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Apparatus for Simulating a High Five
A self-righting hand-arm configuration which is adapted to pivot when struck by a user, thereby simulating a "high five."
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| Number | Title | Issue Date |
| 8097753 | Mixtures composed or monocarboxy-functionalized dialkylphosphinic acids, their use and a process for their preparation The invention relates to mixtures composed of monocarboxy-functionalized dialkylphosphinic acids and of further components, which comprise A) from 98 to 100% by weight of monocarboxy-functionalized dialkylphosphinic acids of the fo... | 01/17/2012 |
| 7485745 | Mixtures composed of monocarboxy-functionalized dialkylphosphinic esters and of further components The invention relates to mixtures composed of dialkylphosphinic esters and of further components, which comprise A) from 98 to 100% by weight of monocarboxy-functionalized dialkylphosphinic esters of the formula (I) | 02/03/2009 |
| 7294733 | Method for preparing formylphosphonic acid An improved process for the manufacture of formylphosphonic acid derivatives is reported. An aminomethylphosphonic acid substrate is contacted with a reagent selected from the group consisting of water, an alcohol, a phenol compound, and mixtures thereof and an oxid... | 11/13/2007 |
| 7145034 | Method for producing N-phosphonomethylglycine The invention relates to a process for preparing N-phosphono-methylglycine by reacting a hexahydrotriazine compound with a triacyl phosphite in an organic solvent, hydrolyzing the resulting phosphono compound after prior extraction into an aqueous phase and separati... | 12/05/2006 |
| 7091376 | Method for preparing formylphosphonic acid An improved process for the manufacture of formylphosphonic acid derivatives is reported. An aminomethylphosphonic acid substrate is contacted with a reagent selected from the group consisting of water, an alcohol, a phenol compound, and mixtures thereof and an oxid... | 08/15/2006 |
| 6943194 | Synthesis of phenstatin and prodrugs thereof A newly discovered antineoplastic compound denominated “phenstatin” is herein described as are synthetic methods for producing phenstatin and the active prodrug thereof. Phenstatin was converted to the sodium phosphate prodrug (3d) by a dibenzylphosphite phospho... | 09/13/2005 |
| 6924390 | Surface coating agents Compounds useful as surface coating agents, including compounds of the formula: wherein X1 comprises a first photoreactive species; X2 comprises a second photoreactive species; Y comprises a nonpo... | 08/02/2005 |
| 6919322 | Phenyl Phosphonate Fructose-1,6-Bisphosphatase Inhibitors Novel FBPase inhibitors of the formula I are useful in the treatment of diabetes and other conditions associated with elevated blood glucose. ... | 07/19/2005 |
| 6753431 | Production of mixed acid anhydride and amide compound There is disclosed an advantageous mixed acid anhydride production method of formula (1): R1C(O)OY(O)n(R2)p (1) wherein R1, R2 and Y denote the same as defined bel... | 06/22/2004 |
| 6603040 | Surface coating agents Compounds useful as surface coating agents, including compounds of the formula: ##STR1## wherein X1 comprises a first photoreactive species; X2 comprises a second photoreactive species; Y comprises a nonpolymeric core molecule c... | 08/05/2003 |
| 6528499 | Ligands for metabotropic glutamate receptors and inhibitors of NAALADase The present invention relates to novel compounds and formulations thereof which compounds are ligands, e.g., agonists or antagonists, for a metabotropic glutamate receptor or a NAALADase enzyme or both. The present invention also relates to methods of mod... | 03/04/2003 |
| 6486142 | Phosphonic acid derivatives as inhibitors of protein tyrosine phosphatase 1B (PTP-1B) The invention encompasses the novel class of compounds represented by formula I, which are inhibitors of the PTP-1B enzyme. ##STR1## The invention also encompasses pharmaceutical compositions and methods of treating or preventing PTP-1B mediated diseases,... | 11/26/2002 |
| 6486141 | Phosphonic acid biaryl derivatives as inhibitors of protein tyrosine phosphatase 1B (PTP-1B) The invention encompasses the novel class of compounds represented by formula I which are inhibitors of the PTP-1B enzyme. ##STR1## The invention also encompasses pharmaceutical compositions and methods of treating or preventing PTP-1B mediated diseases, ... | 11/26/2002 |
| 6479470 | Ligands for metabotropic glutamate receptors and inhibitors of NAALAdase The present invention relates to novel compounds and formulations thereof which compounds are ligands, e.g., agonists or antagonists, for a metabotropic glutamate receptor or a NAALADase enzyme or both. The present invention also relates to methods of mod... | 11/12/2002 |
| 6444837 | Synthesis and antiviral activity of a series of pyrophosphate analogs Preparations of pyrophosphate analogues, including phosphonoformic acid, bisphosphonic acid, and phosphonoacetic acid derivatives, exhibiting antiviral activity. Such compounds, are used directly, or as prodrugs, in compositions and methods for treating v... | 09/03/2002 |
| 6441214 | Derivatives and analogs Preparation of phosphonoformic acid analogues containing one, two, three, or more sulfur atoms are described, with specific examples. Such compounds, not excluding cognates, derivatives, and homologues thereof, are proposed to be used directly, or as prod... | 08/27/2002 |
| 6441223 | Method of making phosphorus-containing compounds and products thereof A process for oxidizing a hydroxymethylphosphonic acid compound to produce a formylphosphonic acid compound is described. The oxidation reaction is carried out in the presence of an oxidant and a catalyst. For example, hydroxymethylphosphonic acid (HMPA) ... | 08/27/2002 |
| 6399814 | Process for the preparation of 2-carboxyalkyl(aryl)phosphinic acid and corresponding anhydride(s) An improved hydrolysis process comprising a process for the preparation of 2-carboxyalkyl(aryl)phosphinic acid using a controlled addition of water to an acrylation reaction mixture, and control of the temperature. Preparation of 2-carboxyalkyl(aryl)phosp... | 06/04/2002 |
| 6359162 | Method for producing glufosinates and intermediate products for the same Glufosinate and the 2-methyl analog thereof can be prepared in a multi-step synthesis from methylphosphorus compounds (II) with unsaturated keto compounds (III) via adducts (IV), subsequent reaction under the conditions of a Strecker synthesis and finally... | 03/19/2002 |
| 6355805 | 댣-adrenergic receptor agonists The present invention is directed to multibinding compounds which are 댣 adrenergic receptor agonists and are therefore useful in the treatment and prevention of metabolic disorders such as obesity, diabetes, and the like.... | 03/12/2002 |
| 6333426 | Chiral adsorbents and preparation thereof as well as compounds on which the absorbents are based and preparation of the compounds Opticallly active adsorbents based on network polymerized derivative of dicarboxylic acids, diamines or diols which are chemically bonded to a carrier. The derivatives can be polymerized by radical polymerization or through hydrosilylation in the presence... | 12/25/2001 |
| 6329547 | Vinylbenzene derivatives The present invention provides compounds represented by the following general formula [I] and salts thereof, which are useful as therapeutic agents for glaucoma, ##STR1## wherein R1 is H, lower alkyl or phenyl, and the phenyl can be substi... | 12/11/2001 |
| 6320071 | Production of 2-carboxyalkyl (phenyl)phosphinic acid Processes for producing 2-carboxyalkyl(phenyl)phosphinic acid comprising hydrolyzing the reaction mixture produced from the reaction of dichloro(phenyl)phosphine with a carboxylic acid in the presence of water, wherein the hydrolysis is conducted with red... | 11/20/2001 |
| 6274760 | Preparation of formylphosphonic acid from tertiary aminomethylphosphonic acid N-oxides Formylphosphonic acid derivatives are prepared by the catalytic decomposition of a (phosphonomethyl)amine N-oxide compound to form the formylphosphonic acid derivative and a dephosphonomethylated amine.... | 08/14/2001 |
| 6218570 | Method for preparing formylphosphonic acid An improved process for the manufacture of formylphosphonic acid derivatives is reported. An aminomethylphosphonic acid substrate is contacted with a reagent selected from the group consisting of water, an alcohol, a phenol compound, and mixtures thereof ... | 04/17/2001 |
| 6174874 | Phosphonic acids derivatives as inhibitors of protein tyrosine phosphate 1B (PTP-1B) The invention encompasses the novel class of compounds represented by formula I which are inhibitors of the PTP-1B enzyme. ##STR1## The invention also encompasses pharmaceutical compositions and methods of treating or preventing PTP-1B mediated diseases.... | 01/16/2001 |
| 6160166 | Phosphonated agents and their antiangiogenic and antitumorigenic use Phosphonic acid agents are synthesized and characterized which are potent inhibitors of angiogenesis, tumorigenesis and metalloproteinase activity. Their method of use for the inhibition of angiogenesis and metalloproteinase and the treatment of tumors is... | 12/12/2000 |
| 6090976 | Method for preparation 3-(hydroxyphenylphosphinyl)-propanoic acid Disclosed is a method for the preparation of 3-(hydroxyphenylphosphinyl)-propanoic acid which is commonly used as a flame retardant for polyester resins. The preparation of 3-(hydroxyphenylphosphinyl)-propanoic acid is attained by the condensation of... | 07/18/2000 |
| 6071965 | Phosphinic alkanoic acid derivatives The present invention relate to phosphinic alkanoic acid derivatives that inhibit N-Acetylated -Linked Acidic Dipeptidase (NAALADase) enzyme activity, pharmaceutical compositions comprising the same, and methods of using the same to inhibit NAALADa... | 06/06/2000 |
| 6054608 | Method for preparing formylphosphonic acid A process for the manufacture of formylphosphonic acid derivatives is reported. An aminomethylphosphonic acid substrate is contacted with a reagent selected from the group consisting of water, an alcohol, a phenol compound, and mixtures thereof and an oxi... | 04/25/2000 |
| 6054444 | Phosphonic acid derivatives The present invention relates to phosphonic acid derivatives that inhibit N-Acetylated -Linked Acidic Dipeptidase (NAALADase) enzyme activity, pharmaceutical compositions comprising such derivatives, and methods of using such derivatives to inhibit... | 04/25/2000 |
| 6046180 | NAALADase inhibitors The present disclosure relates to dipeptidase inhibitors, and more particularly, to novel phosphonate derivatives, hydroxyphosphinyl derivatives, and phosphoramidate derivatives that inhibit N-Acetylated -Linked Acidic Dipeptidase (NAALADase) enzym... | 04/04/2000 |
| 6028216 | Asymmetric syntheses and intermediates for preparing enantiomer-enriched hydroxyphosphinyl derivatives The present invention relates to asymmetric syntheses and intermediates for preparing enantiomer-enriched hydroxyphosphinyl derivatives.... | 02/22/2000 |
| 6025344 | Certain dioic acid derivatives useful as NAALADase inhibitors The present disclosure relates to dipeptidase inhibitors, and more particularly, to novel phosphonate derivatives, hydroxyphosphinyl derivatives, and phosphoramidate derivatives that inhibit N-Acetylated -Linked Acidic Dipeptidase (NAALADase) enzym... | 02/15/2000 |
| 5880309 | Phenylphosphonic acid derivative and production process therefor A dialkyl dialkoxycarbonylphenylphosphonate which is useful as a resin modifier, a process for producing the same in high yield at a low cost, and a process for producing a dicarboxyphenylphosphonic acid in high yield at a low cost are described. The proc... | 03/09/1999 |
| 5804602 | Methods of cancer treatment using naaladase inhibitors The present invention is based upon the surprising discovery that NAALADase inhibitors exhibit a significant inhibitory effect on the growth of prostate cancer cells. The present disclosure relates to methods of treating diseases of the prostate, in parti... | 09/08/1998 |
| 5795877 | Inhibitors of NAALADase enzyme activity The present invention includes compounds, compositions, and methods of treatment for glutamate abnormalities and associated nervous tissue insult in a animal by inhibition of NAALADase enzyme. Compositions include phosphonate derivatives and mixtures ther... | 08/18/1998 |
| 5770587 | Antifungal agents There are disclosed novel compounds having the formula ##STR1## which exhibit antifungal activity.... | 06/23/1998 |
| 5739373 | Optically active phosphono analogs of succinates and synthesis thereof The present invention relates to catalytic asymmetric hydrogenation of phosphorus analogs of itaconic acid to synthesize novel optically active phosphono succinates.... | 04/14/1998 |
| 5731299 | Phosphonosulfonate compounds, pharmaceutical compositions, and methods for treating abnormal calcium and phosphate metabolism The present invention relates to phosphonsulfonates and the pharmaceutically-acceptable salts and esters thereof, having the following structure according to formula (I): ##STR1## The present invention further relates to pharmaceutical compositions ... | 03/24/1998 |
