Class 560/134 - Ortho fused

Subclass of Class 560 - Organic compounds -- part of the class 532-570 series
Definition: Compounds wherein the carbocyclic groups are joined through
No. of patents: 85
Last issue date: 05/30/2006

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Number	Title	Issue Date
7052913	Matrices for drug delivery and methods for making and using the same In one aspect, biocompatible matrices such as sol-gels encapsulating a reaction center may be administered to a subject for conversion of prodrugs into biologically active agents. In certain embodiments, the biocompatible matrices of the present invention are sol-ge...	05/30/2006
6462222	Aminoindan derivatives This invention is directed to compounds of the following formula: ##STR1## wherein when a is 0, b is 1 or 2; when a is 1, b is 1, m is from 0-3, X is 0 or S, Y is halogeno, R1 is hydrogen C1-4 alkyl, R2 is hydrogen, C...	10/08/2002
6310248	Process and intermediates The invention relates to a process for the enantioselective preparation of tolterodine and analogues and salts thereof comprises the steps of: a) enantioselectively reducing the carbonyl function in a compound of formula (II): ##STR1## wherein R1	10/30/2001
5958971	Chemical compounds Prodrugs, of generic formula I, are disclosed for use in antibody directed enzyme prodrug therapy (ADEPT). The prodrugs are substrates for carboxypeptidase G2 (CPG2) and yield more active cytotoxic drugs than known products of CPG2 catalyzed reactions....	09/28/1999
5714148	Chemical compounds Prodrugs, of generic formula I, are disclosed for use in antibody directed enzyme prodrug therapy (ADEPT). The prodrugs are substrates for carboxypeptidase G2 (CPG2) and yield more active cytotoxic drugs than known products of CPG2 catalysed reactions....	02/03/1998
5660829	Process for antibody directed enzyme prodrug therapy Prodrugs, of generic formula I, are disclosed for use in antibody directed enzyme prodrug therapy (ADEPT). The prodrugs are substrates for carboxypeptidase G2 (CPG2) and yield more active cytotoxic drugs than known products of CPG2 catalysed reactions....	08/26/1997
5587161	Prodrugs for antibody directed enzyme prodrug therapy Prodrugs, of generic formula I, are disclosed for use in antibody directed enzyme prodrug therapy (ADEPT). The prodrugs substrates for carboxypeptidase G2 (CPG2) and yield more cytotoxic drugs than known products of CPG2 catalysed...	12/24/1996
5407956	2-amino-1,2,3,4-tetrahydronaphthalene derivatives active on the cardiovascular system, processes for their preparation and pharmaceutical compositions containing them Derivatives of 2-amino-1,2,3,4-tetrahydronaphthalene and their use in therapeutic field are described. The compounds are particularly useful in the treatment of arterial hypertension, cardiac decompensation and renal failure, in the treatment of periphera...	04/18/1995
5405990	Chemical compounds Prodrugs, of generic formula I, are disclosed for use in antibody directed enzyme prodrug therapy (ADEPT). The prodrugs are substrates for carboxypeptidase G2 (CPG2) and yield more active cytotoxic drugs than known products of CPG2 catalyzed reactions....	04/11/1995
5254715	Aminosulfonyl carbamates A compound of the following general formula which is useful in treating hypocholesterolemia and atherosclerosis: ##STR1## wherein X is oxygen or sulfur; R is hydrogen, alkyl having from 1 to 8 carbon atoms, or benzyl; R1 is phenyl, substit...	10/19/1993
5206417	Radiation-sensitive, ethylenically unsaturated copolymerizable compounds and their preparation The ethylenically unsaturated organic compounds are of the general formula ##STR1## where R is alkyl, aryl or a radical R1, and R1 is a radical ##STR2## where R2 to R6 are each H, alkyl, OH, Oalkyl, SH, Sal...	04/27/1993
5101063	Preparation of urethanes by carbonylation A process for preparation of urethanes by reacting an organic hydroxyl group-containing compound and carbon monoxide with a primary amine and oxygen in the presence of a non-noble metal or lanthanide metal catalyst system, particularly a cerium catalyst....	03/31/1992
5098999	Amino-protected dopa derivative and production thereof 3,4-Dihydroxyphenylalanine wherein the amino group is protected with a 9-fluorenylmethyloxycarbonyl group, or a derivative thereof can be produced by reacting 3,4-dihydroxyphenylalanine with a boron compound or phosphorus compound to stabilize the hydroxy...	03/24/1992
5066674	Carbamate inhibitors of cholesterol esterase and their use as hypolipidemic and hypocaloric agents Certain carbamate esters are used as inhibitors as cholesterol esterase and function as hypolipidemic and hypocaloric agents. The invention also relates to a method of decreasing the absorption of dietary cholesterol and fats through the wall of the intes...	11/19/1991
5066819	Process for the preparation of aryl esters of N-alkyl carbamic acids The invention relates to a process for the preparation of aryl esters of N-alkyl carbamic acids. The process comprises reacting an alkyl N-alkyl carbamate of the general formula: R1 --NH--COO--R3 wherein R1 and R3 ar...	11/19/1991
5021590	Process for producing N-alkyl-carbamates A process is provided for the preparation of N-alkyl-carbamates by directly reacting low-molecular weight alkyl-isocyanates, in particular methyl isocyanate, and a substituted phenolic precursor in solution in the presence of a basic catalyst compound sel...	06/04/1991
5008435	Preparation of urethanes Process for producing urethanes, by reacting an organic hydroxyl group containing compound and carbon monoxide, either (i) with an organic nitro group containing compound, e.g. nitrobenzene, or (ii) with a primary amine, e.g. aniline, and oxygen, the reac...	04/16/1991
4946863	CNS-affecting 6-oxy-3-aminomethyl indanes, compositions thereof, and method of treating therewith The present invention relates to 3-aminomethyl derivatives of indane, dihydrobenzofurane, dihydrobenzothiophene, and indoline, acid addition salts thereof, isomers thereof, methods of preparation, pharmaceutical compositions and method of treating CNS-dis...	08/07/1990
4939169	1,4-naphthalenediol and 1,4-hydroquinone derivatives Novel 1,4-naphthalenediol and 1,4-hydroquinone derivatives of formula I, II, III and IV and their therapeutic uses as 5-lipoxygenase inhibitors, leukotriene inhibitors, antiinflammatory and/or inhibitors of mucus secretion agents are described. Also provi...	07/03/1990
4925971	Method for producing aliphatic o-arylurethanes A method for producing aliphatic O-arylurethanes by the reaction of an aliphatic primary amine with an aromatic hydroxyl compound and urea. Ammonia produced as a by-product in the reaction is removed during the reaction so that the ammonia concentration o...	05/15/1990
4914124	N-organooxycarbamic acid esters for combating endoparasites A method of combating endoparasites which comprises applying thereto or to an endoparasite habitat an endoparasiticidally effective amount of an N-organooxycarbamic acid ester of the formula ##STR1## in which R1 represents alkyl, cycloalky...	04/03/1990
4786652	Naphthalene anti-psoriatic agents Psoriasis in mammals is relieved by topically administering naphthalenes of the formula: ##STR1## wherein: R1 is lower alkoxy or optionally substituted phenoxy, R2 is the same as R1, or R2 is hydrogen, lower alk...	11/22/1988
4782175	Urethanes composed of aliphatic fluoroalcohols, isocyanates and aromatic compounds, a process for their preparation and their use The molecule of the new urethanes contains an aliphatic fluoroalcohol, an isocyanate and an aromatic dihydroxy, diamino, aminohydroxy, aminocarboxy or hydroxycarboxy compound. They are prepared by reacting an aliphatic fluoroalcohol with a diisocyanate or...	11/01/1988
4758587	Naphthalene anti-psoriatic agents Psoriasis in mammals is relieved by topically administering naphthalenes of the formula: ##STR1## wherein: R1 is lower alkoxy or optionally substituted phenoxy; R2 is hydrogen, lower alkyl, optionally substituted phenyl or optio...	07/19/1988
4698438	Process for the preparation of methyl carbamates and thioimidates A continuous, close-coupled method for making N-methyl carbamate pesticides which comprises contacting the methyl isocyanate in a vapor phase mixture containing methyl isocyanate and water with a selected oxime or phenol, said mixture being the reaction p...	10/06/1987
4691048	Process for reducing carbonylation of aldehydes, uses as hemiacetalesters, catalyzed by cobalt carbonyl complexes The invention concerns a process for reducing carbonylation of an aldehyde wherein the aldehyde is used as hemiacetalester, the reaction being conducted in the presence of a catalyst consisting of a cobalt carbonyl complex. The hemiacetal-ester may be for...	09/01/1987
4668806	Process for preparing methylcarbamate insecticides Reacting an alkali metal cyanate salt with dimethyl sulfate in acetonitrile, heating in a steady stream of nitrogen and thereafter immediately bubbling the formed methyl isocyanate into a solution of an appropriate oxime or phenol to form an N-methylcarba...	05/26/1987
4659845	Process for the production of N-methylcarbamates Process for the production of N-methylcarbamates: ##STR1## (wherein RO- is the radical of a substituted phenol or of a naphthol), wherein: in a first reaction step methylamine and diphenyl carbonate are reacted with each other, operating in the liqui...	04/21/1987
4605667	Pesticidal water-soluble aminoacid sulfenylated carbamates Pesticidal water-soluble aminoacid sulfenylated carbamates useful as broad spectrum insecticides and miticides, particularly useful as systemic insecticides....	08/12/1986
4595769	Carbamate-sulfenyl-carbamoyl fluoride compounds Carbamate-sulfenyl-carbamoyl fluoride compounds are valuable insecticidal compositions and are also useful intermediates in the production of bis-carbamate compounds....	06/17/1986
4532256	Pesticidal N-methyl-carbamic acid esters N-Methyl-carbamic acid esters of the formula ##STR1## wherein R1 is unsubstituted or substituted 2,3-dihydrobenzofuranyl, phenyl, naphthyl or ##STR2## R2 is hydroxyl, halogen, --OR1, C1 -C10...	07/30/1985
4496584	Amidine derivatives with anti-complement activity Amidino compounds represented by the formula ##STR1## and pharmaceutically acceptable acid addition salts thereof are novel compounds and are useful as powerful antitrypsin, antiplasmin, antikallikrein and antithrombin agents. Having strong anti-Cl a...	01/29/1985
4491671	Process for the preparation of N-substituted imido-dicarboxylic acid diaryl esters The present invention relates to a process for the preparation of N-substituted imido-dicarboxylic acid diaryl ester compound of the formula wherein R1 is an optionally substituted aliphatic, cycloaliphatic, araliphatic, aromatic or heterocyclic rad...	01/01/1985
4474808	Pesticidally active novel N-sulphenylated biuret-N"-carboxylic acid esters N-Sulphenylated biuret-N"-carboxylic acid esters of the general formula ##STR1## in which R1 and R2 can be identical or different and represent an optionally substituted aliphatic, cycloaliphatic, aromatic or araliphatic radical...	10/02/1984
4451406	N-Substituted imido-dicarboxylic acid diaryl ester method of preparation Novel N-substituted imido-dicarboxylic acid diaryl ester compounds of the general formula ##STR1## in which R1 represents an optionally substituted aliphatic, cycloaliphatic, araliphatic, aromatic, heterocyclic radical and R2 an...	05/29/1984
4400389	Pesticidal symmetrical bis-sulfenylated-bis carbamate compounds Bis-sulfenylated bis-carbamate compounds exhibit activity against insect and mite pests....	08/23/1983
4399148	Hydroxyarylalkyleneaminoaryl carbamates and derivatives thereof useful as insecticidal compositions This invention relates to novel hydroxyarylalkyleneaminoaryl carbamate compounds and derivatives thereof and to their preparation. This invention is also directed to insecticidal compositions comprising an acceptable carrier and an insecticidally effectiv...	08/16/1983
4394383	N-Alkoxysulfenylcarbamates useful as insecticides A novel class of chemical compounds useful as pesticides consists of N-alkoxysulfenylcarbamate esters. The preparation of these compounds, their physical properties, formulations, and use to control both household insects and crop pests are exemplified....	07/19/1983
4390710	Catalyst system for manufacturing p-chlorophenyl-N-methyl carbamate Aromatic esters of carbamic acid derivatives, e.g., p-chlorophenyl-N-methyl carbamate, are prepared by reaction of the corresponding aromatic alcohol, e.g., p-chlorophenol, and monoisocyanate, e.g., methyl isocyanate, in the presence of a catalytic amount...	06/28/1983
4387058	Carbamic acid derivatives Novel phenyl and naphthyl esters of 2-(1-oxo-alkoxy)ethyl carbamic acids are prepared. The compounds are useful as pharmacological and agricultural agents....	06/07/1983

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Class 560/134 - Ortho fused