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| Number | Title | Issue Date |
| 7332616 | Polymerizable compound, polymer, positive-resist composition, and patterning process using the same The present invention provides a polymer which has at least one or more of a repeating unit represented by a following general formula (1a), a repeating unit represented by a following general formula (2a) and a repeating unit represented by a followin... | 02/19/2008 |
| 7238348 | Method of treatment of osteoporosis with compositions of red rice fermentation products Methods are disclosed for using red rice fermentation products for the treatment or prevention of osteoporosis and abnormal bone mass conditions. Particular Monascus strains yield fermentation products with the desired biological activities. ... | 07/03/2007 |
| 7141602 | Process for obtaining HMG-CoA reductase inhibitors of high purity Lovastatin, pravastatin, simvastatin, mevastatin, atorvastatin, and derivatives and analogs thereof are known as HMG-CoA reductase inhibitors and are used as antihypercholesterolemic agents. The majority of them are produced by fermentation using microorganisms of d... | 11/28/2006 |
| 7109383 | Fluorine-containing allyl ether compounds, their copolymers, and resist compositions and anti-reflection film materials using such copolymers The invention relates to a fluorine-containing allyl ether compound represented by the formula 1, wherein R represents an organic group containing at least one fluorine atom and an alicyclic structure. The invent... | 09/19/2006 |
| 7078558 | Crystals of the sodium salt of pravastatin Lovastatin, pravastatin, simvastatin, mevastatin, atorvastatin, fluvastatin and cervastatin and derivatives and analogs thereof are known as HMG-CoA reductase inhibitors and are used as antihypercholesterolemic agents. The majority of them are produced by fermentati... | 07/18/2006 |
| 7057055 | Process for preparing a deuterated or tritiated compound A process for labeling organic compounds with deuterium and tritium is described using specific catalysts. ... | 06/06/2006 |
| 7057060 | Modified silane compounds This invention relates to the reversible protection of hydroxy-silane functional groups by acid cleavable protecting groups. The development of reversible protecting groups greatly enhances the current utility of silanes while introducing further novel applications.... | 06/06/2006 |
| 7052743 | Chiral compounds and compositions containing the same The invention relates to a novel class of compounds useful as chiral dopants, which compounds are available in both enantiomeric forms. Another aspect of the invention relates to such compounds having a enantiomeric excess of one enantiomeric form, which are useful ... | 05/30/2006 |
| 7052886 | Process for the isolation of lovastatin The process for the preparation and isolation of the hypolipaemic active substance lovastatin in substantially pure form having a purity of at least 95% which comprises lactonizing the mevinolinic acid to lovastatin in a totally aqueous medium. ... | 05/30/2006 |
| 7001919 | Forms of pravastatin sodium New polymorphic forms of pravastatin sodium are provided. Each of the new forms is selectively obtained by crystallization from different solvent systems, each solvent system having a protic component, and by controlling the rate of crystallization through temperatu... | 02/21/2006 |
| 6972297 | 2-Hydroxy-mutilin carbamate derivatives for antibacterial use 2-(S)-hydroxymutilin carbamate derivatives of formula (I), in which R1 is a 5- or 6-membered optionally substituted heteroaryl group; and R2 is vinyl or ethyl, are useful in the treatment of bacterial infections | 12/06/2005 |
| 6943272 | Norbornane and norbornene derivatives, use thereof and perfumed products containing same The invention concerns a novel compounds of formula (I), wherein the dotted line bond is present or not, and wherein R1 represents: when the dotted line bond is present —CHCH3OH or —CHCH3OCOR or —CHCH3XCH2... | 09/13/2005 |
| 6936731 | Pravastatin sodium substantially free of pravastatin lactone and epi-pravastatin, and compositions containing same The present invention provides pravastatin sodium substantially free of pravastatin lactone and epiprava, the C-6 epimer of pravastatin. The present invention further provides a novel process for recovering pravastatin sodium from a fermentation broth in such high p... | 08/30/2005 |
| 6924262 | Use of unsaturated esters as perfuming ingredients The compound of formula in which the wavy line represents a bond having a configuration of the type (Z) or (E), or a mixture of the two configurations; R1 represents a hydrogen atom, a C1 to C | 08/02/2005 |
| 6838566 | Salts of HMG-CoA reductase inhibitors Lovastatin, pravastatin, simvastatin, mevastatin, atorvastatin, and derivatives and analogs thereof are known as HMG-CoA reductase inhibitors and are used as antihypercholesterolemic agents. The majority of them are produced by fermentation using microorganisms of d... | 01/04/2005 |
| 6790984 | Process for purifying pravastatin sodium from a fermentation broth A process for purifying pravastatin sodium comprising the steps of: a. clarifying a fermentation broth containing pravastatin sodium to obtain a clear solution; and adjusting the clear solution to be basic having pH value ranging from pH 10˜13; b. ads... | 09/14/2004 |
| 6756507 | Process for the preparation of sodium salts of statins A process for the preparation of sodium salts of statins, namely Compactin, Lovastatin and Pravastatin. ... | 06/29/2004 |
| 6740775 | Crystalline sodium salt of pravastatin A crystalline form of the sodium salt of pravastatin, which is known by the chemical name 1-naphthaleneheptanoic acid, 1,2,6,7,8,8a-hexahydro-β, δ,6-trihydroxy-2-methyl-8-(2-methyl-1-oxobutoxy)-, mono sodium salt, which is useful as a pharmaceutical substance. A m... | 05/25/2004 |
| 6696599 | Microbial process for preparing pravastatin The present invention relates to a new microbial process for the preparation of the compound formula (I) ##STR1## from a compound of general formula (II) ##STR2## wherein R stands for an alkali metal or ammonium ion, by the submerged cultivation of a... | 02/24/2004 |
| 6689590 | Process for recovering statin compounds from a fermentation broth A composition comprising pravastatin sodium substantially free of pravastatin lactone is described.... | 02/10/2004 |
| 6599861 | Herbicides Compounds of formula I ##STR1## wherein the substituents are defined as in claim 1, as well as the agronomically acceptable salts, isomers and enantiomers of these compounds, as well as the agronomically acceptable salts/N-oxides/isomers/enantiomers ... | 07/29/2003 |
| 6583295 | Salts of HMG-CoA reductase inhibitors Lovastatin, pravastatin, simvastatin, mevastatin, atorvastatin, and derivatives and analogs thereof are known as HMG-CoA reductase inhibitors and are used as antihypercholesterolemic agents. The majority of them are produced by fermentation using microorg... | 06/24/2003 |
| 6506929 | Process to manufacture simvastatin and intermediates A process is disclosed for the preparation of simvastatin which enables highly regio selective C-methylation of the 2'-position group of lovastatin without requiring protection/deprotection of 13-OH of lovastatin and lactone ring opening/closure.... | 01/14/2003 |
| 6479549 | Carnosic acid derivatives for promoting synthesis of nerve growth factor A novel carnosic acid derivative for promoting the synthesis of nerve growth factor (NGF), a composition comprising the carnosic acid derivative as an effective ingredient, as well as, a method of promoting the synthesis of NGF comprising administering an... | 11/12/2002 |
| 6444452 | Process for recovering statin compounds from a fermentation broth A novel process for recovering a compound from a fermentation broth that includes the stages of forming an enriched solution of the compound by extraction, obtaining a salt of the compound from the enriched solution, purifying a salt of the compound and t... | 09/03/2002 |
| 6365382 | Biotechnological process for preparing hydroxylated ML-236B derivatives, known as M-4 and M-4', and analogues thereof The very effective conversion of ML-236B substances and derivatives thereof into 6'-hydroxylated products with the microorganisms of species Amycolatopsis orientalis, or with an extract or a hydroxylation-effective enzyme derived from said microorganism, ... | 04/02/2002 |
| 6326369 | Bicyclic quinone compounds, their production and use A compound of the formula: ##STR1## wherein R1 and R2 each represents a lower alkyl, or R1 and R2 may be bonded together to form a ring; X represents a spacer of which the number of atoms constituting the princi... | 12/04/2001 |
| 6306629 | Microorganism streptomyces exfoliatus yj-118 and a method for producing pravastatin sodium by using the strain The present invention is related to a new microorganism Streptomyces exfoliatus YJ-118 and a method for producing pravastatin sodium by using this microorganism which shows a strong tolerance to ML-236B and a high hydroxylation activity of ML-236B to prav... | 10/23/2001 |
| 6235926 | Perfuming ingredients of woody, fruity odor The present invention relates to perfumery of compounds of the general formula ##STR1## in which R1 and R2 are identical or different and represent each a methyl or ethyl group, R3 represents hydrogen or an alkyl group fro... | 05/22/2001 |
| 6225334 | Glyoxylic acid derivatives The invention concerns novel glyoxylic acid derivatives, a process for their preparation and their use as pesticides.... | 05/01/2001 |
| 6177586 | Vitamin D3 derivative and production process thereof The starting materials for a production process of a vitamin D3 derivative are disclosed, e.g., a cyclopentene derivative represented by the formula (1-2): ##STR1## wherein R11 is a hydrogen atom, tri(C1 to C | 01/23/2001 |
| 6080784 | Protein kinase C modulators N Compositions with protein kinase C-modulatory, anti-inflammatory and other activities are disclosed.... | 06/27/2000 |
| 6025328 | Antitumor agents The present invention provides illudin analogs of the general formula I: ##STR1## wherein R1, R2, R3, R4, R5, and R6 have any of the values defined in the specification, and pharmaceuticall... | 02/15/2000 |
| 5989877 | Selective process for the deacylation of acylated compounds The invention provides a simple and selective method for the deacylation of 4-acylated statins during the preparation of statins from a fermentation broth, more specifically a reduction of impurities from the process, by increasing the pH of the fermentat... | 11/23/1999 |
| 5955501 | Protein kinase C modulators O Compounds having anti-inflammatory and other activities are disclosed. The compounds are derived from phorboids of the diterpene- and benzolactam-classes.... | 09/21/1999 |
| 5900369 | Method for producing oxodicyclopentadiene Optically active oxodicyclopentadiene is produced by adding lipase into ketoalcohol (1) and vinyl acetate, stirring them to obtain optically active acetate, and methylating and oxidizing to cleavage the reactant, and treating the product under basic condi... | 05/04/1999 |
| 5861385 | Substituted triols Substituted triols are prepared by reducing appropriately substituted carboxylic esters. The substituted triols can be used as active substances in medicaments.... | 01/19/1999 |
| 5789374 | Methyl-substituted 1(2-norbornyl) alkanols acetate esters thereof and perfumery uses of said esters, and process intermediates for producing same Described are methyl-substituted 1(2-norbornyl) alkanols and acetate esters thereof defined according to the structures: ##STR1## (wherein Z represents hydrogen or acetyl). The compounds wherein Z is acetyl, the esters, are useful in augmenting or en... | 08/04/1998 |
| 5643948 | Protein kinase C modulators. K. Compounds having anti-inflammatory and other activities are disclosed. The compounds are derived from diterpenes of the phorbol-, resiniferonol- and ingenol-classes.... | 07/01/1997 |
| 5571939 | Method for preparing dodecahydro-3a,6,6,9a-tetramethylnaphtho[2,1-b]furan and novel haloethyl decalin derivatives The method is directed to the preparation of dodecohydro-3a,6,6,9a-tetramethyl-naphtho[2,1-b]furan from sclareol using an alkoxy-radical fragmentation reaction. A novel 9-haloethyl decalin derivative is an intermediate in this method.... | 11/05/1996 |
