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| Number | Title | Issue Date |
| 8093420 | Functionalized amino acids and absorbable polymers therefrom The present invention relates to compounds of formula I and II, which are functionalized amino acids, and polymers formed from the same. Polymers formed from the functionalized amino acids are expected to have controllable de... | 01/10/2012 |
| 7935843 | Functionalized diphenolics and absorbable polymers therefrom The present invention relates to dephenolic compounds, an example of which is shown below, which are functionalized, and polymers formed from the same. Polymers formed from the functionalized diphenolics are expected to hav... | 05/03/2011 |
| 7368169 | Hydrazide compounds with angiogenic activity Compounds exhibiting angiogenic properties incorporating the structure of Formula I: R3—NH—NH—C(═O)—R2—P—R1 (I) wherein P is a water-soluble, biodegradable polymer, R1 is hydrogen, l... | 05/06/2008 |
| 7326430 | Method of preparing liquid compositions for delivery of N-[N- (3,3-dimethylbutyl-L-α-aspartyl]-L-phenylalanine 1-methyl ester in food and beverage systems This invention provides a method for preparing a liquid composition of N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester comprising the steps of (a) providing a liquid carrier; and (b) mixing N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalani... | 02/05/2008 |
| 7288670 | Synthesis of N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester using 3,3-dimethylbutyraldehyde precursors N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester is produced by hydrogenation of L-α-aspartyl-L-phenylalanine 1-methyl ester and 3,3-dimethylbutyraldehyde produced in situ by the hydrolysis or cleavage of a 3,3-dimethylbutyraldehyde precursor.... | 10/30/2007 |
| 7271234 | Polyarylates for drug delivery and tissue engineering Biocompatible polyarylates of tyrosine-derived diphenol compounds and poly(alkylene oxide) dicarboxylic acids, articles formed therefrom and therapeutic uses are disclosed. ... | 09/18/2007 |
| 7247724 | Method for the production of phenylalanine derivatives The invention relates to an improved method for the production of 3-amidinophenylalanine derivatives, especially triisopropylphenyl-sulfonyl-substituted 3-amidinophenylalanine derivatives. ... | 07/24/2007 |
| 7193103 | Synthesis of N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester using oxazolidinone derivatives Synthesis of N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester by treating N-(3,3-dimethylbutyl)-L-aspartic acid with ketones to give oxazolidinone derivatives, which are condensed with L-phenylalanine methyl ester. ... | 03/20/2007 |
| 7183425 | Diastereoselective reductive amination process This invention describes a reductive amination process whereby perfluorinated ketones or ketals are combined with α-aminoesters under basic conditions to form metal carboxylates. Diastereoselective reductions of the metal carboxylates enable access to two diastereo... | 02/27/2007 |
| 7141263 | Process for producing cinnamaldehyde derivatives, use thereof and the like A process for conveniently and efficiently producing a highly pure cinnamaldehyde derivative, for example, (2E)-(3-hydroxy-4-methoxy)cinnamaldehyde, which comprises reacting a benzaldehyde derivative, such as isovanillin and the like, with acetaldehyde in the presen... | 11/28/2006 |
| 7115296 | N-alkylaspartyl amide derivative and sweetening agent The present invention relates to a novel N-alkylaspartyl amide derivative, a salt form thereof, a sweetening agent containing the same and a sweetened food or drink containing the N-alkylaspartyl amide derivative as an effective ingredient. ... | 10/03/2006 |
| 7060708 | Active agent delivery systems and methods for protecting and administering active agents The present invention relates to active agent delivery systems and more specifically to compositions that comprise amino acids, as single amino acids or peptides, covalently attached to active agents and methods for administering conjugated active agent compositions... | 06/13/2006 |
| 7056493 | Radio-opaque polymer biomaterials Iodinated and/or brominated derivatives of aromatic dihydroxy monomers are prepared and polymerized to form radio-opaque polymers. The monomers may also be copolymerized with other dihydroxy monomers. The iodinated and brominated aromatic dihydroxy monomers can be e... | 06/06/2006 |
| 7057038 | Kinetic resolutions of chiral 2- and 3-substituted carboxylic acids One aspect of the present invention relates to a method for the kinetic resolution of racemic and diastereomeric mixtures of chiral compounds. The critical elements of the method are: a non-racemic chiral tertiary-amine-containing catalyst; a racemic or diastereomer... | 06/06/2006 |
| 7053125 | Controlled dispersion of colloidal suspension by comb polymers Comb polymers are used as dispersants to increase the stability of colloidal suspensions containing multivalent or high concentrations of monovalent ions. Stabilized colloidal suspensions and methods of forming stabilized colloidal suspensions are described, includi... | 05/30/2006 |
| RE39088 | Amide compounds and use of the same An amide compound of the formula (I): wherein R is amino and the like, A is alkylene and the like, X is O, S and the like, M is arylene and the like, R1, R2, R3 and R4 ... | 05/02/2006 |
| 7026003 | Processes for preparing an aspartame slurry The present invention provides processes for preparing a slurry containing aspartame, which is stable and is useful as a sweetener; as well as methods of assessing the stability of an aspartame slurry. ... | 04/11/2006 |
| 6994791 | Adsorbent material and method of preparing an adsorbent material The present invention relates to an adsorbent material for chromatography comprising a polymer immobilized onto a support, wherein the polymer backbone is attached to the support by one or more linkages which comprise one or more amide groups. It further relates to ... | 02/07/2006 |
| 6989461 | Catalyst for asymmetric (transfer) hydrogenation Catalyst for the asymmetric (transfer) hydrogenation represented by the formula MLaXbSc, where M is a transition metal, to be chosen from rhodium and ruthenium, and X is a counter ion and S is a ligand, a ranges from 0.5 to 3 and b a... | 01/24/2006 |
| 6943182 | Cyclopentabenzofuran derivatives and their use The invention relates to cyclopentabenzofuran derivatives, process for their preparation, the use of cyclopentabenzofuran derivatives for the production of a medicament for the therapy of NF-κB-dependent diseases and medicaments which contain the cyclopentabenzofur... | 09/13/2005 |
| 6939987 | Method for producing Aspartame derivative, method for purifying the same, crystals thereof and uses of the same N-[N-[3-(3-methoxy-4-hydroxyphenyl)propyl]-L-α-aspartyl]-L-phenylalanine 1-methyl ester is prepared by a process comprising: subjecting Aspartame and 3-(3-methoxy-4-hydroxyphenyl)propionaldehyde or derivatives thereof to reductive... | 09/06/2005 |
| 6930200 | Multicomponent synthesis of amino acids and derivatives thereof Mono-substituted and di-substituted alpha-amino acids and derivatives thereof, substituted at the alpha positon with one (mono-) or two (di-) substituents (R2 and/or R3) as shown in Formula 1: N(R4R5)C(R2R3... | 08/16/2005 |
| 6919380 | Derivatives of C2-substituted indan-1-ol systems for the prophylaxis or treatment of obesity Derivatives of C2-substituted indan-1-ol compounds of formula I: its physiologically acceptable salts, and its physiologically functional derivatives for the prophylaxis or treatment of obesity are disclosed herein. Co... | 07/19/2005 |
| 6914151 | Crystallization processes for the formation of stable crystals of aspartame derivative A crystallization process for forming a stable crystal of N-(3,3-dimethylbutyl)-APM, which comprises using either water or a mixture of water with a lower alcohol as the crystallizing solvent and controlling the crystallization point to 30° C. or above; and another... | 07/05/2005 |
| 6899912 | Method for producing aspartame derivative, method for purifying the same, crystals thereof and uses of the same N-[N-[3-(3-methoxy-4-hydroxyphenyl)propyl]-L-α-aspartyl]-L-phenylalanine 1-methyl ester is prepared by a process comprising: subjecting Aspartame and 3-(3-methoxy-4-hydroxyphenyl)propionaldehyde or derivatives thereof to reductive... | 05/31/2005 |
| 6855843 | Inhibitors of α4 mediated cell adhesion The present invention relates to a pharmaceutical composition comprising as an active ingredient a compound of formula (I), wherein Ring A is an aromatic or a heterocyclic ring; Q is a bond, carbonyl, lower alkylene, lower alkenylene, —O— -(lower alkylene)-, etc... | 02/15/2005 |
| 6852875 | Synthesis of N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester using oxazolidinone derivatives Synthesis of N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester by treating N-(3,3-dimethylbutyl)-L-aspartic acid with ketones to give oxazolidinone derivatives, which are condensed with L-phenylalanine methyl ester. ... | 02/08/2005 |
| 6844465 | Method for preparing highly stable crystals of aspartame derivative Disclosed in the present application are a method for preparing highly-stable A-type crystals by controlling and maintaining the product temperature of B-type N-(3,3-dimethylbutyl)-APM crystals at 25 to 80° C. under an absolute humidity of 0.203 kg/kg or less envir... | 01/18/2005 |
| 6841183 | Process for producing aspartame derivatives, process for purifying aspartame derivatives, production intermediates, and process for producing production intermediates N-[N-[3-(2-hydroxy-substituted phenyl)propyl]-L-α-aspartyl]-L-phenylalanine 1-methyl ester derivatives, which are useful as sweeteners, may be conveniently produced by subjecting a 2-hydroxychroman derivative having various substituents on the benzene ring and aspa... | 01/11/2005 |
| 6822111 | Process for production of aspartyl dipeptide ester derivatives N-[N-[3-(phenyl having various substituent group(s) on the benzene ring)propyl]-L-α-aspartyl]-L-phenylalanine 1-methyl ester derivatives, which are useful as sweeteners, may be conveniently produced on an industrial scale at a high yield by reductively alkylating a... | 11/23/2004 |
| 6818243 | Crystals of aspartame derivative N-[N-[3-(3-hydroxy-4-methoxyphenyl)propyl]-L-α-aspartyl]-L-phenylalanine 1-methyl ester useful as a sweetener with a high potency of sweetness, is provided in the crystalline form having a high stability and a good purity which is favorable as a commercial product.... | 11/16/2004 |
| 6812256 | Polysubstituted indan-1-ol systems for the prophylaxis or treatment of obesity Polysubstituted indan-1-ol compounds of formula I, its physiologically acceptable salts and physiologically functional derivatives are disclosed Compositions comprising the same, methods of preparation and methods for ... | 11/02/2004 |
| 6794531 | Process for production of aspartyl dipeptide ester derivative, novel production intermediate therefor, and process for production thereof The present invention relates to a method of manufacturing aspartyl dipeptide ester compounds, which can be used as sweeteners, and aldehydes that can be used in the manufacturing processes. ... | 09/21/2004 |
| 6790470 | Aspartame derivative crystal and process for producing the same For example, N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine methyl ester (A-type crystal) showing characteristic peaks in diffractive X-ray at diffraction angles (2θ, CuKα ray) of at least 6.0°, 24.8°, 8.2° and 16.5° is dried to its water content belo... | 09/14/2004 |
| 6784309 | Method for the purification of N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester This invention relates to the purification of N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester by slurrying a mixture containing N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester with organic or aqueous organic solvents. | 08/31/2004 |
| 6767572 | Process for production of aspartame derivative, crystal thereof, novel production intermediate therefor, and process for production of intermediate thereof The present invention relates to a method of manufacturing aspartyl dipeptide ester compounds, which can be used as sweeteners. ... | 07/27/2004 |
| 6720446 | Catalyst modification to enhance neotame production Processes for using modified catalysts with improved functionality in the production of neotame are disclosed. The modified catalysts surprisingly have been found to improve the selectivity over conventional catalysts and to reduce the level of certain impurities in... | 04/13/2004 |
| 6689902 | Arylpropyl aldehyde derivatives, processes for producing the same, and methods of using the same 3-(3-Methyl-4-hydroxyphenyl)-3-methylbutyl aldehyde may be produced from 3-(3-methyl-4-hydroxyphenyl)-3-methylbutyric acid by converting the carboxyl group into a formyl group. N-[N-[3-(3-methyl-4-hydroxyphenyl)-3-methylbutyl]-L--aspartyl]-L-ph ... | 02/10/2004 |
| 6657073 | Crystallization of -L-aspartyl-L-phenylalanine methyl ester The present invention provides a novel process for the crystallization of -L-aspartyl-L-phenylalanine methyl ester crystals wherein initial nucleation and initial crystal growth is conducted in a controlled manner in a metastable supersaturated sol... | 12/02/2003 |
| 6642406 | Synthesis of N-[N-(3,3-dimethylbutyl)-L--aspartyl]-L-phenylalanine 1-methyl ester using L--aspartyl-L-phenylalanine 1-methyl ester precursors N-[N-(3,3-dimethylbutyl)-L--aspartyl]-L-phenylalanine 1-methyl ester is produced by hydrogenation of a mixture of 3,3-dimethylbutyraldehyde and a precursor of L--aspartyl-L-phenylalanine 1-methyl ester. In particular, N-[N-(3,3-dimethylbutyl... | 11/04/2003 |
