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| Number | Title | Issue Date |
| 8026385 | Creatine oral supplementation using creatine hydrochloride salt Creatine oral supplementation using creatine hydrochloride salt, that may be added to a liquid or other beverage, or may be also used as an additive to solid oral dosages, or as a supplement, and which may be consumed by the athlete, or other party looking for immed... | 09/27/2011 |
| 7767844 | Method for manufacturing diethylene triamine pentaacetic acid derivative The present invention at first prepares a penta-alkyl DTPA and then processes a regioselective hydrolysis over the penta-alkyl DTPA while using a metal ion as a catalyst to obtain a tetra-alkyl DTPA, where, by the above two steps, a monoreactive DTPA derivative is m... | 08/03/2010 |
| 7488841 | Composition containing acyl group According to the present invention, a process is provided for producing an acyl group-containing composition that includes a step of reacting a long chain N-acyl acidic amino acid anhydride with one or more compounds which have, per molecule, m functional groups of ... | 02/10/2009 |
| 7425645 | Ester-linked gemini surfactant compounds for use in gene therapy This invention relates to newly identified ester-linked Gemini surfactant compounds of formula (I), where Y is either H or (Aa)x where (Aa) is a basic amino acid and x is 1 to 6, to the use of such compounds and to their production. The invention also relates to the... | 09/16/2008 |
| 7345192 | Reduction of hair growth Compositions including a conjugate of α-difluoromethylornithine can be applied topically to reduce hair growth. ... | 03/18/2008 |
| 7332183 | Multilayer dosage forms containing NSAIDs and triptans The present invention is directed to multilayer pharmaceutical tablets in which an NSAID and a triptan are present in separate and distinct layers. The layers are in a side-by-side configuration, which allows the dissolution of triptan and NSAID to occur independent... | 02/19/2008 |
| 7279587 | Photoinitiator with phase change properties and gellant affinity Disclosed is a compound of the formula wherein R1 is an alkylene, arylene, arylalkylene, or alkylarylene group, R2 and R2′ each independently of the other, are alkylene, arylene... | 10/09/2007 |
| 7276614 | Curable amide gellant compounds Disclosed is a compound of the formula wherein R1 and R1′ each, independently of the other, is an alkyl group having at least one ethylenic unsaturation, an arylalkyl group having at least... | 10/02/2007 |
| 7271284 | Process for making curable amide gellant compounds Disclosed is a process for preparing a compound of the formula wherein R1 is an alkyl group having at least one ethylenic unsaturation, an arylalkyl group having at least one ethylenic unsaturation, or... | 09/18/2007 |
| 7259275 | Method for preparing curable amide gellant compounds Disclosed is a process for preparing a compound of the formula wherein R1 is an alkyl group having at least one ethylenic unsaturation, an arylalkyl group having at least one ethylenic unsaturation, or... | 08/21/2007 |
| 7238339 | Bifunctional chelating compounds containing hydroxamic acid residues New types of hydroxamic acid-based bifunctional chelators are provided. These chelators are designed to chelate metal ions that can be detected either by their paramagnetic or radioactive properties. Conjugation with peptides or protein can be achieved by the presen... | 07/03/2007 |
| 7214813 | Preparation of chiral cyclic amino acids and derivatives Cyclic β-(acylamino)acrylate derivatives were hydrogenated using Ru-chiral phosphine ligand catalysts and thereafter converted to the corresponding cyclic β-aminoacids in high yield and enantioselectivity according to the reaction scheme: | 05/08/2007 |
| 7196117 | Use of cationic surfactant as activity enhancer in deodorants and oral care Antimicrobial system which comprises a cationic surfactant, derived from the condensation of fatty acids and esterified dibasic amino acids, according to the following formula (I), where: X is Br, Cl or HSO4R1: is linear alkyl chain from an sat... | 03/27/2007 |
| 7157423 | Fumaric acid amides Fumaric acid amides of the general formula (I) wherein R1 represents OR3 or a D- or L-amino acid radical —NH—CHR4—COOH bonded via an amide bond, wherein R3 is hyd... | 01/02/2007 |
| 7148257 | Methods of treating mesothelioma with suberoylanilide hydroxamic acid Methods for treating mesothelioma comprising administering the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) are disclosed. ... | 12/12/2006 |
| 7148371 | Method for producing lysine derivative The present invention provides a method for industrially producing an optically active lysine derivative useful as a pharmaceutical intermediate. More particularly, the present invention provides a production method including protecting an amino group or an amino gr... | 12/12/2006 |
| 7141573 | Polypharmacophoric agents One aspect of the present invention relates to polypharmacophoric compounds. In certain embodiments, the polyphamacophore compounds comprise individual pharmacophore units selected from the group consisting of D-1 agonists, D-2 agonists, D-3 agonists, D-4 agonists, ... | 11/28/2006 |
| 7135587 | Urea and urethane derivatives as integrin inhibitors Novel urea and urethane derivatives of general formula (I) in which R1, R2, R3, R5, R5′, X, Y, B, m, n and o are as defined in Patent Claim 1, and physiologically acceptable salts or solvates thereof are integrin inhibitors and can be employed for combating... | 11/14/2006 |
| 7094917 | Processes for refining compositions containing dialkyl carbonates Processes for refining dialkyl carbonate-containing compositions are described, wherein a composition comprising a dialkyl carbonate is provided; and the composition is subjected to a rectification wherein low-boiling impurities are removed, and a rectification wher... | 08/22/2006 |
| 7078475 | Synergistic amine chain-extenders in polyurea spray elastomers Disclosed are derivatives of isophorone diamine exhibiting a synergistic relationship with other commonly employed chain extenders offering enhanced efficacy with regard to slowing of the polyurea elastomer cure profile, and processes employing their use. According ... | 07/18/2006 |
| 7034015 | Aminobenzoephenones The invention relates to a novel class of aminobenzophenones derivatives, to pharmaceutical preparations comprising said compounds, to dosage units of such preparations, to methods of treating patients comprising administering said compounds, and to the use of said ... | 04/25/2006 |
| 7015349 | Reduction of hair growth Compositions including a conjugate of α-difluoromethylornithine can be applied topically to reduce hair growth. ... | 03/21/2006 |
| 7012152 | Method for producing lysine derivative The present invention provides a method for industrially producing an optically active lysine derivative useful as a pharmaceutical intermediate. More particularly, the present invention provides a production method including protecting an amino group or an amino gr... | 03/14/2006 |
| 6965049 | Zwitterionic lipid compound and uses thereof Provided is a zwitterionic lipid compound represented by formula (I) given below: In formula (I), m and n are independently integers of 1 to 4, p is an integer of 7 to 21, one R is NH3+, and each ... | 11/15/2005 |
| 6962905 | Pharmaceutical formulation comprising a low molecular weight thrombin inhibitor and its prodrug A kit of parts containing (a) a pharmaceutical formulation including a low molecular weight thrombin inhibitor, or a pharmaceutically acceptable derivative thereof, in admixture with a pharmaceutically acceptable adjuvant, diluent or carrier, and (b) a pharmaceutica... | 11/08/2005 |
| 6949516 | Dipeptide apoptosis inhibitors and the use thereof The present invention is directed to novel dipeptides thereof, represented by the general Formula I: where R1-R3 and AA are defined herein. The present invention relates to the discovery that comp... | 09/27/2005 |
| 6939986 | Process for preparing 1,2-diamino compounds The invention provides a multistep process for preparing 1,2-diamino compounds and pharmaceutically acceptable addition salts thereof from 1,2-epoxides. ... | 09/06/2005 |
| 6916948 | Bis(1,3-dihydroxy-prop-2-yl) amine and derivatives thereof in the manufacture of polymers Derivatives of bis-(1,3-dihydroxy-prop-2-yl)amine are disclosed, together with the use of such derivatives and of bis(1,3-dihydroxy-prop-2-yl)amine itself in the preparation of polymers, in particular dendrimers. Some of the derivatives may be useful as non-ionic su... | 07/12/2005 |
| 6897334 | Production of creatine esters using in situ acid production Methods are provided for the improved production of a creatine ester by in situ production of an acid catalyst. ... | 05/24/2005 |
| 6875884 | Urea derivatives as inhibitors for CCR-3 receptor Urea and thiourea derivatives inhibit cell function of the chemokine receptor CCR-3. These compounds offer an effective means for treating a range of diseases thought to be mediated by the CCR-3 receptor. A variety of useful urea and thiourea derivatives can be synt... | 04/05/2005 |
| 6858748 | Treatment of colon cancer The novel compound of the disclosure is 4-chloro-4-(4-ethoxy-phenyl)-2-(fluoren-9-ylidene-hydrazono)-but-3-enoic acid methyl ester (3F-19), and it alone or in combination with 4-(4-Ethoxy-phenyl)-2-(N′-fluoren-9-ylidene-hydrazino)-2-hydroxy-4-oxo-butyric acid meth... | 02/22/2005 |
| 6855711 | Pharmaceutical compositions comprising iron chelators for the treatment of neurodegenerative disorders and some novel iron chelators Use of a compound of formula (I), wherein R1 is H or hydrocarbyl; R2 is a hydrophobic radical; R3 is 3-(C2-C6)acyl-4-hydroxyphenyl, 3-hydroxyimino (C2-C6)-alkyl-4-hydroxyphenyl, or COOZ, wh... | 02/15/2005 |
| 6844299 | Polyol ester derivatives of polyamines and use in turbine oils to improve cleanliness This invention generally relates to new polyol ester derivatives of polyamines for use as dispersant additives compatible in synthetic ester-based turbo oils. The dispersant additives of the present invention consist of a hydrocarbon acid, a polyol, an amine carrier... | 01/18/2005 |
| 6774243 | Efficient synthetic routes for the preparation of rhinovirus protease inhibitors and key intermediates Efficient synthetic routes for the preparation of rhinovirus protease inhibitors of formula I, as well as key intermediates useful in those synthetic routes. These compounds of formula I, as well as pharmaceutical compositions that contain these compounds, are suita... | 08/10/2004 |
| 6750253 | Aminobenzophenones as inhibitors of il-1β and tnf-α The present invention relates to compounds of the formula wherein R1 independently represents one or more, same or different substituents selected from the group consisting of halogen, hydroxy, mercapto, trifl... | 06/15/2004 |
| 6720400 | Process for the preparation of polyisocyanates with a biuret structure The present invention relates to an improved process for the continuous preparation of polyisocyanates with a biuret structure comprising the steps of continuously reacting excess amounts of organic diisocyanates having exclusively aliphatically and/or cycloaliphati... | 04/13/2004 |
| 6706922 | Process of making a compound by forming a polymer from a template drug A method of forming polymers in the presence of nucleic acid using template polymerization. Also, a method of having the polymerization occur in heterophase systems. These methods can be used for the delivery of nucleic acids, for condensing the nucleic acid, for fo... | 03/16/2004 |
| 6693187 | Phosphinoamidite carboxlates and analogs thereof in the synthesis of oligonucleotides having reduced internucleotide charge Phosphinoamidite carboxylates and analogs are provided that have the structure of formula (I) ##STR1## wherein R1, R2, R3, R4, X, Y, Z and n are as defined herein. The compounds are useful as phosphitylating age... | 02/17/2004 |
| 6664412 | Method for producing lysine derivative The present invention provides a method for industrially producing an optically active lysine derivative useful as a pharmaceutical intermediate. More particularly, the present invention provides a production method including protecting an amino group or ... | 12/16/2003 |
| 6649587 | Polyamine analog conjugates and quinone conjugates as therapies for cancers and prostate diseases Peptide conjugates in which cytocidal and cytostatic agents, such as polyamine analogs or naphthoquinones, are conjugated to a polypeptide recognized and cleaved by enzymes such as prostate-specific antigen (PSA) and cathepsin B are provided, as well as c... | 11/18/2003 |
