherein Y and y2 are divalent bridging groups which may be the same or different in each unit; Ro | 06/04/2002 |
| 6376684 | Stereoselective process for alkyl phenylglycolic acids A process for preparing an alkyl phenylglycolic acid is disclosed. It follows the sequence of condensing a substituted acetaldehyde with mandelic acid to provide a 5-phenyl-1,3-dioxolan-4-one, which is condensed with an alkyl ketone or aldehyde to provide... | 04/23/2002 |
| 6323190 | Estrogen mimetics lacking reproductive tract effects A method for treating symptoms, diseases and conditions in extra-reproductive tract tissues that are responsive to treatment with estrogen, using triarylethanes of formula (I) ##STR1## wherein R1 is --O(CH2)m R3... | 11/27/2001 |
| 6316665 | Process for producing diacids by carboxylation of phenolic compounds An oxidation free process for converting a hydroxy substituted aromatic to an aromatic diacid which comprises reacting a hydroxy substituted aromatic with excess basic salt in the presence of carbon dioxide at disproportionation/isomerization reaction con... | 11/13/2001 |
| 6307089 | Biphenyl butyric acids and their derivatives as inhibitors of matrix metalloproteinases Biphenyl butyric acid compounds and derivatives are described as well as acid methods for the preparation and pharmaceutical compositions of same, which are useful as inhibitors of matrix metalloproteinases, particularly gelatinase A (72 kD gelatinase) an... | 10/23/2001 |
| 6288265 | Phloroglucidic acid and derivatives as antibacterial agents A series of phloroglucide derivatives are synthesized, which possess potent antibacterial activities. They include unsymmetrical phloroglucide analogs, phloroglucides attached to cephalosporins at the C-3' position, and 7-(phloroglucidamido)cephalosporins... | 09/11/2001 |
| 6121255 | Phloroglucide derivatives and their pharmceutical use A phloroglucide derivative having the following formula: ##STR1## wherein Q is halogen; X is CH2 or C.dbd.O; Y is cephalosporin having a formula of ##STR2## wherein Ph is phenyl, Ac is acetoxy, or pharmaceutically acceptable salts ... | 09/19/2000 |
| 6090971 | Resolution process for cyclohexylphenyl glycolic acid A process for the preparation of optically active phenylcyclohexylglycolate esters is described. The process utilizes carboxylic acid activation to couple (R)-- or (S)-cyclohexylphenylglycolic acid (CHPGA) with 4-N,N-diethylamino butynol or other propargy... | 07/18/2000 |
| 6005125 | Universal allyl linker for solid-phase nucleic acid synthesis A universal linker for solid-phase nucleic acid synthesis that is cleaved under conditions orthogonal to those used during the synthesis and deprotection of nucleic acids such as dsDNA or RNA fragments is disclosed. The invention includes compounds of the... | 12/21/1999 |
| 6001877 | Phenylalkan(en)oic acid The phenylalkan(en)oic acids of the formula: ##STR1## as defined herein, posses an antagonistic activity on leukotriene B4.... | 12/14/1999 |
| 5969180 | Method for making bis-xylenols containing acid moieties An improved method for the preparation of functionalized substituted bisphenol compound is provided. In particular, there is provided a method of making a functionalized substituted bisphenol compound of the formula: ##STR1## which comprises heating ... | 10/19/1999 |
| 5955492 | Carboxylic acid indole inhibitors of chemokines This invention relates to novel carboxylic acid indole compounds and compositions for use in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).... | 09/21/1999 |
| 5795914 | Phenylalkan(en)oic acid The phenylalkan(en)oic acids of the formula: ##STR1## wherein the substituents are defined in the specification.... | 08/18/1998 |
| 5620949 | Condensation products of alkylphenols and aldehydes, and derivatives thereof The reaction product of a hydroxyaromatic compound, at least some of the units of which are hydrocarbyl-substituted, a carboxy-substituted aldehyde, and an aldehyde other than a carboxy-substituted aldehyde, provides an additive for lubricants as well as ... | 04/15/1997 |
| 5612479 | Polyphenols containing mesogenic moieties as lateral substituents Novel polycyanate compositions containing one or more mesogenic moieties as lateral substituents are disclosed which provide improved processability relative to polycyanates containing one or more mesogenic moieties in the main chain of the molecule. Mole... | 03/18/1997 |
| 5530157 | Anti-inflammatory benzoic acid derivatives Novel benzoic acid derivatives have the formula: ##STR1## wherein --X-- represents C1 to C6 alkylene, C2 to C6 alkenylene or a divalent moiety having the structure --(CH2)m --Z-- in wh... | 06/25/1996 |
| 5527827 | Bisarylcarbinol cinnamic acids as inhibitors of leukotriene biosynthesis Compounds having the Formula I: R1 R2 C(OR3)--Ar1 --X--Ar2 --C(Ar3).dbd.CHCO2 H I are inhibitors of leukotriene biosynthesis. These compounds are useful as ... | 06/18/1996 |
| 5512595 | Substituted phenoxyisobutyric acids and esters New substituted phenoxyisobutyric acids and esters that can be used as medicaments and correspond to the formula: ##STR1## wherein X, A, R, R1, R2, R3, R4, R5, R6, R7 and Z ... | 04/30/1996 |
| 5502152 | Carboxyl group-containing polyoxyalkylene derivative Disclosed is a polyoxyalkylene derivative which is useful for a carboxyl group-containing polyurethane resin, can easily introduce a carboxyl group into a polyurethane resin skeleton, and has a low melting point or is in a liquid state at normal temperatu... | 03/26/1996 |
| 5434292 | Phenylalkanoic acid derivatives, process for producing the same and process for separating optical isomers thereof A novel phenylalkanoic acid derivative represented by the following formula ##STR1## wherein n is an integer of 1-2, X is a halogen atom, alkoxyl group or nitro group, R is a hydrogen atom or alkyl group, and Z is a hydrogen atom or acyl group, a met... | 07/18/1995 |
