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| Number | Title | Issue Date |
| 8188307 | Method for producing an optically active tetrahydroquinoline Disclosed is an industrially advantageous production method of optically active β-amino acid of formula (5a), which includes subjecting an enaminoester of formula (4a) to an asymmetric hydrogenation: ... | 05/29/2012 |
| 7872151 | Inhibitors of αmediated cell adhesion The present invention relates to a phenylalanine derivative of Formula (I) wherein X1 is a halogen atom, X2 is a halogen atom, Q is a CH2R— is a carboxyl group which may be esterified; or a pharmaceutically acceptable salt thereof.... | 01/18/2011 |
| 7612225 | Crystal of triterpene derivative Disclosed herein are a novel crystal of a novel triterpene derivative, a method for producing the crystals, and a pharmaceutical preparation obtained by using the crystals. The novel crystal is a crystal of a compound (I) of the formula (I): | 11/03/2009 |
| 7414040 | Thrombopoietin mimetics Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comp... | 08/19/2008 |
| 7408078 | Anthranilic acid derivatives useful in treating infection with hepatitis C virus The present invention provides pharmaceutical compositions useful in treating hepatitis C infection. The present invention also provides methods of treating hepatitis C infection by administering to a mammal the pharmaceutical compositions of the present invention. | 08/05/2008 |
| 7381831 | Colorant compounds Disclosed is a compound of the formula and dimers thereof, wherein R, R2, X and Z are as described herein. The compounds are useful as colorants, particularly in applications such as phase change inks. ... | 06/03/2008 |
| 7371867 | Non-racemic trifluoroleucine, and methods of making and using One aspect of the invention relates to hexafluoroleucine and congeners thereof, and methods of making the compounds. Another aspect of the invention relates to the synthesis of protein cores comprising hexafluoroleucine and congeners thereof. Certain peptides compri... | 05/13/2008 |
| 7351849 | Process for producing optically active β-amino acid derivatives The present invention is to provide a method for producing the desired optically active β-amino acid derivatives of high optical purities in high yields, without requiring a step of deprotection. More particularly, the present invention relates to a method for prod... | 04/01/2008 |
| 7351719 | Amide compounds having MCH-antagonistic activity and medicaments comprising these compounds The present invention relates to amide compounds of general formula I wherein the groups and residues A, B, b, W, X, Y, Z, R1, R2 and R3 have the meanings given in claim 1. Moreover t... | 04/01/2008 |
| 7312031 | Alpha-complementation viral fusion assay The present invention relates to the use of an alpha complementation assay as a quick, effective, and safe method for the detection of cell fusion mediated by viral proteins. Additionally, the method disclosed herein permits the identification of inhibitors of cell ... | 12/25/2007 |
| 7253192 | Phenyl derivatives comprising an acetylene group This invention is concerned with compounds of the formula I: wherein one of R5, R6 and R7 is and X1, X2 | 08/07/2007 |
| 7247654 | 3,4-disubstituted benzamidines and benzylamines, and analogues thereof, useful as serine protease inhibitors The present invention relates generally to compounds that inhibit serine proteases. In particular it is directed to novel 3,4-disubstituted benzamidines and benzylamines, or a stereoisomer or pharmaceutically acceptable salt form thereof, which are useful as selecti... | 07/24/2007 |
| 7244864 | Process for the preparation of N,N-substituted 5-amino-1,3-benzenedicarboxamides The invention relates to a process for the preparation of a compound of formula (I), wherein R represents a 2,3-dihydroxy-1-propyl or a 1,3-dihydroxy-2-propyl radical, via direct amidation of a dialkyl ester of 5-amino-1,3-benzenedicarboxylic acid of formula (V), wh... | 07/17/2007 |
| 7235587 | Diesters containing two crylene or fluorene moieties, sunscreen compositions containing the same, and methods of photostabilizing a sunscreen compositions containing the same Diesters that include one or more of a crylene and/or a fluorene moiety, and sunscreen compositions including a mixture of a photoactive compound and one or more of a diester that includes one or more of a crylene and/or a fluorene moiety are described herein. Also ... | 06/26/2007 |
| 7202275 | Malonamic acids and derivatives thereof as thyroid receptor ligands The present invention relates to novel thyroid receptor ligands and, more particularly, relates to malonamic acids and derivatives thereof of Formula I, which are useful in the treatment of obesity, overweight condition, hyperlipidemia, glaucoma, cardiac arrhythmias... | 04/10/2007 |
| 7147864 | Methods for preventing photodamaged skin by administering selegiline or desmethylselegiline The present invention is directed to methods that can be used in the treatment of wounds, burns, and photodamaged skin. Methods can be used for both humans and animals and involve the administration of compositions containing selegiline and/or desmethylselegiline. | 12/12/2006 |
| 7145030 | Production method for optically active N-aryl-β-amino acid compounds The present invention provides an effective method for the production of optically active N-aryl-β-amino acid compounds, which at the same time is suitable for industrial production. In the method of the present invention optically active sulfonylated β-hydroxycar... | 12/05/2006 |
| 7138539 | Colorant compounds containing copolymerizable vinyl groups Disclosed are novel colorant compounds which contain one or more ethylenically-unsaturated (vinyl), photopolymerizable radicals which may be copolymewrized (or cured) with ethylenically-unsaturated monomers to produce colored compositions such as colored acrylic coa... | 11/21/2006 |
| 7132559 | Non-racemic hexafluoroleucine, and methods of making and using it One aspect of the invention relates to hexafluoroleucine and congeners thereof, and methods of making the compounds. Another aspect of the nvention relates to the synthesis of protein cores comprising hexafluoroleucine and congeners thereof. Certain peptides compris... | 11/07/2006 |
| 7125991 | Compounds derived from benzoic acid esters, composition containing said compounds and use thereof The invention relates to novel compounds of formula (I) wherein R1 represents a polymer, aryl or alkyl group, R2 represents a hydrogen atom, a halogen atom, a radical CN, CF3, OH, OCF3, COOH, R7, OR7 ... | 10/24/2006 |
| 7115767 | Tetraline derivatives as ghrelin receptor modulators The present invention is related to compounds of formula (I), or a therapeutically suitable salt or prodrug thereof, the preparation of the compounds, compositions containing the compounds and the use of the comp... | 10/03/2006 |
| 7087778 | Process for producing benzoxazine derivative and production intermediate thereof Processes for producing antibacterial agents and intermediates useful in producing antibacterial agents are provided and include producing compound (VI-a) in accordance with the following reaction schema, as well as production intermediates thereof | 08/08/2006 |
| 7034015 | Aminobenzoephenones The invention relates to a novel class of aminobenzophenones derivatives, to pharmaceutical preparations comprising said compounds, to dosage units of such preparations, to methods of treating patients comprising administering said compounds, and to the use of said ... | 04/25/2006 |
| 6989384 | Antipicornaviral compounds and compositions, their pharmaceutical uses, and materials for their synthesis Compounds of the formula: where the formula variables are as defined in the disclosure, advantageously inhibit or block the biological activity of the picomaviral 3C protease. These compounds, as well as pharmaceutical ... | 01/24/2006 |
| 6960604 | Thyroid receptor ligands The invention provides thiazolidinedione, oxadiazolidinedione, and triazolone compounds of Formula (I) which compounds are thyroid receptor ligands. The invention further provides pharmaceutical compositions and kits com... | 11/01/2005 |
| 6949575 | Method of inhibiting amyloid protein aggregation and imaging amyloid deposits using aminoindane derivatives The present invention provides compounds of Formula (I) and a method of treating Alzheimer's disease using a compound of Formula (I), wherein: R1 and R2 include alkyl and phenylalkyl; R3 is hydrogen or alkyl; and R4 and R | 09/27/2005 |
| 6924310 | Malonamic acids and derivatives thereof as thyroid receptor ligands The present invention relates to novel thyroid receptor ligands and, more particularly, relates to malonamic acids and derivatives thereof of Formula I, which are useful in the treatment of obesity, overweight condition, hyperlipidemia, glaucoma, cardiac arrhythmias... | 08/02/2005 |
| 6919473 | Photostabilizers, UV absorbers, and methods of photostabilizing a sunscreen composition Derivatives of fluorene, including ester derivatives of cyano(9H-fluoren-9-ylidene) acetic acid, and sunscreen compositions including a mixture of a photoactive compound and an ester derivative of cyano(9H-fluoren-9-ylidene) acetic acid are disclosed herein. Also di... | 07/19/2005 |
| 6908934 | Therapeutic compounds for treating dyslipidemic conditions Compounds of Formula I and the pharmaceutically acceptable salts and esters thereof, wherein Z is selected from the group consisting of: (a) Formula Ia | 06/21/2005 |
| 6861391 | Trifluoromethyl-substituted spirocyclic ketoenols Trifluoromethyl-substituted spirocyclic ketoenols of the formula (I) are provided wherein Het represents one of the groups and G, V, W, X, Y, and Z are as defin... | 03/01/2005 |
| 6852876 | Treatment of colon cancer The novel compound of the disclosure is 4-chloro-4-(4-ethoxy-phenyl)-2-(fluoren-9-ylidene-hydrazono)-but-3-enoic acid methyl ester (3F-19), and it alone or in combination with 4-(4-Ethoxy-phenyl)-2-(N′-fluoren-9-ylidene-hydrazino)-2-hydroxy-4-oxo-butyric acid meth... | 02/08/2005 |
| 6844003 | Compounds derived from benzoic acid esters, composition containing said compounds and use thereof The invention relates to novel compounds of formula (I) wherein R1 represents a polymer, aryl or alkyl group, R2 presents a hydrogen atom, a halogen atom, a radical CN, CF3, OH, OCF3, COOH, R7, OR7 or... | 01/18/2005 |
| 6835848 | One-pot synthesis of alkyl 3-cyclopropylamino-2-[2,4-dibromo-3-(difluromethoxy) benzoyl]-2-propenoate as a useful intermediate for antibacterial quinolone medicaments The present invention relates to a new and industrially advantageous one-pot process for the preparation of alkyl 3-cyclopropyl amino-2-[2,4-dibromo-3-(difluoromethoxy) benzoyl]-2-propenoates of in which R represents methyl or ethyl, which are valuable intermediates... | 12/28/2004 |
| 6806381 | Process for the preparation of aniline-derived thyroid receptor ligands Provided are processes for the synthesis of aniline derivatives, specifically certain aniline derivatives which have activity as thyroid receptor ligands. ... | 10/19/2004 |
| 6787562 | Substituted aryl and heteroaryl compounds as E-type prostaglandin antagonists Compounds of the formula I; useful for the treatment of pain wherein A, Z, B, R1, X and D are as defined in the specification, methods of making such compounds, methods of using such compounds and pharmaceutical c... | 09/07/2004 |
| 6780874 | Enamine derivatives Enamine derivatives of formula (1) are described: wherein R1 is a group Ar1L2Ar2Alk- in, which Ar1 is an aromatic or heteroaromatic group, L2 is a ... | 08/24/2004 |
| 6765021 | 2,3,5-substituted biphenyls useful in the treatment of insulin resistance and hyperglycemia This invention provides compounds of formula I having the structure wherein: B, D, C, and R1 as defined herein. ... | 07/20/2004 |
| 6743940 | 4-aminobut-2-ynecarboxylic acid derivatives There are described 4-aminobut-2-ynecarboxylic acid derivatives of formula wherein R1 and R2 are each independently of the other hydrogen, C1-C20alkyl; C3-C | 06/01/2004 |
| 6696489 | 2-Methylpropionic acid derivatives and medicinal compositions containing the same The present invention provides novel 2-methylpropionic acid derivatives represented by the general formula: ##STR1## (wherein R1 represents a hydrogen atom, a lower alkyl group or an aralkyl group; R2 represents a hydrogen atom a low... | 02/24/2004 |
| 6689897 | Intermediates of CETP inhibitors This invention relates to intermediates useful in the preparation of CETP inhibitors and methods of preparation thereof.... | 02/10/2004 |
