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| Number | Title | Issue Date |
| 8124802 | MAO inhibiting N-benzyl-N-propargyl-amines useful for treating obesity The invention provides novel N-benzyl-N-propargyl-amines that are monoamine oxidase inhibitors, but generally exhibit little or no CNS effects. ... | 02/28/2012 |
| 8106231 | Process for the preparation of (2R,3S)-3-phenylisoserine methyl ester acetate salt A process for the enantioselective preparation of (2R,3S)-3-phenylisoserine methyl ester acetate salt of formula (I) which is an useful building block for the synthesis of taxane derivatives. The process involves the resolution of racemic threo-phenylisoserine amide... | 01/31/2012 |
| 8053590 | Method for producing enantiomeric form of 2,3-diaminopropionic acid derivatives The invention relates to a method for producing enantiomers form of 2,3-diaminopropionic acid derivatives of formula (I) by asymmetric hydrogenation from compounds of formula (II). ... | 11/08/2011 |
| 7939689 | Short-acting sedative hypnotic agents for anesthesia and sedation The invention provides compounds compositions and methods useful for inducing or maintaining general anesthesia or sedation in mammals. ... | 05/10/2011 |
| 7592477 | Substituted methylene amide derivatives as modulators of protein tyrosine phosphatases (PTPs) The present invention is related to substituted methylene amide derivatives of formula (I) and use thereof for the treatment and/or prevention of metabolic disorders mediated by insulin resistance or pyperglycemia, comprising diabetes type I and/or II, inadequate gl... | 09/22/2009 |
| 7528276 | Process for preparing the intermediate compounds for PPAR α ligands The present invention provides a process for preparing the compounds of formula (II) according to a single reaction, which is an important intermediate compound for synthesizing GW7647 (III) and GW9578 (IV) activating Peroxisome Proliferator Activated Receptor (hPPA... | 05/05/2009 |
| 7514578 | Method for producing enantiomeric form of 2,3-diaminopropionic acid derivatives The invention relates to a method for producing enantiomeris form of 2, 3-diaminopropionic acid derivatives of formula (I) by asymetric hydrogenation from compounds of formula (II). ... | 04/07/2009 |
| 7427688 | Production method of optically active diphenylalanine compounds The present invention provides a production method including reacting a diphenylmethylene halide compound represented by the following formula (1) with a malonic acid diester compound represented by the following formula (2) in an organic solvent selected from N-met... | 09/23/2008 |
| 7410965 | Delayed release pharmaceutical composition containing 1-dimethyl-amino-3-(3-methoxyphenyl)-2-methyl-pentan-3-ol A delayed release pharmaceutical formulation containing 1-dimethylamino-3-(3-methoxyphenyl)-2-methylpentan-3-ol or a pharmaceutically acceptable salt thereof in a matrix; said matrix containing from 1 to 80 wt. % of at least one pharmaceutically acceptable, matrix-f... | 08/12/2008 |
| 7375245 | N-(4-oxo-butanoic acid) -L-amino acid-ester derivatives and methods of preparation thereof The present invention provides a compound of the following formula (I): wherein R1 is methyl or 4-aminobutyl, which may be acylated; X is phenyl or substituted phenyl; W is an esterified group removable by hydrog... | 05/20/2008 |
| 7220422 | Methods and compositions for treating eye disorders The present invention provides methods of treating an eye disorder. The methods comprise a step of locally administering a Clostridial toxin to the eye of a patient to treat the disorder. The eye disorder may be associated with an inflammation of the eye, inc... | 05/22/2007 |
| 7220876 | Arylcycloalkyl derivatives having branched side chains, processes for their preparation and their use as pharmaceuticals Arylcycloalkyl derivatives having branched side chains, processes for their preparation and their use as pharmaceuticals The invention relates to arylcycloalkyl derivatives having branched side chains and to their physiologically acceptable salts and physiolo... | 05/22/2007 |
| RE39593 | 1-phenyl-3-dimethylaminopropane compounds with a pharmacological effects 1-phenyl-3-dimethylaminopropane compounds corresponding to the formula I a method of preparing them, and the use of these substances as analgesic active ingredients in pharmaceutical compositions. ... | 04/24/2007 |
| 7208520 | Crystals of hydroxynorephedrine derivative The present invention provides ethyl (−)-2-[4-[2-[[(1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]amino]ethyl]-2,5-dimethylphenoxy]acetate hydrochloride, crystalline forms thereof and pharmaceutical compositions containing them, which have excellent β3 | 04/24/2007 |
| 7148066 | Dye solutions for use in methods to detect the prior evaporation of anhydrous ammonia and the production of illict drugs Systems and methods providing for the introduction of a dye, particularly a xanthene dye, and more particularly a rhodamine dye, to liquid anhydrous ammonia to discourage theft of the anhydrous ammonia and provide for leak detection in storage vessels. The dye will ... | 12/12/2006 |
| 7138538 | Process for the separation of enantiomers and enantiopure reagent Process for the separation of enantiomers comprising at least one free functional group, in which process a reagent based on an enantiopure amino acid is reacted in basic medium with a mixture comprising enantiomers. ... | 11/21/2006 |
| 7135586 | Biphenylcarboxamides useful as lipid lowering agents Biphenylcarboxamide compounds of formula (I) methods for preparing such compounds, pharmaceutical compositions comprising said compounds as well as the use of said compounds as a medicine for the treatment of hyp... | 11/14/2006 |
| 7115631 | Methods for treatment of cognitive and menopausal disorders with D-threo methylphenidate In one aspect, the present invention is directed to methods for treating fatigue, neurobehavioral slowing and other cognitive disorders and defects due to cancers and treatments associated with cancers, and similar conditions. In a further aspect, the present invent... | 10/03/2006 |
| 7057038 | Kinetic resolutions of chiral 2- and 3-substituted carboxylic acids One aspect of the present invention relates to a method for the kinetic resolution of racemic and diastereomeric mixtures of chiral compounds. The critical elements of the method are: a non-racemic chiral tertiary-amine-containing catalyst; a racemic or diastereomer... | 06/06/2006 |
| 7030160 | Propanolaminotetralines, preparation thereof and compositions containing same The invention relates to phenoxypropanolamines, to pharmaceutical compositions containing them, to processes for preparing them, and to the method of use thereof in the treatment of diseases that are improved by beta-3 agonist action. ... | 04/18/2006 |
| 7015348 | Method for producing an optically active β-amino acid To provide a producing method of an optically active β-amino acid useful as intermediate for the production of medicines, agricultural chemicals and physiologically active substances, by means of a catalytic and asymmetric synthesis method of high performance and a... | 03/21/2006 |
| 7015346 | Short-acting sedative hypnotic agents for anesthesia and sedation The invention provides a process for preparing a compound useful for inducing or maintaining general anesthesia or sedation in mammals. ... | 03/21/2006 |
| 6967220 | Peptide deformylase inhibitors PDF inhibitors and novel methods for their use are provided. ... | 11/22/2005 |
| 6894076 | Esters derived from (RR,SS)-2-hydroxybenzoate of 3-(2-dimethylaminomethyl-1-hydroxycyclohexyl)phenyl New esters derived from (RR, SS)-3-(2-dimethylaminomethyl-1-hydroxycyclohexyl)phenyl 2-hydroxybenzoate, analog to Tramadol, a process for obtaining them and the use of these compounds for the production of a medicament with analgesic properties. These new pro... | 05/17/2005 |
| 6887866 | Short-acting sedative hypnotic agents for anesthesia and sedation The invention provides compounds compositions and methods useful for inducing or maintaining general anesthesia or sedation in mammals. ... | 05/03/2005 |
| 6875831 | Mono and multifunctional alkoxyamines for the preparation of functionalized macromers The invention pertains to a compound of formula (I), (II) or (III) wherein R1 and R2 are independently of each other hydrogen, C1-C18alkyl, C3-C18alkeny... | 04/05/2005 |
| 6844448 | Main-group metal-based asymmetric catalysts and applications thereof The present invention relates to a method and catalysts for the stereoselective addition of a nucleophile to a reactive π-bond of a substrate. The chiral, non-racemic catalysts of the present invention constitute the first examples of catalysts for nucleophilic add... | 01/18/2005 |
| 6841183 | Process for producing aspartame derivatives, process for purifying aspartame derivatives, production intermediates, and process for producing production intermediates N-[N-[3-(2-hydroxy-substituted phenyl)propyl]-L-α-aspartyl]-L-phenylalanine 1-methyl ester derivatives, which are useful as sweeteners, may be conveniently produced by subjecting a 2-hydroxychroman derivative having various substituents on the benzene ring and aspa... | 01/11/2005 |
| 6835848 | One-pot synthesis of alkyl 3-cyclopropylamino-2-[2,4-dibromo-3-(difluromethoxy) benzoyl]-2-propenoate as a useful intermediate for antibacterial quinolone medicaments The present invention relates to a new and industrially advantageous one-pot process for the preparation of alkyl 3-cyclopropyl amino-2-[2,4-dibromo-3-(difluoromethoxy) benzoyl]-2-propenoates of in which R represents methyl or ethyl, which are valuable intermediates... | 12/28/2004 |
| 6809207 | Amino acid derivatives The present invention provides certain alpha-amino acids and derivatives thereof, such as, but not limited to, esters, amides and salts. These derivatives may comprise such representative side groups as a phenyl, pyridyl, piperidinyl, tetrahydropyranyl, tetrahydroth... | 10/26/2004 |
| 6794531 | Process for production of aspartyl dipeptide ester derivative, novel production intermediate therefor, and process for production thereof The present invention relates to a method of manufacturing aspartyl dipeptide ester compounds, which can be used as sweeteners, and aldehydes that can be used in the manufacturing processes. ... | 09/21/2004 |
| 6784311 | Method of producing 3-aminoalkanoic acid esters Process for the preparation of 3-aminoalkanoic acid esters of the general formula: in which R is C1-6-alkyl and R1 is hydrogen, C1-6-alkyl or phenyl, or their salts, by catalytic hydrogen... | 08/31/2004 |
| 6743914 | Kinetic resolutions of chiral 2-and 3-substituted carboxylic acids One aspect of the present invention relates to a method for the kinetic resolution of racemic and diastereomeric mixtures of chiral compounds. The critical elements of the method are: a non-racemic chiral tertiary-amine-containing catalyst; a racemic or diastereomer... | 06/01/2004 |
| 6699463 | Photostable cationic organic sunscreen compounds with antioxidant properties and compositions obtained therefrom Compounds of Formula I ##STR1## Each R is independently linear or branched C1 to C8 alkyl, or linear or branched C1 to C8 alkoxy or one R is H and the other R is linear or branched C1 to C8 | 03/02/2004 |
| 6699904 | PPAR agonists PPAR alpha activators, pharmaceutical compositions containing such compounds and the use of such compounds to elevate certain plasma lipid levels, including high density lipoprotein-cholesterol and to lower certain other plasma lipid levels, such as LDL-c... | 03/02/2004 |
| 6677360 | Biphenyl and biphenyl-analogous compounds as integrin antagonists The present invention relates to biphenyl and biphenyl-analogous compounds, their preparation and use as pharmaceutical compositions, as integrin antagonists and in particular for the production of pharmaceutical compositions for the treatment and prophyl... | 01/13/2004 |
| 6667314 | Tropane derivatives useful in therapy The present invention provides compounds of the formula: ##STR1## wherein R1 is C3-6 cycloalkyl optionally substituted by one or more fluorine atoms, or C1-6 alkyl optionally substituted by one or more fluorine atoms, ... | 12/23/2003 |
| 6653500 | Method for the manufacture of Anagrelide Methods are provided for making Anagrelide base from 2,3-dichlorobenzaldehyde. A method is also provided for making an intermediate compound ethyl N-(2,3-dichloro-6-nitrobenzyl)glycine from 2,3-dichlorobenzaldehyde and for reducing the glycine compound us... | 11/25/2003 |
| 6645992 | Malonamid and malonamic ester derivatives with antithrombotic activity, their preparation, and their use Compounds of formula I, ##STR1## in which R1, R2, A, and B having the definitions set forth in the claims, are valuable pharmacologically active compounds, which exhibit a strong antithrombotic effect and are suitable, for example, f... | 11/11/2003 |
| 6627767 | Amino(oxo) acetic acid protein tyrosine phosphatase inhibitors ##STR1## or therapeutically acceptable salts thereof, are protein tyrosine kinase PTP1B inhibitors. Preparation of the compounds, compositions containing the compounds, and treatment of diseases using the compounds are disclosed.... | 09/30/2003 |
