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Class 560/142 - Nitrogen or sulfur in phenolic moiety


Subclass of Class 560 - Organic compounds -- part of the class 532-570 series
Definition: Compounds wherein the phenolic moiety contains sulfur or
No. of patents: 225
Last issue date: 11/24/2009


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NumberTitleIssue Date
7622604Process of preparing esters and ethers of probucol and derivatives thereof
A probucol or a probucol derivative can be efficiently converted to a monoester or monoether of probucol by reacting the free hydroxyl-containing probucol or a derivative thereof (by which is meant a probucol compound with at least one substituent that is different ...
11/24/2009
7345191Process for preparation of probucol derivatives
A method is described for the preparation of polymorphic forms of water-soluble derivatives of probucol compounds having the following formula where R1, R2, R3, R4, R5,...
03/18/2008
7294737Process of preparing esters and ethers of probucol and derivatives thereof
Provided are methods for manufacturing compounds of Formula I wherein all substituents are described herein. ...
11/13/2007
7294736Process for preparation of probucol derivatives
A method is described for the preparation of polymorphic forms of water-soluble derivatives of probucol compounds having the following formula where R1, R2, R3, R4, R
11/13/2007
7273948Process of preparing esters and ethers of probucol and derivatives thereof
A probucol or a probucol derivative can be efficiently converted to a monoester or monoether of probucol by reacting the free hydroxyl-containing probucol or a derivative thereof (by which is meant a probucol compound with at least one substituent that is different ...
09/25/2007
7189870Compounds and methods for the inhibition of the expression of VCAM-1
This invention is in the area of methods and compositions for the inhibition of the expression of VCAM-1 and, in particular, for the treatment of diseases mediated by VCAM-1, including cardiovascular and inflammatory diseases. ...
03/13/2007
7118768Medicaments for treating colics
A medicament for use in treating babies suffering from colic. The medicament comprises diphenhydramine hydrocloride (HCl), belladonna tincture, a buffer, flavorants, such as sweetener and absolute alcohol. The medicament is treated by gamma ray bombardment or having...
10/10/2006
6864381Process for preparing acyloxybenzenesulfonates
A process for preparing acyloxybenzenesulfonates by reacting a carboxylic acid derivative with a salt of a phenolsulfonic acid in the presence of an antioxidant, preferably 2,6-di-tert-butyl-4-methylphenol. The addition of such antioxidants gives a product having a ...
03/08/2005
6858650Stable salts of novel derivatives of 3,3-diphenylpropylamines
The present invention concerns highly pure, crystalline, stable compounds of novel derivatives of 3,3-diphenylpropylamines in the form of their salts, a method for the manufacture and highly pure, stable intermediate products. The method is in particular char...
02/22/2005
6822113Process for preparing acyloxybenzenesulfonates
A process for preparing acyloxybenzenesulfonates by reacting anhydrous phenolsulfonates with carboxylic acid derivatives comprises conducting the reaction with a salt of a phenolsulfonic acid which has a water content of less than 0.5% by weight and has been contact...
11/23/2004
6790981Process for the preparation of acyloxybenzenesulfonates
The invention relates to a process for the preparation of acyloxybenzenesulfonates starting from carbonyl halides and salts of phenolsulfonic acid which have a low water content. Surprisingly, it was discovered that acyloxybenzenesulfonates can be prepared in high y...
09/14/2004
6639096Process for the preparation of acyloxybenzenesulfonates
Process for the preparation of acyloxybenzenesulfonates by reaction of phenolsulfonate with a water content of less than 0.5% by weight and alkanecarbonyl halide in a hydrocarbon as solvent and in the presence of a catalyst in the form of a basic nitrogen...
10/28/2003
6624193Preventive and therapeutic agents for eye diseases
The present invention provides a prophylactic and therapeutic medicament for ophthalmic diseases, especially ophthalmic inflammatory diseases and corneal ulcer, comprising as an active ingredient a compound represented by the formula (I): ##STR1## or...
09/23/2003
6573297(2-substituted oxyphenyl)alkanamide derivative, hair growth promoter and external composition for skin using the same
A (2-substituted oxyphenyl)alkanamide derivative or a salt thereof expressed by the following Formula (I): ##STR1## wherein one of A and B is a hydrocarbon group of C3-30 expressed by R1 and the other is --(CH2)n-NR2
06/03/2003
6566394Salicylamide derivatives
Salicylamide derivatives represented by formulae (1a) and (1b); intermediates in the production thereof; a process for producing the same; and drugs containing the same as the active ingredient. The salicylamide derivatives represented by formulae (1a) an...
05/20/2003
6527690Purification of phenyl ester salts
The invention relates to a process for purifying and decolorizing a phenyl ester salt. The process combines a phenyl ester salt with a solvent to form a mixture and then stirs the mixture to form a slurry. The phenyl ester salt is substantially insoluble ...
03/04/2003
6476076Vanilloid analogues containing resinferatoxin pharmacophores as potent vanilloid receptor agonists and analgesics, compositions and uses thereof
The present invention is related to new vanilloid analogues containing resiniferatoxin pharmacophores, pharmaceutical compositions comprising such analogues, and their uses as vanilloid receptor agonists and potent analgesics. The present invention provid...
11/05/2002
6448442Contrast media
The invention provides low viscosity iodinated aryl compounds, useful as X-ray contrast agents of formula I ##STR1## wherein n is 0 or 1, and where n is 1 each C6 R5 moiety may be the same or different; X denotes a bond or a group pr...
09/10/2002
6410775APL immunoreactive peptides, conjugates thereof and methods of treatment for APL antibody-mediated pathologies
aPL analogs that (a) bind specifically to B cells to which an aPL epitope binds and are disclosed. Optimized analogs lack T cell epitope(s) are useful as conjugates for treating aPL antibody-mediated diseases. Conjugates comprising aPL analogs and nonimmu...
06/25/2002
6380181Synthetic catechol derivatives, method for production and use thereof
Catechol derivatives of general formula (I) ##STR1## in which R1 denotes O-acyl and R2 represents amino acid residues in the 3- and/or 4-position function as siderophores and/or as biological chelating agents for iron in gram-negativ...
04/30/2002
6323359Process for preparing probucol derivatives
A method is described for the preparation of water-soluble derivatives of probucol compounds having the following formula ##STR1## where R1 and R2 are the same or different and are alkyl, alkenyl or aryl having from 1 to 8 carbon ato...
11/27/2001
6310243Iodinated x-ray contrast media
The invention provides low viscosity iodinated aryl compounds, useful as X-ray contrast agents, of formula C6 R6 wherein three non-adjacent R groups are iodine and the remaining R groups are non-ionic, hydrophilic moieties, said comp...
10/30/2001
6284918Selective inhibitors of prostaglandin endoperoxide synthase-2
The present invention provides a compound of the formula ##STR1## wherein when X is S; R is selected from the group consisting of CH3, CH2 CH3, CH2 Ph, (CH2)2 Ph, (CH2)2 ...
09/04/2001
6162933Process for the preparation of amido acid phenyl esters
A process for the preparation of amido acid phenyl esters of the formula ##STR1## by reaction of a compound of the formula ##STR2## with a compound of the formula ##STR3## in the presence of an acid halide, where A, R1, R2
12/19/2000
6066757Stilbene compound and process for producing same
A stilbene compound is disclosed which has the following general formula (I): ##STR1## wherein R1 and R2 each stand for hydrogen, an alkyl group or an acyl group and Ar1 and Ar2 each stand for a monovalent ...
05/23/2000
6040338N,n-bis(sulfonyl)hydrazines useful as antineoplastic agents
The present invention relates to a compound of the formula wherein R1 and R2 are selected from lower alkyl groups having 1-6 carbon atoms, substituted or unsubstituted aryl groups, and unsaturated alkyl groups having 1-6 carbon atoms...
03/21/2000
5993780Contrast media
The invention provides low viscosity iodinated aryl compounds, useful as X-ray contrast agents, of formula I ##STR1## (wherein n is 0 or 1, and where n is 1 each C6 R5 moeity may be the same or different; each group R is a hydro...
11/30/1999
5985927Medicaments for the selective treatment of tumor tissues
Medicinal products for the selective control of tumor tissue and a method for control of such tumor tissue by administration of such product to a host. The products comprise: (a) two different compounds having a pH below 7 when the compounds are present i...
11/16/1999
5985859Methods of inhibiting bacterial sialidase
A method of inhibiting bacterial sialidase comprising administering to a subject an inhibiting effective amount of a compound of formula I: ##STR1## wherein A is CO2 H, PO2 H, or SO2 H; B is N; R1 and R
11/16/1999
5973191Selective inhibitors of prostaglandin endoperoxide synthase-2
The present invention provides a compound of the formula ##STR1## wherein R is selected from the group consisting of CH3, CH2 CH3, (CH2)2 CH3, (CH2)3 CH3, ...
10/26/1999
5882628Contrast media
The invention provides low viscosity iodinated aryl compounds, useful as X-ray contrast agents, of formula I ##STR1## (wherein n is 0 or 1, and where n is 1 each C6 R5 moeity may be the same or different; each group R is a hydro...
03/16/1999
5811579Method of synthesizing a 2-substituted nitrogen-containing compound
The present invention relates to a method of synthesizing a 2-substituted nitrogen containing compound having a formula (I): ##STR1## by reacting a hydroxylamine of formula (II); ##STR2## or a nitrone of formula (III): ##STR3## with a ...
09/22/1998
5728588Coating of hydrophobic surfaces to render them protein resistant while permitting covalent attachment of specific ligands
A surface of specific reactivity is formed by adsorbing a modified block polymeric surfactant of the Pluronic-type, i.e., containing pendant poly(ethylene oxide) blocks attached at an end to poly(propylene oxide) center blocks and with specifically reacti...
03/17/1998
5723651Process for producing ଱-l-aspartyldipeptide amide derivatives
An economical process for producing ଱-L-aspartyldipeptide amide derivatives useful as sweeteners, by using amino protecting groups which can be removed by hydrolysis under acidic conditions, resulting in conversion of a ଲ-carboxyl acid ester t...
03/03/1998
5703073Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs
Nonsteroidal antiinflammatory drugs which have been substituted with a nitrogen monoxide group; compositions comprising (i) a nonsteroidal antiinflammatory drug, which can optionally be substituted with a nitrogen monoxide group and (ii) a compound that d...
12/30/1997
5681965Spin trapping compounds
Compositions containing as the active ingredient a spin-trapping reagent, preferably ଱-phenyl butyl nitrone (PBN) or spin-trapping derivatives thereof, in a suitable pharmaceutical carrier for administration to a patient are disclosed for treating o...
10/28/1997
5663308Organosilicon polymers, and dyes, exhibiting nonlinear optical response
Organosilicon polymers, including crosslinked polymers and crosslinkable prepolymers, of cyclic polysiloxane, organic dyes, and, optionally, polyenes. The dyes include those with delocalized Pi electron systems linking electron donor groups and electron a...
09/02/1997
5599990Process for preparing quaternary ammonium compounds
A quaternary ammonium halide is prepared by reacting a substituted or unsubstituted haloalkane with a tert-amine in a mol ratio not higher than 1.1/1 in the absence of a solvent and at a temperature such as to maintain the reaction mixture liquid....
02/04/1997
5587509Caged caboxyl compounds and use thereof
A method of releasing a caged carboxylic acid in which a 2-alkoxy-5-nitro-phenyl photosensitive group blocks a carboxyl function and the compositions so produced are disclosed....
12/24/1996
5565490P-hydroxyaniline derivatives, their preparation and their use
p-Hydroxyaniline derivatives of the formula I ##STR1## where the substituents have the following meanings: R1 is hydrogen, or unsubstituted or substituted alkyl; R2 and R3 independently of one another are halogen, alkyl, ...
10/15/1996
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