Did You Know...
...that in the early 1940s GE engineer James Wright was charged with a task of utmost importance to the war effort: develop a cheap substitute for rubber that could be used to produce tires, gas masks and a whole host of military gear. Wright tackled the task diligently -- and wound up inventing Silly Putty.
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| Number | Title | Issue Date |
| 8076502 | 2-amino-bicyclo(3.1.0) hexane-2,6-dicarboxylic ester derivative A drug effective for the treatment and prevention of psychiatric disorders such as schizophrenia, anxiety and related ailments thereof, depression, bipolar disorder and epilepsy. The drug antagonizes the action of group II metabotropic glutamate receptors and shows ... | 12/13/2011 |
| 7425644 | Method of purifying pravastatin The present invention provides pure pravastatin compositions and pure compactin compositions, and methods for the preparation thereof. ... | 09/16/2008 |
| 7261880 | Methods of treating Syndrome X with aliphatic polyamines The invention relates to a method for treating Syndrome X, or inhibiting the onset of symptoms of Syndrome X in a patient, and includes administering a therapeutically effective amount of a salt of at least one alkylated and cross-linked polymer, or a copolymer ther... | 08/28/2007 |
| 7157594 | 6-Fluorobicyclo[3.1.0]hexane derivatives An antidepressant comprising, as an active ingredient, a compound having an antagonistic effect on group II metabotropic glutamate receptors, as well as a 2-amino-3-alkoxy-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid derivative of Formula [I]: | 01/02/2007 |
| 7115640 | Heterocyclic modulators of nuclear receptors Compounds, compositions and methods for modulating the activity of nuclear receptors are provided. In particular, heterocyclic compounds are provided for modulating the activity of farnesoid X receptor (FXR), liver X receptor (LXR) and/or orphan nuclear receptors. I... | 10/03/2006 |
| 7078558 | Crystals of the sodium salt of pravastatin Lovastatin, pravastatin, simvastatin, mevastatin, atorvastatin, fluvastatin and cervastatin and derivatives and analogs thereof are known as HMG-CoA reductase inhibitors and are used as antihypercholesterolemic agents. The majority of them are produced by fermentati... | 07/18/2006 |
| 7071359 | Neuropathy improvers containing nitrogenous compounds as the active ingredient A compound represented by the Formula below, and an agent for the remedy of neural damage having the said compound as the active ingredient. [Here, G represents G1 shown below | 07/04/2006 |
| 7034180 | Method for crystallization of hydroxycarboxylic acids The invention aims at producing high-purity crystals of a hydroxycarboxylic acid represented by the following formula (1): in high yield. Provided are a method for crystallization of a compound (1) which compris... | 04/25/2006 |
| 7018818 | Intermediates in the preparation of therapeutic fused bicyclic amino acids The invention presents compounds of formula (I), where R represents H or a suitable carboxylic acid protecting group, which are intermediates in the preparation of therapeutic fused bicyclic amino acids. ... | 03/28/2006 |
| 6965026 | Nanoscale faceted polyhedra The subject invention pertains to nanoscale polyhedron-shaped molecules having molecular building blocks connected at their vertices. The subject invention also concerns methods of producing nanoscale polyhedrons utilizing a self-assembly reaction. The resultant mol... | 11/15/2005 |
| 6951844 | Phenyl naphthol ligands for thyroid hormone receptor New thyroid receptor ligands are provided which have the general formula I wherein R1 is halogen, trifluoromethyl, substituted or unsubstituted aryl, substituted or ... | 10/04/2005 |
| 6943017 | Method of producing antihypercholesterolemic agents A method of increasing the production of lovastatin or monacolin J in a lovastatin-producing or non-lovastatin-producing organism is disclosed. In one embodiment, the method comprises the steps of transforming an organism with the A. terreus D4B segment, wher... | 09/13/2005 |
| 6936731 | Pravastatin sodium substantially free of pravastatin lactone and epi-pravastatin, and compositions containing same The present invention provides pravastatin sodium substantially free of pravastatin lactone and epiprava, the C-6 epimer of pravastatin. The present invention further provides a novel process for recovering pravastatin sodium from a fermentation broth in such high p... | 08/30/2005 |
| 6875867 | Process for preparing chiral diol sulfones and dihydroxy acid HMG CoA reductase inhibitors A process is provided for preparing chiral diol sulfones of the structure where R3 is preferably where R4a is preferably aryl such as phenyl, and R | 04/05/2005 |
| 6770676 | Dicarboxylic acid derivatives The present invention relates to 2-amino-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid derivatives represented by the formula: the pharmaceutically acceptable salts thereof, or the hydrates thereof. The compounds of... | 08/03/2004 |
| 6756507 | Process for the preparation of sodium salts of statins A process for the preparation of sodium salts of statins, namely Compactin, Lovastatin and Pravastatin. ... | 06/29/2004 |
| 6746728 | Compound having tetrahydronaphthalene skeleton and liquid crystal composition containing same A tetrahydronaphthalene derivative represented by the general formula (I) and a liquid crystal composition containing the same. A compound represented by the general formula (I) shows superior liquid crystallinity and co... | 06/08/2004 |
| 6740775 | Crystalline sodium salt of pravastatin A crystalline form of the sodium salt of pravastatin, which is known by the chemical name 1-naphthaleneheptanoic acid, 1,2,6,7,8,8a-hexahydro-β, δ,6-trihydroxy-2-methyl-8-(2-methyl-1-oxobutoxy)-, mono sodium salt, which is useful as a pharmaceutical substance. A m... | 05/25/2004 |
| 6689590 | Process for recovering statin compounds from a fermentation broth A composition comprising pravastatin sodium substantially free of pravastatin lactone is described.... | 02/10/2004 |
| 6541515 | HIV integrase inhibitors Compounds useful in the inhibition of HIV integrase, the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination w... | 04/01/2003 |
| 6506929 | Process to manufacture simvastatin and intermediates A process is disclosed for the preparation of simvastatin which enables highly regio selective C-methylation of the 2'-position group of lovastatin without requiring protection/deprotection of 13-OH of lovastatin and lactone ring opening/closure.... | 01/14/2003 |
| 6444452 | Process for recovering statin compounds from a fermentation broth A novel process for recovering a compound from a fermentation broth that includes the stages of forming an enriched solution of the compound by extraction, obtaining a salt of the compound from the enriched solution, purifying a salt of the compound and t... | 09/03/2002 |
| 6392086 | Intermediates and process for producing fluorine-containing amino acid compound by using the same The present inventions relate to a (1S,5R,6S)- or (1SR, 5RS, 6SR)-3-fluoro-2-oxobicyclo[3.1.0]hex-3-ene-6-carboxylic acid derivative represented by Formula (1): ##STR1## [in the formula, R represents OR1 or NR1 R2, wherein... | 05/21/2002 |
| 6376700 | Alicyclic compound An alicyclic compound of the formula (1) is disclosed: ##STR1## wherein R1 and R2 each independently is a hydroxyl group, a C1-8 hydroxyalkyl group, or a C3-8 hydroxycycloalkyl group; R3, R4 | 04/23/2002 |
| 6369194 | Vicinyl tricarbonyl compounds and combinatorial libraries containing same The invention relates to compounds of formula ##STR1## where R is a structural diversity element selected from the group consisting of alkyl, cycloalkyl, aryl, heteroaryl, peptidyl, heteroatom-substituted alkyl, cycloalkyl, and amines; and Nu is a st... | 04/09/2002 |
| 6365382 | Biotechnological process for preparing hydroxylated ML-236B derivatives, known as M-4 and M-4', and analogues thereof The very effective conversion of ML-236B substances and derivatives thereof into 6'-hydroxylated products with the microorganisms of species Amycolatopsis orientalis, or with an extract or a hydroxylation-effective enzyme derived from said microorganism, ... | 04/02/2002 |
| 6333428 | 6-fluorobicyclo[3.1.0]hexane derivatives The present invention provides fluorobicyclo[3.1.0]hexane derivatives represented by the formula ##STR1## [wherein R1 and R2 are the same or different and each represents a hydrogen atom, a C1-10 alkyl group, a C3-8 | 12/25/2001 |
| 6326369 | Bicyclic quinone compounds, their production and use A compound of the formula: ##STR1## wherein R1 and R2 each represents a lower alkyl, or R1 and R2 may be bonded together to form a ring; X represents a spacer of which the number of atoms constituting the princi... | 12/04/2001 |
| 6316498 | Fluorine-containing amino acid derivatives Fluorine-containing amino acid derivatives represented general formula (I), pharmaceutically acceptable salts thereof or hydrates of the same, wherein X1 represents hydrogen or fluorine; and R1 and R2 are the same or diffe... | 11/13/2001 |
| 6306629 | Microorganism streptomyces exfoliatus yj-118 and a method for producing pravastatin sodium by using the strain The present invention is related to a new microorganism Streptomyces exfoliatus YJ-118 and a method for producing pravastatin sodium by using this microorganism which shows a strong tolerance to ML-236B and a high hydroxylation activity of ML-236B to prav... | 10/23/2001 |
| 6217793 | Acetylene compound, liquid crystal composition and liquid crystal element Provided are novel acetylene compounds which are useful as a component for a liquid crystal composition used for a liquid crystal element, a liquid crystal composition containing said compounds and a liquid crystal element using said liquid crystal compos... | 04/17/2001 |
| 6204292 | Bicyclic metabotropic glutamate receptor ligands The present invention provides bicyclic metabotropic glutamate receptor ligands, as well as compositions comprising such ligands, and and methods for their use.... | 03/20/2001 |
| 6177586 | Vitamin D3 derivative and production process thereof The starting materials for a production process of a vitamin D3 derivative are disclosed, e.g., a cyclopentene derivative represented by the formula (1-2): ##STR1## wherein R11 is a hydrogen atom, tri(C1 to C | 01/23/2001 |
| 6160009 | Excitatory amino acid receptor modulators Compounds of the formula ##STR1## in which R1 and R2 are as defined in the specification, and non-toxic metabolically labile ester and amides thereof are useful as modulators of metabotropic glutamate receptor function.... | 12/12/2000 |
| 6143783 | Excitatory amino acid receptor modulators The present invention relates to compounds of the formula ##STR1## in which R1 is defined in the specification, and non-toxic metabolically labile esters and amides thereof are useful as modulators of metabotropic glutamate receptor functi... | 11/07/2000 |
| 6118019 | 3-alkoxypropionic ester derivative A 3-alkoxypropionic ester derivative, an olefin polymerization solid catalyst component using the same, an olefin polymerization catalyst using the same, and a process for the preparation of a polyolefin using the same. The 3-alkoxypropionic ester derivat... | 09/12/2000 |
| 5958960 | Excitatory amino acid receptor modulators Compounds of the formula ##STR1## in which R1 and R2 are as defined in the specification, and non-toxic metabolically labile ester and amides thereof are useful as modulators of metabotropic glutamate receptor function.... | 09/28/1999 |
| 5925782 | Synthetic excitatory amino acids The present invention provides novel compounds that affect certain excitatory amino acid receptors, and are useful in the treatment of neurological disorders and psychiatric disorders.... | 07/20/1999 |
| 5916920 | 3-substituted Bicyclo3.1.0!hexane-6-carboxylic acids Compounds of the formula ##STR1## in which X represents a bond, S, O or NRa ; and R is as defined in the specification are useful as modulators of metabotropic glutamate receptor function.... | 06/29/1999 |
| 5834404 | Substituted bicycloheptanedione derivative and herbicide The present invention is directed to substituted bicycloheptanedion e derivatives represented by a general formula I!; ##STR1## wherein R represents C1 -C4 alkyl, R1 represents hydrogen, C1 -C10 | 11/10/1998 |
