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| Number | Title | Issue Date |
| 8163955 | Process for the synthesis of 2,6-diamino-3,5-dinitrotoluene An improved process is provided for the preparation of 2,6-diamino-3,5-dinitrotoluene by amination of 2,6-dichloro-3,5-dinitrotoluene. The presence of water unexpectedly results in a highly pure product, free of glycol ether impurities. This product can be used to m... | 04/24/2012 |
| 7772425 | Vitamin D receptor modulators The present invention relates to novel, non-secosteroidal, diaryl compounds with vitamin D receptor (VDR) modulating activity that are less hypercalcemic than 1α,25 dihydroxy vitamin D3. These compounds are useful for treating bone disease and psoriasis. ... | 08/10/2010 |
| 7566803 | Vitamin D receptor modulators The present invention relates to novel, non-secosteroidal, diaryl compounds with vitamin D receptor (VDR) modulating activity that are less hypercalcemic than 1α,25 dihydroxy vitamin D3. These compounds are useful for treating bone disease and psoriasis. ... | 07/28/2009 |
| 7321055 | Production method of optically active dephenylalanine compounds Optically active diphenylalanine compounds may be conveniently prepared in a good yield by reacting a diphenylalanine compound represented by formula (1) with an optically active amine compound represented by formula (2) in the presence of an organic solvent to give... | 01/22/2008 |
| 7314888 | Compounds and medicinal use thereof A compound or a salt thereof having the atom corresponding to N3 and the two or more atoms selected from N1, N2, N4 and N5, said atoms constitute the pharmacophore represented by the following formula: | 01/01/2008 |
| 7220880 | Amide linker peroxisome proliferator activated receptor modulators The present invention is directed to compounds, compositions, and use of compounds the structural Formula (I) ... | 05/22/2007 |
| 7074959 | Methods and systems for remediating hydrazine-contaminated equipment and/or surfaces Methods of and systems for remediating hydrazine spills, solutions and hydrazine-contaminated objects including areas thereof. Initially, an aqueous solution comprising a dicarbonyl-compound can be prepared. The aqueous solution can then be provided for application ... | 07/11/2006 |
| 7057066 | Process for producing 3-amino-2-hydroxypropionic acid derivatives The present invention provides a process for preparing 3-amino-2-hydroxypropionic acid derivatives (1) which does not use dangerous reagents, is economically advantageous, and is suitable for an industrial production, which process comprises: ... | 06/06/2006 |
| 7034015 | Aminobenzoephenones The invention relates to a novel class of aminobenzophenones derivatives, to pharmaceutical preparations comprising said compounds, to dosage units of such preparations, to methods of treating patients comprising administering said compounds, and to the use of said ... | 04/25/2006 |
| 7030160 | Propanolaminotetralines, preparation thereof and compositions containing same The invention relates to phenoxypropanolamines, to pharmaceutical compositions containing them, to processes for preparing them, and to the method of use thereof in the treatment of diseases that are improved by beta-3 agonist action. ... | 04/18/2006 |
| 6979566 | Method of treatment of viral infection including HIV using water soluble fullerenes—III A water soluble derivative of buckministerfullerene (C50) having antiviral and virucidal properties is used to inhibit human retroviral replication and infections. The derivatized fullerene is symmetrically substituted with polar organic moieties containi... | 12/27/2005 |
| 6924391 | Alpha-amino,-thio,-oxo substituted ketones as phospholipase inhibitors Inhibitors of the cytosolic phospholypase A2 enzymes are provided which are of use in controlling a wide variety of inflammatory diseases. The inhibitors of the present invention have the general formula wherein X, Z, ... | 08/02/2005 |
| 6906046 | Pharmaceutical uses and synthesis of benzobicyclooctanes Benzobicyclooctane compounds, their use in inhibiting cellular events involving TNF-α and IL-8, and in the treatment of inflammation events in general; a combinatorial library of diverse bicyclooctanes and process for their synthesis as a library and as individual ... | 06/14/2005 |
| 6809214 | Shortened synthesis of 3,3-diarylpropylamine derivatives The invention relates to a method for producing derivatives of 3,3-diarylpropylamines of general formula (I) and sterically highly pure, stable intermediate products, and to their use for producing pharmaceutical compositions. ... | 10/26/2004 |
| 6806365 | N-alkanoylphenylalamine derivatives Compounds of the formula: are disclosed which have activity as inhibitors of binding between VCAM-1 and cells expressing VLA-4. Such compounds are useful for treating diseases whose symptoms and/or damage are related t... | 10/19/2004 |
| 6710205 | Benzoic acid derivatives, processes for producing the same and drugs containing the same as the active ingredient An agent comprising the benzoic acid of formula (I) wherein A, B, R6, R7 are carbocyclic ring, heterocyclic ring, etc.; R1 is hydroxy etc.; R2, R3, R4 are... | 03/23/2004 |
| 6664291 | Malonamic acids and derivatives thereof as thyroid receptor ligands The present invention relates to novel thyroid receptor ligands and, more particularly, relates to malonamic acids and derivatives thereof of Formula I, which are useful in the treatment of obesity, overweight condition, hyperlipidemia, glaucoma, cardiac ... | 12/16/2003 |
| 6649656 | Anthranilic acid derivatives The present invention relates to an anthranilic acid derivative expressed by the following formula (1) or the following formula (2), or its pharmacologically permissible salt or solvate. ##STR1##... | 11/18/2003 |
| 6566554 | Aminobenzophenones as inhibitors of IL-1ଲ and TNF- The present invention relates to a compound of general formula (I) wherein R1, R2, and R3 represents one or more, same or different substituents selected from the group consisting of halogen, hydroxy, mercapto, trifluorome... | 05/20/2003 |
| 6504052 | Excitatory amino acid receptor modulators Compounds of the formula (I) in which R1 is C1-10 allyl; C2-10 alkenyl; C2-10 alkynyl; phenyl-C2-10 alkyl or phenyl-C2-10 alkenyl; and salts and esters thereof, modulate metabotropic glutam... | 01/07/2003 |
| 6409995 | Use of amino-substituted hydroxybenzophenones as photostable UV filters in cosmetic and pharmaceutical preparations Use of amino-substituted hydroxybenzophenones of the formula I ##STR1## in which the variables have the meanings explained in the description, as photostable UV filters in cosmetic and pharmaceutical preparations for protecting human skin or human hair fr... | 06/25/2002 |
| 6380249 | HIV integrase inhibitors Certain six-membered aromatic and heteroaromatic-dioxobutyric acid derivatives are described as inhibitors of HIV integrase and inhibitors of HIV replication. These compounds are useful in the prevention or treatment of infection by HIV and the treatment ... | 04/30/2002 |
| 6323240 | 4-phenyl-4-oxo-butanoic acid derivatives with kynurenine-3-hydroxylase inhibiting activity 4-phenyl-4-oxo-butanoic acid derivatives for use in the treatment of the human or animal body by therepy; particularly as kynurenine-3-hydroxylase inhibitors, in the prevention and/or treatment of a neurodegenerative disease wherein the inhibition of such... | 11/27/2001 |
| 6310238 | O-amino(thio)phenolcarboxylic acids, and their preparation The invention relates to novel o-aminophenolcarboxylic acids or o-aminothiophenolcarboxylic acids of the following structure ##STR1## in which: A1 to A7 are--independently of one another--H, CH3, OCH3, CH2 | 10/30/2001 |
| 6245938 | 4-pentenoyl groups for derivatization and protection of amino acids A method of separating a racemic mixture of amino acid enantiomers, which entails reacting the mixture with a 4-pentenoyl compound, thereby derivatizing the enantiomers to form two diastereomers, and separating the diastereomers.... | 06/12/2001 |
| 6232467 | Method for the synthesis of amines and amino acids with organoboron derivatives Amines and amino acids are prepared by reacting an amine, a carbonyl derivative, and an organoboron compound under mild conditions.... | 05/15/2001 |
| 6214876 | Indene-1-acetamide sPLA2 inhibitors Indene-1-acetamide compounds of the general formula (I) below; ##STR1## inhibit sPLA2 mediated release of fatty acids and are useful for treatment of conditions such as septic shock.... | 04/10/2001 |
| 6204391 | Water soluble fullerenes with antiviral activity A water soluble derivative of buckministerfullerene (C60) having antiviral and virucidal properties is used to inhibit human retroviral replication and infections. The derivatized fullerene is symmetrically substituted with polar organic moieti... | 03/20/2001 |
| 6172058 | Compounds with pharmaceutical properties A pharmaceutical compound of the formula ##STR1## in which R1 is C1-10 alkyl, C2-10 alkenyl, C2-10 alkynyl, C3-10 cycloalkyl, C3-10 cycloalkyl-C1-10 alkyl, C3-10 cyclo... | 01/09/2001 |
| 6103743 | Unsaturated amino acid derivatives Described herein are compounds having the general formula: ##STR1## Ar1 and Ar2 are independently selected aryl groups, optionally substituted with substituents selected from the group consisting of alkyl, cycloalkyl, alkoxy, al... | 08/15/2000 |
| 6063815 | Benzopenones useful in the treatment of insulin resistance and hyperglycemia This invention provides compounds of Formula I having the structure ##STR1## wherein Y is ##STR2## R1 and R2 are each, independently, hydrogen, alkyl of 1-6 carbon atoms, halogen, perfluoroalkyl of 1-6 carbon atoms, cycloal... | 05/16/2000 |
| 6043247 | Modulators of molecules with phosphotyrosine recognition units The present invention relates to novel substituted acrylic acids, to methods for their preparation, compositions containing them, and their use for treatment of human and animal disorders, to their use for purification of proteins or glycoproteins, and to... | 03/28/2000 |
| 6013811 | Preparation process of benzodifuranone dyes A process for the preparation of a polycyclic dye of Formula (1) which comprises steps: i) reaction of a compound of formula (2) with a compound of formula (3) or a derivative thereof to form an intermediate of formula (4) and ii) reaction of the intermed... | 01/11/2000 |
| 5998662 | O-amino (thio) phenolcarboxylic acids and their preparation The invention relates to novel o-aminophenolcarboxylic acids, and o-aminothiophenolcarboxylic acids of the following structure: ##STR1## where A1 to A7 are--independently of one another--H, F, CH3, CF3, OCH... | 12/07/1999 |
| 5936055 | Acid functionalized polyurethane adducts Disclosed is an acid-funtionalized polyurethane adduct and a process for the preparation of such adduct. The adduct having a linear or preferably branched structure comprises a plurality of internal urethane linkages and one or more terminal carboxylic ac... | 08/10/1999 |
| 5925787 | Production of keto acids A method for the production of a keto acid having the general formula ##STR1## wherein R1 and R2 independently represent a straight or branched chain alkyl of 1-18 carbon atoms, a cycloalkyl of 4-8 carbon atoms or a phenyl, each of which may be subst... | 07/20/1999 |
| 5916922 | Phenyl glyoxamides as SPLA2 inhibitors A class of novel phenyl glyoxamides is disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of conditions such as septic shock.... | 06/29/1999 |
| 5917086 | Purification process A method for the purification of a keto acid having the general formula ##STR1## wherein R1 and R2 independently represent a straight or branched chain alkyl of 1-18 carbon atoms, a cycloalkyl of 4-8 carbon atoms or a phenyl both of which may be subs... | 06/29/1999 |
| 5908851 | Derivatives of succinamide and their use as metalloproteinase inhibitor Compounds of formula (I), ##STR1## wherein X is a --CO2 H or --CONHOH group; R4 is a group --CHRx Ry wherein Rx and Ry independently represent optionally substituted phenyl or monocycl... | 06/01/1999 |
| 5863947 | Phenylglycine derivatives useful for treating disorders of the central nervous system A pharmaceutical compound of the formula: ##STR1## in which R1 is hydrogen, hydroxy or C1-6 alkoxy, R2 is hydrogen, carboxy, tetrazolyl, --SO2 H, --SO3 H, --OSO3 H, --CONHOH, or --P(OH... | 01/26/1999 |
