Did You Know...
...that in 1800 ether was first used by partyers as a fun diversion? Sniffing the gas led to hilarious and raucous laughter as people watched each other become more and more intoxicated and silly. Several doctors independently realized the value ether would have to anesthetize surgery patients. Of those who claimed rights to the "discovery," none had a happy ending. One had a seizure and died defending his rights. Another spent his life in an asylum because he had been denied acclaim. A third became addicted to chloroform and, in a New York City jail, he soaked a cloth in the drug, severed an artery and bled to death.
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| Number | Title | Issue Date |
| 7812190 | Derivatization and solubilization of fullerenes for use in therapeutic and diagnostic applications The invention provides improved therapeutic and diagnostic fullerenes and endohedral fullerenes. The fullerenes and endohedral fullerenes of the invention are derivatized with at least two charged functional groups (and preferably more than two charged functional gr... | 10/12/2010 |
| 7709677 | Process of preparing arylethanoldiamines An improved process for preparing arylethanoldiamines is described. Compounds of this type are known to be useful as agonists at atypical beta-adrenoceptors (also known as beta-3-adrenoceptors). ... | 05/04/2010 |
| 7592476 | Process for producing enantiopure β-amino acid derivatives, and enantiopure β-amino acid derivatives Process for producing enantiopure β-amino acid derivatives corresponding to general formula (I) R1-NZ-CHR2-CH2—COOR3 (I) in which R1 and R2 independently denote organic residues optionally forming a cyclic substituent, R3 denotes H or an organic residu... | 09/22/2009 |
| 7442796 | Compounds for the treatment of metabolic disorders Agents useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, hyper-lipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis are disclosed. Formula (I) wherein n is 1 or 2; m is 0 to 4; ... | 10/28/2008 |
| 7442718 | Inhibitors of aspartyl protease The present invention relates to a novel class of sulfonamides which are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of HIV aspartyl protease inhibitors characterized by specific structural and physicochemical features. T... | 10/28/2008 |
| 7432388 | Disubstituted chalcone oximes having RARγ retinoid receptor antagonist activity Compounds of the formula where the variables have the values described in the specification are antagonists of RARγretinoid receptors. ... | 10/07/2008 |
| 7411084 | Method of preparing phenoxy alkanoic, alkenoic, and alkynoic acids and salts thereof via a dicarboxylate intermediate The present invention relates to a method of preparing a phenoxy alkanoic, alkenoic, or alkynoic acid or a salt thereof from a phenoxy containing compound via a dicarboxylate intermediate. The phenoxy alkanoic, alkenoic, and alkynoic acids and salts thereof prepared... | 08/12/2008 |
| 7408078 | Anthranilic acid derivatives useful in treating infection with hepatitis C virus The present invention provides pharmaceutical compositions useful in treating hepatitis C infection. The present invention also provides methods of treating hepatitis C infection by administering to a mammal the pharmaceutical compositions of the present invention. | 08/05/2008 |
| 7375245 | N-(4-oxo-butanoic acid) -L-amino acid-ester derivatives and methods of preparation thereof The present invention provides a compound of the following formula (I): wherein R1 is methyl or 4-aminobutyl, which may be acylated; X is phenyl or substituted phenyl; W is an esterified group removable by hydrog... | 05/20/2008 |
| 7374749 | Amino substituted hydroxyphenyl benzophenone derivatives Described are amino substituted hydroxyphenyl benzophenone derivatives of formula (I), wherein R1, and R2 independently from each other are; C1-C20alkyl; C2-C20-alken... | 05/20/2008 |
| 7371867 | Non-racemic trifluoroleucine, and methods of making and using One aspect of the invention relates to hexafluoroleucine and congeners thereof, and methods of making the compounds. Another aspect of the invention relates to the synthesis of protein cores comprising hexafluoroleucine and congeners thereof. Certain peptides compri... | 05/13/2008 |
| 7368592 | Process for the preparation of alkyl n-alkylanthranilate This invention is directed to a process of preparing alkyl N-alkylanthranilate, specially Methyl N-methylanthranilate, represented by Formula (I), in a one pot synthesis, using available and cheap commercial chemicals such as Isatoic anhydride, solid sodium hydroxid... | 05/06/2008 |
| 7365197 | Method for the regioselective preparation of substituted benzo[g]quinoline-3-carbonitriles and benzo[g]quinazolines This invention relates to a method for the regioselective synthesis of 4,6,7,8-substituted benzo[g]quinoline-3-carbonitriles and 4,6,7,8-substituted benzo[g]quinazolines as well as intermediates thereof. The compounds derived from this invention are useful for the t... | 04/29/2008 |
| 7329515 | Solid support for the synthesis of 3′-amino oligonucleotides The present invention discloses novel methods and solid supports for the synthesis of 3′-amino oligonucleotides. The novel supports are based on an unsubstituted or ring-substituted hydroxymethylbenzoyl linker element wherein the hydroxymethyl group is esterified ... | 02/12/2008 |
| 7314888 | Compounds and medicinal use thereof A compound or a salt thereof having the atom corresponding to N3 and the two or more atoms selected from N1, N2, N4 and N5, said atoms constitute the pharmacophore represented by the following formula: | 01/01/2008 |
| 7312350 | Process for preparing arylalkynes The invention relates to a process for preparing arylvinyl halides and sulphonates and arylalkynes by reacting haloaromatics or aryl sulphonates with vinyl halides or sulphonates in the presence of a palladium catalyst and a base and, if appropriate, subsequent elim... | 12/25/2007 |
| 7312245 | Diamine derivatives, process for producing the diamine derivatives, and fungicides containing the diamine derivatives as an active ingredient A fungicide can be provided by using, as an active ingredient, a diamine derivative of the following general formula (1): wherein R1 to R7 represent a specific substituen... | 12/25/2007 |
| 7294639 | Biaromatic ligand activators of PPARγ receptors Novel pharmaceutical/cosmetic compositions contain at least one biaromatic ligand activator of a PPARγ receptor, such biaromatic ligand having the structural formula (I): and are well suited, inter alia, for reg... | 11/13/2007 |
| RE39850 | Inhibitors of histone deacetylase The invention relates to the inhibition of histone deactylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and condi... | 09/18/2007 |
| 7268233 | Nickel-carbene, palladium-carbene and platinum-carbene complexes, their production and use in catalytic reactions The invention relates to novel monocarbene complexes of nickel, palladium or platinum with electron-deficient olefin ligands, to their preparation and to their use in the homogeneous catalysis of organic reactions. ... | 09/11/2007 |
| 7265136 | Substituted stilbene compounds with vascular damaging activity A compound for use in inducing necrosis in vascular tissue of a tumor in an animal. The compound contains a first moiety which is a cis-stilbene moiety and a second moiety which is an inhibitor of the formation or action of nitric acid. Also, a method for inducing n... | 09/04/2007 |
| 7265238 | Process for preparing methyl 4-(aminomethyl)benzoate An advantageous process is provided for preparing methyl 4-(aminomethyl)benzoate by esterifying 4-(aminomethyl)benzoic acid and subsequently obtaining the methyl 4-(aminomethyl)benzoate, this process proceeding under specific pH and temperature control and isolation... | 09/04/2007 |
| 7247741 | Acetylamino benzoic acid compounds and their use for nonsense suppression and the treatment of disease Novel acetylamino benzoic acid compounds, methods of using and pharmaceutical compositions comprising an acetylamino benzoic acid derivative are disclosed. The methods include methods of treating or preventing a disease ameliorated by modulation of premature transla... | 07/24/2007 |
| 7238831 | Mesogens Novel platform mesogens, intermediates, and polymerizable mesogens made therefrom. ... | 07/03/2007 |
| 7220876 | Arylcycloalkyl derivatives having branched side chains, processes for their preparation and their use as pharmaceuticals Arylcycloalkyl derivatives having branched side chains, processes for their preparation and their use as pharmaceuticals The invention relates to arylcycloalkyl derivatives having branched side chains and to their physiologically acceptable salts and physiolo... | 05/22/2007 |
| 7220875 | Amino acid derived prodrugs of propofol, compositions and uses thereof The present invention provides propofol prodrugs, methods of making propofol prodrugs, pharmaceutical compositions of propofol prodrugs and methods of using propofol prodrugs and pharmaceutical compositions thereof to treat or prevent diseases or disorders such as m... | 05/22/2007 |
| 7208630 | Heat shock protein 90 inhibitors Novel compounds useful for inhibiting the 90 kDa heat shock proteins containing a quinone-like moiety and a di-hydroxy phenol like moiety, similar to geldanamycin and radicicol. ... | 04/24/2007 |
| 7199141 | Drugs for chronic pains Nitro-oxyderivative compounds or salts thereof having the following general formula (I): A—(B)b0—(C)c0—NO2 wherein: c0 is an integer and is 0 or 1, b0 is an integer and is 0 or 1, A=R—T1—, wherein R is the radica... | 04/03/2007 |
| 7192980 | Certain substituted polyketides, pharmaceutical compositions containing them and their use in treating tumors The present invention relates to certain substituted polyketides of formula I, wherein A, B, C, D, E, F and m are as defined herein, pharmaceutical compositions containing said compounds, and the use of said comp... | 03/20/2007 |
| 7193034 | Synthetic peptides, conjugation reagents and methods The invention provides methods and compositions useful for making synthetic peptide conjugates. In one embodiment, the invention provides compositions comprising the structure: wherein R is selected from lower su... | 03/20/2007 |
| 7179941 | Carbonylamino-substituted acyl phenyl urea derivatives, process for their preparation and their use The invention relates to compounds of the formula I in which the radicals are defined as specified, and also to their physiologically tolerated salts. The compounds are suitable, for example, as medicaments for p... | 02/20/2007 |
| 7169879 | Bisphenyl-2,3,5,6-tetrafluoro-4-trifluoromethylphenyl phosphine oxide derivative and synthesis thereof The present invention relates to bisphenyl-2,3,5,6-tetrafluoro-4-trifluoromethylphenylphosphine oxide compounds and synthesis thereof, more particularly to novel bisphenyl-2,3,5,6-tetrafluoro-4-trifluoromethylphenylphosphine oxide compounds having both a perfluorina... | 01/30/2007 |
| 7141312 | Organic electroluminescent device based on 2,5-diaminoterephthalic acid derivatives The application relates to an organic electroluminescent device which contains 2,5 diaminoterephthalic acid derivatives of formula 1a as emitter substances in one or several emitter layers in a pure or doped manner. The ring A is a triple unsaturated benzene ... | 11/28/2006 |
| 7138538 | Process for the separation of enantiomers and enantiopure reagent Process for the separation of enantiomers comprising at least one free functional group, in which process a reagent based on an enantiopure amino acid is reacted in basic medium with a mixture comprising enantiomers. ... | 11/21/2006 |
| 7138539 | Colorant compounds containing copolymerizable vinyl groups Disclosed are novel colorant compounds which contain one or more ethylenically-unsaturated (vinyl), photopolymerizable radicals which may be copolymewrized (or cured) with ethylenically-unsaturated monomers to produce colored compositions such as colored acrylic coa... | 11/21/2006 |
| 7135587 | Urea and urethane derivatives as integrin inhibitors Novel urea and urethane derivatives of general formula (I) in which R1, R2, R3, R5, R5′, X, Y, B, m, n and o are as defined in Patent Claim 1, and physiologically acceptable salts or solvates thereof are integrin inhibitors and can be employed for combating... | 11/14/2006 |
| 7132559 | Non-racemic hexafluoroleucine, and methods of making and using it One aspect of the invention relates to hexafluoroleucine and congeners thereof, and methods of making the compounds. Another aspect of the nvention relates to the synthesis of protein cores comprising hexafluoroleucine and congeners thereof. Certain peptides compris... | 11/07/2006 |
| 7125910 | Compounds and compositions for delivering active agents Carrier compounds and compositions therewith which are useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well. ... | 10/24/2006 |
| 7122564 | Biaromatic ligand activators of PPARγ receptors Novel pharmaceutical/cosmetic compositions contain at least one biaromatic ligand activator of a PPARγ receptor, such biaromatic ligand having the structural formula (I): and are well suited, inter alia, for reg... | 10/17/2006 |
| 7119119 | Immunoregulatory compounds and derivatives and methods of treating diseases therewith Compounds are disclosed having the structure of Formula I: where R1 , R3, and R4 are independently hydrogen or C1 to C4 alkyl, and R2 is: ... | 10/10/2006 |
