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| Number | Title | Issue Date |
| 7432391 | Process for the production of tert-butyl N-(2-bromoethyl)carbamate The present invention is to provide a safe process for the production of tert-butyl N-(2-bromoethyl)carbamate where operation is simple, handling of the final product is easy, working efficiency is good and yield is high. A process for the production of tert-... | 10/07/2008 |
| 7189680 | 5-halo-6-aryl[1,2,4]triazolo[1,5-a]pyrimidin-7-amines The invention relates to novel triazolopyrimidines of the formula in which R1, R2, R3 and X have the meanings given in the disclosure, and acid addition s... | 03/13/2007 |
| 6794384 | Hydroxylation activated drug release The present invention concerns prodrugs whose aromatic oxidation, particularly their enzymatic aromatic hydroxylation, results in their activation by the release of a drug moiety. It particularly concerns anti-tumor prodrugs and those which are specifically activate... | 09/21/2004 |
| 6639094 | Process for producing -aminoketone derivatives A process for producing -amino-dihalogenated methyl ketone derivatives by reacting an N-protected -amino acid ester with a dihalomethyl lithium is provided. This process is suitable for the production on an industrial scale and by this proce... | 10/28/2003 |
| 6399628 | N-(aryl/heteroaryl) amino acid esters, pharmaceutical compositions comprising same, and methods for inhibiting alpha- amyloid peptide release and/or its synthesis by use of such compounds Disclosed are compounds which inhibit ଲ-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits ଲ-amyloid... | 06/04/2002 |
| 6204361 | Method of peptide synthesis The present invention relates to a process for forming an N--amino protected amino acid fluoride in situ by reacting an N--amino protected amino acid with an ionic fluoride salt in the presence of a peptide coupling agent. It is also directe... | 03/20/2001 |
| 6160161 | Per(poly)fluorinated polyoxyethylated carbamates Per(poly)fluorinated polyoxyethylated carbamates of general formula (I) in which RF represents a perfluorinated group containing between 1 and 18 carbon atoms, W represents an oxo group or nothing, n is an integer from 1 to 10, m is from values... | 12/12/2000 |
| 6040422 | Synthesis and use of amino acid fluorides as peptide coupling reagent The present invention is directed to a process for forming a peptide bond between a first amino acid having a free amino group and a protected carboxy group and a second amino acid or between a peptide having a free amino group and a blocking carboxy grou... | 03/21/2000 |
| 6020518 | Process for preparing ଲ-amino--hydroxy acid derivatives An object of the present invention is to provide a process for producing a ଲ-amino--hydroxy acid derivative via efficient and industrially utilizable steps. The present invention provides a process for producing a ଲ-amino--hydrox... | 02/01/2000 |
| 5750767 | Synthesis and use of amino acid fluorides as peptide coupling reagents The present invention is directed to the process of preparing a peptide comprising reacting a first amino acid or peptide with an amino acid fluoride of the formula: ##STR1## or the acid fluoride salts thereof wherein BLK is an N-amino protecting ... | 05/12/1998 |
| 5688795 | 3-(4-phenylpiperazin-1-yl)propyl-amino, thio and oxy!-pyridine, pyrimidine and benzene derivatives as 1 -adrenoceptor antagonists The present invention relates to novel 댑 -adrenoceptor antagonists of Formula I: ##STR1## in which: p is 0 or 1; t is 0, 1 or 2; X is O, S or NR6 (in which R6 is hydro or (C1-6)alkyl); Y and Z are indepen... | 11/18/1997 |
| 5643438 | Process for the preparation of substituted diamino-dicarboxylic acid derivatives The invention relates to a new process for the preparation of substituted diaminodicarboxylic acid derivatives of the formula ##STR1## in a high yield by a modified Kolbe synthesis.... | 07/01/1997 |
| 5523463 | Method of producing halogenated and alpha-aminoalchohols A process for the manufacture of N-protected -aminoketones and N-protected -aminoalcohols of the formula ##STR1## wherein X is halogen, one of Q1 and Q2 is hydrogen and the other is hydroxy or Q1 and Q | 06/04/1996 |
| 5502225 | Perfluoroalkyl terminated urethane lubricants This invention relates to perfluoroalkyl group terminated urethanes, thiourethanes and ureas of the general formula (R--X--CONH)m A where m is 1, 2 or 3, R is Rf -E and optionally R1 with the proviso that at least one R is R | 03/26/1996 |
| 5476974 | Omega-hydrofluoroalkyl ethers, precursor carboxylic acids and derivatives thereof, and their preparation and application Normally liquid, omega-hydrofluoroalkyl ether compounds (and selected mixtures thereof) have a saturated perfluoroaliphatic chain of carbon atoms interrupted by one or more ether oxygen atoms. The compounds can be prepared, e.g., by decarboxylation of the... | 12/19/1995 |
| 5442088 | Process for the preparation of phosphorus-containing L-amino acids, their derivatives and intermediates for this process Process for the preparation of phosphorus-containing L-amino acids, their derivatives and intermediates for this process L-amino acids of the formula I and salts thereof, ##STR1## in which R1 to R5 are defined as in claim 1 and n is ... | 08/15/1995 |
| 5360928 | Synthesis and use of amino acid fluorides as peptide coupling reagents A compound of the formula ##STR1## or the acid fluoride salts thereof wherein BLK is an N-amino protecting group or hydrogen AA is an amino acid residue and X is H or a protecting group useful as a coupling agent in peptide synthesis.... | 11/01/1994 |
| 5198569 | Process for the preparation of optically active aliphatic hydroxycarboxylic acids The asymmetric hydrogenation of aliphatic -keto esters in the presence of rhodium catalysts which contain as chiral ligand a diphosphine of formula IV (R3)2 P--Q--P(R3)hd 2 (IV) wherein R3 | 03/30/1993 |
| 5194660 | Processes for producing carbamates and isocyanates Processes for producing carbamates comprise contacting a first reactant selected from primary amine components, secondary amine components, urea components and mixtures thereof; carbon monoxide; at least one organic hydroxyl component and at least one oxy... | 03/16/1993 |
| 5102911 | 4-Substituted HMG-CoA reductase inhibitors HMG-CoA reductase inhibitors of formulae (I) and (II) are disclosed. ##STR1##... | 04/07/1992 |
| 5078783 | Substituted alkyl carbamates and their use as herbicides Substituted 1-alkyl carbamates of the formula ##STR1## in which: R is a member selected from the group consisting of halogen, trifluoromethyl, cyano, NO2 and C1 -C3 haloalkyloxy; R1 is selected from the group co... | 01/07/1992 |
| 5037991 | Novel substituted aromatic compounds Substituted phenoxy, phenylthio and anilino compounds, intermediates therefor, synthesis thereof, and their use for the control of pests.... | 08/06/1991 |
| 5017718 | Process for preparing polyfluoroalkyl-substituted compounds A process for preparing a perfluoroalkyl-substituted compound is disclosed. The process comprises reacting a halopolyfluoroalkane having 1 to 20 carbon atoms with a compound selected from the group consisting of (1) a substituted or unsubstituted ethylene... | 05/21/1991 |
| 5001148 | Mevinic acid derivatives Antihypercholesterolemic activity, due to competitive inhibition of HMG CoA reductase, has been found in compounds of the formula ##STR1## wherein: R1, R2 and R3 are independently selected from: (1) alkyl, (2) substituted ... | 03/19/1991 |
| 4987248 | Acid catalyzed formation of carbamates from olefins An improved for preparing N-substituted carbamate comprising reaction of a selected olefin or alcohol with a carbamate in the presence of a catalyst comprising a blend of a perfluorinated sulfonic acid polymer and a perfluorinated polymer diluent in a sub... | 01/22/1991 |
| 4845267 | Alkyl 2-fluoro-1-methoxyethylcarbamates Alkyl esters of 2-fluoro-1-methoxyethylcarbamic acid, which are useful intermediates in the preparation of compounds, such as 4-amino-5- fluoropentanoic acid, are prepared by the electrochemical anodic oxidation of esters of 2-fluoroethylcarbamic acid in ... | 07/04/1989 |
| 4786745 | 2,2-dihalovinyl haloformates and process of preparation Novel 2,2-dihalovinyl haloformates are described of general formula: ##STR1## in which: X is a chlorine or bromine atom; X1 and X2 are the same or different and are chlorine or bromine. The compounds are prepared by reaction of a 1,2,2,2-... | 11/22/1988 |
| 4772695 | Process for the preparation of vinyl carbamates A process for the preparation of vinyl carbamates of formula I ##STR1## is described which comprises heating an -halogeno-carbamate of formula II ##STR2## in which X is a halogen atom at a temperature between 70° and 250° C. for a ... | 09/20/1988 |
| 4760057 | (Acyloxyalkoxy)carbonyl derivatives as bioreversible prodrug moieties for primary and secondary amine functions in drugs This invention relates to novel (acyloxyalkoxy)carbonyl derivatives as bioreversible prodrug moieties for primary and secondary amine functions in drugs having a primary or secondary amine function thereon. Hydrolytic enzymes are used to trigger the regen... | 07/26/1988 |
| 4740600 | Photolabile blocked surfactants and compositions containing the same Surfactants which are blocked against surfactant action (identified herein as "photolabile blocked surfactants") by a photolabile protective or masking group but which, on exposure to actinic radiation, become unblocked are provided. Coating compositions ... | 04/26/1988 |
| 4697033 | Carbamic and carbamothioic acid esters as pesticides Certain novel derivatives of carbamates and their use for the control of pests.... | 09/29/1987 |
| 4668703 | γ-allenyl-γ-aminobutyric acids This invention is for γ-allenyl-γ-aminobutyric acid derivatives which are γ-aminobutyric acid transaminase inhibitors.... | 05/26/1987 |
| 4609648 | Halogenoalkylcarbamic acid ester pesticides Halogenoalkylcarbamic acid esters of the formula ##STR1## in which R, R1 and R2 independently of one another represent methyl which is optionally substituted by halogen, at least one of the methyl groups R, R1 and R | 09/02/1986 |
| 4603216 | Process for the preparation of urethanes This invention relates to a process for preparing urethanes by reacting a solution of a nitrogen-containing organic compound and a hydroxyl-containing organic compound with carbon monoxide in the presence of a ruthenium catalyst comprising a bis phosphine... | 07/29/1986 |
| 4594441 | Process for the preparation of urethanes A process for the preparation of urethanes. Urethanes having the general formula R1 (NHCOOR2)n are reacted with an alcohol at a temperature of 120° to 400° C. in amounts such that, for every mol of the urethane, at least... | 06/10/1986 |
| 4554372 | Preparation of carbamates 2-Substituted alkyl (2-substituted alkyl)carbamates useful as intermediates in the preparation of epoxy derivatives of olefins are prepared by reacting 2-oxazolidones with an olefin and an electrophile such as halogen.... | 11/19/1985 |
| 4549994 | Preparation of new fluoropivalic acid fluorides A process for the preparation of a compound according to claim 1, comprising reacting a compound of the formula ##STR1## in which R3, R4 and R5 each independently is CH3 or CH2 Cl, at least one o... | 10/29/1985 |
| 4511730 | Carbamates of beta-hydroxyethylsulfoxides This invention relates to carbamates of beta-hydroxyethylsulfoxides which are useful as cosurfactants in enhanced oil recovery, surfactants and biocides, and as hydraulic fluids when of sufficiently low molecular weight.... | 04/16/1985 |
| 4505859 | Preparation of 2-haloethylamides 2-Haloethylamides are prepared by reaction of 2-oxazolidinone or C1-6 alkyl or phenyl derivatives thereof with an acid halide.... | 03/19/1985 |
| 4448773 | Microbicidal N-alkoxycarbonyl-alkyl-N-substituted acetyl-anilines and -naphthylamines Compounds of the formula ##STR1## in which Ar is 2-alkyl-, -alkoxy- or -halo-methyl-phenyl or -naphthyl, each of which is further substituted, R1 is 2-furyl, 2-tetrahydrofuryl, alkenyl, cyclopropyl, ଲ-alkoxyethyl, hydroxymethy... | 05/15/1984 |