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| Number | Title | Issue Date |
| 7432388 | Disubstituted chalcone oximes having RARγ retinoid receptor antagonist activity Compounds of the formula where the variables have the values described in the specification are antagonists of RARγretinoid receptors. ... | 10/07/2008 |
| 7414040 | Thrombopoietin mimetics Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comp... | 08/19/2008 |
| 7351849 | Process for producing optically active β-amino acid derivatives The present invention is to provide a method for producing the desired optically active β-amino acid derivatives of high optical purities in high yields, without requiring a step of deprotection. More particularly, the present invention relates to a method for prod... | 04/01/2008 |
| 7314888 | Compounds and medicinal use thereof A compound or a salt thereof having the atom corresponding to N3 and the two or more atoms selected from N1, N2, N4 and N5, said atoms constitute the pharmacophore represented by the following formula: | 01/01/2008 |
| 7282605 | Optically active 2-allylcarboxylic acid derivative and process for producing the same The present invention provides a process for producing an optically active 2-allylcarboxylic acid derivative, which is useful as a pharmaceutical intermediate, from readily available and inexpensive starting materials by the process which can be practiced on a comme... | 10/16/2007 |
| 7244864 | Process for the preparation of N,N-substituted 5-amino-1,3-benzenedicarboxamides The invention relates to a process for the preparation of a compound of formula (I), wherein R represents a 2,3-dihydroxy-1-propyl or a 1,3-dihydroxy-2-propyl radical, via direct amidation of a dialkyl ester of 5-amino-1,3-benzenedicarboxylic acid of formula (V), wh... | 07/17/2007 |
| 7138538 | Process for the separation of enantiomers and enantiopure reagent Process for the separation of enantiomers comprising at least one free functional group, in which process a reagent based on an enantiopure amino acid is reacted in basic medium with a mixture comprising enantiomers. ... | 11/21/2006 |
| 7094919 | Preparation of substituted aromatic carboxylic acid esters Methods for preparing substituted aromatic carboxylic acid esters are described. In particular, the invention relates a method for preparing a nitro-substituted aromatic carboxylic acid ester: Additionally the inventio... | 08/22/2006 |
| 7037938 | Aminoalcohol derivatives The present invention relates to a compound formula [I]: wherein Y is bond, —O—(CH2)n— (in which n is 1, 2, 3 or 4), etc., Z is ... | 05/02/2006 |
| 7012151 | Method for nitrating aniline derivatives The present invention relates to a process for the highly regioselective aromatic nitration of alkyl 4-alkanoylamino-3-alkyl-benzoates in the 5-position in a mixture containing nitric acid and the use of the resulting products for preparing, in particular, pharmaceu... | 03/14/2006 |
| 6949585 | Cyclooctanone derivatives and cyclodecanone derivative, and use thereof The present invention provides a compound which has cytokine production inhibitory activity and is useful for the treatment of diseases which is associated with cytokine. The compound is represented by the following general formula (I) [wherein A represents a cyclic... | 09/27/2005 |
| 6855842 | Intermediates for making a bezofuran or benzothiophene derivative nitrated in position 5 and uses thereof The invention concerns novel nitroaromatic compounds of general formula (I′) wherein: R, R′1, R2, Z and n are as defined in claim 1. The invention also concerns a method for preparing nitroaromatic compounds nitrated in position 4. The invention further c... | 02/15/2005 |
| 6753347 | Intermediates for the synthesis of benzimidazole derivatives and a process for the preparation thereof This invention provides a process for the preparation of a benzimidazole derivative (I) or a pharmaceutically acceptable salt thereof, wherein R1 is C1-C6 alkyl, C1-C6 | 06/22/2004 |
| 6727098 | Biaryl-type compounds, CD color fixing agent and method for determination of absolute configuration A novel achiral biaryl-type compound and a circular dichroism (CD) color fixing agent are provided. Furthermore, a method for determining an absolute configuration of a chiral compound is carried out by introducing the above achiral biaryl-type compound into the chi... | 04/27/2004 |
| 6699463 | Photostable cationic organic sunscreen compounds with antioxidant properties and compositions obtained therefrom Compounds of Formula I ##STR1## Each R is independently linear or branched C1 to C8 alkyl, or linear or branched C1 to C8 alkoxy or one R is H and the other R is linear or branched C1 to C8 | 03/02/2004 |
| 6686496 | Treatment of myeloma The compounds of the invention which encompasses a class of compounds having the property of anti-carcinogenic activity against human myeloma r comprising 4-oxo-2-butenoic acid compounds and 3-hydrazino-2,4-dioxobutanoic acid compounds and more specifical... | 02/03/2004 |
| 6656737 | Isocynate derivatizing agent and methods of production and use An organic compound useful for detecting the total quantity of isocyanate in an environmental sample is provided. The compound is 9-anthrcenylmethyl-1-piperazinecarboxylate (PAC), an isocyanate derivatizing agent. A process for producing PAC and methods f... | 12/02/2003 |
| 6630598 | Process for producing N-acylnitroaniline derivative A process of reacting a nitroaniline compound of formula (2): ##STR1## with an acid anhydride or acid halide is carried out in the presence of an alkali metal compound or an alkaline earth metal compound to produce an acylnitroaniline derivative. The proc... | 10/07/2003 |
| 6555703 | Process for the preparation of carboxylic acid benzyl esters The invention relates to a process for forming a carboxylic benzyl ester comprising reacting a dibenzyl ether with a carboxylic acid in the presence of a heteropolyacid and forming a carboxylic acid benzyl ester.... | 04/29/2003 |
| 6538150 | Substituted sulfonylaminomethylbenzoic acid (derivatives) and their preparation The present invention relates to a compound of the formula (I) ##STR1## The compound according to the invention is suitable for the preparation of herbicidal active substances such as sulfonylureas.... | 03/25/2003 |
| 6531624 | Aminoacrylic acid derivatives and process for producing the same A process for producing a benzoylacrylic acid derivative (formula 1) in high yield through a small number of steps and a simple purification step. The process comprises reacting 2,4,5-trifluoro-3-methyl-6-nitrobenzoyl chloride with a compound (formula 2) to yi... | 03/11/2003 |
| 6403638 | 2,4-pentadienoic acid derivatives having selective activity for retinoid X (RXR) receptors Compounds having the formulas below, where R is H, lower alkyl, or a pharmaceutically acceptable salt, and where R1 represents i-propyl, t-butyl or n-butyl groups, have selective RXR retionoid agonist activity. ##STR1##... | 06/11/2002 |
| 6369194 | Vicinyl tricarbonyl compounds and combinatorial libraries containing same The invention relates to compounds of formula ##STR1## where R is a structural diversity element selected from the group consisting of alkyl, cycloalkyl, aryl, heteroaryl, peptidyl, heteroatom-substituted alkyl, cycloalkyl, and amines; and Nu is a st... | 04/09/2002 |
| 6348619 | Process for producing a carboxylic acid ester by reacting an aldehyde and an alcohol using a palladium type catalyst A carboxylic acid ester is prepared by a process comprising: reacting an aldehyde and an alcohol in a liquid phase in the presence of molecular oxygen as indicated by the following reaction: RCHO+R'OH+O2.fwdarw.RCOOR'+H2 O in the presence of a... | 02/19/2002 |
| 6337418 | Preparation of C1-C5 alkyl esters of nitro or thioether substituted aromatic carboxylic acids Methods for preparing substituted aromatic carboxylic acid esters are described. In particular, the invention relates a method for preparing a nitro-substituted aromatic carboxylic acid ester: ##STR1## Additionally the invention relates to a method for pr... | 01/08/2002 |
| 6329377 | Ketomethylene group-containing cysteine and serine protease inhibitors The present invention is directed to novel ketomethylene group-containing inhibitors of cysteine or serine proteases. Methods for the use of the protease inhibitors are also described.... | 12/11/2001 |
| 6310245 | 3-aminocarbonyl/3-aminothiocarbonyl-substituted 2-benzoyl-cyclohexan-1,3-diones with herbicidal effect The invention relates to 2-benzoylcyclohexane-1,3-diones of the formula I ##STR1## where R1, R2 are hydrogen, nitro, halogen, cyano, thiocyanato, alkyl, haloalkyl, alkoxyalkyl, alkenyl, alkynyl, --OR5, --OCOR6, ... | 10/30/2001 |
| 6284910 | Farnesyl pyrophosphate analogs The post-translational addition of a farnesyl moiety to the Ras oncoprotein is essential for its membrane localization and is required for both its biological activity and ability to induce malignant transformation. The present invention describes design ... | 09/04/2001 |
| 6284894 | Preparation of allylic aromatic compounds A process for the preparation of an allylic aromatic compound in which an aromatic amine is reacted first with a nitrite and then with an allylic olefin having an eliminatable terminal substituent. Novel allylic derivatives of disubstituted benzene compou... | 09/04/2001 |
| 6258982 | Process for the preparation of substituted aromatic amino compounds The present invention relates to a hydrogenation process for the preparation of aromatic amino compounds containing directly on the aryl ring or in a side chain one or more entities that may also undergo hydrogenation, such as carbon multiple bonds, nitri... | 07/10/2001 |
| 6255517 | Thymol derivatives having anti-tumor activity, and anti-cancer agent comprising the same The present invention relates to a thymol derivative represented by following Chemical Formula 1, pharmaceutically acceptable salts or esters thereof, and anti-cancer agents comprising the same as an active ingredient. ##STR1##... | 07/03/2001 |
| 6251944 | Para-substituted phenylene derivatives The present invention relates to a class of compounds represented by Formula I ##STR1## or a pharmaceutically acceptable salt thereof, pharmaceutical composition comprising compounds of the Formula I, and methods of selectively inhibiting or antagoni... | 06/26/2001 |
| 6162943 | Method for producing -alkoxy--trifluoromethyl-aryl acetic esters and -aryl acetic acids Process for the preparation of -alkoxy--trifluoromethyl-arylacetic esters of the formula (I) ##STR1## wherein R is a component selected from the group consisting of C1 -C6 -alkyl, C2 -C6 ... | 12/19/2000 |
| 6147224 | 2,4-pentadienoic acid derivatives having selective activity for retinoid X (RXR) receptors Compounds of Formula 1, Formula 2 or Formula 3 where X is O, S, or (CR1 R1)n where n is 0, 1 or 2; Y is a bivalent radical having Formula 4 or Formula 5 where o is an integer from 1 to 4 ##STR1## or Y is a bivalent ar... | 11/14/2000 |
| 6057269 | Benzylhydroxylamines and intermediates used to prepare them Benzylhydroxylamines I ##STR1## (X=--N(R7)--O--; Y=O, S; R1 =halogen, CN, NO2, CF3 ; R2 =H, halogen; R3 =H, NH2, CH3 ; R4 =H, halogen, C1 -C... | 05/02/2000 |
| 6054457 | Benzamide derivatives and their use as vasopressin antagonists This invention relates to new benzamide derivatives having a vasopressin antagonistic activity, etc, and represented by general formula (I): ##STR1## wherein R1 is aryl optionally substituted with lower alkoxy, etc., R2 is lower... | 04/25/2000 |
| 6043360 | Intermediates and a process for preparing benzo[B]thiophenes The instant invention provides intermediates and processes for the preparation of compounds of formula IV ##STR1## wherein: n is 0, 1, or 2; R is hydrogen or C1 -C4 alkyl; X1 is hydrogen, cyano, 4-hydroxybenzoyl, 4-haloben... | 03/28/2000 |
| 6030803 | Dibenzodihydropyridinecarboxylic esters and their use in chemiluminescent assay methods Dibenzodihydropyridinecarboxylic esters are provided which comply with formula (1) or (2), wherein: R1 is substituted alkyl or cyano; R2 and R3 are independently hydrogen, alkyl, substituted alkyl, aryl or substituted aryl... | 02/29/2000 |
| 6002041 | Process for preparing di-C1 - C4 -alkyl 5-nitro-isophthalates Particularly pure di-C1 -C4 -alkyl 5-nitro-isophthalates are obtained in good yield and in a simple process by dissolving 5-nitro-isophthalic acid in a mixture of a C1 -C4 -alkyl alcohol and a solvent which is m... | 12/14/1999 |
| 5985919 | (Het)aryloxy-, -thio- , aminocrotonates, methods of preparing them and their use as insecticides and fungicides (Het)aryloxy-, -thio- and -aminocrotonates of the formula I ##STR1## where the substituents have the following meanings: U is oxygen, sulfur or amino; V is oxygen, sulfur, amino or alkylamino; X, Y and Z independently of one another are .dbd.N-- or .dbd.C... | 11/16/1999 |
