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| Number | Title | Issue Date |
| 8119830 | Dual function UV-absorbers for ophthalmic lens materials Disclosed are UV absorbers that contain a labile functional group capable of initiating free radical polymerization. ... | 02/21/2012 |
| 8097750 | Cinchona alkaloid-catalyzed asymmetric mannich reactions The instability of carbamate-protected alkyl imines has greatly hampered the development of catalytic asymmetric Mannich reactions suitable for the synthesis of optically active carbamate-protected chiral alkyl amines. A highly enantioselective Mannich reaction with... | 01/17/2012 |
| 8076503 | Process for production of optically active aminophosphinylbutanoic acids The present invention is a process for producing optically active aminophosphinylbutanoic acids represented by the formula (2), comprising asymmetrically hydrogenating a compound represented by the formula (1) | 12/13/2011 |
| 8044230 | Water-soluble prodrugs of chloramphenicol, thiamphenicol, and analogs thereof The present invention discloses certain novel prodrugs of chloramphenicol or thiamphenicol, or of an analog of either, including prodrugs of pharmaceutically acceptable salts of chloramphenicol or thiamphenicol or of their analogs, including nitrogen-containing este... | 10/25/2011 |
| 8039662 | Process for the preparation of amino acid methyl esters The present invention describes a process for the synthesis of an amino acid methyl ester comprising the following steps: (a) refluxing a reaction mixture comprising a free amino acid, methanol and a strong acid; (b) concentrating the mixture; (c) adding methanol; (... | 10/18/2011 |
| 8026383 | Process for the preparation of intermediates useful in the synthesis of statin derivatives The invention relates to novel synthesis methods for the preparation of statin derivatives, which methods proceed by way of a key intermediate of formula I wherein X is halogen, acyloxy, activated hydrocarbyloxy, activated ... | 09/27/2011 |
| 7985874 | Polymer particle A support comprising functional groups supported therein that specifically react with an aldehyde group of a sugar chain, and a polymer particle and a glycochip to which the support is applied, and uses thereof. ... | 07/26/2011 |
| 7893296 | Method for producing an optically active β-amino acid Disclosed is a producing method of an optically active β-amino acid useful as intermediate for the production of medicines, agricultural. chemicals and physiologically active substances, by means of a catalytic and asymmetric synthesis method of high performance an... | 02/22/2011 |
| 7855302 | Process for the preparation of intermediates useful in the synthesis of statin derivatives especially 7-amino-3.5-dihydroxyhepanoic acid derivatives and intermediates thereof The invention relates to novel synthesis methods for the preparation of statin derivatives, which methods proceed by way of a key intermediate of formula I wherein X is halogen, acyloxy, activated hydrocarbyloxy, activated ... | 12/21/2010 |
| 7709678 | Method for producing asymmetric alkyl compound using alkali-treated solid support, and alkali-treated solid support used in this method An asymmetric alkyl compound producing method of the present invention includes a synthesizing step of carrying out an asymmetric synthesis reaction by mixing (i) a reaction solution containing a glycine imine ester, an alkyl halide, and an asymmetric catalyst havin... | 05/04/2010 |
| 7667067 | Cosmetic emulsifiers A composition, process of preparation, and utility of salts of fatty acid esters of amino-alcohols such as dimethylaminoethanol (DMAE) as emulsifiers useful for formulating with lipids and waxes is described. DMAE fatty acid esters were prepared enzymatically in the... | 02/23/2010 |
| 7638646 | Processes and intermediates for preparing benzyl epoxides Disclosed are intermediates and processes for preparing epoxides of the formula: where R and PROT are defined herein. These epoxides are useful as intermediates in the production of biologically active compounds, i.e., in t... | 12/29/2009 |
| 7550625 | Esters of florfenicol The invention relates to compounds of formula (I): wherein R is —C(O)CH2OCH2CH2OCH3 or —C(O)CH2N(CH3)2. The invention also relates to pharmace... | 06/23/2009 |
| 7495123 | Process for the preparation of enantiomerically enriched beta amino acid derivatives The present invention relates to a process for the efficient preparation of enantiomerically enriched beta amino acid derivatives wherein the amino group is unprotected. The product chiral beta amino acid derivatives are useful in the asymmetric synthesis of biologi... | 02/24/2009 |
| 7459581 | Anti-bacterial compounds Ester compounds of the formula I-a wherein R1 is selected from OH, NH2 and NH3+X−, wherein X is an inorganic anion, wherein R2 is a singly-branched saturat... | 12/02/2008 |
| 7442718 | Inhibitors of aspartyl protease The present invention relates to a novel class of sulfonamides which are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of HIV aspartyl protease inhibitors characterized by specific structural and physicochemical features. T... | 10/28/2008 |
| 7435845 | Corrosion and gas hydrate inhibitors having improved water solubility and increased biodegradability Corrosion and gas hydrate inhibitors having improved water solubility and increased biodegradability The invention thus provides the use of compounds of the formula (1) where R... | 10/14/2008 |
| 7429674 | Process for preparing fluoroleucine alkyl esters This invention relates to a stereoselective preparation of fluoroleucine alkyl esters. ... | 09/30/2008 |
| 7425645 | Ester-linked gemini surfactant compounds for use in gene therapy This invention relates to newly identified ester-linked Gemini surfactant compounds of formula (I), where Y is either H or (Aa)x where (Aa) is a basic amino acid and x is 1 to 6, to the use of such compounds and to their production. The invention also relates to the... | 09/16/2008 |
| 7420078 | Process for the preparation of intermediates useful in the synthesis of statin derivatives especially 7-amino 3,5-dihydroxy heptanoic acid derivatives, and intermediates thereof The invention relates to synthesis methods for the preparation of statin derivatives, which methods proceed by way of a key intermediate of formula I wherein X is halogen, acyloxy, activated hydrocarbyloxy, activated hydrocarbylthio or N(CH3)OCH3 | 09/02/2008 |
| 7420079 | Methods and compounds for producing dipeptidyl peptidase IV inhibitors and intermediates thereof Methods and compounds for production of cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV are provided. ... | 09/02/2008 |
| 7393972 | Process for preparing amino acid esters and their acid addition salts The invention provides a process for preparing amino acid esters and/or their acid addition salts from monomeric or polymeric amino acids, peptides, proteins and alcohols, which comprises carrying out the reaction in supercritical alcohols, preferably at pressures a... | 07/01/2008 |
| 7375241 | Ferrocenyl-1,2-diphosphines, the production thereof and their use The invention relates to compounds of formula (I) provided in the form of racemic compounds, mixtures of diastereomers or essentially pure diastereomers, wherein R1 represents a hydrogen atom or C1-C4-alkyl, and at least one secondar... | 05/20/2008 |
| 7371867 | Non-racemic trifluoroleucine, and methods of making and using One aspect of the invention relates to hexafluoroleucine and congeners thereof, and methods of making the compounds. Another aspect of the invention relates to the synthesis of protein cores comprising hexafluoroleucine and congeners thereof. Certain peptides compri... | 05/13/2008 |
| 7351852 | T-butoxycarbonylaminoethylamine for the synthesis of PNA monomer units, amino acid derivatives, intermediates therof, and processes for productions of them A process for amino acid derivatives shown by the below general formula (I): (wherein R1 means a hydrogen atom or a straight chain or branched chain alkyl group with 1-5 carbon atoms.) having an object to provide... | 04/01/2008 |
| 7351849 | Process for producing optically active β-amino acid derivatives The present invention is to provide a method for producing the desired optically active β-amino acid derivatives of high optical purities in high yields, without requiring a step of deprotection. More particularly, the present invention relates to a method for prod... | 04/01/2008 |
| 7348361 | Solution for diagnosing or treating tissue pathologies The invention concerns a 5-aminolevulinic acid ester (E-ALA) solution for producing a pharmaceutical preparation useful for diagnosing and/or treating tissue and/or cell pathologies by local radiation exposure using radiation emitted by a light source energy followe... | 03/25/2008 |
| 7348451 | Additives for inhibiting gas hydrate formation The invention provides the use of compounds of the formula (1) where R1, R2 are each independently C1- to C22-alkyl, C2- to C22-alkenyl, C6... | 03/25/2008 |
| 7345190 | Carnitine conjugates as dual prodrugs and uses thereof The present invention discloses novel dual prodrug compositions of Formula 1, wherein A is a single bond, —O—, or —CH2—; m and n vary from 0 to 15; p and q vary from 0 to 4; B is a single bond or —CR | 03/18/2008 |
| 7335684 | Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy The present invention relates to compounds being esters of 5-aminolevulinic acids or pharmaceutically acceptable salts thereof, including compounds of formula (I) R22N—CH2COCH2-CH2CO—OR1 (wherein R1 may represent alkyl optionally substituted by hydroxy, alkoxy, ... | 02/26/2008 |
| 7314951 | Process and composition for lower toxicity quaternary ammonium compounds Betaine ester quaternary ammonium compounds with reduced toxicity and improved biodegradability are formed by esterification of a haloacetic acid with an alcohol containing at least 4 carbon atoms, followed by quaternization of the halo-acetate with a tertiary amine... | 01/01/2008 |
| 7279550 | Irreversible cysteine protease inhibitors of legumain Presented are compounds represented by the following general formulas (I) and (II), for inhibiting cysteine protease legumain for modulating associated disease states in subjects ... | 10/09/2007 |
| 7253297 | Astaxanthin esters Astaxanthin derivatives of the general formula (I) wherein R is in each case group —NH—CH(R1)—COOR2, —OR3 or —(Y)n-Z and R1, R2, R3, Y, Z and n are significances given in detail i... | 08/07/2007 |
| 7247655 | Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy The present invention relates to compounds being esters of 5-aminolevulinic acids or pharmaceutically acceptable salts thereof, including compounds of formula (I) R22N—CH2COCH2—CH2CO—OR1 (wherein R1 may represent alkyl optionally substituted by hydroxy, alkoxy... | 07/24/2007 |
| 7244859 | Method for producing δ-aminopentadienoate derivatives The invention is a method for producing δ-aminopentadienoate derivatives of formula (1), the method comprising reacting a streptocyanine derivative of formula (2) with an ester derivative of formula (3) in the presence of an organic base. In formulae (1) to (3), R | 07/17/2007 |
| 7217736 | Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy The invention provides compounds for use in photochemotherapy or diagnosis, said compounds being branched alkyl esters or substituted alkyl esters of 5-aminolevulinic acid, or derivatives or pharmaceutically acceptable salts thereof. In particular, the invention pro... | 05/15/2007 |
| 7214814 | Additives for inhibiting gas hydrate formation The invention provides the use of compounds of the formula (1) where R1, R2 are each independently C1- to C22-alkyl, C2- to C22-alken... | 05/08/2007 |
| 7214813 | Preparation of chiral cyclic amino acids and derivatives Cyclic β-(acylamino)acrylate derivatives were hydrogenated using Ru-chiral phosphine ligand catalysts and thereafter converted to the corresponding cyclic β-aminoacids in high yield and enantioselectivity according to the reaction scheme: | 05/08/2007 |
| 7186870 | Process for the preparation of 1,3-substituted indenes and aryl-fused azapolycyclic compounds The present invention relates to processes for the preparation of any of the intermediate 1,3-substituted indenes of the formulae (Ia), (Ib) and (Ic) or a mixture thereof: wherein R1, R2, R | 03/06/2007 |
| 7153822 | Compositions and methods for modulating connexin hemichannels Disclosed are compositions and methods for modulating hemichannel function in a cell, tissue or organ. The invention also relates to useful screens for detecting such compounds, particularly those capable of modulating connexin phosphorylation. Further provided are ... | 12/26/2006 |
