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| Number | Title | Issue Date |
| 7381831 | Colorant compounds Disclosed is a compound of the formula and dimers thereof, wherein R, R2, X and Z are as described herein. The compounds are useful as colorants, particularly in applications such as phase change inks. ... | 06/03/2008 |
| 7312244 | Polyamine analog-amino acid conjugates useful as anticancer agents Conjugates in which polyamine analogs are conjugated to an amino acid are provided, as well as compositions comprising these conjugates. Methods of using these conjugates as anticancer treatments are also provided. ... | 12/25/2007 |
| 7129357 | Synthesis of quinoline 5-carboxamides useful for the preparation of PDE IV inhibitors In one embodiment, the present application discloses a process for making the compound of the formula: ... | 10/31/2006 |
| 6852874 | Second cycle asymmetric dihydroxylation reaction A process for catalyzing asymmetric dihydroxylations of olefins employs an Os(VI) complex as a catalytic intermediate in the formation of chiral vicinal diol products. The process requires a chiral bidentate ligand that favors diol formation in the “second cycleâ€... | 02/08/2005 |
| 6846936 | 2-butyl-3-(4-[3(dibutylamino)propoxy]benzoyl)-5-nitro-benzofuran hydrochloride and preparation thereof The invention relates to 2-butyl-3-(4-[3-(dibutylamino)propoxy]benzoyl-5-nitrobenzofuran hydrochloride, to its preparation and to its use as synthetic intermediate, in particular in preparing 2-butyl-3-(4-[3-(dibutylamino)propoxy]benzoyl)-5-nitrobenzofuran, itself a... | 01/25/2005 |
| 6730700 | 3,4,5,-trisubstituted aryl nitrone compounds and pharmaceutical compositions containing the same Disclosed are 3,4,5-trisubstituted aryl nitrone compounds and pharmaceutical compositions containing such compounds. The 3,4,5-trisubstituted aryl nitrone compounds have formula (I); where R1-R4 are as defined in the specification. The disclose... | 05/04/2004 |
| 6696592 | Methods of making 21-[4'-(nitrooxyalkyl)benzoate] corticosteroid derivatives and intermediates useful in the synthesis thereof The present invention provides methods of making 21-[4'-(nitrooxyalkyl)benzoate] corticosteroid derivatives according to the following general reaction scheme: ##STR1## The invention also provides intermediates useful in making such 21-[4'-(nitrooxya... | 02/24/2004 |
| 6639093 | Process for the preparation of hydroxybenzoic benzyl esters The invention relates to the preparation of hydroxybenzoic benzyl esters by reacting benzyl chloride with hydroxybenzoic acids in the presence of one or more amides.... | 10/28/2003 |
| 6630600 | 3-aryl propionic acid derivatives and analogs Novel 3-aryl propionic acid derivatives and analogs, process and intermediate for their manufacture, pharmaceutical preparations containing them and the use of the compounds in clinical conditions associated with insulin resistance.... | 10/07/2003 |
| 6630598 | Process for producing N-acylnitroaniline derivative A process of reacting a nitroaniline compound of formula (2): ##STR1## with an acid anhydride or acid halide is carried out in the presence of an alkali metal compound or an alkaline earth metal compound to produce an acylnitroaniline derivative. The proc... | 10/07/2003 |
| 6600063 | Derivatives of phenyl 4-aminosalicylate and method of making the same The present invention relates to novel antimycobacterial compounds and in particular to antimycobacterial compounds comprised of derivatives of phenyl 4-aminosalicylate. This invention further relates to methods for their preparation, to their use as ther... | 07/29/2003 |
| 6566547 | Fungicides This invention relates to derivatives of acrylic acid useful as fungicides, to processes for preparing them, to fungicidal compositions containing them, and to methods of combating fungi, especially fungal infections in plants, using them.... | 05/20/2003 |
| 6531624 | Aminoacrylic acid derivatives and process for producing the same A process for producing a benzoylacrylic acid derivative (formula 1) in high yield through a small number of steps and a simple purification step. The process comprises reacting 2,4,5-trifluoro-3-methyl-6-nitrobenzoyl chloride with a compound (formula 2) to yi... | 03/11/2003 |
| 6469181 | Process for preparing 2-oxindoles and N-hydroxy-2-oxindoles The present invention provides a processes, having practical utility, for preparing 2-oxindoles, N-hydroxy-2-oxindoles, or mixtures thereof comprising: catalytically hydrogenating a 2-nitroarylmalonate diester to produce a 2-(N-hydroxyamino)arylmalonate d... | 10/22/2002 |
| 6403638 | 2,4-pentadienoic acid derivatives having selective activity for retinoid X (RXR) receptors Compounds having the formulas below, where R is H, lower alkyl, or a pharmaceutically acceptable salt, and where R1 represents i-propyl, t-butyl or n-butyl groups, have selective RXR retionoid agonist activity. ##STR1##... | 06/11/2002 |
| 6379590 | Method for making unsymmetrically substituted fluorenyl compounds for nonlinear optical applications A new method for producing unsymmetrically substituted fluorenyl compounds, one step of which is the preparation of 2,7-disubstituted fluoren-9-one derivatives via the nucleophilic substitution of a compound of the formula D ##STR1## wherein A' is se... | 04/30/2002 |
| 6369194 | Vicinyl tricarbonyl compounds and combinatorial libraries containing same The invention relates to compounds of formula ##STR1## where R is a structural diversity element selected from the group consisting of alkyl, cycloalkyl, aryl, heteroaryl, peptidyl, heteroatom-substituted alkyl, cycloalkyl, and amines; and Nu is a st... | 04/09/2002 |
| 6342523 | 3,4,5-trisubstituted aryl nitrone compounds, pharmaceutical compositions containing the same and methods for treating inflammation Disclosed are 3,4,5-trisubstituted aryl nitrone compounds and pharmaceutical compositions containing such compounds. The 3,4,5-trisubstituted aryl nitrone compounds have the formula: ##STR1## where R1 -R4 are as defined in the specif... | 01/29/2002 |
| 6329547 | Vinylbenzene derivatives The present invention provides compounds represented by the following general formula [I] and salts thereof, which are useful as therapeutic agents for glaucoma, ##STR1## wherein R1 is H, lower alkyl or phenyl, and the phenyl can be substi... | 12/11/2001 |
| 6310245 | 3-aminocarbonyl/3-aminothiocarbonyl-substituted 2-benzoyl-cyclohexan-1,3-diones with herbicidal effect The invention relates to 2-benzoylcyclohexane-1,3-diones of the formula I ##STR1## where R1, R2 are hydrogen, nitro, halogen, cyano, thiocyanato, alkyl, haloalkyl, alkoxyalkyl, alkenyl, alkynyl, --OR5, --OCOR6, ... | 10/30/2001 |
| 6307088 | Synthesis of taxol, taxol analogs and their intermediates with variable A-ring side chain structures and compositions thereof The present invention concerns alkyl esters of ଲ-amino acid derivatives which are useful in the synthesis of taxol and analogs.... | 10/23/2001 |
| 6306840 | Cell adhesion inhibitors The present invention relates to novel compounds that are useful for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. This invention also relates to pharmaceutical formulations comprising these compounds and methods of us... | 10/23/2001 |
| 6147224 | 2,4-pentadienoic acid derivatives having selective activity for retinoid X (RXR) receptors Compounds of Formula 1, Formula 2 or Formula 3 where X is O, S, or (CR1 R1)n where n is 0, 1 or 2; Y is a bivalent radical having Formula 4 or Formula 5 where o is an integer from 1 to 4 ##STR1## or Y is a bivalent ar... | 11/14/2000 |
| 6136999 | C-2 hydroxyl protected-n-acyl (2R,3S)-3-phenylisoserine substituted phenyl activated esters and method for production thereof A chemical compound having the formula: ##STR1## wherein P1 is a hydroxyl protecting group, R1 may be H or electron withdrawing group, R2 may be H or electron withdrawing group, R3 may be H or electron with... | 10/24/2000 |
| 6130246 | Pesticides The compounds of formula I ##STR1## wherein: a) X is O, and Y is OC1 -C4 alkyl; or b) X is O or S, and Y is NHCH3 have fungicidal properties and can be used in plant protection for controlling and preventing disease infest... | 10/10/2000 |
| 6111115 | Preparation of 2-(10,11-dihydro-10-oxodibenzo-[b,f]thiepin-2-yl) propionic acid A process for preparation of 2-(10,11-dihydro-10-oxodibenzo[b,f]thiepin-2-yl)propionic acid (i.e., Zaltoprofen) is performed by subjecting 2-(4-amino-3-carboxy-methylphenyl)propionic acid or its salt to diazotization and subsequent reaction with thio... | 08/29/2000 |
| 6072060 | Synthesis of taxol, taxol analogs and their intermediates with variable A-ring side chain structures and compositions thereof An efficient protocol for the synthesis of taxol, taxol analogs and their intermediates is described. The process incudes the attachment of the taxol A-ring side chain to baccatin III and for the synthesis of taxol and taxol analogs with variable A-ring s... | 06/06/2000 |
| 6054457 | Benzamide derivatives and their use as vasopressin antagonists This invention relates to new benzamide derivatives having a vasopressin antagonistic activity, etc, and represented by general formula (I): ##STR1## wherein R1 is aryl optionally substituted with lower alkoxy, etc., R2 is lower... | 04/25/2000 |
| 6049006 | Elevation of HDL cholesterol by N-[2-[(aminothioxomethyl) hydrazono]-2-arylethyl]amides This invention relates to the treatment of atherosclerosis via raising the level of HDL cholesterol by administration of a compound of the formula ##STR1## wherein: R1, R2, and R3 are independently hydrogen, C1 ... | 04/11/2000 |
| 6034272 | Elevation of HDL cholesterol by N-[4-[(aminothioxomethyl) hydrazono]-4-arylbutyl]amides This invention relates to the treatment of atherosclerosis via raising the level of HDL cholesterol by administration of a compound of the formula ##STR1## wherein: R1, R2, and R3 are independently hydrogen, C1 ... | 03/07/2000 |
| 6028205 | C2 tricyclic taxanes Taxane derivatives having alternative C2 substituents.... | 02/22/2000 |
| 6025516 | Resolution of 2-hydroxy-3-amino-3-phenylpropionamide and its conversion to C-13 sidechain of taxanes The present invention provides an efficient route to the C-13 side chain of the anti-cancer drug paclitaxel (TAXOL) and its analogs. The process includes the resolution of racemic erythro 2-hydroxy-3-amino-3-phenylpropionamide by diastereomeric crystalliz... | 02/15/2000 |
| 6025507 | Borneol derivatives, methods of manufacturing them, and their pharmaceutical use Borneol derivatives of formula I ##STR1## in which R1 to R5 and X1 to X2 are defined in the specification, and the method of making the same.... | 02/15/2000 |
| 5985919 | (Het)aryloxy-, -thio- , aminocrotonates, methods of preparing them and their use as insecticides and fungicides (Het)aryloxy-, -thio- and -aminocrotonates of the formula I ##STR1## where the substituents have the following meanings: U is oxygen, sulfur or amino; V is oxygen, sulfur, amino or alkylamino; X, Y and Z independently of one another are .dbd.N-- or .dbd.C... | 11/16/1999 |
| 5952386 | Dihalopropene compounds, insecticides containing them as active ingredients, and intermediates for their production The present invention provides dihalopropene compounds of the general formula: ##STR1## wherein R1 is C1 -C10 alkyl or the like; L is C(.dbd.O)NH or the like; R2, R3 and R4 are indepen... | 09/14/1999 |
| 5886206 | Process for production of methanediphosphonic acid compound A process for production of l-alkylthiomethanediphosphonic acid compound or 1-arylthiomethanediphosphonic acid compound characterized by removing a thiolate byproduct as an insoluble salt, in the condensation represented by the following formula: ##S... | 03/23/1999 |
| 5856578 | Process for the preparation of unsaturated amino compounds The present invention relates to a process for the preparation of aromatic amino compounds which are substituted by a least one group comprising at least one unsaturated carbon-carbon bond, by catalytic hydrogenation of corresponding aromatic nitro compou... | 01/05/1999 |
| 5834620 | Aromatic polyamides and polyesters containing ortho-ether groups Described herein are polyesters and polyamides which contain repeat units derived from novel dicarboxylic acids comprising arylene groups having ortho ethers substituted thereon. Also disclosed are novel compounds from which these polymers can be made. Th... | 11/10/1998 |
| 5834511 | DL- DI- or tri-hydroxyphenylglycine alkyl esters for the treatment of inflammatory and allergic conditions The invention relates to DL-hydroxyphenylamino acid esters of formula ##STR1## wherein n is 3 to 12 and m is 2 or 3. The compounds are useful as therapeutic agents having antiinflammatory, analgesic, antiallergic and antiasthmatic properties, and also as ... | 11/10/1998 |
| 5786499 | Aromatic amides of poly(oxyalkylene)carbamates and fuel compositions containing the same Aromatic amides of poly(oxyalkylene) carbamates having the formula: ##STR1## or a fuel-soluble salt thereof; wherein A, R1 -R10, x, y, and z are as defined herein.... | 07/28/1998 |
