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| Number | Title | Issue Date |
| 8115027 | NPY Y5 antagonist The present invention provides a pharmaceutical composition for use as an NPY Y5 receptor antagonist comprising a compound or the formula (I): wherein R1 is lower alkyl, cycloalkyl or the... | 02/14/2012 |
| 8039661 | Thiophene-carboxamides useful as inhibitors of protein kinases The present invention relates to compounds useful as inhibitors of protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising said compounds and methods of using the compounds and compositions in the treatment of various diseas... | 10/18/2011 |
| 7897803 | Cis-alkoxy-substituted spirocyclic 1H-pyrrolidine-2,4-dione derivatives serving as pesticides The invention relates to a plurality of processes for the preparation of novel cis-alkoxy-substituted spirocyclic 1 H-pyrrolidine-2,4-dione derivatives of the formula (I) in which A, G, X and Y are as defined in the disclos... | 03/01/2011 |
| 7858820 | Solid compositions suitable for oral administration containing non-hygroscopic salts of L-carnitine and the alkanoyl L-carnitines with taurine chloride and glycine chloride Described herein are both non-hygroscopic salts of L-carnitine and alkanoyl L-carnitine with taurine chloride (2-aminoethane-sulphonic chloride) and non-hygroscopic salts of L-carnitine and alkanoyl L-carnitine with glycine chloride which lend themselves favorably t... | 12/28/2010 |
| 7732632 | Process for obtaining pure oseltamivir The present invention provides a process for obtaining highly pure crystalline form of oseltamivir free base, thus, for example, suspending or dissolving impure or non-crystalline oseltamivir free base in a hydrocarbon solvent and then isolating crystals to obtain o... | 06/08/2010 |
| 7687658 | Process for oseltamivir phosphate The present invention provides an improved and commercially viable process for the preparation of oseltamivir phosphate. Thus, for example, ethyl (3R,4R,5S)-4-amino-5-azido-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylate is acetylated with acetic anhydride in methyle... | 03/30/2010 |
| 7615661 | Thioester compounds and their use in fragrance or flavor applications The present invention relates to thioester compounds and the incorporation and use of the new chemical entities as flavor and fragrance chemicals. ... | 11/10/2009 |
| 7553987 | Synthesis of 3-(5-nitrocyclohex-1-enyl) acrylic acid and esters thereof This application discloses provides a process for the introduction of nitro-group functionality into a compound which contains also a site of unsaturation and/or oxygen functionality by direct (one step) oxidation of an oxime functional group mediated by a molybdenu... | 06/30/2009 |
| 7547800 | Process for trans-4-amino-1-cyclohexanecarboxylic acid derivatives A process for the preparation of Compound (I) comprising reacting Compound (II) with a base in an aprotic solvent, which is represented by the following scheme: wherein R1 and R2 are each independently... | 06/16/2009 |
| 7531687 | Preparation of oseltamivir phosphate The invention provides a new process for the conversion of shikimic acid to oseltamivir (I), and optionally to an acid addition salt, via the intermediate phosphoramide VII. ... | 05/12/2009 |
| 7459580 | Process for trans-4-amino-1-cyclohexanecarboxilic acid derivatives A process for the preparation of Compound (I) comprising reacting Compound (II) with a base in an aprotic solvent, which is represented by the following scheme: wherein R1 and R2 are each independently... | 12/02/2008 |
| 7375135 | Fatty acid derivatives; preparation and uses thereof The invention concerns novel molecules, their preparation and their uses, in particular in the field of human and veterinary medicine and cosmetics. The inventive compounds are partly fatty acid derivatives and exhibit advantageous pharmacological and cosmetic prope... | 05/20/2008 |
| 7358276 | 2-Oxo-1-pyrrolidine derivatives, processes for preparing them and their uses The invention concerns 2-oxo-1-pyrrolidine derivatives of formula I, wherein the substituents are as defined in the specification, as well as their use as pharmaceuticals. The compounds of the invention are particul... | 04/15/2008 |
| 7345196 | Convenient process of manufacture for difluoromethylornithine and related compounds A process for the manufacture of α-Difluoromethylornithine, analogs and derivatives is described from ornithine hydrochloride or from Nδ-phthaloyl ornithine hydrochloride, conversion to an alkyl ester, conversion to solid derivatives through the formati... | 03/18/2008 |
| 7314950 | Process for producing trans-4-amino-1-cyclohexanecarboxilic acid derivative A process for the preparation of Compound (I) comprising reacting Compound (II) with a base in an aprotic solvent, which is represented by the following scheme: wherein R1 and R2 are each in... | 01/01/2008 |
| 7301046 | Boronate esters The present invention relates to optically active boronate derivatives which are useful as intermediates for the synthesis of HMG-CoA enzyme inhibitors such as atorvastatin, cerivastatin rosuvastatin, pitavastatin, and fluvastatin. ... | 11/27/2007 |
| 7271283 | High refractive index, UV-curable monomers and coating compositions prepared therefrom Disclosed herein are high refractive index monomers that are curable by ultraviolet light. These monomers may be a component of curable compositions useful in the preparation of optical articles. Also disclosed is a method of synthesizing the monomers. ... | 09/18/2007 |
| 7265130 | NPY Y5 antagonist The present invention provides a pharmaceutical composition for use as an NPY Y5 receptor antagonist comprising a compound of the formula (I): wherein R1 is lower alkyl, cycloalkyl or the like, ... | 09/04/2007 |
| 7214813 | Preparation of chiral cyclic amino acids and derivatives Cyclic β-(acylamino)acrylate derivatives were hydrogenated using Ru-chiral phosphine ligand catalysts and thereafter converted to the corresponding cyclic β-aminoacids in high yield and enantioselectivity according to the reaction scheme: | 05/08/2007 |
| 7199141 | Drugs for chronic pains Nitro-oxyderivative compounds or salts thereof having the following general formula (I): A—(B)b0—(C)c0—NO2 wherein: c0 is an integer and is 0 or 1, b0 is an integer and is 0 or 1, A=R—T1—, wherein R is the radica... | 04/03/2007 |
| 7189760 | Physiological cooling compositions containing highly purified ethyl ester of N-[[5-methyl-2-(1-methylethyl) cyclohexyl] carbonyl]glycine The present invention provides, in one aspect, a substantially pure ethyl ester of N-[[5-methyl-2-(1-methylethyl)cyclohexyl]carbonyl]glycine. In another aspect, disclosed is a method for producing substantially pure ethyl ester of N-[[5-methyl-2-(1-methylethyl)cyclo... | 03/13/2007 |
| 7179934 | Amino acids with affinity for the α2δ-protein Certain β-amino acids that bind to the alpha-2-delta (α2δ) subunit of a calcium channel are disclosed. These compounds and their pharmaceutically acceptable salts are useful in the treatment of a variety of psychiatric, pain and other disorders. Also disclosed ar... | 02/20/2007 |
| 7144939 | Organic nucleating agents that impart very high impact resistance and other beneficial physical properties within polypropylene articles at very low effective amounts The use of organic based nucleating agents to induce certain specific polymer orientations into the molded polypropylene articles such that the resultant part has improved stiffness-impact properties without sacrificing other attributes of the polypropylene is provi... | 12/05/2006 |
| 7141695 | Methods for producing substituted acrylic acid esters and use of the latter for producing substituted γ-amino acids The invention relates to methods for producing substituted acrylic acid esters and to the use of the latter for producing substituted γ-amino acids, such as gabapentin and pregabalin. The substituted acrylic acid esters are produced by Wadsworth-Emmons olefination ... | 11/28/2006 |
| 7125950 | Polyol fatty acid polyesters process and polyurethanes therefrom A solvent-free process for making a polyol fatty acid polyester composition useful for preparation of polyurethanes is described. These compositions are preferably made by reaction of a natural oil (from plant or animal) with a multi-functional hydroxyl compound der... | 10/24/2006 |
| 7122684 | Process for preparing 1,2-diamino compounds The invention provides a multi-step process for preparing 1,2-diamino compounds of formula wherein R1, R1′, R2, R2′, R3 and R4 have the meanin... | 10/17/2006 |
| 7109383 | Fluorine-containing allyl ether compounds, their copolymers, and resist compositions and anti-reflection film materials using such copolymers The invention relates to a fluorine-containing allyl ether compound represented by the formula 1, wherein R represents an organic group containing at least one fluorine atom and an alicyclic structure. The invent... | 09/19/2006 |
| 7109370 | Substituted phenylketoenols The invention relates to novel phenyl-substituted cyclic ketoenols of the formula (I) in which A, B, G, X, Y, Z and W are each as defined in the description, to processes and intermediat... | 09/19/2006 |
| 7064231 | Optically active diamines and their use in catalytic processes The invention relates to stereoisomerically enriched diamines, to metal complexes comprising these diamines and also to their use in a process for asymmetrically reducing ketones using silanes, in particular polymethylhydrosiloxane, as reducing agents. ... | 06/20/2006 |
| 6960681 | Guanidinomethyl cyclohexane carboxylic acid ester derivatives The invention relates to novel and valuable intermediate compounds of the general formula (VIII) which can be used for the preparation of novel compounds comprising an antibacterial action, especially with a strong antibacterial action against helicobacter pylori... | 11/01/2005 |
| 6951955 | Process for the synthesis of intermediates useful for the synthesis of tubulin inhibitors The invention is a process for the preparation of compounds of the Formula I: where R1, R2, R3, R4 and R5 are defined in the specification, which are intermediates... | 10/04/2005 |
| 6946474 | Nitrogen-containing compounds and their use as glycine transport inhibitors The present invention provides trichloroethyl-sulfonylurea-containing compounds that inhibit glycing transporters, pharmaceutical compositions comprising such compounds, methods for using such compounds for inhibiting glycine transporters and methods for using such ... | 09/20/2005 |
| 6939986 | Process for preparing 1,2-diamino compounds The invention provides a multistep process for preparing 1,2-diamino compounds and pharmaceutically acceptable addition salts thereof from 1,2-epoxides. ... | 09/06/2005 |
| 6884821 | Carboxylic acid derivatives and drugs containing the same Novel carboxylic acid derivatives of general formula (I), salts of the same, esters thereof, or hydrates of them, which are useful as insulin resistance improvers; and drugs containing the derivatives as the active ingredient. In said formula, R1 is hydro... | 04/26/2005 |
| 6849756 | Process for making optically active α-amino ketones and selected novel optically active α-amino ketones The invention includes selected novel optically active α-amino ketones which either are themselves useful or are intermediates for the preparation of known ketomethylene pseudopeptides useful as antibiotics, antibiotic enhancers, or enzyme inhibitors. Further, the ... | 02/01/2005 |
| 6784310 | Methods for crystallization of N-(1(s)-ethoxycarbonyl-3-phenylpropyl)-L-alanine N-carboxyanhydride A crystallization is carried out by adding a solution of N-(1(S)-ethoxycarbonyl-3-phenylpropyl)-L-alanine N-carboxylic anhydride in a good solvent to an aliphatic hydrocarbon solvent while inhibiting the oil formation and scaling of said N-carboxylic anhydride. ... | 08/31/2004 |
| 6777573 | Method for the synthesis of ceralure B1 A method has been developed for the preparation of ceralure B1, a potent attractant for the Mediterranean fruit fly. The method utilizes trans-siglure acid as starting material to produce iodolactone which is subsequently reduced to lactone. The lactone is converted... | 08/17/2004 |
| 6770676 | Dicarboxylic acid derivatives The present invention relates to 2-amino-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid derivatives represented by the formula: the pharmaceutically acceptable salts thereof, or the hydrates thereof. The compounds of... | 08/03/2004 |
| 6753445 | Pleuromutilin derivatives having antibacterial activity A compound selected from 14—O—[(cycloalkyl-sulfanyl)acetyl]mutilins; 14—O—[(cycloalkyl-alkyl-sulfanyl)acetyl] mutilins; 14—O—[(cycloalkoxy)acetyl] mutilins; and 14—O—[(cycloalkyl-alkoxy)acetyl] mutilins and its use as a pharmaceutical. ... | 06/22/2004 |
| 6720400 | Process for the preparation of polyisocyanates with a biuret structure The present invention relates to an improved process for the continuous preparation of polyisocyanates with a biuret structure comprising the steps of continuously reacting excess amounts of organic diisocyanates having exclusively aliphatically and/or cycloaliphati... | 04/13/2004 |
