Class 560/312 - Hydroxamate esters or chalcogen analogues thereof (i.e., compounds having the -C(=X)-NH-X- group, wherein the X's may be the same or diverse chalcogens and substitution may be made for hydrogen only, and wherein the single bonded X is bonded directly to carbon, which carbon may be single bonded to any atom but may be multiple bonded only to carbon)

Subclass of Class 560 - Organic compounds -- part of the class 532-570 series
Definition: Compounds under Class 532, ... having the hydroxmate group
No. of patents: 110
Last issue date: 09/02/2008

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Number	Title	Issue Date
7420089	Hydroxamates as therapeutic agents The present invention is directed to certain hydroxamate derivatives that are useful in the treatment of hepatitis C. These compounds are also inhibitors of histone deacetylase and are therefore useful in the treatment of diseases associated with histone deacetylase...	09/02/2008
7348436	Compounds useful for the synthesis of (+)-discodermolide and methods thereof Compounds and methods useful for the synthesis of (+)-discodermolide, a naturally occurring microtubule stabilizing agent useful as an anti-cancer agent. ...	03/25/2008
7314953	Treatment of lung cells with histone deacetylase inhibitors Lung disease, such as cystic fibrosis (CF), chronic obstructive pulmonary disease (COPD), asthma or acute and chronic bronchitis, can be treated with an oxyamide-containing compound. ...	01/01/2008
7232929	Amide derivatives of 2,2,3,3-tetramethylcyclopropane carboxylic acid The invention relates to new 2,2,3,3-tetramethylcyclopropane carboxamide derivative compounds, pharmaceutical compositions thereof and uses thereof for treating psychotic disorders, neurodegenerative diseases, epilepsy and pain. ...	06/19/2007
7211684	Method for preparing methyl 2-diphenylmethylsulfinylacetate The invention relates to a method for preparing methyl 2-diphenylmethylsulfinylacetate (MDMSA) comprising the steps of: (i) conversion of benzhydrol into methyldiphenylmethylthioacetate (MDMTA); and (ii) conversion of methyldiphenylmethylthioacetate (MDMTA) into met...	05/01/2007
7144856	Inhibitors of dipeptidyl peptidase I The present invention relates to specific inhibitors of the cysteine protease dipeptidyl peptidase I (DP I)which can be used in the treatment of malignant cell degeneration, immune diseases impaired wound healing and metabolic diseases of humans and are represented ...	12/05/2006
7135593	Degradable crosslinkers, and degradable crosslinked hydrogels comprising them One aspect of the present invention relates to base-labile crosslinkers. A second aspect of the present invention relates to degradable crosslinked polymers and hydrogels comprising a base-labile crosslinker. The present invention also relates to a method of influen...	11/14/2006
7087764	Process for producing arylsulfenyl halide A process for producing a compound of the formula (II): wherein Hal1 represents halogen and R1 and R2 each independently represents halogen, alkyl, alkoxy, nitro or cyano, which c...	08/08/2006
7088400	Display apparatus having TV tuner and method thereof A display apparatus includes an LCD panel, a main PCB having a signal processor processing and transmitting a video signal to the LCD panel, and a PCB supporting member supporting the main PCB, a front cover, and a rear cover attached to the front cover to accommoda...	08/08/2006
6844316	Inhibitors of dipeptidyl peptidase I The present invention relates to specific inhibitors of the cysteine protease dipeptidyl peptidase I (DP I), which can be used in the treatment of malignant cell degeneration, immune deseases impaired wound healing and metabolic diseases of humans and are represente...	01/18/2005
6713646	Degradable crosslinkers, and degradable crosslinked hydrogels comprising them One aspect of the present invention relates to base-labile crosslinkers. A second aspect of the present invention relates to degradable crosslinked polymers and hydrogels comprising a base-labile crosslinker. The present invention also relates to a method of influen...	03/30/2004
6699990	3-(2,5-diaminophenyl)-acrylamide derivatives and coloring agents containing said compounds The present patent application relates to 3-(2,5-diaminophenyl)acrylamide derivatives of general formula (I) or to physiologically tolerated, water-soluble-salts thereof ##STR1## and to agents containing said compounds and used for oxidative dyeing of ...	03/02/2004
6670400	Phenoxyethylamine derivatives having high affinity for the 5-HT1A receptor, preparation thereof, use thereof as drugs, and pharmaceutical compositions containing said derivatives Phenoxyethylamine derivatives of general formula (I) having high affinity for the 5-HT1A receptor, methods for preparing same, pharmaceutical compositions containing said derivatives, and their use, in particular as gastric acid secretion inhib...	12/30/2003
6583299	଱-amino-ଲ-sulfonyl hydroxamic acid compounds A family of molecules is disclosed that inhibit matrix metalloprotease (MMP) activity, and particularly inhibit the activity of one or more of MMP-2, MMP-9, or MMP-13, while generally exhibiting little activity against MMP-1. A contemplated compound also ...	06/24/2003
6569636	Assay for modulators of metallo-enzyme activity An assay is disclosed for determining whether a test compound modulates the activity of an enzyme having a metallated active site. The assay method employs a comparison of the binding ability of the metallated and unmetallated forms of the enzyme to the t...	05/27/2003
6498150	Low molecular weight cell, bone marrow and immune stimulants The present invention relates to peptide-like compounds, eg aminocarboxylic acid amide derivatives, and to methods of using same to stimulate cells of the immune system, bone marrow and other organs. The present compounds can be used to enhance vaccinatio...	12/24/2002
6495719	Histone deacetylase inhibitors Compounds having a zinc-binding moiety, such as, for example, a hydroxamic acid group, can inhibit histone deacetylase. Histone deacetylase inhibition can repress gene expression, including expression of genes related to tumor suppression. Inhibition of h...	12/17/2002
6486341	N-alkoxy-n-phenylcarbamate derivatives Compounds of formula (I) wherein R1 is C1 -C4 -alkyl or cyclopropyl; R2 is C1 -C6 -alkyl, C2 -C6 -alkenyl, C2 -C6 -alkinyl; or C1 -C6	11/26/2002
6462023	Cytostatic agents The present invention provide compounds exemplified by 2(R or S)-[2R-(S-Hydroxy-hydroxycarbamoyl-methyl)-4-methyl-pentanoylamine]-2-phen yl-ethanoic acid cyclopentyl ester; 2(R or S)-(3S-Hydroxycarbamoyl-2R-isobutyl-hex-5-enoylamino)-2-phenylethanoic ...	10/08/2002
6384236	N-(aroyl)glycine hydroxamic acid derivatives and related compounds Compounds of formula (I) ##STR1## and pharmaceutically acceptable salts thereof, wherein R1, R2, AA and Y are as defined herein, inhibit phosphodiesterase type IV or inhibit the production of tumor necrosis factor, and therefore are ...	05/07/2002
6350902	Process for the selective N-formylation of N-hydroxylamines The instant invention provides a process for the selective N-formylation of N-hydroxylamines....	02/26/2002
6331564	Use of triaryl methane compounds for inhibiting unwanted cellular proliferation associated with inflammatory disease The present invention provides a class of chemical compounds useful as efficacious drugs in the treatment of sickle cell disease and diseases characterized by unwanted or abnormal cell proliferation, and in particular inflammatory diseases associated with...	12/18/2001
6251913	Hydroxamic acids substituted by heterocycles useful for inhibition of tumor necrosis factor Compounds of formula (I), ##STR1## wherein: n is 1 to 6; Het is a nitrogen containing ring fused to the benzene ring on two adjacent carbon atoms to form a bicyclic ring system which ring system may be optionally substituted; R1 is hydrogen, ...	06/26/2001
6232492	Process for the preparation of N-aryl-N-hydroxamides The invention relates to a method for preparing n-aryl-n-hydroxamides, whereby arylhydroxamines are reacted with ketones to n-aryl-n-hydroxamides, without using acyloxindoles-generating solvents....	05/15/2001
6228988	Synthesis of hydroxamic acid derivatives The present invention describes processes for preparing desired synthetic products that comprise a covalently bonded hydroxamic acid group --CONHOH by forming a mixture of a liquid reaction medium and a solid phase reaction product that carries a pluralit...	05/08/2001
6225351	N-(aroyl) glycine hydroxamic acid derivatives and related compounds Compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein R1, R2, AA and Y are as defined herein, inhibit phosphodiesterase type IV or inhibit the production of tumor necrosis factor, and therefore are useful in...	05/01/2001
6180818	Silver halide photographic material and hydroxamic acid-base compound for use therein A silver halide photographic material is disclosed, comprising a support having thereon at least one light-sensitive silver halide emulsion layer, wherein said silver halide photographic material contains a compound by formula (IA), or which contains at l...	01/30/2001
6159983	Method and composition for treatment of inflammatory bowel disease A composition in unit dosage form for the inhibition, prevention or treatment of inflammatory bowel disease comprising an effective amount of a compound having the formula: ##STR1## and a pharmaceutically acceptable carrier therefor. Also disclosed i...	12/12/2000
6156798	Cyclobutyl-aryloxyarylsulfonylamino hydroxamic acid derivatives A compound of the formula ##STR1## wherein Y and R1 are defined in the specification, useful in the treatment of arthritis or cancer and other diseases involving selective inhibition of matrix metalloproteinase-13....	12/05/2000
6147114	Highly water-soluble metalloproteinase inhibitors New compounds of the general formula (I) ##STR1## (wherein R1 is a hydrogen atom, or a hydroxyl, aryl (C1 -C6)alkylene or --A--SOn--B group (A is a (C1 -C6) alkylene group; B is a (C1 ...	11/14/2000
6124333	Metalloproteinase inhibitors Therapeutically active hydroxamic acid derivatives, processes for their preparation, pharmaceutical compositions containing them, and the use of such compounds in medicine. The compounds are inhibitors of metalloproteinases involved in tissue degradation....	09/26/2000
6124332	Metalloproteinase inhibitors Therapeutically active hydroxamic acid derivatives, processes for their preparation, pharmaceutical compositions containing them, and the use of such compounds in medicine. The compounds are inhibitors of metalloproteinases involved in tissue degradation....	09/26/2000
6124329	Metalloproteinase inhibitors Compounds of general formula (II) ##STR1## wherein R1, R2 and Z are defined in the claims, are matrix metalloproteinase inhibitors....	09/26/2000
6114570	Silver halide photographic material and hydroxamic acid-based compound for use therein A silver halide photographic material is disclosed, comprising a support having thereon at least one light-sensitive silver halide emulsion layer, wherein said silver halide photographic material contains a compound by formula (IA), or which contains at l...	09/05/2000
6093798	Synthesis of hydroxamic acid derivatives The present invention describes solid phase reaction products of a solid substrate carrying a plurality of covalently bound hydroxylamine or protected hydroxylamine groups of formula (A) or (B): ##STR1## where P1 is hydrogen or an amino pr...	07/25/2000
6028103	Triaryl methane compounds and analogues thereof useful for the treatment or prevention of sickle cell disease or diseases characterized by abnormal cell proliferation The present invention provides a class of chemical compounds useful as efficacious drugs in the treatment of sickle cell disease and diseases characterized by unwanted or abnormal cell proliferation. The active compounds are substituted triaryl methane co...	02/22/2000
6022893	Hydroxamic acid derivatives The present invention relates to: (i) hydroxamic acid derivative of the formula (I): ##STR1## wherein R1 is hydrogen, or C1-4 alkyl; R2 is hydrogen, C1-8 alkyl, phenyl, C1-4 alkyl substituted by phenyl; E is --CONR3 --, i...	02/08/2000
6018050	Method of preparing optically active ଱-amino acids and ଱-amino acid derivatives The invention relates to a new process for the preparation of optically active amino acids and amino acid derivatives of the general formula (I), wherein *, X and R1 to R4 have the meaning given in the description. Starting from comm...	01/25/2000
6015922	N-alkyl-N-alkoxycarboxamides and methods of use in prostaglandin synthesis Novel N-alkyl-N-alkoxycarboxamides useful for prostaglandin synthesis are disclosed. Also disclosed are novel synthetic methods for preparing the novel intermediates of the present invention....	01/18/2000
5969174	Competitive inhibitors of glyoxalase I and method of generating such competitive inhibitors inside tumor cells The present invention provides a compound having the structure ##STR1## wherein S* is S.dbd.O or O.dbd.S.dbd.O; and wherein R1 is selected from the group consisting of (C1 -C9) alkyl, (C3 -C8) cy...	10/19/1999

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