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| Number | Title | Issue Date |
| 7411076 | Coumarin derivative A medicament for enhancing an effect of a cancer therapy based on a mode of action of DNA injury, which comprises as an active ingredient a compound represented by the following general formula (I): wherein X represents a s... | 08/12/2008 |
| 7388064 | Stereoregular polymer and monomer thereof and process for production of both An ester derivant having a crystal structure in which the molecules in two adjacent molecule planes are antiparallel is created from a carboxylic acid having carbon-carbon double bond and a compound having a functional group that can react to a carboxyl group of the... | 06/17/2008 |
| 7381831 | Colorant compounds Disclosed is a compound of the formula and dimers thereof, wherein R, R2, X and Z are as described herein. The compounds are useful as colorants, particularly in applications such as phase change inks. ... | 06/03/2008 |
| 7258236 | Methods and devices utilizing adsorption of chiral molecules at a surface or interface The present invention is concerned with the adsorption of chiral molecules at surfaces or interfaces, with the arrangement and properties of adsorbed chiral molecules, and with devices and methods based thereupon. In particular, an apparatus allows the influence of ... | 08/21/2007 |
| 7078426 | Aryl substituted pyrazoles, triazoles, and tetrazoles, and the use thereof This invention relates to compounds having the Formula I: or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein Het and R5-R8 are set in the specification. The invention also ... | 07/18/2006 |
| 6987128 | Compounds of the N-acylamino amide family, compositions comprising same, and uses The invention concerns novel compounds of the N-acylamino-amide family, compositions, in particular cosmetic or pharmaceutical, containing them, and their use for treating body or face skin ageing, whether chronobiologic or light-induced, and in particular skin agei... | 01/17/2006 |
| 6919363 | Aryl substituted pyrazoles, triazoles and tetrazoles, and the use thereof This invention relates to compounds having the Formula I: or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein Het and R5-R8 are set in the specification. The invention also ... | 07/19/2005 |
| 6803479 | Reagents and method for spatio-temporal control of gene expression by illumination A caged non-steroidal ecdysome memetic (NSE) compound and a method for producing free NSE by subjecting the charged NSE to UV irradiation. ... | 10/12/2004 |
| 6753347 | Intermediates for the synthesis of benzimidazole derivatives and a process for the preparation thereof This invention provides a process for the preparation of a benzimidazole derivative (I) or a pharmaceutically acceptable salt thereof, wherein R1 is C1-C6 alkyl, C1-C6 | 06/22/2004 |
| 6730700 | 3,4,5,-trisubstituted aryl nitrone compounds and pharmaceutical compositions containing the same Disclosed are 3,4,5-trisubstituted aryl nitrone compounds and pharmaceutical compositions containing such compounds. The 3,4,5-trisubstituted aryl nitrone compounds have formula (I); where R1-R4 are as defined in the specification. The disclose... | 05/04/2004 |
| 6699463 | Photostable cationic organic sunscreen compounds with antioxidant properties and compositions obtained therefrom Compounds of Formula I ##STR1## Each R is independently linear or branched C1 to C8 alkyl, or linear or branched C1 to C8 alkoxy or one R is H and the other R is linear or branched C1 to C8 | 03/02/2004 |
| 6686496 | Treatment of myeloma The compounds of the invention which encompasses a class of compounds having the property of anti-carcinogenic activity against human myeloma r comprising 4-oxo-2-butenoic acid compounds and 3-hydrazino-2,4-dioxobutanoic acid compounds and more specifical... | 02/03/2004 |
| 6673942 | Resolution of DL-racemic mixtures The present invention relates to a process for the resolution of DL-racemic mixtures of compounds which crystalize in the form of a conglumerate. Both, the D and L-enantiomers are obtained according to the invention in a industrially feasable process by a... | 01/06/2004 |
| 6653500 | Method for the manufacture of Anagrelide Methods are provided for making Anagrelide base from 2,3-dichlorobenzaldehyde. A method is also provided for making an intermediate compound ethyl N-(2,3-dichloro-6-nitrobenzyl)glycine from 2,3-dichlorobenzaldehyde and for reducing the glycine compound us... | 11/25/2003 |
| 6639093 | Process for the preparation of hydroxybenzoic benzyl esters The invention relates to the preparation of hydroxybenzoic benzyl esters by reacting benzyl chloride with hydroxybenzoic acids in the presence of one or more amides.... | 10/28/2003 |
| 6630598 | Process for producing N-acylnitroaniline derivative A process of reacting a nitroaniline compound of formula (2): ##STR1## with an acid anhydride or acid halide is carried out in the presence of an alkali metal compound or an alkaline earth metal compound to produce an acylnitroaniline derivative. The proc... | 10/07/2003 |
| 6596863 | Medical composition containing nitroetheneamine Derivative or salt there of as active constituent Process for producing a nitroetheneamine derivative ##STR1## or its stereoisomer, its tautomer or a salt thereof comprising reacting a compound of the formula ##STR2## with a compound of the formula R6 --CH2 NO2 to obtain ... | 07/22/2003 |
| 6589970 | 6-(aryl-amido or aryl-amidomethyl)-naphthalen-2-yloxy-acidic derivatives as inhibitors of plasminogen activator inhibitor type-1 (PAI-1) This invention provides novel compounds, pharmaceutical compositions and methods of treating thrombotic disorders in mammals, the compounds having the formula: ##STR1## Wherein: Ar is phenyl, naphthyl, furanyl, benzofuranyl, indolyl, pyrazolyl, oxazo... | 07/08/2003 |
| 6552076 | Compounds for altering mitochondrial function and cellular responses Compounds for treating diseases by altering mitochondrial function that affects cellular processes, as well as to compositions and methods related thereto. The compounds have the structure ##STR1## wherein R1, R2, R3 and A... | 04/22/2003 |
| 6552216 | Molecular model for VLA-4 inhibitors Pharmacophore models of VLA-4 inhibitors, methods of identifying novel inhibitors and novel inhibitors identified by these methods.... | 04/22/2003 |
| 6531624 | Aminoacrylic acid derivatives and process for producing the same A process for producing a benzoylacrylic acid derivative (formula 1) in high yield through a small number of steps and a simple purification step. The process comprises reacting 2,4,5-trifluoro-3-methyl-6-nitrobenzoyl chloride with a compound (formula 2) to yi... | 03/11/2003 |
| 6495546 | Propanolamine derivatives Propanolamine derivatives represented by the following formula (I): ##STR1## These derivatives may be 댣 agonists and exert sympathomimetic, anti-ulcerous, anti-pancreatitis, lipolytic and anti-urinary incontinence and anti-pollakiuria ac... | 12/17/2002 |
| 6486202 | Inhibitors of isoprenyl transferase Provided are novel peptidomimetic isoprenyl transferase inhibitors, methods for synthesizing such inhibitors, and methods for the use of such inhibitors for the treatment of tumors.... | 11/26/2002 |
| 6462221 | Synthesis of nitroalcohol diastereomers The present invention relates to a method of preparing a 1-nitro-3-substituted-3-amino-2-propanol diastereomer represented by Structural Formula I: ##STR1## In Structural Formula I, R is an amine protecting group, and R1 is an amino acid s... | 10/08/2002 |
| 6451792 | Medical composition containing nitroetheneamine derivative or salt thereof as active constituent A medical composition containing, as an active constituent, a nitroetheneamine derivative represented by the formula (I): ##STR1## wherein the substituents are as defined in the disclosure, its stereoisomers, its tautomers or a salt thereof.... | 09/17/2002 |
| 6410749 | Process for the preparation of optically active amino alcohols Process for preparing optically active ଲ-amino alcohols represented by a general formula (2): Ra--C*H(OH)--C*H(Rb)--Rc wherein Ra and Rc are each independently hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, Rb is one memb... | 06/25/2002 |
| 6407100 | Fungicidal aromatic oximes The invention relates to novel compounds of the formula ##STR1## in which R1 is C1-4 alkyl and (Y--X) is CH2, C1-2 alkylthio-CH.dbd. or C1-2 alkyl-ON.dbd. and Z is an aldimino or ketimino group, and t... | 06/18/2002 |
| 6403789 | Method of halogenating hydroxyl group A halogenating agent of the formula (1) and a method of halogenating hydroxyl group ##STR1## wherein R1 and R2 are the same or different and are each ethyl, propyl, isopropyl, butyl, isobutyl or allyl; X is chlorine atom or bromine ... | 06/11/2002 |
| 6384264 | Photoactive materials applicable to imaging systems Organic photoprecursors of amines are provided for use in photosensitive imaging systems, finding particular application in the preparation of lithographic printing plates. Said photoprecursors generate free amines on exposure to long wavelength UV or vis... | 05/07/2002 |
| 6379590 | Method for making unsymmetrically substituted fluorenyl compounds for nonlinear optical applications A new method for producing unsymmetrically substituted fluorenyl compounds, one step of which is the preparation of 2,7-disubstituted fluoren-9-one derivatives via the nucleophilic substitution of a compound of the formula D ##STR1## wherein A' is se... | 04/30/2002 |
| 6369194 | Vicinyl tricarbonyl compounds and combinatorial libraries containing same The invention relates to compounds of formula ##STR1## where R is a structural diversity element selected from the group consisting of alkyl, cycloalkyl, aryl, heteroaryl, peptidyl, heteroatom-substituted alkyl, cycloalkyl, and amines; and Nu is a st... | 04/09/2002 |
| 6342523 | 3,4,5-trisubstituted aryl nitrone compounds, pharmaceutical compositions containing the same and methods for treating inflammation Disclosed are 3,4,5-trisubstituted aryl nitrone compounds and pharmaceutical compositions containing such compounds. The 3,4,5-trisubstituted aryl nitrone compounds have the formula: ##STR1## where R1 -R4 are as defined in the specif... | 01/29/2002 |
| 6331542 | Protease inhibitors The present invention provides compounds which inhibit proteases, including cathepsin K, pharmaceutical compositions of such compounds, and methods for treating diseases of excessive bone loss or cartilage or matrix degradation, including osteoporosis; gi... | 12/18/2001 |
| 6329372 | Phenylalanine derivatives Phenylalanine derivatives of formula (1) are described: ##STR1## wherein R is a carboxylic acid or a derivative thereof; L1 is a linker atom or group; Het is an optionally substituted heteroaromatic group; and the salts, solvates, hydrates and N-oxides t... | 12/11/2001 |
| 6303791 | One pot synthesis of 2-oxazolidinone derivatives The invention provides an improved process for preparing compounds of formula (I) ##STR1##... | 10/16/2001 |
| 6284777 | Carbohydrazide protease inhibitors The present invention provides compounds which inhibit proteases, including cathepsin K, pharmaceutical compositions of such compounds, and methods for treating diseases of excessive bone loss or cartilage or matrix degradation, inducing osteoporosis; gin... | 09/04/2001 |
| 6194567 | Halogenating agent and process for halogenating hydroxyl group A halogenating agent of the formula (1) and a method of halogenating hydroxyl group ##STR1## wherein R1 and R2 are the same or different and are each ethyl, propyl, isopropyl, butyl, isobutyl or allyl; X is chlorine atom or bromine ... | 02/27/2001 |
| 6130246 | Pesticides The compounds of formula I ##STR1## wherein: a) X is O, and Y is OC1 -C4 alkyl; or b) X is O or S, and Y is NHCH3 have fungicidal properties and can be used in plant protection for controlling and preventing disease infest... | 10/10/2000 |
| 6127568 | Phenylacetic acid derivatives, preparation thereof and intermediates thereof, and compositions containing them Phenylacetic acid derivatives of the formula I ##STR1## where the substituents and the index have the following meanings: X is NOCH3, CHOCH3, CHCH3 and [sic] CHCH2 CH3 ; R1 is hydrogen and ... | 10/03/2000 |
| 6096773 | Compounds that inhibit the binding of integrins to their receptors A method for the inhibition of the binding of 댔 댡 integrin to its receptors, for example VCAM-1 (vascular cell adhesion molecule-1) and fibronectin; compounds that inhibit this binding; pharmaceutically active compositi... | 08/01/2000 |
