Bizarre Patents
User-operated amusement apparatus for kicking the user's buttocks
An apparatus including a user-operated and controlled apparatus for self-infliction of repetitive blows to the user's buttocks by a plurality of elongated arms bearing flexible extensions that rotate under the user's control.
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| Number | Title | Issue Date |
| 7875741 | Site-specific inhibitors of histone methyltransferase [HMTase] and process of preparation thereof The present invention relates to compounds of structural formula I as site-specific inhibitors of histone methyltransferase, where R1 and R1 is —OCH3 or —OH, R2 and R2 is —OH or —OAc; a process of isolat... | 01/25/2011 |
| 7442418 | Polymerizable liquid crystal compound, liquid crystal composition, optical anisotropic material and optical element The present compound represented by formula(I) CH2═CR1—COO—(L)k-E1-E2-E3-(E4)m-(E5)n-R2 (1) provided that the symb... | 10/28/2008 |
| 7427685 | Therapeutic substituted cyclopentanes Therapeutic compounds according to one of the structures below are disclosed herein. ... | 09/23/2008 |
| 7425603 | Polymers, polymer compositions, and method of preparation A polymer comprising structural units derived from a polycyclic dihydroxy compound of Formula (I) wherein R1, R2 and R3 are independently at each occurrence selected from the group consistin... | 09/16/2008 |
| 7358052 | Catalytic amplification of multiplexed assay signals Methods, compositions, kits, and a system are disclosed for detecting one or more analytes in a sample. A mixture comprising the (i) sample, (ii) a first binding reagent comprising a cleavage-inducing moiety and a first binding agent specific for an analyte, and (ii... | 04/15/2008 |
| 7279585 | Lipophilic electrophoretic probes Compounds, compositions, and methods for labeling membranes are disclosed. Compounds of formula G-L-E are described wherein G is a lipophilic group, L is a cleavable linkage and E is an electrophoretic group. The compounds become associated with membranes, and can b... | 10/09/2007 |
| 7255999 | Methods and compositions for analyzing proteins Methods, compositions and kits are disclosed for determining one or more target polypeptides in a sample where the target polypeptides have undergone a post-translational modification. A mixture comprising the sample and a first reagent comprising a cleavage-inducin... | 08/14/2007 |
| 7247434 | Methods and compositions for determining the sequence of nucleic acid molecules Methods and compounds, including compositions therefrom, are provided for determining the sequence of nucleic acid molecules. The methods permit the determination of multiple nucleic acid sequences simultaneously. The compounds are used as tags to generate tagged nu... | 07/24/2007 |
| 7232821 | (2-((2-alkoxy)-phenyl) -cyclopent-1enyl) aromatic carbo and heterocyclic acid and derivatives Compounds of formula (I) or a pharmaceutically acceptable derivative thereof: wherein A, R1, R2, Rx, R8, R9 and n are as defined in the specification, a proc... | 06/19/2007 |
| 7226951 | Compounds having selective cytochrome P450RAI-1 or selective cytochrome P450RAI-2 inhibitory activity and methods of obtaining the same Compounds of formulas 1 through 17 provided in the specification specifically or selectively inhibit either the cytochrome P450RAI-1 enzyme or the cytochrome P450RAI-2 enzyme. ... | 06/05/2007 |
| 7217531 | Multiplex analysis using membrane-bound sensitizers The present invention is directed to methods and compositions for determining the presence, absence, and/or amounts of one or more membrane-associated analytes in a sample. In accordance with the invention, binding compounds derivatized with releasable molecular tag... | 05/15/2007 |
| 7195719 | High polarization ferroelectric liquid crystal compositions The invention relates to chiral nonracemic liquid crystal compounds having achiral tails comprising a perfluoroalkyl terminal portion which are useful as components in liquid crystal to impart high polarization to the mixture. The materials of this invention can be ... | 03/27/2007 |
| 7160735 | Tagged microparticle compositions and methods Compositions and methods are disclosed for detecting multiple target analytes in a sample using microparticles having molecular tags attached by cleavable linkages. Generally, an assay mixture is formed comprising a sample and a reagent comprising multiple such micr... | 01/09/2007 |
| 7135300 | Profiling frequencies of receptor heterodimers Methods are provided for detecting formation of oligomeric complexes of molecules on the surface of cell membranes. These methods employ pairs of tagged probes and cleaving probes, each of which binds specificly to a cell surface molecule. The tagged probe includes ... | 11/14/2006 |
| 7132519 | Releasable nonvolatile mass-label molecules Releasable tag reagents for use in the detection and analysis of target molecules, particular in mass spectrometric analyses are provided. Also provided are methods of detection that employ releasable tag reagents. ... | 11/07/2006 |
| 7105308 | Detecting receptor oligomerization Methods are provided for detecting formation of oligomeric complexes of molecules on the surface of cell membranes. These methods employ pairs of tagged probes and cleaving probes, each of which binds specificly to a cell surface molecule. The tagged probe includes ... | 09/12/2006 |
| 7083832 | Partially fluorinated liquid crystal material The invention provides LC compositions that exhibit V-shaped switching when aligned in an analog device configuration and exhibit bistability when aligned in a bookshelf-type device configuration. The invention more specifically provides LC compositions of formula 1... | 08/01/2006 |
| 7052846 | Methods and compositions for analyzing nucleic acid molecules utilizing sizing techniques Tags and linkers specifically designed for a wide variety of nucleic acid reactions are disclosed, which are suitable for a wide variety of nucleic acid reactions wherein separation of nucleic acid molecules based upon size is required. ... | 05/30/2006 |
| 7045311 | Whole cell assay systems for cell surface proteases The activity of a cell surface protease, particularly an ADAM, is determined in a rapid and sensitive assay employing a whole cell system. The assays are effective to identify effector molecules that affect the activity of a cell surface protease directly or indirec... | 05/16/2006 |
| 7041459 | Analyzing phosphorylated proteins Methods, compositions and kits are disclosed for determining one or more target polypeptides in a sample where the target polypeptides have undergone phosphorylation. A mixture comprising the sample and a first reagent comprising a cleavage-inducing moiety and an IM... | 05/09/2006 |
| 7037914 | Carboxylic acid derivative and a pharmaceutical composition containing the derivative as active ingredient A peroxisome proliferator activated receptor regulator containing a carboxylic acid derivative of formula (I) (wherein all symbols are as defined in the specification), a non-toxic acid thereof or a hydrate thereof as ... | 05/02/2006 |
| 7001725 | Kits employing generalized target-binding e-tag probes Kits for the multiplexed detection of the binding of, or interaction between, one or more ligands and target antiligands are provided. Detection involves the release of identifying tags as a consequence of target recognition. The kits include sets of electrophoretic... | 02/21/2006 |
| 6960681 | Guanidinomethyl cyclohexane carboxylic acid ester derivatives The invention relates to novel and valuable intermediate compounds of the general formula (VIII) which can be used for the preparation of novel compounds comprising an antibacterial action, especially with a strong antibacterial action against helicobacter pylori... | 11/01/2005 |
| 6949347 | Multiplex analysis using membrane-bound sensitizers The present invention is directed to methods and compositions for determining the presence, absence, and/or amounts of one or more membrane-associated analytes in a sample. In accordance with the invention, binding compounds derivatized with releasable molecular tag... | 09/27/2005 |
| 6936638 | Ligands of adenine nucleotide translocase (ANT) and compositions and methods related thereto Compounds which have utility in the treatment of conditions associated with altered mitochondrial function. The compounds have the following structure (I): including stereoisomers, prodrugs, and pharmaceutically accept... | 08/30/2005 |
| 6909012 | Diflunisal esters and related compounds O-medium alkyl esters of diflunisal and related compounds are disclosed having anti-platelet activity, hydroxy radical scavenging properties, enhanced hepatic clearance and low ulcerogenic potential. These compounds have general formula (I) wherein n equals 3-13. | 06/21/2005 |
| 6903082 | Methods of treating inflammatory conditions of the gastrointestinal tract using 4-APAA and compositions thereof Compounds are disclosed having the structure of Formula I: where R1, R3, and R4 are independently hydrogen or C1 to C4 alkyl, and R2 is: | 06/07/2005 |
| 6869967 | Peroxisome proliferator-activated receptor (PPAR) active vinyl carboxylic acid derivatives Novel compounds of the general formula (I), the use of these compounds as pharmaceutical compositions, pharmaceutical compositions comprising the compounds and methods of treatment employing these compounds and compositions. The present compounds may be useful in th... | 03/22/2005 |
| 6831190 | Guanidinomethyl cyclohexane carboxylic acid ester derivatives The invention relates to novel and valuable intermediate compounds of the general formula (VIII) which can be used for the preparation of novel compounds comprising an antibacterial action, especially with a strong antibacterial action against helicobacter pylori... | 12/14/2004 |
| 6762315 | Method for producing (1,1′,4, 11″)-terphenyl compounds The invention relates to a method for producing [1,1′:4′,1″]-terphenyl compounds of the formula which comprises reacting a metal aryl of the formula with a boric ester ... | 07/13/2004 |
| 6677475 | Optically active compound and liquid crystal composition containing the compound Optically active compounds of the following general formula (1) useful as chiral dopant, ##STR1## wherein n is an integer of 0 to 5, provided that when n is 0, A is a single bond (--) and that when n is 1 to 5, A is a single bond (--), --O--, --C... | 01/13/2004 |
| 6653499 | Photoactive propane derivatives and orientation layers Compounds of formula (I) may be used as alignment layers in liquid crystal devices wherein X1-5 are idependently selected from H, F, CN, phenylene, C1-10 alkyl, whereby when X1 =X2, then X1,2 =H and w... | 11/25/2003 |
| 6627656 | Method of treatment using phenyl and biaryl derivatives as prostaglandin E inhibitors and compounds useful therefore This invention encompasses a method for the treatment or prevention of prostaglandin mediated diseases comprising administering to a mammalian patient a compound of formula I: ##STR1## in an amount that is effective to treat or prevent said prostaglandin ... | 09/30/2003 |
| 6596193 | Electrooptical liquid crystal system To improve switching times, especially at low temperatures, one or more reactive liquid crystalline compounds is added to a liquid crystal mixture used in an electrooptical system. The electrooptical system comprises a PDLC film comprising a liquid crysta... | 07/22/2003 |
| 6565769 | Electrooptical liquid crystal system To improve switching times, especially at low temperatures, one or more reactive liquid crystalline compounds is added to a liquid crystal mixture used in an electrooptical system. The electrooptical system comprises a PDLC film comprising a liquid crystal mix... | 05/20/2003 |
| 6555577 | Compounds, their preparation and use The present invention relates to compounds of the general formula (I) ##STR1## The compounds are useful in the treatment and/or prevention of conditions mediated by nuclear receptors, in particular the Peroxisome Proliferator-Activated Receptors (PPAR).... | 04/29/2003 |
| 6518306 | 1,4-substitued 4,4-diaryl cyclohexanes This invention relates to compounds of Formula (I) where Z is an amine, alcohol or derivative thereof, and the ketone analog thereof.... | 02/11/2003 |
| 6515021 | Bicyclic aromatic compounds The invention relates to novel bicyclic aromatic compounds which have the general formula (I): ##STR1## as well as to the use of these compounds in pharmaceutical compositions intended for use in human or veterinary medicine (dermatological, rheumati... | 02/04/2003 |
| 6452022 | Method for preparing substituted 4-phenyl-4-cyanocyclohexanoic acids This invention relates to a method of preparing a compound type where at least one of R' or R" is a carboxyl group (I) by treating a compound of formula (II) with a Group I(a) or Group II(a) metal halide, with an aprotic dipolar amide-based solvent and wa... | 09/17/2002 |
| 6376546 | Biphenyl-5-alkanoic acid derivatives and use thereof ##STR1## Compounds represented by general formula I or salts thereof, wherein n is an integer of 2 or 3; R represents a straight-chain or branched saturated alkyl group having 4 or 4 carbon atoms, a cyclopentyl group, a cyclohexyl group or the like, Y rep... | 04/23/2002 |
