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| Number | Title | Issue Date |
| 8168820 | Deuterated catecholamine derivatives and medicaments comprising said compounds The present invention concerns deuterated catecholamine derivatives as well as pharmaceuticals containing these compounds. In addition, the invention concerns the use of deuterated catecholamine derivatives as well as physiologically compatible salts thereof, and al... | 05/01/2012 |
| 7141312 | Organic electroluminescent device based on 2,5-diaminoterephthalic acid derivatives The application relates to an organic electroluminescent device which contains 2,5 diaminoterephthalic acid derivatives of formula 1a as emitter substances in one or several emitter layers in a pure or doped manner. The ring A is a triple unsaturated benzene ... | 11/28/2006 |
| 7112674 | Organic electroluminescent device based on 2,5-diaminoterephthalic acid derivatives The invention relates to an organic electroluminescent device which contains 2,5-diaminoterephthalic acid derivatives of formula 1a as emitter substances in one or several emitter layers in a pure or doped manner. The ring A is a triple unsaturated benzene ring wher... | 09/26/2006 |
| 6700025 | Process for stereoselective synthesis of prostacyclin derivatives An improved method is described for making 9-deoxy-PGF1 -type compounds. In contrast to the prior art, the method is stereoselective and requires fewer steps than the known methods for making these compounds.... | 03/02/2004 |
| 6610710 | Phenylalanine derivatives Phenylalanine derivatives of the following formula and analogues thereof have an antagonistic activity to 댔댧 integrin and a selectivity toward 댔댡 integrin. They are used as therapeutic agents for various diseases to which ... | 08/26/2003 |
| 6254850 | Metal complexes, suitable for use in diagnosis and therapy The invention relates to diethylenetriaminepentaacetic acid derivatives, their complexes and complex salts, containing an element of atomic numbers 20-32, 39-51 or 57-83, pharmaceutical agents containing these compounds, their use as contrast media and an... | 07/03/2001 |
| 6229011 | N-aroylphenylalanine derivative VCAM-1 inhibitors Compounds of the formula: ##STR1## are disclosed which have activity as inhibitors of binding between VCAM-1 and cells expressing VLA-4. Such compounds are useful for treating diseases whose symptoms and/or damage are related to the binding of VCAM-1 ... | 05/08/2001 |
| 6040432 | Metal complexes, of DTPA derivatives suitable for use in diagnosis and therapy The invention relates to diethylenetriaminepentaacetic acid derivatives, their complexes and complex salts, containing an element of atomic numbers 20-32, 39-51 or 57-83, pharmaceutical agents containing these compounds, their use as contrast media and an... | 03/21/2000 |
| 6017918 | Phenyl glycine compounds and methods of treating atherosclerosis and restenosis The present invention provides compounds having the Formula I ##STR1## The present invention also provides methods of treating atherosclerosis, coronary heart disease, and restenosis using the compounds of Formula I, and pharmaceutical compositions c... | 01/25/2000 |
| 5668176 | Phenoxyphenylacetic acid derivatives Phenoxyphenylacetic acids and derivatives of the general structural formula I ##STR1## have endothelin antagonist activity and are useful in treating cardiovascular disorders, such as hypertension, postischemic renal failure, vasospasm, cerebral... | 09/16/1997 |
| 5658943 | Phenylalanine derivatives as endothelin antagonists Novel antagonists of endothelin are described, as well as novel intermediates used in their preparation, methods for the preparation and pharmaceutical compositions of the same, which are useful in treating elevated levels of endothelin, essential, renova... | 08/19/1997 |
| 5510522 | Synthesis of N-formyl-3,4-di-t-butoxycarbonyloxy-6-(trimethylstannyl)-L-phenylalanine ethyl ester and its regioselective radiofluorodestannylation to 6- 18 F!fluoro-1-dopa A process for forming a 6-fluoro derivative of compounds in the L-Dopa family comprising the steps of protecting the groups attached to the benzene ring in the compound followed by serially reacting the protected compound with (a) iodine and silver triflu... | 04/23/1996 |
| 5489686 | Substituted 1,2,3,4-tetrahydroisoquinolines with angiotensin II receptor antagonist properties This invention relates to novel substituted 1,2,3,4-tetrahydroisoquinolines which are useful in the treatment of vascular restenosis, various disorders of the central nervous system, in the regulation of female reproductive functions, in cognitive enhance... | 02/06/1996 |
| 5393908 | Synthesis of N-formyl-3,4-di-t-butoxycarbonyloxy-6-(trimethylstannyl)-L-phenylalanine ethyl ester and its regioselective radiofluorodestannylation to 6-[18 F]fluoro-L-dopa A protected 6-trimethylstannyl dopa derivative has been synthesized for the as a precursor for the preparation of 6-[18 F]fluoro-L-dopa. The tin derivative readily reacts with electrophilic radiofluorinating agents such as [18 F]F | 02/28/1995 |
| 5338859 | Process for the production of calcium salts of hydantoic acids The present invention provides a process for the production of calcium salts of hydantoic acids and which comprises the steps of reacting a hydantoin with a calcium base material such as calcium hydroxide in an aqueous medium at a sufficient temperature a... | 08/16/1994 |
| 5288898 | N-methylphenylserine alkyl ester derivatives and uses thereof As new compounds are now provided N-methyl-3-(3,4-dihydroxyphenyl)serine alkyl esters which are effective as an -adrenergic and ଲ-adrenergic agent to stimulate the -adrenergic and ଲ-adrenergic functions of the central nervous sys... | 02/22/1994 |
| 5254726 | No-carrier-added (NCA) aryl (18E) fluorides via the nucleophilic aromatic substitution of electron rich aromatic rings A method for synthesizing no-carrier-added (NCA) aryl [18 F] fluoride substituted aromatic aldehyde compositions bearing an electron donating group is described. The method of the present invention includes the step of reacting aromatic nitro a... | 10/19/1993 |
| 5246943 | Substituted 1,2,3,4-tetahydroisoquinolines with angiotensin II receptor antagonist properties This invention relates to novel substituted 1,2,3,4-tetrahydroisoquinolines which are useful in the treatment of vascular restenosis, various disorders of the central nervous system, in the regulation of female reproductive functions, in cognitive enhance... | 09/21/1993 |
| 5194663 | Aromatic derivatives of butyric acid, a process for their preparation and their use in cosmetics and in human and veterinary medicine An aromatic derivative of butyric acid has the formula ##STR1## These aromatic derivatives of butyric acid are useful in human and veterinary medicines as well as in cosmetic compositions.... | 03/16/1993 |
| 5041637 | Process for the synthesis of optically active aminoacids New process for the synthesis of optically active aminoacids of formula ##STR1## by treating compounds of formula ##STR2## which an optically active alcohol of formula R4 --OH (III) d or 1 To o... | 08/20/1991 |
| 5013868 | Process for treating amphoteric amino acids The present invention relates to a process for treating amphoteric amino acids, and/or amphoteric amino acid derivatives in a fluid bed, whereby in order to maintain fluidizing conditions one adds at least 0.2% by weight of a fatty acid, fatty alcohol and... | 05/07/1991 |
| 4962223 | Process for the synthesis of the levodopa New process for the synthesis of the levodopa, L-(-)-2-amino-3-(3,4-dihydyphenyl)propionic acid, drug used in the treatment of the Parkinson's disease. The process consists in resolving with d-camphorsulfonic acid, or with a salt thereof, the d,l-2-... | 10/09/1990 |
| 4929755 | Process for making an optically active mixture of an N-acyl-amino acid or ester containing at least two chiral centers In the process of hydrocarboxylating an -enamide with CO and H2 O or an organic hydroxyl compound to produce an N-acyl--amino acid or ester, respectively, the improvement comprising using as the -enamide reactant, an ³... | 05/29/1990 |
| 4888043 | Herbicidal amino-mesityl cyclohexane-1,3-dione compounds The invention concerns compounds of the formula I ##STR1## wherein: Z is selected from hydrogen, alkyl, alkanoyl, sulfamoyl, carboxy and trifluoroacetamido; Y is selected from various carboxy or thiocarboxy groups, haloalkanoyl, alkylsulfonyl and hal... | 12/19/1989 |
| 4879398 | Process for producing 2,6-disubstituted tyrosine A process for making 2,6-disubstituted tyrosine by the noble metal coupling of a disubstituted aromatic halide or diazonium salt with an amino-protected 2-aminoacrylic acid to form a (Z)-ଲ-(disubstituted phenyl)--acylaminoacrylate, and asymme... | 11/07/1989 |
| 4837332 | Process for blocking amino acids with the tertiary-alkoxycarbonyl group Amino acid salt having at least one unblocked amino group and comprising at least one cation which has a nitrogen cationic atom is reacted with 1-(tertiary-alkoxycarbonyl)imidazole in the liquid phase and in the presence of essentially inert organic solve... | 06/06/1989 |
| 4833273 | Process for the resolution of 1-aminoindanes An improved process for the resolution of 1-aminoindanes into the R-isomer on a large scale is described. The resolving agent used in the process is R-N-acetyl-3,4-dimethoxyphenylalanine. The process is of intermediates in the production of certain adenos... | 05/23/1989 |
| 4769486 | Method for racemizing an optically active amino acid A method for racemizing an optically active amino acid, which comprises heating the optically active amino acid in an aqueous solution under an alkaline condition in the presence of an alkali metal salt.... | 09/06/1988 |
| 4740615 | Process for purified amino acids A process for the recovery in substantially pure form of an amino acid represented by the formula ##STR1## from an aqueous production mixture by a low pressure temperature gradient chromatographic process is described.... | 04/26/1988 |
| 4721803 | Method of making a diastereomeric mixture containing two diastereomeric N-acyl-amino acid esters In the process of hydrocarboxylating an -enamide with CO and an organic hydroxyl compound to produce a N-acyl--amino acid ester, the improvement comprising using as the organic hydroxyl compound reactant, an organic hydroxyl compound which h... | 01/26/1988 |
| 4716246 | Process for L-dopa A process for the preparation of (S)- or L-3-(3,4-dihydroxyphenyl)alanine (L-dopa) is described. The process utilizes water as reaction process solvent and proceeds via formation of an intermediate which can be kinetically resolved in a polar solvent to a... | 12/29/1987 |
| 4695588 | Fluorinated amino acids Novel substituted -fluoromethyl--amino alkanoic acids and esters thereof are disclosed. The novel compounds have biological activity including decarboxylase inhibition.... | 09/22/1987 |
| 4675439 | Preparation process of N-acylphenylalanines A process for preparing an N-acylphenylalanine represented by the formula (II): ##STR1## wherein R3 and R4 mean individually a hydrogen atom or an alkyl, alkoxy, phenoxy, hydroxy or methylenedioxy group, and R denotes a methyl ... | 06/23/1987 |
| 4661510 | -allenic--amino acids as enzyme inhibitors Novel -allenic--amino acids which are enzyme inhibitors of the suicide or kcat type are disclosed herein.... | 04/28/1987 |
| 4652657 | Chiral rhodium-diphosphine complexes There are described novel chiral rhodium-diphosphine complexes of the formula wherein X, which may be fixed to a carrier, is Z--COO-, wherein Z is ##STR1## perfluorophenyl, perfluorobiphenyl or a residue of the formula ##STR2## and R | 03/24/1987 |
| 4638086 | Process for the racemization of optically active aminoacids The racemization of optically active aminoacids (including their N-acyl derivatives) by heating with carboxylic acids takes place particularly readily with carboxylic acids of low volatility. Only catalytic quantities of acid are needed; it is advantageou... | 01/20/1987 |
| 4634775 | Optically active 3,4-bis-(diphenylphosphino)-pyrrolidine, and rhodium complexes, containing it as chiral ligands There are described new optically active 3,4-bis-(diphenylphosphino)-pyrrolidines of the formula ##STR1## wherein Ph is a phenyl group and R is hydrogen, an alkyl group, an arylalkyl group or an acyl group, rhodium complexes containing a compound ... | 01/06/1987 |
| 4613691 | Preparation of amino acids from unsaturated hydantoins Amino acids can be easily prepared by reducing unsaturated hydantoins to the corresponding saturated hydantoins by hydrogenating the unsaturated hydantoin using either Raney Nickel catalyst in the presence of more than a stoichiometric amount of caustic o... | 09/23/1986 |
| 4612388 | Process for producing N-acylphenylalanines Disclosed herein is a process for producing an N-acyl-substituted or unsubstituted phenylalanine comprising hydrolyzing a 2-substituted-4-substituted or unsubstituted benzylidene-5-oxazolone with alkali, adjusting pH of the reaction solution containing it... | 09/16/1986 |
| 4508921 | Process for preparation of alpha-alkyl amino acids A process for preparing -alkyl amino acids by enantioretentive -alkylation of -amino acids is described. The products are bioactive compounds including some useful as therapeutic agents.... | 04/02/1985 |
