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| Number | Title | Issue Date |
| 6673837 | Acetyl L-carnitine salt with a dicarboxylic organic acid and process for preparing same A novel solid, crystalline and non-hygroscopic substance consisting of acetyl L-carnitine acid fumarate and a process for preparing same are disclosed.... | 01/06/2004 |
| 6653504 | Non-hygroscopic salts of active ingredients having therapeutical and/or nutritional activities and orally administrable compositions containing same Derivatives of active ingredients with creatine and ornithine are disclosed having enhanced nutritional and/or therapeutic effects which favorably lend themselves to the preparation of orally administrable solid compositions.... | 11/25/2003 |
| 6503945 | Cationic amphiphiles containing N-hydroxyalkyl group for intracellular delivery of biologically active molecules The present invention provides novel cationic amphiphiles containing novel N-hydroxyalkyl group and therapeutic formulations containing the said amphiphiles that are capable of facilitating transport of biologically active molecules into cells. The said n... | 01/07/2003 |
| 6472555 | Process for the production of esters from alcohols using acetic acid as acetylating and clays as catalysts The present invention relates to a process for the preparation of esters from alcohols using acetic acid as acetylating agent and clays as catalysts, which comprises the preparation of esters in a single step from the reaction of aliphatic, acyclic, cycli... | 10/29/2002 |
| 6346516 | Cationic amphiphiles containing N-hydroxyalkyl group for intracellular delivery of biologically active molecules The present invention provides novel cationic amphiphiles containing novel N-hydroxyalkyl group and therapeutic formulations containing the said amphiphiles that are capable of facilitating transport of biologically active molecules into cells. The said n... | 02/12/2002 |
| 6130249 | Solid compositions suitable for oral administration comprising L-carnitine and alkanoyl-L-carnitine magnesium tartrate Stable and nonhygroscopic salts consisting of L-carnitine magnesium tartrate or lower alkanoyl-L-carnitine magnesium tartrate are disclosed that are suitable for preparing solid compositions useful as dietary or nutritional supplements for human use and a... | 10/10/2000 |
| 6124360 | Solid compositions suitable for oral administration comprising non hygroscopic salts of L-carnitine and alkanoyl-L-carnitine with 2-aminoethanesulfonic acid Stable and non hygroscopic salts of L-carnitine or lower alkanoyl-L-carnitine with 2-aminoethanesulfonic acid are disclosed suitable for preparing solid compositions useful as dietary/nutritional supplements for human use and as fodder supplement for vete... | 09/26/2000 |
| 6124270 | Use of a cationic amphipathic compound as a transfection agent, vaccine additive or drug A cationic amphipathic compound of formula (I), ##STR1## wherein A is a single bond, an NH--R' grouping or (a), wherein --R'-- is a straight or branched, optionally substituted, saturated or unsaturated C1-22 aliphatic chain optionally int... | 09/26/2000 |
| 6084131 | Process for the preparation of protected dihydroxypropyl trialkylammonium salts and derivatives thereof A process for the preparation of protected dihydroxypropyl trialkylammonium salts, particularly in chiral form is described. In particular, a process for the preparation of (2,2-dimethyl-1,3-dioxolan-4-ylmethyl)trialkylammonium salts, particularly in... | 07/04/2000 |
| 5962708 | Process for preparation of highly concentrated free-flowing aqueous solutions of betaines The invention relates to a process for the preparation of highly concentrated free-flowing and pumpable aqueous solutions of betaines by quaternization of a compound which contains tertiary amine nitrogen with a ω-halo carboxylic acid characterized in th... | 10/05/1999 |
| 5929272 | Aliphatic epoxide-amine adducts with substantial side-chain, branching process for their preparation, and their use Epoxide-amine adducts having a proportion by mass of at least 20% of aliphatic epoxide or amine units which comprise at least one tertiary or quaternary carbon atom are disclosed. The adducts are employed as binders for coatings of relatively high environ... | 07/27/1999 |
| 5892061 | Process for preparing isoimides A preparation process of isoimide comprising reacting a compound having one or more carboxyl group and one or more amide bond in the same molecule in the presence of a haloiminium salt and basic substance, and a preparation process of isoimide comprising ... | 04/06/1999 |
| 5883284 | Method for producing -hydroxy-ଲ-aminocarboxylic acids The present invention provides a simple and inexpensive method for producing -hydroxy-ଲ-aminocarboxylic acids and their esters. An ester of an N-protected -amino acid ester is converted into a ଲ-ketosulfoxide, which is then processed ... | 03/16/1999 |
| 5710279 | N-acyloxyalkyl-carboxamides and process for their preparation The invention provides novel N-acyloxyalkyl-carboxamides of the general formula (I): ##STR1## in which R1 is alkyl, alkenyl, alkinyl, cycloalkyl, cycloalkylalkyl, arylalkyl or heteroarylalkyl, each of which is optionally substituted, R | 01/20/1998 |
| 5698523 | Acylated enol derivatives as prodrugs of elastase inhibitors This invention relates to acylated enol derivatives of known elastase inhibitors. These compounds are useful in the treatment of various inflammatory diseases, including cystic fibrosis and emphysema or as prodrugs of compounds which are useful in the tre... | 12/16/1997 |
| 5599940 | N-acyloxyalkyl-carboxamides and process for their preparation The invention provides novel N-acyloxyalkyl-carboxamides of the general formula (I): ##STR1## in which R1 is alkyl, alkenyl, alkinyl, cycloalkyl, cycloalkylalkyl, arylalkyl or heteroarylalkyl, each of which is optionally substituted, R | 02/04/1997 |
| 5395971 | Molybdenum-catalyzed amination of olefins A process for making unsaturated -amines from olefins wherein the process includes adding an aminating agent, an olefin and a molybdenum based catalyst to a reaction vessel having a nitrogen atmosphere. The catalyst may be described by the general ... | 03/07/1995 |
| 5349109 | Molybdenum-catalyzed amination of olefins A process for making unsaturated -amines from olefins wherein the process includes adding an aminating agent, an olefin and a molybdenum based catalyst to a reaction vessel having a nitrogen atmosphere. The catalyst may be described by the general ... | 09/20/1994 |
| 5344952 | Fluoroketone enzyme inhibitors A method for enzyme immunoassay for a ligand suspected to be present in a liquid sample includes signal amplification by use of at least two enzymes and a blocked modulator for one of the enzymes. Ligand present in the liquid binds to an antiligand and an... | 09/06/1994 |
| 5227518 | L-carnitine derivatives as therapeutical agents for treating myopathies and neuronal degeneration and for inhibiting proteolysis The use is disclosed of compounds of general formula ##STR1## wherein: Y is hydrogen or methyl and R is an unsubstituted or substituted alkyl group selected from methyl, ethyl and isopropyl, and the pharmacologically acceptable salts thereof, for treating... | 07/13/1993 |
| 5155254 | Substituted diones as intermediates for a process for the manufacture of γ-pyrones A process for the manufacture of 3-hydroxy-2-alkyl-4-pyrones of formula I is provided. ##STR1## The process comprises cyclizing a compound of formula II, ##STR2## an acidic medium and hydrolyzing the ester formed thereby to produce compound... | 10/13/1992 |
| 5134231 | 3(1-hydoxyethyl)azetidinone compounds and their production An amino acid compound of the formula: ##STR1## wherein R is a lower alkyl group, R1 is a hydrogen atom or a protecting group for carboxyl, R2 is a hydrogen atom, a protecting group for amino, an optionally substituted allyl gro... | 07/28/1992 |
| 5098934 | Method of relieving pain with mercaptoalkanamides Novel ω-mercaptopropanamides and their homologs of the formula ##STR1## wherein R1 is selected from the group consisting of hydrogen and ##STR2## R1 ' is selected from the group consisting of alkyl of 1 to 5 carbon atoms a... | 03/24/1992 |
| 5049698 | Process for manufacturing 2-chloro-1,3-diketo compounds A novel process for producing 2-chloro-1,3-diketo compounds of the formula ##STR1## wherein Q is an amino, substituted amino or hydrocarbyloxy group, e.g., --OCH3, wherein the 1,3-diketo precursor in solution in a low boiling alcohol is ne... | 09/17/1991 |
| 5047577 | Quaternary ammonium compounds Peroxygen laundry bleach (e.g. sodium perborate) is activated to be effective at a lower temperature by use in combination with a hydrocarbonyloxyhydrocarbyl trihydracarbyl quaternary ammonium salt, e.g. dodecyldimethyl 2-acetyloxyethylammonium bromide.... | 09/10/1991 |
| 4892687 | Process for synthesis of amidoacids using a cobalt catalyst and a bidental phosphine ligand A process is disclosed for producing N-acetyl-aminoacid which comprises reacting a feedstock from the group consisting of simple olefins, acetamide and synthesis gas with a catalyst comprising a cobalt-containing compound promoted by a bidental-phosphine ... | 01/09/1990 |
| 4877824 | Sulfur-containing compounds as antioxidants for lubricants and elastomers Compounds of the formula (I) ##STR1## in which the Rs independently of one another are H, phenyl, naphthyl or C7 -C30 alkaryl and R1 is H, C1 -C8 alkyl, C7 -C9 aralkyl, C | 10/31/1989 |
| 4874554 | Quaternary ammonium compounds Quaternary ammonium compounds corresponding to the formula ##STR1## are produced by esterification of ether amines corresponding to the formula ##STR2## with a fatty acid of the formula R2 --COOH and quaternization of the product... | 10/17/1989 |
| 4855489 | 2-acyloxypropylamino derivatives, processes for the preparation thereof, and pharmaceutical compositions containing them The present invention covers a novel series of 2-acyloxypropylamine derivatives, processes for preparing them, compositions containing them, and methods for using them. The compounds are active in the inhibition of protein kinase C and thrombocyto aggrega... | 08/08/1989 |
| 4808755 | Lubricant compositions, novel glucamine derivatives and complex compounds containing same The invention relates to compositions comprising a lubricant or a hydraulic fluid and at least one compound of the general formula ##STR1## wherein n is 2, 3 or 4, X is --S--, --O--, --O--CO-- or --CH2 --, R1 is C1 -C... | 02/28/1989 |
| 4808572 | -Hydroxy thioethers Novel asymmetric thioethers of the formula ##STR1## in which the general symbols have the following meanings: a is an integer of from 1 to 7, Ro represents hydrogen or C1-7 -alkanoyl, R1 represents C1-3 -alkyl w... | 02/28/1989 |
| 4782088 | Nitro aliphatic compounds and use thereof The invention relates to compounds of antihypertensive and antithrombotic activity of the formula or its pharmaceutically acceptable salt: ##STR1## wherein R1 is hydrogen, lower alkyl, or lower alkoxyphenyl, R2 is hydrogen or lower a... | 11/01/1988 |
| 4758594 | Inhibitors of slow reacting substance of anaphylaxis Novel compounds and compositions which inhibit SRS-A in mammals are disclosed. Methods for preparing said compounds and compositions and methods for their use for treating allergic reactions, inflammation and for reducing the severity of myocardial infarc... | 07/19/1988 |
| 4727151 | Labile quaternary ammonium salts as prodrugs Labile quaternary ammonium salts of the following formula (I) and (II) are provided: ##STR1## wherein N represents a tertiary aliphatic amine; wherein N represents an unsaturated amine; wherein R represents a member selected from the group con... | 02/23/1988 |
| 4709083 | Method of making boron analogues A method of synthesizing boron analogues of choline and choline related mrials is disclosed. The method comprises reacting N,N dimethylethanolamine with hydrogen chloride or an acid chloride to form an ester hydrochloride. The resulting aminoalcohol hydr... | 11/24/1987 |
| 4643990 | N-acyl peptide, processes for their preparation and pharmaceutical compositions thereof N-acylpeptides are disclosed of the formula: ##STR1## wherein R1 is alkanoyloxy or alkenoyloxy; R2 is alkyl or alkenyl; R3 and R4 are each lower alkyl, hydroxy(lower)alkyl, ar(lower)alkyl, esterified carbox... | 02/17/1987 |
| 4638089 | Fluorine-containing quaternary ammonium compounds and their production A fluorine-containing quaternary ammonium compound of the formula: ##STR1## wherein Rf is a fluorine-containing straight or branched aliphatic hydrocarbon or polyether group, R1, R2 and R3 are each a C... | 01/20/1987 |
| 4629736 | Fatty acid derivatives and process of producing them Fatty acid derivatives represented by the general formula ##STR1## and salts thereof. The compounds of this invention have excellent fibrinolytic action and a highly improved solubility.... | 12/16/1986 |
| 4609673 | Carboxylic acid derivatives, processes for the preparation thereof and pharmaceutical compositions containing them The present invention provides carboxylic acid derivatives of the general formula: ##STR1## wherein R is a hydrogen atom, alkyl, a metal cation or an ammonium or alkylammonium ion, R1 is a hydrogen atom, a hydroxyl group or an alkyl, ... | 09/02/1986 |
| 4593120 | Naphthalene anti-psoriatic agents Psoriasis in mammals is relieved by topically administering naphthalenes of the formula: ##STR1## wherein: R1 and R2 are the same and are lower alkoxy, lower alkylthio, optionally substituted phenoxy or optionally substituted ... | 06/03/1986 |
