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| Number | Title | Issue Date |
| 4279836 | Hydroxamic acid derivative and method of preparing metoclopramide using same 2-Chloro-4-N-(ଲ-diethylaminoethyl)aminocarbonyl-5-methoxybenzhydroxami c acid of the formula, ##STR1## or its metal salt, a process for their preparation and a process for preparing metoclopramide of the formula, ##STR2## using the abo... | 07/21/1981 |
| 4275229 | Polymers having improved water resistance and monomers for same Monoethylenically unsaturated beta-carbonyl-containing carboxyl functional monomers and addition polymers containing them and other monoethylenically unsaturated monomers are disclosed, as are methods of coating substrates with the polymers to provide fil... | 06/23/1981 |
| 4264515 | Process for manufacturing a N-acyl -amino acid A N-acyl -amino acid is manufactured by reacting an unsaturated vegetable oil or a C8 -C30 mono-olefinic compound with an amide, carbon monoxide and hydrogen, in the presence of a cobalt catalyst. The process is operated in on... | 04/28/1981 |
| 4254035 | Process for the production of 2-acetamidocinnamic acid 2-acetamidocinnamic acid and substituted 2-acetamidocinnamic acids are prepared by reacting glycine with an aromtic aldehyde in the presence of acetic anhydride and a tertiary amine and subsequently treating with water.... | 03/03/1981 |
| 4250183 | N-(Substituted amino)alkanoyl-aminoalkanoic acids and salts, their use and their compositions N-substituted ω-aminoalkanoyl-ω-aminoalkanoic acids and their pharmacologically-acceptable salts (with a base) are useful, e.g., in pharmaceutical-composition form for the treatment or prophylaxis of diseases which are based on inadequate performance of... | 02/10/1981 |
| 4250192 | Novel substituted phenylacetic acid amide compounds Phenylacetic acid amide compounds of the formula ##STR1## in which R1 is hydrogen, lower alkyl, lower alkoxy, halogen having an atomic number of not more than 35 or trifluoromethyl, R2 is hydrogen, lower alkyl, lower alkoxy, hal... | 02/10/1981 |
| 4242273 | 4-(Monoalkylamino)benzoic acid amides and imidates This disclosure describes 4-(monoalkylamino)benzoic acid amides and imidates useful as hypolipidemic and antiatherosclerotic agents.... | 12/30/1980 |
| 4235969 | Procainamide antigen conjugates and antibodies Compounds are provided for use in the preparation of reagents which can be used in immunoassays for the determination of benzamides of N,N-dialkylethyleneamines. A linking group is provided, at a particular site of the drug, which provides a link between ... | 11/25/1980 |
| 4228304 | Novel cyclohexanecarboxylic acid and its derivatives The present invention relates to novel cyclohexanecarboxylic acid and its derivatives represented by the general formula: ##STR1## (wherein R1 is selected from the group consisting of hydrogen or methyl; R2 is selected from the ... | 10/14/1980 |
| 4228184 | Carboxyalkylacylamino acids New carboxyalkylacylamino acids which have the general formula ##STR1## are useful as angiotensin converting enzyme inhibitors.... | 10/14/1980 |
| 4220590 | Asymmetric catalysis New optically active bis phosphine compounds which are usful in optically active catalysts. Such catalysts are particularly useful in catalytic asymmetric hydrogenation.... | 09/02/1980 |
| 4194050 | Process for producing an enamide Enamides are prepared by hydrogenating oximes having at least one hydrogen atom at the -position in the presence of a carboxylic anhydride using a ruthenium catalyst. These enamides are important to obtain amino group-containing compounds by reduct... | 03/18/1980 |
| 4182891 | -Acetylenic derivatives of -amino acids Novel acetylenic derivatives of -amino acids of the following general structure: ##STR1## wherein Z is ଲ-methylthioethyl, ଲ-benzylthioethyl, S-(5'-desoxyadenosin-5' -yl)-S-methylthioethyl, γ-guanidinopropyl, or RHN(CH2 | 01/08/1980 |
| 4182904 | Method of racemizing optically active N-acyl amino acids in aqueous solution A process has been invented for the racemization of optically active N-acylamino acids in aqueous solution which comprises treating said optically active N-acylamino acids with ketene.... | 01/08/1980 |
| 4182899 | Optical resolution of amino acids into optical antipodes The present application relates to the optical resolution into optical antipodes of compounds of the formula ##STR1## as well as to salts consisting of an optical isomer of a compound of the above formula and an optical isomer of 2-aminobutanol. The ... | 01/08/1980 |
| 4177109 | γ-glutamyl-p-aminoanilide derivatives for measuring activity of γ-glutamyl transpeptidase A γ-glutamyl-p-aminoanilide derivative of the formula: ##STR1## wherein R1 and R2 are independently lower alkyl; and R3 is hydrogen, lower alkyl, carboxyl or sulfo, can be produced by reacting a N-phthalyl-γ-glutamy... | 12/04/1979 |
| 4154756 | 2-Substituted-4'-(monoalkylamino)-acetophenones This disclosure describes 2-substituted 4'-(monoalkylamino)-acetophenones useful as hypolipidemic and anti-atherosclerotic agents.... | 05/15/1979 |
| 4147873 | -Vinyl derivatives of -amino acids Novel vinyl derivatives of -amino acids of the following general structure: ##STR1## wherein R is hydrogen, alkylcarbonyl wherein the alkyl moiety has from 1 to 4 carbon atoms and is straight or branched, alkoxycarbonyl wherein the alkoxy... | 04/03/1979 |
| 4124533 | Metal coordination complexes containing optically active phosphine or arsine ligands Process for the homogeneous catalytic hydrogenation of ଲ-substituted--acylamido-acrylic acids which yields, after hydrogenation, an optically active mixture. The process comprises the hydrogenation of ଲ-substituted--acylamido-acr... | 11/07/1978 |
| 4123611 | N-protected amino compounds 6-Aminoacylamidopenicillanic acid or 7-amino-acylamidocephalosporanic acids are produced in high yields by acylating 6-aminopenicillanic acid or 7-aminocephalosporanic acid with an amino acid, or a functional equivalent thereof, having its amino group pro... | 10/31/1978 |
| 4120870 | Metal phosphine complex Group IB and IIB metal phosphine complexes are disclosed. These complexes are reacted with rhodium complex precursors to form useful enantioselective hydrogenation catalysts. Also disclosed is a method of preparing useful compounds having optical activity... | 10/17/1978 |
| 4113943 | 7ଲ-[(2-Amino-1,2-dioxoethyl)amino]acyl cephalosporins 7ଲ-[(2-Amino-1,2-dioxoethyl)amino]acyl cephalosporins of the formula ##STR1## wherein R is hydrogen, lower alkyl, phenyl-lower alkyl, diphenyl-lower alkyl, tri(lower alkyl)silyl, trihaloethyl or a salt forming ion; R1 is hydrogen, lo... | 09/12/1978 |
| 4111925 | Hydrolysis of esters of -L-aspartyl-L-phenylalanine A process which comprises contacting alkyl esters of -L-aspartyl-L-phenylalanine with an aqueous solution containing barium ions, at a reaction pH greater than 7, to form -L-aspartyl-L-phenylalanine.... | 09/05/1978 |
| 4105789 | Carboxyalkylacylamino acids New carboxyalkylacylamino acids which have the general formula ##STR1## are useful as angiotensin converting enzyme inhibitors.... | 08/08/1978 |
| 4088657 | Process for manufacturing N-acyl derivatives of glycines -substituted by radicals of aromatic nature and novel products thereof This is an improved process of manufacturing N-acyl derivatives of glycines -substituted by radicals with an aromatic nature by condensation of the addition product of glyoxylic acid and an amide, with an aromatic compound. In a first stage, the re... | 05/09/1978 |
| 4025551 | 3-Amino-N-substituted succinamic acids 3-Amino-N-substituted succinamic acids, prepared by coupling of a protected L-aspartic acid derivative with the appropriate amine followed by cleavage of the protecting groups, are potent sweetening agents and also exhibit pharmacological, e.g. anti-infla... | 05/24/1977 |
| 4011260 | 3-Amino-N-substituted succinamic acids and intermediates thereto The above-captioned compounds, prepared by coupling of a protected L-aspartic acid derivative with the appropriate amine followed by cleavage of the protecting groups, are potent sweetening agents and exhibit also pharmacological, e.g. anti-inflammatory, ... | 03/08/1977 |
| 4008281 | Asymmetric catalysis New optically active bis phosphine compounds which are useful in optically active catalysts. Such catalysts are particularly useful in catalytic asymmetric hydrogenation.... | 02/15/1977 |
| 4002671 | Substituted alkyl, aryl, aralkyl thio alkanamine addition salts Organic amine-organic acid addition salts are employed in compositions for topical application to a human being having a scalp or skin characterized by an excessive secretion of sebum to improve the condition of the scalp or skin by reducing said excessiv... | 01/11/1977 |
| 3996288 | Method of producing aldehydes by hydroformylation When an alcohol or its hydrochloric or hydrobromic acid ester is held at 50° to 200° C and 10 to 500 atmospheres in the presence of hydrogen, carbon monoxide, the amide of a carboxylic acid, and a carbonylation catalyst, an aldehyde having one more carb... | 12/07/1976 |
| 3978101 | Rhodium complexes of asymmetric diphosphines, their preparation and their use Optically active diphosphines of the formula: ##EQU1## in which the phosphinomethyl groups are trans to each other, from rhodium complexes useful as catalysts in hydrogenating substituted acrylic acids and their esters to optically active propionic a... | 08/31/1976 |
| 3960927 | Olefinic derivatives of amino acids Novel compounds of the following general formula are useful pharmacologic agents: ##EQU1## R is selected from hydrogen, alkylcarbonyl wherein the alkyl moiety contains from 1 to 4 carbon atoms, alkoxycarbonyl wherein the alkoxy moiety contains f... | 06/01/1976 |
| 3959356 | Acetylene derivatives of amino acids Novel compounds of the following general formula are useful pharmacologic agents: ##EQU1## R is selected from hydrogen, alkylcarbonyl wherein the alkyl moiety contains from 1 to 4 carbon atoms, alkoxy-carbonyl wherein the alkoxy moiety contains ... | 05/25/1976 |
| 3949000 | Asymmetric diphosphines, their preparation and their use Optically active diphosphines of the formula: ##EQU1## in which the phosphinomethyl groups are trans to each other, form rhodium complexes useful as catalysts in hydrogenating substituted acrylic acids and their esters to optically active propionic a... | 04/06/1976 |
| 3941836 | Cycloaliphatic carboxamides Fuel compositions for internal combustion engines containing Diels-Adler adducts of N-3-oxohydrocarbon acrylamides or N-3-hydroxyhydrocarbon acrylamides with conjugated diene compounds such as 1,3-butadiene, cyclopentadiene. The adducts also have utility ... | 03/02/1976 |