Quotables
"To place a man in a multi-stage rocket and project him into the controlling gravitational field of the moon where the passengers can make scientific observations, perhaps land alive, and then return to earth--all that constitutes a wild dream worthy of Jules Verne. I am bold enough to say that such a man-made voyage will never occur regardless of all future advances."
Lee deForest, American radio pioneer ; 1957
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| Number | Title | Issue Date |
| 8026384 | Process for the synthesis of alkyl phosphinic acids by initiation of an amine and an amineoxide The present invention relates to a new process for the synthesis of alkyl phosphinic acids, and more particularly to a coupling reaction between an alkylhalide and a hypophosphorous acid derivative in the presence of an amine and an amineoxide. ... | 09/27/2011 |
| 7560588 | Poly(ethylene glycol) containing chemically disparate endgroups The present invention provides bifunctional polymers, methods of preparing the same, and intermediates thereto. These compounds are useful in a variety of applications including the PEGylation of biologically active molecules. The invention also provides methods of ... | 07/14/2009 |
| 7414145 | Method of enantioselective nucleophilic addition reaction of enamide to carbonyl group and synthesis method of optically active α-hydroxy-γ-keto acid ester and hydroxydiketone A method of an enantioselective nucleophilic addition reaction to carbonyl, which enables an asymmetric synthesis of an optically active α-hydroxy-γ-keto acid ester, an optically active α-hydroxy-γ-amino acid ester, hydroxydiketone compounds, etc. being useful a... | 08/19/2008 |
| 7405319 | Process for the preparation of carbamates The present invention provides an improved process for the preparation of carbamates with high selectivity of pharmaceutical interest by an eco-friendly, non-toxic, phosgene-/isocyanate-/CO-free clean route through a reaction of amine, organic halide compound and ca... | 07/29/2008 |
| 7291713 | Branched polyalkylene glycols The present invention provides a branched polyalkylene glycol wherein three or more single-chain polyalkylene glycols and a group having reactivity with an amino acid side chain, the N-terminal amino group or the C-terminal carboxyl group in a polypeptide or a group... | 11/06/2007 |
| 7238834 | Piperidine derivatives and process for their production The present invention relates to substantially pure piperidine derivative compounds of the formulae: wherein R1 is hydrogen or hydroxy; R2 | 07/03/2007 |
| 7223784 | Compounds for the modulation of the glycolysis enzyme and/or transaminase complex The invention relates to compounds for the modulation of the glycolysis enzyme complex and of the transaminase complex, pharmaceutical compositions containing such compounds as well as uses of such compounds for preparing pharmaceutical compositions for treating var... | 05/29/2007 |
| 7189857 | Processes for the preparation of oxo-oxazoline or alloamino acid derivatives A method for producing a compound represented by the general formula (I-A) or the general formula (I-B), comprising the following step: wherein R1 is an optionally substituted lower alkyl, and the like... | 03/13/2007 |
| 7189680 | 5-halo-6-aryl[1,2,4]triazolo[1,5-a]pyrimidin-7-amines The invention relates to novel triazolopyrimidines of the formula in which R1, R2, R3 and X have the meanings given in the disclosure, and acid addition s... | 03/13/2007 |
| 7109246 | Pharmaceutical compositions comprising an amphoteric surfactant an alkoxylated cetyl alcohol and a polar drug A formulation, for example an oil-in-water emulsion, comprising an amphoteric surfactant, alkoxylated cetyl alcohol and a polar drug. The drug may be sodium cromoglycate or nedocromil sodium. The formulation may be useful in the treatment of skin disease such as ato... | 09/19/2006 |
| 7101915 | P-terphenyl compounds The present invention provides a selective suppressor of the IgE production comprising a compound which suppresses the IgE production in a process from a differentiation of a mature B cell into an antibody-producing cell to the production of an antibody and which do... | 09/05/2006 |
| 7057066 | Process for producing 3-amino-2-hydroxypropionic acid derivatives The present invention provides a process for preparing 3-amino-2-hydroxypropionic acid derivatives (1) which does not use dangerous reagents, is economically advantageous, and is suitable for an industrial production, which process comprises: ... | 06/06/2006 |
| 6979719 | Coating composition comprising a compound comprising at least one bicyclo-orthoester group and at least one other functional group The invention pertains to a coating composition comprising a compound comprising at least one bicyclo-orthoester group and at least one other functional group. The invention also comprises a process for curing the present coating composition. Further, a process for ... | 12/27/2005 |
| 6972341 | Prodrugs of GABA analogs, compositions and uses thereof The present invention provides prodrugs of GABA analogs, pharmaceutical compositions of prodrugs of GABA analogs and methods for making prodrugs of GABA analogs. The present invention also provides methods for using prodrugs of GABA analogs and methods for using pha... | 12/06/2005 |
| 6936739 | Fluorine-containing bisphenols, their preparation, their precursors and intermediates, and use of the fluorine-containing bisphenols This invention relates to 1,2-di(4-hydroxyaryl)tetrafluoroethanes of the general formula (I) wherein R are each, independently of one another, hydrogen, F, Cl, Br, I, CN, COOR2, C1-C | 08/30/2005 |
| 6914075 | Cystine derivative and agent for suppressing activation of inflammatory factors The present invention provides cystine derivatives, which may be in a free form, a salt form, a solvate form. The cystine derivatives of the present invention may be used to suppress activation of inflammatory factors. Accordingly, the present invention provides: co... | 07/05/2005 |
| 6872842 | Butenyl substituted taxanes Taxane derivatives having a 3′ butenyl substituted C13 side chain. ... | 03/29/2005 |
| 6803378 | HIV integrase inhibitors Novel diketoacid compounds of Formula I are provided which are useful as HIV integrase inhibitors and for the treatment of AIDS or ARC. ... | 10/12/2004 |
| 6765100 | Method for producing epoxide crystal The invention relates to a method for industrially producing highly pure (2R, 3S)- or (2S, 3R)-N-carbamate-protected β-aminoepoxide (crystal) or (2R, 3S)- or (2S, 3R)-N-carbamate-protected β-aminoalcohol. The method for producing N-carbamate-protected β-aminoepox... | 07/20/2004 |
| 6759511 | Compound used as an amino-protecting group, process for preparing the same, and synthetic method of a peptide using the same The present invention relates to a carbonic acid ester compound of the following formula (1): in which X, Y, and Ar are defined in the specification, which can be easily combined with the amino group of an amino acid or ... | 07/06/2004 |
| 6710203 | Preparation of hydroxyalkylcarbamates from six-membered cyclic carbonates A method of preparing hydroxyalkylcarbamates from six-membered cyclic carbonates. The method involves reacting a six-membered cyclic carbonate with anhydrous ammonia or aqueous ammonium hydroxide. The present invention also provides for hydroxyalkylcarbamates prepar... | 03/23/2004 |
| 6646150 | Processes for producing (aminomethyl)trifluorocarbinol derivatives The present invention provides a process for industrially producing (aminomethyl)trifluoromethylcarbinol derivatives, in particularly, optically active compounds thereof, which are useful as starting compounds for drugs such as protease inhibitors, etc.... | 11/11/2003 |
| 6569411 | Serine carbonates Serine carbonates of formula I are precursors for organoleptic compounds, masking agents and antimicrobial agents. Further they are alternative substrates for malodor producing enzymes. The symbols in formula I are defined in claim 1.... | 05/27/2003 |
| 6515179 | Process for the removal of nitrobenzenesulfonyl A 2- or 4-nitrobenzenesulfonamide is allowed to react with an alkali metal alkoxide to remove a nitrobenzenesulfonyl group to thereby obtain an amine corresponding to the amide. Furthermore, a method for producing an amine derivative by allowing the resul... | 02/04/2003 |
| 6465679 | Carbamate functional oligomers and coatings therefrom This invention involves a carbamate functional polymer or oligomer made by reacting a cyclic carbonate with ammonia or a primary amine, then reacting the resulting hydroxycarbamate with a polyfunctional material containing groups reactive with hydroxyl gr... | 10/15/2002 |
| 6462208 | C7 acyloxy and hydrido taxane derivatives and pharmaceutical compositions containing them Taxane derivatives having alternative C7 substituents.... | 10/08/2002 |
| 6362359 | One-component thermoset coating compositions The present invention relates to compounds containing modified hydrazide groups and corresponding to formula I ##STR1## wherein R represents the residue obtained by removing the isocyanate groups from a monomeric polyisocyanate, a polyisocyanate adduct or... | 03/26/2002 |
| 6350905 | Aminohydroxylation of Olefins Osmium-catalyzed aminohydroxylation reactions are accelerated and expanded in scope by the use of olefinic substrates having ionic groups, either anionic or cationic. The use of ionic groups on olefinic substrates also extends the aminohydroxylatable posi... | 02/26/2002 |
| 6326369 | Bicyclic quinone compounds, their production and use A compound of the formula: ##STR1## wherein R1 and R2 each represents a lower alkyl, or R1 and R2 may be bonded together to form a ring; X represents a spacer of which the number of atoms constituting the princi... | 12/04/2001 |
| 6316662 | Carbamate solutions with bound carbon dioxide prepared from alkanolamines Carbamate solutions are obtainable by reacting at least one alkanolamine with carbon dioxide in, as solvent, at least one organic compound having a molecular weight of from 60 to 600 and containing at least one hydroxyl group, wherein the carbamate contai... | 11/13/2001 |
| 6265590 | N-2-(4-nitrophenylsulfonyl)ethoxycarbonyl-amino acids Protected amino acid derivatives of general formula (I) ##STR1## and methods for the prepatation of the derivatives are provided.... | 07/24/2001 |
| 6239175 | Carbamoyloxy derivatives of mutiline and their use as antibacterials Derivatives of mutiline of formula (1A) and pharmaceutically acceptable salts and derivatives thereof, in which R1 is ethyl or vinyl, Y is a carbamoyloxy group, in which the N-atom is unsubstituted, or mono- or di-substituted, are useful in the... | 05/29/2001 |
| 6180374 | Method for preparing tert-leucine and analogues thereof in enantiomeric form and intermediates therein Azlactone (3), or the opposite enantiomer thereof, undergoes biotransformation, using suitable enzymatic activity, in the presence of a compound YH to form a N-acyl-amino acid (2), wherein R1, R2 and R3 are each not hydrog... | 01/30/2001 |
| 6160161 | Per(poly)fluorinated polyoxyethylated carbamates Per(poly)fluorinated polyoxyethylated carbamates of general formula (I) in which RF represents a perfluorinated group containing between 1 and 18 carbon atoms, W represents an oxo group or nothing, n is an integer from 1 to 10, m is from values... | 12/12/2000 |
| 6150542 | Fragrance precursor compounds for preventing human malodor The invention relates to agents preventing (the formation of) human malodor. In particular, the invention relates to the use of several classes of compounds which can act as such agents in cosmetic products, such as deodorants and antiperspirants. These c... | 11/21/2000 |
| 6150457 | One-component thermoset coating compositions The present invention relates to compounds containing modified hydrazide groups and corresponding to formula I ##STR1## wherein R represents the residue obtained by removing the isocyanate groups from a monomeric polyisocyanate, a polyisocyanate addu... | 11/21/2000 |
| 6143919 | Polymerizable acidic compounds and methods of preparation Polymerizable urethane acid compounds are provided. Preferred compounds additionally comprise a hydroxy functionality. These compounds are made by reaction of hydroxy functional acid compounds with isocyanates.... | 11/07/2000 |
| 6063955 | Method for producing optically active erythro-3-amino-2-hydroxybutyric esters and acids thereof A method for producing an optically active erythro-3-amino-2-hydroxybutyric ester as an important intermediate of pharmaceutical agents, specifically HIV protease inhibitor, in high purity and in high yield. The method includes producing an optically acti... | 05/16/2000 |
| 6063962 | Process for the preparation of NMDA antagonists This invention relates to an improved process for the production of known amine compounds which are useful as medicaments.... | 05/16/2000 |
| 6034137 | Cationic lipids for gene therapy This invention provides novel cationic lipids, particularly guanidino lipids, and methods for their preparation. Also provided are polyanionic-lipid complexes comprising the lipids of the invention, their preparation and use to deliver biologically active... | 03/07/2000 |
