Did You Know...
...that it was melting ice cream that inspired the invention of the outboard motor? It was a lovely August day and Ole Evinrude was rowing his boat to his favorite island picnic spot. As he rowed, he watched his ice cream melt and wished he had a faster way to get to the island. At that moment the idea for the outboard motor was born!
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| Number | Title | Issue Date |
| 7906676 | Process for preparing 3-amino-5-fluoro-4-dialkoxypentanoic acid ester The present invention relates to a novel process for the production of 3-amino-5-fluoro-4-dialkoxypentanoic acid ester used in the precursor of 3-amino-5-fluoro-4-oxopentanoic acid, represented by the following formula (I): wherein R1 and R2 are as defined in the De... | 03/15/2011 |
| 7888526 | Acid addition salts of 5-aminolevulinic acid or its derivatives The present invention provides an acid addition salt of 5-aminolevulinic acid (5-ALA) or of a 5-ALA derivative (e.g. a 5-ALA ester) with an acid which has a pKa of about 5 or less, preferably about 3 or less, with the proviso that the acid is other than hydrochloric... | 02/15/2011 |
| 7692034 | Process for the preparation of 7-amino syn 3,5-dihydroxy heptanoic acid derivatives via 6-cyano syn 3,5-dihydroxy hexanoic acid derivatives The invention relates to novel synthesis methods for the preparation of the intermediates, which are suitable for the preparation of statin derivatives, especially to novel synthesis methods of the intermediate of formula VI wherein Ra and Rc a... | 04/06/2010 |
| 7687660 | Process for preparing intermediates of HMG-CoA reductase inhibitors The present invention relates to intermediates of rosuvastatin and processes for the production thereof. ... | 03/30/2010 |
| 7671231 | Process for making amino acids A process for making an amino acid by the steps of: (a) contacting a compound of formula I with a hydroformylation catalyst and synthesis gas to produce a mixture of aldehyde compounds comprising the formulas IIa, IIb and I... | 03/02/2010 |
| 7601864 | Method for synthesizing 4,4-dihalogen-2-(dialkylamino)methylene-3-oxy-alkylbutyrate and derivatives thereof A method for synthesizing 4,4-dihalogen-2-(dialkylamino)methylene-3-oxy-alkylbutyrate and its derivatives has acts of: (a) providing N,N-dialkylamino-alkyl-acrylate in a reaction vessel; (b) adding organic alkali, organic solvent and multiple molecular sieves into t... | 10/13/2009 |
| 7504532 | Process for the preparation of 7-amino syn 3,5-dihydroxy heptanoic acid derivatives, intermediates thereof and methods for their preparation Synthesis methods for the preparation of intermediates which are suitable for the preparation of statin derivatives, and especially to synthesis methods for the intermediate of formula (VI) wherein Ra′ and Rc′ are each independently of the ... | 03/17/2009 |
| 7375241 | Ferrocenyl-1,2-diphosphines, the production thereof and their use The invention relates to compounds of formula (I) provided in the form of racemic compounds, mixtures of diastereomers or essentially pure diastereomers, wherein R1 represents a hydrogen atom or C1-C4-alkyl, and at least one secondar... | 05/20/2008 |
| 7358387 | Method for producing 2-dihaloacyl-3-amino-acrylic acid esters and 3-dihalomethyl pyrazole-4-carboxylic acid esters The present invention relates to a process for preparing 2-dihaloacyl-3-aminoacrylic esters of the formula (I) by reacting acid halides of the formula (II) with dialkyla... | 04/15/2008 |
| 7326805 | Method for the synthesis of 4-hydroxyisoleucine and the derivatives thereof The invention relates to a method for the synthesis of two isomers, at function OH, alone or in mixtures, of amino acids α or the derivatives thereof, having general formula (B), wherein: linkage C—O of the 4-position carbon (represented by symbol) denotes one or... | 02/05/2008 |
| 7323609 | Corrosion and gas hydrate inhibitors having improved water solubility and increased biodegradability The invention provides the use of compounds of the formula (1) where R1, R2 are each independently C1- to C22-alkyl, C2- to C22-alken... | 01/29/2008 |
| 7317123 | Process for preparation of 7-amino syn 3,5-dihydroxy heptanoic acid derivatives, intermediates thereof and methods for their preparation The invention relates to novel synthesis methods for the preparation of the intermediates, which are suitable for the preparation of statin derivatives, especially to novel synthesis methods of the intermediate of formula VI wherein Ra′ and Rc | 01/08/2008 |
| 7301031 | Methods for producing hydroxy amino acids, esters, and derivatives thereof A method for producing a hydroxy-amino ester, or derivative thereof, is provided. A substituted β-ketodiester having a ketone group and two ester functional groups is contacted with a ketoreductase under conditions permitting the reduction of the ketone group to an... | 11/27/2007 |
| 7259264 | 3-methylamino-1-(2-thienyl)-1-propanone, production and use thereof The present invention relates to the preparation of 3-methylamino-1-(2-thienyl)-1-propanone and its use for preparing the pharmaceutical (+)-(S)-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine oxalate—(trade name Duloxetine®). ... | 08/21/2007 |
| 7217736 | Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy The invention provides compounds for use in photochemotherapy or diagnosis, said compounds being branched alkyl esters or substituted alkyl esters of 5-aminolevulinic acid, or derivatives or pharmaceutically acceptable salts thereof. In particular, the invention pro... | 05/15/2007 |
| 7199261 | Process for the preparation of 7-amino syn 3,5-dihydroxy heptanoic acid derivatives via 6-cyano syn 3,5-dihydroxy hexanoic acid derivatives The invention relates to novel synthesis methods for the preparation of the intermediates, which are suitable for the preparation of statin derivatives, especially to novel synthesis methods of the intermediate of formula VI wherein Ra and Rc a... | 04/03/2007 |
| 7183240 | Additives for inhibiting the formation of gas hydrates The present invention relates to an additive, and its use for inhibiting nucleation, growth and agglomeration of gas hydrates by adding an effective amount of an inhibitor to a multiphasic mixture which tends to hydrate formation and consists of water, gas and optio... | 02/27/2007 |
| 7169953 | P-chiral phospholanes and phosphocyclic compounds and their use in asymmetric catalytic reactions Chiral ligands and metal complexes based on such chiral ligands useful in asymmetric catalysis are disclosed. The metal complexes according to the present invention are useful as catalysts in asymmetric reactions, such as, hydrogenation, hydride transfer, allylic al... | 01/30/2007 |
| 7161043 | Process for the carbonylation of ethylenically unsaturated compounds and bidentate diphosphine composition used in this process Process for the carbonylation of optionally substituted ethylenically unsaturated compounds by reaction with carbon monoxide and a coreactant in the presence of a catalyst system. The catalyst system includes (a) a source of Pt group metal cations,... | 01/09/2007 |
| 7160507 | Corrosion inhibitors with improved water solubility and improved film persistence The invention relates to an additive and to a method of corrosion inhibition on devices for the recovery and transportation of hydrocarbons in crude oil recovery and processing by adding an effective amount of an inhibitor. The inhibitor comprises an alkoxylated qua... | 01/09/2007 |
| 7157596 | Inhibitors of serine protease activity of matriptase or MTSP1 The present invention provides compounds which inhibit serine protease activity of matriptase or MTSP1. Also provided are pharmaceutical compositions comprising those compounds and methods of using the compounds and pharmaceutical compositions to treat conditions am... | 01/02/2007 |
| 7105702 | P-chiral phospholanes and phosphocyclic compounds and their use in asymmetric catalytic reactions Chiral ligands and metal complexes based on such chiral ligands useful in asymmetric catalysis are disclosed. The metal complexes according to the present invention are useful as catalysts in asymmetric reactions, such as, hydrogenation, hydride transfer, allylic al... | 09/12/2006 |
| 7084089 | Process for the carbonylation of ethylenically unsaturated compounds, bidentate diphosphine composition used in this process and a process for preparation of this bidentate diphosphine composition Process for the carbonylation of optionally substituted ethylenically unsaturated compounds by reaction with carbon monoxide and a coreactant in the presence of a catalyst system. The catalyst system includes (a) a source of Pt group metal cations,... | 08/01/2006 |
| 7067689 | Process for production of pentahydroxyhexylcarbamoyl alkanoic acids The present invention relates to improved processes for the production of compounds of formula I: ... | 06/27/2006 |
| 7057038 | Kinetic resolutions of chiral 2- and 3-substituted carboxylic acids One aspect of the present invention relates to a method for the kinetic resolution of racemic and diastereomeric mixtures of chiral compounds. The critical elements of the method are: a non-racemic chiral tertiary-amine-containing catalyst; a racemic or diastereomer... | 06/06/2006 |
| 7056854 | Process for the carbonylation of ethylenically unsaturated compounds and bidentate diphosphine composition used in this process Process for the carbonylation of optionally substituted ethylenically unsaturated compounds by reaction with carbon monoxide and a coreactant in the presence of a catalyst system. The catalyst system includes (a) a source of Pt group metal cations,... | 06/06/2006 |
| 6992107 | Esters of 5-aminolevulinic acid and their use as photosensitizing compounds in photochemotherapy The present invention provides a compound of formula I; R22N—CH2COCH2—CH2CO—OR1 (I) wherein R1 represents (a) an optionally substituted branched C6-30 | 01/31/2006 |
| 6974879 | Process for preparing single enantiomers of 5,5,5,5′,5′,5′-hexafluoroleucine and protected analogs A process for synthesizing L and D-5,5,5,5′,5′,5′-hexafluoroleucine and protected analogs is disclosed. These compounds have utility in the preparation of fluorous peptides and proteins, which display interesting and unusual properties including strong self-as... | 12/13/2005 |
| 6965049 | Zwitterionic lipid compound and uses thereof Provided is a zwitterionic lipid compound represented by formula (I) given below: In formula (I), m and n are independently integers of 1 to 4, p is an integer of 7 to 21, one R is NH3+, and each ... | 11/15/2005 |
| RE38796 | Process for producing 3-amino-2-oxo-1-halogenopropane derivatives Compounds formed by reacting a protected amino acid with an alkali metal enolate of an alkyl acetate are reacted with a halogenating agent for halogenation of the 2-position, or a protected amino acid is reacted with an alkali metal enolate of an alkyl halogenoaceta... | 09/13/2005 |
| 6855847 | Process for producing optically active amide from α β- unsaturated amide derivative in the presence of transition metal complex containing phosphine-phosphorane compound and transition metal A novel process for producing an optically active amide excellent in chemical selectivity and enantioselectivity by asymmetric hydrogenation of an α,β-unsaturated amide and also allowing the reaction to proceed efficiently even when a trace amount of a catalyst is... | 02/15/2005 |
| 6849756 | Process for making optically active α-amino ketones and selected novel optically active α-amino ketones The invention includes selected novel optically active α-amino ketones which either are themselves useful or are intermediates for the preparation of known ketomethylene pseudopeptides useful as antibiotics, antibiotic enhancers, or enzyme inhibitors. Further, the ... | 02/01/2005 |
| 6777443 | Dipeptide derivatives Compounds of the formula wherein R, R1, COOR2, R3-R7, alk, and X have meaning as defined, such being useful as dual inhibitors of angiotensin converting enzyme and neutral endo... | 08/17/2004 |
| 6743914 | Kinetic resolutions of chiral 2-and 3-substituted carboxylic acids One aspect of the present invention relates to a method for the kinetic resolution of racemic and diastereomeric mixtures of chiral compounds. The critical elements of the method are: a non-racemic chiral tertiary-amine-containing catalyst; a racemic or diastereomer... | 06/01/2004 |
| 6740774 | Preparation of N-acylamino acid esters and N-acylamino acetals A process for preparing N-acyl derivatives of the formula I, in which the substituents independently of one another have the following meanings: X is CH(OR3)2, COOR3; R... | 05/25/2004 |
| 6624142 | Trimethyl lock based tetrapartate prodrugs The invention is directed primarily to compounds of Formula I: ##STR1## wherein: R1 is a polymeric residue; L1 is a bifunctional linking group; Y1 and Y2 are independently O, S or NR7 ; R2-... | 09/23/2003 |
| 6583216 | Malonic ester-blocked HDI trimer with IPDA stabilization and formaldehyde stabilization The present invention relates to blocked polyisocyanate cross-linking agents and their use in one-component stoving lacquers, in particular in solvent-containing or predominantly water-based plastics coatings having a soft-feel effect.... | 06/24/2003 |
| 6569967 | Alkoxyamines derived from ଲ-phosphorous nitroxides The invention concerns alkoxyamines derived from ଲ-phosphorous nitroxides corresponding to formula (I). Said compounds can be used as (co)polymerization initiators of at least a monomer polymerizable by radical polymerization. ##STR1##... | 05/27/2003 |
| 6569899 | 4-aminobutanoic acid derivatives and drugs containing these derivatives as the active ingredient Aminobutylic acid derivatives of the formula (I) ##STR1## wherein the symbols are as defined in specification; and non-toxic salts thereof. Because of inhibiting matrix metalloproteinase, the compounds of the formula (I) are useful for prevention and/or t... | 05/27/2003 |
| 6566552 | Industrial process for the production of L-carnitine The present invention describes a process for the industrial production of L-carnitine, comprising the enantioselective reduction of an alkyl 4-chloro-3-oxobutyrate or 4-chloro-3-oxobutyramide. The optically active 3-hydroxy derivative thus obtained is re... | 05/20/2003 |
