Did You Know...
...that several people are credited with the invention of the flush toilet? Most people have heard of Thomas Crapper (1837-1910), the sanitary engineer who invented the valve-and-siphon arrangement that made the modern toilet possible. Another claimant to "the throne" was British inventor Alexander Cumming who patented a toilet in 1775. Then there's a nameless Minoan (a native of ancient Crete) who lived 4,000 years ago who supposedly was ahead of his time and created the first flush toilet!
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| Number | Title | Issue Date |
| 8173831 | Fatty acid acetylated salicylates and their uses The invention relates to Fatty Acid Acetylated Salicylate Derivatives; compositions comprising an effective amount of a Fatty Acid Acetylated Salicylate Derivative; and methods for treating or preventing an inflammatory disorder comprising the administration of an e... | 05/08/2012 |
| 8168623 | Prodrugs of GABA analogs, compositions and uses thereof The present invention provides prodrugs of GABA analogs, pharmaceutical compositions of prodrugs of GABA analogs and methods for making prodrugs of GABA analogs. The present invention also provides methods for using prodrugs of GABA analogs and methods for using pha... | 05/01/2012 |
| 8143437 | Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof The present invention provides a method for synthesizing 1-(acyloxy)-alkyl derivatives from 1-acyl-alkyl derivatives, which typically proceeds stereospecifically, in high yield, does not require the use of activated intermediates and/or toxic compounds and is readil... | 03/27/2012 |
| 8030513 | Rheology control agents The present invention provides for a rheology control agent that includes a following compound represented by the following formula: wherein A, B, C and D equal CH2, CHR, NH, or O, and A, B, C and D may be the sa... | 10/04/2011 |
| 7923574 | Prepolymers The invention relates to novel prepolymers which are accessible from the formamides of oligomeric di- or polyamines (formamide-terminated oligomers) and di- or polyisocyanates. ... | 04/12/2011 |
| 7790708 | Prodrugs of GABA analogs, compositions and uses thereof The present invention provides prodrugs of GABA analogs, pharmaceutical compositions of prodrugs of GABA analogs and methods for making prodrugs of GABA analogs. The present invention also provides methods for using prodrugs of GABA analogs and methods for using pha... | 09/07/2010 |
| 7777070 | Acyloxyalkyl carbamate prodrugs of tranexamic acid, methods of synthesis and use Acyloxyalkyl carbamate prodrugs of trans-4-(aminomethyl)-cyclohexanecarboxylic acid, pharmaceutical compositions thereof, methods of making prodrugs of trans-4-(aminomethyl)-cyclohexane-carboxylic acid, and methods of using prodrugs of trans-4-(aminomethyl)-cyclohex... | 08/17/2010 |
| 7745657 | D-homoandrosta-17-yl carbamate derivatives as selective glucocorticoid receptor ligands The present invention is directed to D-homoandrosta-17-yl-carbamate derivatives as selective glucocorticoid receptor ligands useful for treating a variety of autoimmune and inflammatory diseases or conditions. Pharmaceutical compositions and methods of use are also ... | 06/29/2010 |
| 7741510 | Rheology control agents The present invention provides for a rheology control agent that includes a following compound represented by the following formula: wherein A, B, C and D equal CH2, CHR, NH, or O, and A, B, C and D may be the sa... | 06/22/2010 |
| 7737295 | CETP inhibitors Compounds of Formula I, including pharmaceutically acceptable salts of the compounds, are CETP inhibitors, and are useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis. In the compounds of Formula 1, A1 | 06/15/2010 |
| 7595419 | Process and intermediates for the preparation of 3-(amino)-3-cyclobutylmethyl-2-hydroxy-propionamide or salts thereof In one embodiment, the present application relates to a process of making a compound of formula I: and to certain intermediate compounds that are made within the process of making the compound of formula I. ... | 09/29/2009 |
| 7585996 | Acyloxyalkyl carbamate prodrugs, methods of synthesis and use Acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphinic acid and analogs thereof, methods of making acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphinic acid and analogs thereof, methods of using acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphinic ac... | 09/08/2009 |
| 7423169 | Methods for synthesis of acyloxyalkyl derivatives of GABA analogs The synthesis of 1-(acyloxy)-alkyl carbamates of GABA analogs from 1-haloalkyl carbamates of GABA analogs are described. Also described are new 1-haloalkyl carbamates of GABA analogs. ... | 09/09/2008 |
| 7351740 | Acyloxyalkyl carbamate prodrugs of tranexamic acid, methods of synthesis and use Acyloxyalkyl carbamate prodrugs of trans-4-(aminomethyl)-cyclohexanecarboxylic acid, pharmaceutical compositions thereof, methods of making prodrugs of trans-4-(aminomethyl) -cyclohexane-carboxylic acid, and methods of using prodrugs of trans-4-(aminomethyl) -cycloh... | 04/01/2008 |
| 7339020 | High-functionality polyisocyanates High-functionality polyisocyanates are prepared by a process which comprises (i) preparation of an addition product (A) which contains one group which is reactive toward isocyanate and at least two isocyanate groups by reacting | 03/04/2008 |
| 7323532 | Low-viscosity radiation-curing and thermally curing polyisocyanates The present invention concerns a process for producing low-viscosity polyisocyanates or secondary products thereof, which carry activated, radiation-curable double bonds and can optionally also cure thermally, and low-viscosity polyisocyanate mixtures or secondary p... | 01/29/2008 |
| 7317122 | Curable trans-1,2-cyclohexane bis(urea-urethane) compounds Curable trans-1,2-cyclohexane bis(urea-urethane) compounds of the formulae wherein R1 and R′1 each, independently of the other, are alkylene, arylene, arylalkylene, or alkylarylene groups,... | 01/08/2008 |
| 7314949 | Trans-1,2-cyclohexane bis(urea-urethane) compounds Disclosed are trans-1,2-cyclohexane bis(urea-urethane) compounds of the formulae wherein R1 and R′1 each, independently of the other, is an alkylene group, an arylene group, an arylalkylen... | 01/01/2008 |
| 7307184 | Processes for preparing oxazolidinone derivatives of β-hydroxyethlamine compounds and for preparing β-hydroxyethlamine compounds The present invention provides a process of starting from N-alkoxycarbonyl-ethylamine compounds having a leaving group at the β-position to prepare oxazolidinone derivatives of β-hydroxyethylamine compounds having an inverted steric configuration at the β-positio... | 12/11/2007 |
| 7282605 | Optically active 2-allylcarboxylic acid derivative and process for producing the same The present invention provides a process for producing an optically active 2-allylcarboxylic acid derivative, which is useful as a pharmaceutical intermediate, from readily available and inexpensive starting materials by the process which can be practiced on a comme... | 10/16/2007 |
| 7238834 | Piperidine derivatives and process for their production The present invention relates to substantially pure piperidine derivative compounds of the formulae: wherein R1 is hydrogen or hydroxy; R2 | 07/03/2007 |
| 7232924 | Methods for synthesis of acyloxyalkyl derivatives of GABA analogs The synthesis of 1-(acyloxy)-alkyl carbamates of GABA analogs from 1-haloalkyl carbamates of GABA analogs are described. Also described are new 1-haloalkyl carbamates of GABA analogs. ... | 06/19/2007 |
| 7226991 | Phenylalanine derivatives Disclosed herein are phenylalanine derivative compounds of the following formula W—Y—(AA)n—Z wherein Y is a phenylalanyl radical, AA is an amino acid, n is an integer of 1 to 15, and substituent variables W and Z are as described... | 06/05/2007 |
| 7223882 | Process for producing triterpene derivative A process for a preparation of Compound (V), a pharmaceutically acceptable salt or a solvate thereof, said process comprising the steps represented by the following formula: wherein R1 and R2 | 05/29/2007 |
| 7220814 | Hydrophilicized blocked polyisocyanates The present invention relates to new hydrophilicized blocked polyisocyanates, a process for preparing them and their use. ... | 05/22/2007 |
| RE39616 | Aminoindan derivatives This invention is directed to compounds of the following formula: wherein when a is 0, b is 1 or 2; when a is 1, b is 1, m is from 0-3, X is O or S, Y is halogeno, R1 is hydrogen C1-4 alkyl, R2 is... | 05/08/2007 |
| 7214813 | Preparation of chiral cyclic amino acids and derivatives Cyclic β-(acylamino)acrylate derivatives were hydrogenated using Ru-chiral phosphine ligand catalysts and thereafter converted to the corresponding cyclic β-aminoacids in high yield and enantioselectivity according to the reaction scheme: | 05/08/2007 |
| 7186491 | Negatively charged coated electrographic toner particles Negatively charged coated toner particles are provided that comprise a plurality of polymeric binder particles that are substantially free of negatively charged pigment and a coating material comprising at least one negatively charged pigment coated on the outside s... | 03/06/2007 |
| 7186855 | Prodrugs of GABA analogs, compositions and uses thereof The present invention provides prodrugs of GABA analogs, pharmaceutical compositions of prodrugs of GABA analogs and methods for making prodrugs of GABA analogs. The present invention also provides methods for using prodrugs of GABA analogs and methods for using pha... | 03/06/2007 |
| 7183031 | Positively charged coated electrographic toner particles Positively charged coated toner particles are provided that comprise a plurality of polymeric binder particles that are substantially free of positively charged pigment and a coating material comprising at least one positively charged pigment coated on the outside s... | 02/27/2007 |
| 7183030 | Negatively charged coated electrographic toner particles and process Negatively charged coated toner particles are provided that comprise a polymeric binder particle and a coating material. The coating material comprises at least one visual enhancement additive coated on the outside surface of the polymeric binder particle. Electrogr... | 02/27/2007 |
| 7176201 | Modulation of anxiety through blockade of anandamide hydrolysis Fatty acid amide hydrolase inhibitors of the Formula: are provided wherein X is NH, CH2, O, or S; Q is O or S; Z is O or N; R is an aromatic moiety selected from the group consisting of substituted or ... | 02/13/2007 |
| 7166750 | Process for the preparation of 5-[(4-chlorophenyl)methyl]-2,2-dimethylcyclopentanone 5-[(4-chlorophenyl)methyl]-2,2-dimethylcyclopentanone is produced by reacting 1-[(4-chlorophenyl)methyl]-3-methyl-2-oxocyclopentanecarboxylic acid methyl ester or 1-[(4-chlorophenyl)methyl]-3-methyl-2-oxocyclopentanecarboxylic acid... | 01/23/2007 |
| 7166405 | Organosol including high Tg amphipathic copolymeric binder and liquid toners for electrophotographic applications The invention provides liquid toner compositions in which the polymeric binder is chemically grown in the form of copolymeric binder particles dispersed in a liquid carrier. The polymeric binder includes one amphipathic copolymer comprising one or more S material po... | 01/23/2007 |
| 7160907 | Pleuromutilin derivatives Pleuromutilin compounds of the formula: are of use in anti-bacterial therapy. ... | 01/09/2007 |
| 7141616 | Radically curable urethane prepolymers and their use in dental materials The invention relates to urethane prepolymers, obtainable by reaction of: (A) 15 to 85 wt.-% of one or more α,ω-terminated poly(meth)acrylate diols, (B) 0 to 30 wt.-% of one or more radically curable, polyhydroxy... | 11/28/2006 |
| 7135264 | Organosol including amphipathic copolymeric binder and use of the organosol to make dry toners for electrographic applications The present invention relates to amphipathic copolymeric binder particles chemically grown in a substantially nonaqueous liquid carrier to form an organosol. The invention also pertains to dry particulate electrographic toners incorporating an organosol comprising a... | 11/14/2006 |
| 7135128 | Polyurethane compositions with a low content of diisocyanate monomer(s) At least one isocyanate-reactive monomer is reacted with an excess of molten monomeric diisocynate to produce at least one reaction product and a maximum of 0.5 wt % of free isocyanate groups. The reaction product is then mixed with at least 20 wt. %, based on the t... | 11/14/2006 |
| 7129312 | Adhesion promoters for monomer-free reactive polyurethanes Polyurethane compositions are produced in a two-stage method. In a first step, a diol component with a molecular weight of less than 2000 is reacted with a monomeric diisocyanate with a molecular weight of less than 500 and the unreacted monomeric diisocyanate is re... | 10/31/2006 |
| 7105263 | Dry toner comprising encapsulated pigment, methods and uses Dry electrographic toner particles are provided that comprise at least one visual enhancement additive encapsulated within an amphipathic copolymer. The amphipathic copolymer comprises one or more S portions and one or more D portions. Methods of making and methods ... | 09/12/2006 |
