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| Number | Title | Issue Date |
| 7662991 | Process for the manufacture of aminoalkylenephosphonic acid compounds in the presence of a heterogeneous catalyst A beneficial method for the manufacture of amino polyalkylene phosphonic acids, under substantial absence of hydrohalogenic acid, is disclosed. The method, in essence, is based on reacting narrowly defined ratios of phosphorous acid, an amine and a formaldehyde in p... | 02/16/2010 |
| 7365091 | Derivatives of succinic and glutaric acids and analogs thereof useful as inhibitors of PHEX The present invention relates to derivatives of succinic and glutaric acids and analogues thereof, having the following general formula: useful as inhibitors of PHEX. These derivatives are useful fo... | 04/29/2008 |
| 7199113 | Pharmaceutically active compounds and methods of use thereof The invention includes pharmaceutically active compounds and methods of treatment and pharmaceutical compositions that utilize or comprise one or more such compounds. Compounds of the invention are particularly useful for treatment or prophylaxis of undesired thromb... | 04/03/2007 |
| 7094773 | LTAhydrolase inhibitors The invention relates to compounds which constitute a class of medicaments which have an anti-inflammatory activity and which act by inhibiting leukotriene A4 (LTA4), and enzyme which is responsible for the biosynthesis of leukotriene LTB4... | 08/22/2006 |
| 7067693 | Deeply reduced oxidation catalyst and its use in preparing N-(phosphonomethyl) glycine compounds This invention relates to an improved catalyst, comprising a carbon support having a noble metal at its surface, for use in catalyzing liquid phase oxidation reactions, especially in an acidic oxidative environment and in the presence of solvents, reactants, interme... | 06/27/2006 |
| 6919322 | Phenyl Phosphonate Fructose-1,6-Bisphosphatase Inhibitors Novel FBPase inhibitors of the formula I are useful in the treatment of diabetes and other conditions associated with elevated blood glucose. ... | 07/19/2005 |
| 6894004 | Compounds, compositions, and methods of use for glyphosate salts of ether amines The present invention describes glyphosate salts of ether amines as compounds and compositions, including their methods of use. The compounds include glyphosate salts of the formula (I): Z-CH2—NH—CH2—POR1R2 (I), wher... | 05/17/2005 |
| 6867326 | Method of producing glyphosate or a salt thereof In a process for preparing N-phosphonomethylglycine or a salt thereof by bringing phosphonomethyliminodiacetic acid or a salt thereof into contact with at least one oxygen-containing oxidant in the presence of a heterogeneous catalyst, the heterogeneous catalyst com... | 03/15/2005 |
| 6818450 | Use of infrared spectroscopy for on-line process control and endpoint detection The present invention is directed to an analytical method for measuring the concentration of an N-(phosphonomethyl)iminodiacetic acid (“NPMIDA”) substrate, an N-(phosphonomethyl)glycine product, formaldehyde, formic acid, N-methyl-N-(phosphonomethyl)glycine (“... | 11/16/2004 |
| 6641741 | Removal and recovery of chloride from phosphonomethyliminodiacetic acid process brine Chloride is selectively isolated as NaCl from N-phosphonomethyliminodiacetic acid process wastes by evaporative crystallization of the caustic neutralized brine.... | 11/04/2003 |
| 6441223 | Method of making phosphorus-containing compounds and products thereof A process for oxidizing a hydroxymethylphosphonic acid compound to produce a formylphosphonic acid compound is described. The oxidation reaction is carried out in the presence of an oxidant and a catalyst. For example, hydroxymethylphosphonic acid (HMPA) ... | 08/27/2002 |
| 6326399 | O-benzyloxime ethers and crop protection agents containing these compounds O-Benzyloxime ethers of the formula I ##STR1## where X is substituted or unsubstituted CH2, NOalkyl Y is O, S, NR5 R1, R2, R5 are H, alkyl Z1, Z2 are H, halogen, methyl, methoxy, cyano and... | 12/04/2001 |
| 6191165 | Pharmaceutical for treatment of neurological and neuropsychiatric disorders The invention provides a pharmaceutical for treatment of neurological and neuropsychiatric disorders comprising a compound of the formula: ##STR1## or a pharmaceutically acceptable salt thereof.... | 02/20/2001 |
| 6160166 | Phosphonated agents and their antiangiogenic and antitumorigenic use Phosphonic acid agents are synthesized and characterized which are potent inhibitors of angiogenesis, tumorigenesis and metalloproteinase activity. Their method of use for the inhibition of angiogenesis and metalloproteinase and the treatment of tumors is... | 12/12/2000 |
| 6143776 | Tosylproline analogs as thymidylate synthase inhibitors Tosylproline analogs of formula I, methods of making them, pharmaceutical compositions containing them, and methods for their use. The compounds are thymidylate synthase inhibitors; and are useful as anti-tumor agents and as anti-parasitics, anti-bacteria... | 11/07/2000 |
| 6121252 | Phosphinic acid derivatives The present invention relate to phosphinic acid derivatives that inhibit N-Acetylated -Linked Acidic Dipeptidase (NAALADase) enzyme activity, pharmaceutical compositions comprising the same, and methods of using the same to inhibit NAALADase activi... | 09/19/2000 |
| 6118022 | Synthesis of phosphonomethyliminodiacetic acid with reduced effluent A process for the preparation of phosphonomethylglycine in high yields is disclosed. In accordance with the process of the present invention, alkali metal IDA, such as disodium IDA, is reacted with a strong mineral acid, such as HCl, to convert the salt o... | 09/12/2000 |
| 6084123 | Process for the preparation of optically active 1-aminophosphonic acid derivatives and novel phosphonate compounds Provided is a process for the preparation of an optically active (R)- or (S)-1-aminophosphonic acid derivative of the general formula (Ia) or (Ib) given below, which process comprises reacting an amino-protected imine having general formula (II): R1 | 07/04/2000 |
| 5962729 | Method for the manufacture of N-phosphonomethylglycine from N-phosphonomethyliminodiacetic acid using a catalytic carbon An improved process is provided for the manufacture of N-phosphonomethylglycine from N-phophonomethyliminodiacetic acid in the presence of a molecular-oxygen containing gas utilizing a catalytically active carbonaceous char. The improvement is provided by... | 10/05/1999 |
| 5905163 | Method for preparing aminomethylphosphonate derivatives via hydrogenation of cyanophosphonate derivatives A novel process for preparing aminomethylphosphonate derivatives involves the hydrogenation of cyanophosphonate derivatives in the presence of a catalyst to produce aminomethylphosphonate derivatives.... | 05/18/1999 |
| 5861525 | Method for preparing cyanophosphonate derivatives from phosphate esters and cyanide A process for preparing cyanophosphonate derivatives involves contacting a phosphate ester and cyanide in a reaction mixture under conditions sufficient to produce a cyanophosphonate derivative. That cyanophosphonate derivative product can subsequently be... | 01/19/1999 |
| 5858317 | Method for preparing cyanophosphonate derivatives from phosphoric anhydride and cyanide A process for preparing cyanophosphonate derivatives involves contacting phosphoric anhydride (P4 O10) and a cyanide, preferably in the presence of a Lewis base, in a reaction mixture under sufficient conditions to produce a cyanopho... | 01/12/1999 |
| 5859278 | Method for preparing cyanophosphonate derivatives from pyrophosphate or polyphosphate esters and cyanide A process for preparing cyanophosphonate derivatives involves contacting a pyrophosphate ester or a polyphosphate ester and cyanide in a reaction mixture under conditions sufficient to produce the cyanophosphonate derivative. The cyanophosphonate derivati... | 01/12/1999 |
| 5824809 | Alpha-aminophosphonates and processes for their preparation Novel -aminophosphonates are provided along with processes and intermediates for their preparation. In preferred embodiments, scalemic -aminophosphonates are prepared by the stereoselective addition of phosphite salts to chiral imines.... | 10/20/1998 |
| 5703273 | Process for preparing N-phosphonomethylamino carboxylic acids A process for preparing N-hydroxyalkylaminomethyl-phosphonic acid or salts thereof which comprises contacting an alkanolamine, formaldehyde and a trialkyl phosphite under suitable reaction conditions to produce a reaction mixture, and hydrolyzing the reac... | 12/30/1997 |
| 5654462 | Process for making chiral alpha-amino phosphonates and selected novel chiral alpha-amino phosphonates This invention is selected novel chiral (essentially pure) alpha-amino phosphonates, process for the preparation which is a catalytic asymmetric hydrogenation of olefins and novel intermediates therefor. The alpha-amino phosphonates are useful as antibiot... | 08/05/1997 |
| 5629431 | Inhibitors of retroviral proteases The present invention relates to compounds of the formula I ##STR1## in which A, Q, R2, R3, R4 and the corresponding radicals with an * are defined as indicated in the description, a process for the preparation thereo... | 05/13/1997 |
| 5606106 | Hexamethlene phosphonate concentrate Concentrated aqueous hexamethylene phonic acid solutions are described containing, in addition to high levels e.g. 40%-50% of phosphonic acid a narrowly defined level of non-oxidizing mineral acid, preferrably hydrochloric acid.... | 02/25/1997 |
| 5602276 | Process for preparing N-phosphonomethylamino carboxylic acids A process for preparing N-hydroxyalkylaminomethylphosphonic acid or salts thereof which comprises contacting an alkanolamine, formaldehyde and a dialkyl phosphite in the presence of an alcohol under suitable reaction conditions to produce a reaction mixtu... | 02/11/1997 |
| 5574025 | Inhibitors of prenyl-protein transferases The compounds disclosed inhibit the prenylation of several proteins. These compounds are potent inhibitors of famesyl-protein transferase and geranylgeranyl-protein transferase. Further contained in this invention are chemotherapeutic compositions contain... | 11/12/1996 |
| 5543562 | Non-hygroscopic monoammonium salts of phosphonic acids or phosphinic acids A solid, non-hygroscopic salt of the Formula (I) ##STR1## wherein R1 is hydroxy or alkyl; A is C1 to C4 alkyl-amino or an amino-alkyl group containing a primary or a secondary amino group; and B is ammonium ion or an alkyl... | 08/06/1996 |
| 5510510 | Inhibitors of farnesyl protein transferase Inhibition of farnesyl transferase, which is an enzyme involved in ras oncogene expression, and inhibition of cholesterol biosynthesis, are effected by compounds of the formula ##STR1## their enantiomers, diastereomers, and pharmaceutically acceptabl... | 04/23/1996 |
| 5510504 | Process for the preparation of derivatives of bis(amino-methyl) phosphinic acid A process for the preparation of - or ,'-substituted derivatives of the bis(aminomethyl)phosphinic acid of the formula I and their acid or basic salts, ##STR1## in which R1, R2 and R3 are defined ... | 04/23/1996 |
| 5508463 | -aminophosphonates Novel -aminophosphonates are provided along with processes and intermediates for their preparation. In preferred embodiments, scalemic -aminophosphonates are prepared by the stereoselective addition of phosphite salts to chiral imines.... | 04/16/1996 |
| 5471000 | Process for the manufacture of aminomethanephosphonic acid A process for the manufacture of aminomethanephosphonic acid comprises: a) reacting a compound of formula R--CH2 --NH--CO--NH--CH2 --R' wherein R and R', which may be the same or different, represent a phosphonation leaving group with a p... | 11/28/1995 |
| 5429674 | N-acyl aminomethylene phosphonates and their use in waterborne coating compositions N-acyl aminomethylene phosphonates are provided having a group defined by the following general formula: ##STR1## wherein R1 is hydrogen, an aliphatic radical having 1 to 25 carbon atoms, or an aromatic radical having 6 to 25 carbon atoms;... | 07/04/1995 |
| 5410075 | Non-hygroscopic monoammonium salts of phosphonic and phosphinic acids A solid, non-hygroscopic salt of the Formula (I) ##STR1## wherein R1 is dydroxy or alkyl; A is C1 to C4 alkyl-amino or an amino-alkyl group containing a primary or a secondary amino group; and B is ammonium ion or an alkyl... | 04/25/1995 |
| 5380921 | Aminophosponic acid derivative There are provided novel aminophosphonic acid derivatives of the general formula [I]: ##STR1## wherein n is an integer of 2 or 3; R1 is a phenyl, naphthyl, indolyl, benzothienyl, benzofuryl or benzoxazolyl group which may have 1 to 3 ... | 01/10/1995 |
| 5324855 | Preparation of N-acylaminomethylphosphonic acid N-acylaminomethylphosphonic acid is prepared from an N-methylolamide compound and a phosphorus trihalide. The starting compounds are mixed and heated in an aprotic solvent in the presence of water in a 0.25 to 2.5 times molar amount relative to the phosph... | 06/28/1994 |
| 5324708 | Non-hygroscopic monoammonium salts of phosphonic and phosphinic acids A solid, non-hygroscopic salt of the Formula (I) ##STR1## wherein R1 is hydroxy or alkyl; A is C1 to C4 alkyl-amino or an amino-alkyl group containing a primary or a secondary amino group; and B is ammonium ion or an alkyl... | 06/28/1994 |
