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| Number | Title | Issue Date |
| 7888528 | Photosensitive self-assembled monolayer for selective placement of hydrophilic structures A photosensitive monolayer is self-assembled on an oxide surface. The chemical compound of the photosensitive monolayer has three components. A first end group provides covalent bonds with the oxide surface for self assembly on the oxide surface. A photosensitive gr... | 02/15/2011 |
| 7345033 | Carbamoyl-and thiocarbamoyl-phosphonates and pharmaceutical compositions comprising them The present invention provides a compound of the following formula I: R3—NH—C(═X)—P(═O)OR1OR2 including pharmaceutically acceptable salts, solvates, hydrates and polymorphs of the compounds of formula I... | 03/18/2008 |
| 7226991 | Phenylalanine derivatives Disclosed herein are phenylalanine derivative compounds of the following formula W—Y—(AA)n—Z wherein Y is a phenylalanyl radical, AA is an amino acid, n is an integer of 1 to 15, and substituent variables W and Z are as described... | 06/05/2007 |
| 7157092 | Acyl pseudodipeptides, preparation method and pharmaceutical compositions containing same Compounds of the formula wherein the substitutents are defined as in the specification useful for modulating immune responses in warm-blooded animals. ... | 01/02/2007 |
| 7119220 | Process for preparing dimethyl propanephosphonate Process for preparing dimethyl propanephosphonate, characterized in that dimethyl phosphite is reacted with propene in the presence of a free-radical former at a reaction temperature of 60 to 95° C., the half life of the free-radical former being 0.1 to 20 min at t... | 10/10/2006 |
| 6919322 | Phenyl Phosphonate Fructose-1,6-Bisphosphatase Inhibitors Novel FBPase inhibitors of the formula I are useful in the treatment of diabetes and other conditions associated with elevated blood glucose. ... | 07/19/2005 |
| 6902608 | Dental material containing phosphonic acids The invention relates to dental materials which contain hydrolysis-resistant phosphonic acids with ethylenically unsaturated double bonds and which are especially suitable for use as adhesion promoters. ... | 06/07/2005 |
| 6737416 | Phosphonic acid derivative having inhibitory activity against carboxypeptidase B A compound represented by the following general formula (I) and a pharmacologically acceptable salt thereof: wherein R1 represents hydrogen atom, an alkyl group, a substituted alkyl group and the like; R2... | 05/18/2004 |
| 6576627 | Phosphonic acid derivatives having carboxypeptidase b inhibitory activity A compound represented by the following general formula (I) and a pharmacologically acceptable salt thereof: ##STR1## wherein R1 represents hydrogen atom, an alkyl group, a substituted alkyl group and the like; R2 and R3 r... | 06/10/2003 |
| 6576766 | Signal transduction inhibitors, compositions containing them This invention concerns compounds for inhibiting intracellular signal transduction, especially intracellular signal transduction mediate by one or more molecular interactions involving a phosphotyrosine-containing protein. This invention also relates to p... | 06/10/2003 |
| 6509324 | Chelating compounds, their complexes with paramagnetic metals Compounds able to chelate bi- and trivalent paramagnetic metal ions, their chelated complexes with these metal ions and physiologically compatible salts thereof and therein magnetic resonance imaging.... | 01/21/2003 |
| 6451776 | Water soluble prodrugs of hindered alcohols The present invention is directed to novel water-soluble prodrugs of aliphatic or aromatic hindered hydroxyl group containing pharmaceuticals.... | 09/17/2002 |
| 6306840 | Cell adhesion inhibitors The present invention relates to novel compounds that are useful for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. This invention also relates to pharmaceutical formulations comprising these compounds and methods of us... | 10/23/2001 |
| 6284914 | Highly water-soluble metalloproteinase inhibitors New compounds of general formulae (III), (IV) and (V). ##STR1##... | 09/04/2001 |
| 6242433 | Geranylgeranyl-derivatives, process for the preparation thereof and related pharmaceutical compositions The present invention relates to novel geranylgeranyl derivatives and the pharmaceutically acceptable salts thereof having antiproliferative activity in eukaryotic cells with respect to the inhibition of protein geranygeranylation. The invention also rela... | 06/05/2001 |
| 6214877 | 2,3,5-substituted biphenyls useful in the treatment of insulin resistance and hyperglycemia This invention provides compounds of Formula I having the structure ##STR1## wherein: B, C, D, and R1 are as defined hereinbefore in the specification, or a pharmaceutically acceptable salt thereof, which are useful in treating metabolic disord... | 04/10/2001 |
| 6184214 | Pharmaceutical formulations A pharmaceutical composition is provided comprising an effective amount of a phosphoenolpyruvate compound of the formula: ##STR1## wherein R1 and R2 are independently H, alky, alkenyl, alkoxy (except where applied to OR1),... | 02/06/2001 |
| 6143776 | Tosylproline analogs as thymidylate synthase inhibitors Tosylproline analogs of formula I, methods of making them, pharmaceutical compositions containing them, and methods for their use. The compounds are thymidylate synthase inhibitors; and are useful as anti-tumor agents and as anti-parasitics, anti-bacteria... | 11/07/2000 |
| 6136798 | Compounds inhibiting the association of the PDGF receptor and phosphatidylinositol 3-kinase and their use The present invention provides compounds that inhibit the association of platelet-derived growth factor and phosphatidylinositol 3-kinase. The present invention also provides pharmaceutical compositions that contain a compound that inhibits the associatio... | 10/24/2000 |
| 6096730 | Phosphonated agents and their antiangiogenic and antitumorigenic use Phosphonic acid agents are synthesized and characterized which are potent inhibitors of angiogenesis, tumorigenesis and metalloproteinase activity. Their method of use for the inhibition of angiogenesis and metalloproteinase and the treatment of tumors is... | 08/01/2000 |
| 6090850 | Naphthyl glyoxamides as SPLA2 inhibitors A class of novel naphthyl glyoxamide compounds of formula (I) is disclosed together with a process for making the novel naphthyl glyoxamide compounds and the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatme... | 07/18/2000 |
| 5968916 | Fluoroalkenyl compounds and their use as pest control agents Fluorinated alkene compounds useful for and methods of controlling nematodes, insects, and acarids that prey on agricultural crops. Polar compounds are particularly useful for systemic control of pests.... | 10/19/1999 |
| 5955452 | Covalent lipid-phosphono-carboxylic acid conjugates and application thereof as antiviral medicaments The present invention concerns new lipid derivatives of phosphonocarboxylic acids of the general formula I, ##STR1## in which the meaning of the symbols is elucidated in the description, tautomers thereof and their physiologically tolerated salts of ... | 09/21/1999 |
| 5922697 | Compounds, compositions and methods for inhibiting the binding of proteins containing an SH2 domain to cognate phosphorylated proteins The present invention provides compounds that inhibit the binding of proteins containing an SH2 domain to cognate phosphorylated proteins. The invention also provides pharmaceutical compositions containing the compounds and methods of inhibiting the bindi... | 07/13/1999 |
| 5916922 | Phenyl glyoxamides as SPLA2 inhibitors A class of novel phenyl glyoxamides is disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of conditions such as septic shock.... | 06/29/1999 |
| 5914319 | Antithrombotic agents This invention relates to thrombin inhibiting compounds having the Formula I X--Y--NH--(CH2)r --G I where X, Y, r and G have the values defined in the description, as well as pharmaceutical formulations contain... | 06/22/1999 |
| 5886217 | Method of producing aryl-substituted, amino-acylated phosphonic-acid derivatives with the aid of metal complexes of chiral, amphiphilic ligands The invention is relates to a method of producing aryl-substituted, amino-acylated phosphonic-acid derivatives with the aid of metal complexes of chiral amphiphilic ligands in that according to the invention -N-acyl-protected, ଲ-substituted a... | 03/23/1999 |
| 5824661 | Sulfur-containing phosphonate compounds, pharmaceutical compositions, and methods of treating abnormal calcium and phosphate metabolism Compounds of the formula ##STR1## where m and n are integers 0 to 10 and m+n equals 0 to 10, (a) X is O or S (b) Z is a covalent bond; a monocyclic or polycyclic carbocycle ring moiety; or a monocyclic or polycyclic heterocyclic ring moiety containing ... | 10/20/1998 |
| 5739123 | Phosphinic acid derivatives with metallopeptidase inhibitory activity Compounds of formula (I), ##STR1## wherein R is a biphenyl group optionally substituted, by one or more substituents, the same or different selected among halogen atoms, hydroxy groups, alkoxy, alkyl thioalkyl or alkoxycarbonyl groups having from 1 t... | 04/14/1998 |
| 5726159 | Antithrombotic agents This invention relates to thrombin inhibiting compounds having the Formula I X--Y--NH--(CH2)r --G I where X, Y, r and G have the values defined in the description, as well as pharmaceutical formulations containi... | 03/10/1998 |
| 5716943 | Phosphinic acid derivatives with metallopeptidase inhibitory activity Compounds of formula ##STR1## wherein R, R1, R2, R3, R4 and n have the meanings reported in the description are described. The compounds of formula I are endowed with a dual ACE-inhibitory and NEP-inhibitor... | 02/10/1998 |
| 5710130 | Antithrombotic agents This invention relates to thrombin inhibiting compounds having the Formula I X--Y--NH--(CH2)r --G I where X, Y, r and G have the values defined in the description, as well as pharmaceutical formulations containi... | 01/20/1998 |
| 5707966 | Antithrombotic agents This invention relates to thrombin inhibiting compounds having the Formula I X--Y--NH--(CH2)r --G I where X, Y, r and G have the values defined in the description, as well as pharmaceutical formulations containi... | 01/13/1998 |
| 5707967 | Pain relief compositions Disclosed are compositions containing either aspartame or monosodium glutanate combined with an amino acid.... | 01/13/1998 |
| 5707979 | Phosphinic acid derivatives, their preparation and their use Compounds of the formula I, ##STR1## in which the symbols or substituents A, B, D, D*, E and E* have the meanings given in the specification, inhibit aspartyl proteases and are suitable for controlling viral diseases.... | 01/13/1998 |
| 5705487 | Antithrombotic agents This invention relates to thrombin inhibiting compounds having the Formula I X--Y--NH--(CH2)r --G I where X, Y, r and G have the values defined in the description, as well as pharmaceutical formulations containi... | 01/06/1998 |
| 5703263 | Process for making chiral alpha-amino phosphonates and selected novel chiral alpha-amino phosphonates This invention is selected novel chiral (essentially pure) alpha-amino phosphonates, process for the preparation which is a catalytic asymmetric hydrogenation of olefins and novel intermediates therefor. The alpha-amino phosphonates are useful as antibiot... | 12/30/1997 |
| 5679842 | Process for the preparation of aminomethanephosphonic acid and aminomethylphosphinic acids Aminomethanephosphonic acid and aminomethylphosphinic acids are interesting as biologically active compounds or as intermediates for the preparation of biologically active compounds. According to the invention, such compounds of the formula I ##STR1#... | 10/21/1997 |
| 5654462 | Process for making chiral alpha-amino phosphonates and selected novel chiral alpha-amino phosphonates This invention is selected novel chiral (essentially pure) alpha-amino phosphonates, process for the preparation which is a catalytic asymmetric hydrogenation of olefins and novel intermediates therefor. The alpha-amino phosphonates are useful as antibiot... | 08/05/1997 |
| 5639732 | Phosphorous-containing cysteine and serine protease inhibitors The present invention is directed to novel phosphorous-containing inhibitors of cysteine or serine proteases. Methods for the use of the protease inhibitors are also described.... | 06/17/1997 |
