Class 562/456 - Halogen

Subclass of Class 562 - Organic compounds -- part of the class 532-570 series
Definition: Compounds wherein the acid contains covalently bonded halogen.
No. of patents: 232
Last issue date: 03/15/2011

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Number	Title	Issue Date
7906677	Process for phenylacetic acid derivatives A process for the production of a compound of Formula I, or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable prodrug ester thereof, comprising cleaving a lactam of formula II ...	03/15/2011
7884234	N-phenyloxamide derivatives A compound represented by the following general formula (I) or a salt thereof, or a hydrate thereof or a solvate thereof having an inhibitory action against plasminogen activator inhibitor-1 (PAI-1): wherein R1 r...	02/08/2011
7642373	Radical trap in fluoridation of iodonium salt Decomposition of iodonium salts by a free radical process has been identified as a significant factor in the observed yield variability of fluoridation reactions using said iodonium salts. Accordingly, the inclusion of a free radical trap in the reaction mixture blo...	01/05/2010
7495126	Process of preparation of substituted tetrafluorobenzylaniline compound and its pharmaceutically approved salts This invention relates to a method for preparing tetrafluorobenzyl-5-aminosalicylic acid derivative and its pharmaceutically acceptable salt compounds. In particular, this invention relates to a method for preparing tetrafluorobenzyl-5-aminosalicylic acid derivative...	02/24/2009
7408078	Anthranilic acid derivatives useful in treating infection with hepatitis C virus The present invention provides pharmaceutical compositions useful in treating hepatitis C infection. The present invention also provides methods of treating hepatitis C infection by administering to a mammal the pharmaceutical compositions of the present invention.	08/05/2008
7378546	Method for producing 2-amino-5-iodobenzoic acid A method for producing 2-amino-5-iodobenzoic acid which comprises bringing 2-aminobenzoic acid (A) and molecular iodine (B) into reaction with each other in the liquid phase in the presence of an oxidizing agent. Hydrogen peroxide is preferable as the oxidizing agen...	05/27/2008
7371867	Non-racemic trifluoroleucine, and methods of making and using One aspect of the invention relates to hexafluoroleucine and congeners thereof, and methods of making the compounds. Another aspect of the invention relates to the synthesis of protein cores comprising hexafluoroleucine and congeners thereof. Certain peptides compri...	05/13/2008
7321044	Synthesis of oxygen-substituted benzocycloheptenes as valuable intermediate products for the production of tissue-selective estrogens The invention relates to intermediate products and a new process for the production of benzocycloheptene C. The process for the production of its new intermediate products according to the invention starts from eco...	01/22/2008
7202364	Certain phenylacetic acids and derivatives Compounds of formula (I) wherein R is hydrogen, lower alkyl, (C3–C6)cycloalkyl, hydroxy, halo, lower alkoxy, trifluoromethoxy, trifluoromethyl or cyano; ...	04/10/2007
7132559	Non-racemic hexafluoroleucine, and methods of making and using it One aspect of the invention relates to hexafluoroleucine and congeners thereof, and methods of making the compounds. Another aspect of the nvention relates to the synthesis of protein cores comprising hexafluoroleucine and congeners thereof. Certain peptides compris...	11/07/2006
7115662	Certain 5-alkyl-2-arylaminophenylacetic acids and derivatives Disclosed are the compounds of formula I wherein R is methyl or ethyl; R1 is chloro or fluoro; R2 is hydrogen or fluoro; R3 is hydrogen, fluoro, chloro, methyl, ethyl, methoxy, et...	10/03/2006
7087778	Process for producing benzoxazine derivative and production intermediate thereof Processes for producing antibacterial agents and intermediates useful in producing antibacterial agents are provided and include producing compound (VI-a) in accordance with the following reaction schema, as well as production intermediates thereof	08/08/2006
7019033	2-(4-bromo or 4-iodo phenylamino) benzoic acid derivatives Phenylamino benzoic acid, benzamides, and benzyl alcohol derivatives of the formula where R1, R2, R3, R4, R5, and R6 are hydrog...	03/28/2006
7015349	Reduction of hair growth Compositions including a conjugate of α-difluoromethylornithine can be applied topically to reduce hair growth. ...	03/21/2006
7001905	Substituted diarylamines as MEK inhibitors Diarylamines, such as 5-amide substituted diarylamines of formula (I) or formula (II) wherein A is hydroxy, C1-6 alkoxy, or NR6OR7; X is OR12, NR13R12, or NR14; inhibitors of MEK and are us...	02/21/2006
6974595	Pharmaceutical compositions based on Diclofenae New pharmaceutical compositions for oral use containing Diclofenac together with alkali metal bicarbonates in amounts of from 20 to 80 by weight with respect to Diclofenac are described. These compositions are entirely palatable and free from any unpleasant taste or...	12/13/2005
6900244	Anilino liver X-receptor modulators The present invention is directed to selective LXR modulators, small molecule compounds corresponding to Formula I and is further directed to a process of treating a condition in a mammal that is modulated by LXR using a therapeutically effective dose of a compound ...	05/31/2005
6831102	Phenyl naphthol ligands for thyroid hormone receptor New thyroid receptor ligands are provided which have the general formula I: wherein R1 is halogen, trifluoromethyl, substituted or unsubstituted aryl, substituted or...	12/14/2004
6727281	Certain 5-alkyl-2-arylaminophenylacetic acids and derivatives Disclosed are the compounds of formula I wherein R is methyl or ethyl; R1 is chloro or fluoro; R2 is hydrogen or fluoro; R3 is hydrogen, fluoro, chloro, methyl, ethyl, methoxy, ethoxy or ...	04/27/2004
6727250	Carboxylic acid amides, pharmaceutical compositions containing these compounds, their use and preparation Carboxylic acid amides of general formula which inhibit telomerase and are useful for treating tumor diseases such as carcinomas, sarcomas and leukaemias. Exemplary compounds are: (1) trans-3-(naphth-2-yl)-but-2-e...	04/27/2004
6686499	Method for making 2-(N-phenylamino)benzoic acids The present invention relates to a method for making 2-N-phenylamino)benzoic acids by coupling a benzoic acid and an aniline using an alkaline metal hexamethyldisilazide as a base....	02/03/2004
6677479	Substituted fluoroaromatics, process for preparing them and their use Compounds of the formula (I) and also process for preparing them ##STR1## where substituents X1, X2, Y and Z are defined as follows: X1 is H or F X2 is H or F Y is CI, Br, or I Z is CHO or COOH or CN n...	01/13/2004
6573252	Medicine nitrate salts The present invention relates to nitrate salts of compounds having therapeutic activity in bony disorders, such compounds being characterized in that they contain at least a reactive group capable of being salified with nitric acid....	06/03/2003
6521794	Method for production of aromatic compounds For the production of an aromatic compound by hydrolyzing and decarboxylating a corresponding aromatic cyano compound in the presence of an acidic substance, this invention provides a method for the production of the aromaic compound, characterized by car...	02/18/2003
6504052	Excitatory amino acid receptor modulators Compounds of the formula (I) in which R1 is C1-10 allyl; C2-10 alkenyl; C2-10 alkynyl; phenyl-C2-10 alkyl or phenyl-C2-10 alkenyl; and salts and esters thereof, modulate metabotropic glutam...	01/07/2003
6451858	Certain 5-alkyl-2-arylaminophenylacetic acids and derivatives Disclosed are the compounds of formula I ##STR1## wherein R is methyl or ethyl; R1 is chloro or fluoro; R2 is hydrogen or fluoro; R3 is hydrogen, fluoro, chloro, methyl, ethyl, methoxy, ethoxy or hydroxy; R4 is ...	09/17/2002
6380256	Compounds having activity as inhibitors of cytochrome P450RAI Compounds having Formula 4 wherein the symbols have the meaning defined in the specification are inhibitors of the cytochrome P450RAI (retinoic acid inducible) enzyme, and are used for treating diseases responsive to treatment by retinoids. ##STR1##...	04/30/2002
6369270	Benzoic acid intermediates to 4-benzoylisoxazole herbicides Compound of the formula ##STR1## are useful as intermediates to new 4-benzoylisoxazoles....	04/09/2002
6310099	Certain 5-alkyl-2-arylaminophenylacetic acids and derivatives Disclosed are the compounds of formula I ##STR1## wherein R is methyl or ethyl; R1 is chloro or fluoro; R2 is hydrogen or fluoro; R3 is hydrogen, fluoro, chloro, methyl, ethyl, methoxy, ethoxy or hydroxy; R4 is ...	10/30/2001
6274762	Preparation of tri-iodo benzene compounds The invention provides an improved process for the preparation of a compound containing a 2,4,6-triiodinated benzene ring, said process comprising reacting a 2,4,6-unsubstituted 5-amino-benzoic acid or derivative there of with an iodine halide iodinating ...	08/14/2001
6258982	Process for the preparation of substituted aromatic amino compounds The present invention relates to a hydrogenation process for the preparation of aromatic amino compounds containing directly on the aryl ring or in a side chain one or more entities that may also undergo hydrogenation, such as carbon multiple bonds, nitri...	07/10/2001
6172058	Compounds with pharmaceutical properties A pharmaceutical compound of the formula ##STR1## in which R1 is C1-10 alkyl, C2-10 alkenyl, C2-10 alkynyl, C3-10 cycloalkyl, C3-10 cycloalkyl-C1-10 alkyl, C3-10 cyclo...	01/09/2001
6168913	Coding combinatorial libraries with fluorine tags The present invention relates to coding combinatorial chemical libraries synthesized on a plurality of solid supports by attaching "tags" that comprise fluorine containing compounds in combinations and/or ratios. The tags can be decoded while attached to ...	01/02/2001
6137003	Bis (haloethyl) aminobenzene derivatives The present invention relates to bis(haloethyl)aminobenzene derivatives featured by having carboxyl-containing moiety and one other moiety at the ortho position with respect to the bis(haloethyl)amino substituent of the benzene ring. The moiety at the ort...	10/24/2000
6127392	Anthranilic acid analogs Compounds of the formula: wherein: R1, R2, R3, R4,R5, R6, R7 and R8 are, independently, hydrogen, COOR15, halogen, nitro, cyano, C1-10 alkoxy, C1...	10/03/2000
6114386	Inhibitors of bacterial sialidase A sialidase inhibitor of the shown formula I: ##STR1## where dashed lines d1 and d2, X1, R1, R2, R6, R3, R4 and R5 are as described in the specificatio...	09/05/2000
6096921	O-amino(thio)phenolcarboxylic acids, and their preparation The invention relates to novel o-aminophenolcarboxylic acids, and o-aminothiophenolcarboxylic acids of the following structure: ##STR1## where A1 to A7 are--independently of one another--H, F, CH3, CF3, OCH...	08/01/2000
5945556	Process for preparing N-carboxymethylene-4-chloro-anthranilic acid and its dialkyl esters A process for preparing N-carboxymethylene-4-chloroanthranilic acid, and its dialkyl esters. The invention relates to a process for preparing N-carboxymethylene-4-chloroanthranilic acid and its dialkyl esters, which comprises reacting 2,4-dichlorobenzoic ...	08/31/1999
5916922	Phenyl glyoxamides as SPLA2 inhibitors A class of novel phenyl glyoxamides is disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of conditions such as septic shock....	06/29/1999
5905127	Polymerizable mesophases based on substituted unsaturated carboxylic acids Mesogens are provided based on substituted unsaturated carboxylic acids such as acrylic and methacrylic acid. Substitution of a variety of hydrophobic tails onto the carboxylic acid or acid derivative via the vinyl carbon proximal to the carbonyl of the c...	05/18/1999

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Class 562/456 - Halogen